JOURNAL OF MEDICAL ENTOMOLOGY
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2018
·Vol. 55
·期 4
·787-794
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IF 1.968
Tian Jiaxin,Mao Jie,Yu Baoting,Fouad Hatem,Ga’al Hassan,Mao Guofeng,Mo Jianchu
Efforts to develop mosquito attractants using vertebrate host volatiles have been well made under laboratory conditions but their attractiveness to mosquitoes in the wild still needs to be evaluated. In the present study, we evaluated the attraction of female Culex pipiens pallens Coquillett (Diptera: Culicidae) to 11 individual chemical compounds found in vertebrate host odors, and to synthetic blends, consisting of different combinations of the compounds. These tests were conducted under laboratory and field conditions using a Y-tube olfactometer and odor-baited traps, respectively. When delivered at concentrations ranging from 0.1 to 10.0 μg/kg, 9 of the 11 compounds were attractive to female mosquitoes under laboratory conditions. We developed 47 synthetic blends composed of the 6 most attractive compounds (propionic acid, hexanal, myristic acid, benzaldehyde, 1-octen-3-ol, and geranyl acetone) and 18 of them were significantly attractive to mosquitoes in the olfactometer. Most of the attractive blends contained two to four attractive compounds. In the field, 5 of the 18 blends captured significantly more mosquitoes than did control traps. The findings demonstrate that female mosquitoes can be attracted by single chemical compounds as well as some of their synthetic blends. The effectiveness of synthetic blends depended on specific combinations of several compounds, rather than simply increasing the number of attractive compounds in the blends. Synthetic blends may have potential for use in odor-baited traps for mosquito surveillance.
研究领域:
昆虫学
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公共卫生
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病原生物学
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产品关联
DOI
PubMed
高影响因子
Cell Reports
·
2021
·
IF 9.423
Mengfei Wang,Yanpeng An,Li Gao,Shengzhang Dong,Xiaofeng Zhou,Yuebiao Feng,Penghua Wang,George Dimopoulos,Huiru Tang,Jingwen Wang
Summary Plant-nectar-derived sugar is the major energy source for mosquitoes, but its influence on vector competence for malaria parasites remains unclear. Here, we show that Plasmodium berghei infection of Anopheles stephensi results in global metabolome changes, with the most significant impact on glucose metabolism. Feeding on glucose or trehalose (the main hemolymph sugars) renders the mosquito more susceptible to Plasmodium infection by alkalizing the mosquito midgut. The glucose/trehalose diets promote proliferation of a commensal bacterium, Asaia bogorensis , that remodels glucose metabolism in a way that increases midgut pH, thereby promoting Plasmodium gametogenesis. We also demonstrate that the sugar composition from different natural plant nectars influences A. bogorensis growth, resulting in a greater permissiveness to Plasmodium . Altogether, our results demonstrate that dietary glucose is an important determinant of mosquito vector competency for Plasmodium, further highlighting a key role for mosquito-microbiota interactions in regulating the development of the malaria parasite.
研究领域:
疟疾生物学
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微生物学
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传染病学
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代谢组学
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昆虫学
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DOI
PubMed
高影响因子
ADVANCED MATERIALS
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2022
·Vol. 34
·期 17
·2109126
·
IF 32.086
Neng Xia,Bowen Jin,Dongdong Jin,Zhengxin Yang,Chengfeng Pan,Qianqian Wang,Fengtong Ji,Veronica Iacovacci,Carmel Majidi,Yang Ding,Li Zhang
The efficient motility of invertebrates helps them survive under evolutionary pressures. Reconstructing the locomotion of invertebrates and decoupling the influence of individual basic motion are crucial for understanding their underlying mechanisms, which, however, generally remain a challenge due to the complexity of locomotion gaits. Herein, a magnetic soft robot to reproduce midge larva's key natural swimming gaits is developed, and the coupling effect between body curling and rotation on motility is investigated. Through the authors’ systematically decoupling studies using programmed magnetic field inputs, the soft robot (named LarvaBot) experiences various coupled gaits, including biomimetic side-to-side flexures, and unveils that the optimal rotation amplitude and the synchronization of curling and rotation greatly enhance its motility. The LarvaBot achieves fast locomotion and upstream capability at the moderate Reynolds number regime. The soft robotics-based platform provides new insight to decouple complex biological locomotion, and design programmed swimming gaits for the fast locomotion of soft-bodied swimmers.
研究领域:
生物力学
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机器人学
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生物物理学
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软物质物理
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微流控
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产品关联
DOI
PubMed
高影响因子
PLoS One
·
2020
·Vol. 15
·期 4
·e0226471
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IF 2.74
Yuping Gou,Peter Quandahor,Yanxia Zhang,Jeffrey A. Coulter,Changzhong Liu
The chive maggot Bradysia cellarum and the fungus gnat B . impatiens are two primary root pests of plants, which can coexist on the same host plants and are the devastating pests on liliaceous crops and edible fungi. Their growth and development are affected by the nutrient contents of their host plants. In this study, we assessed the effects of different host plant nutrients on the nutrient contents of these two Bradysia species. The nutrients of the chive ( Allium tuberosum Rottl. ex Spreng.), board bean ( Vicia faba L.), lettuce ( Lactuca sativa L. var. ramosa Hort.), cabbage ( Brassica oleracea L.), wild cabbage ( Brassica oleracea var. capitata rubra) and pepper ( Capsicum annuum L.) roots were determined, and their effect on nutrient content of the two Bradysia species after feeding on the host plant for three continuous generations were evaluated. The results show that chive and B-bean contained higher levels of protein, free amino acid, soluble sugar and starch than others. As a result, the soluble sugar, fat and protein contents were significantly higher in both Bradysia species reared on chive and B-bean than on cabbage, lettuce, W-cabbage and pepper, suggesting nutritional preference of these insects. Based on our results, we concluded that the two Bradysia species displayed nutrient preference toward chive and B-bean, which provides a reference for understanding their host plant range and for control of the insect species via field crop rotations.
研究领域:
昆虫学
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植物科学
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农业害虫管理
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DOI
PubMed
高影响因子
Insects
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2022
·Vol. 13
·期 12
·1077
·
IF 3.139
Weifeng Wu,Yu Yang,Yingmiao Feng,Xiaofei Ren,Yuling Li,Wenjiao Li,Jietong Huang,Lingjia Kong,Xiaole Chen,Zhongze Lin,Xiaohui Hou,Longlai Zhang,Yajie Chen,Zhaojun Sheng,Weiqian Hong
Simple SummaryDue to the environment and human health concerns of synthetic repellents, essential oils (EOs) as natural alternatives have received increased attention. In this study, the repellent activity of 60 commercial EOs againstAedes albopictuswas evaluated. In the initial screening, 8 active EOs including cinnamon, marjoram, lemongrass, bay, chamomile, jasmine, peppermint2, and thyme were selected. Twenty-one major constituents (>5% relative area) in the 8 active EOs were identified via gas chromatography-mass spectrometry (GC-MS) analysis. Cinnamaldehyde, citral and terpinene-4-ol displayed the highest repellent activity with more than 60% RR, which were more active thanN,N-diethyl-3-methyl benzoyl amide (DEET). Next, their nanoemulsions were prepared and characterized. In the arm-in-cage assay, cinnamaldehyde- and citral-based nanoemulsions have prolonged mosquito protection time compared with their normal solutions.AbstractMosquitoes are one of the most important disease vectors from a medical viewpoint in that they transmit several diseases such as malaria, filariasis, yellow and Dengue fever. Mosquito vector control and personal protection from mosquito bites are currently the most efficient ways to prevent these diseases. Several synthetic repellents such as DEET, ethyl butylacetylaminopropionate (IR3535) and 1-(1-methylpropoxycarbonyl)-2-(2-hydroxyethyl)piperidine) (Picaridin), have been widely used to prevent humans from receiving mosquito bites. However, the use of synthetic repellents has raised several environment and health concerns. Therefore, essential oils (EOs) as natural alternatives receive our attention. In order to discover highly effective mosquito repellents from natural sources, the repellent activity of 60 commercial EOs againstAe. albopictuswas screened in this study. Eight EOs including cinnamon, marjoram, lemongrass, bay, chamomile, jasmine, peppermint2, and thyme, showed a suitable repellent rate (>40%) at the tested dose of 10 μg/cm2. Then, their main constituents were analyzed by GC-MS, and the active constituents were identified. The most active compounds including cinnamaldehyde, citral and terpinen-4-ol, exhibited an 82%, 65% and 60% repellent rate, respectively. Moreover, the nanoemulsions of the three active compounds were prepared and characterized. In the arm-in-cage assay, the protection times of the nanoemulsions of cinnamaldehyde and citral were significantly extended compared with their normal solutions. This study provides several lead compounds to develop new mosquito repellents, and it suggests that nanoemulsification is an effective method for improving the duration of the activity of natural repellents.
研究领域:
昆虫学
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药学
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纳米技术
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天然产物化学
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DOI
高影响因子
GREEN CHEMISTRY
·
2024
·
IF 9.3
Qin Li,Changhong Wang,Jiayuan He,Dandan Yang,Ting Li,Huixian Xu,Weifeng Shen,Lian-Di Zhou,Saimeng Jin,Qi-Hui Zhang,James H. Clark
Pyrethrin are effective agents against mosquito larval but their rapid degradation rate in water reduces the deinsectization efficiency and increases the cost of deinsectization. Based on liquid marble,a biodegradable slow-release hydrogel carrier is prepared using green and low-cost materials for the slow release of natural pyrethrin on water surfaces to kill mosquito larvae. Green carriers with high stability and loading of high concentrations of pyrethrin are synthesized by cross-linking Ca2+ in 5% CaCl2 solution with sodium alginate. The superior stability of liquid marble at the water surface and the electrostatic interaction between alginate and gelatin can effectively reduce the degradation rate of pyrethrin in water. Furthermore, the carrier system displayed long sustained-release time (>144 h) and maintained larvicidal performance after 168 h. Good floating stability is demonstrated for the liquid marble hydrogels. The larvicidal activity of obtained drug carrier reached 100% with different water volume but same dosage. This work provides a strategy to highly efficiently exterminate mosquito larvae by preparing a green hydrogel drug slow-release carrier, which provides a new approach to expanding the application of liquid marbles in green chemistry.
研究领域:
环境科学
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材料科学
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害虫管理
✓ 已验证
产品关联
DOI
高影响因子
Journal of Advanced Research
·
2024
·
IF 11.4
Xuequan Liu,Xuequan Sun,Hongyu Zhu,Rubing Yan,Chang Xu,Fangxing Zhu,Ruijie Xu,Jing Xia,He Dong,Bingcheng Yi,Qihui Zhou
Introduction One of the methods for pain management involves the use of local anesthesia, which numbs sensations in specific body regions while maintaining consciousness. Objectives Considering the certain limitations (e.g., pain, the requirement of skilled professionals, or slow passive diffusion) of conventional delivery methods of local anesthetics, developing alternative strategies that offer minimally invasive yet therapeutically effective delivery systems is of great concern for ophthalmic regional anesthesia. Methods and results In this study, a rapidly dissolving cambered microneedle (MNs) patch, composed of poly(vinylpyrrolidone) (PVP) and hyaluronic acid (HA) and served as a delivery system for lidocaine (Lido) in local anesthesia, was developed taking inspiration from the mosquito proboscis’s ability to extract blood unnoticed. The lidocaine-containing MNs patch (MNs@Lido) consisted of 25 microneedles with a four-pronged cone structure (height: 500 μm, base width: 275 μm), arranged in a concentric circle pattern on the patch, and displays excellent dissolubility for effective drug delivery of Lido. After confirming good cytocompatibility, MNs@Lido was found to possess adequate rigidity to penetrate the cornea without causing any subsequent injury, and the created corneal pinhole channels completely self-healed within 24 h. Interestingly, MNs@Lido exhibited effective analgesic effects for local anesthesia on both heel skin and eyeball, with the sustained anesthetic effect lasting for at least 30 min. Conclusions These findings indicate that the mosquito proboscis-inspired cambered MNs patch provides rapid and painless local anesthesia, overcoming the limitations of conventional delivery methods of local anesthetics, thus opening up new possibilities in the treatment of ophthalmic diseases.
研究领域:
药学
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生物医学工程
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眼科学
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药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）