MOLECULES
·
2016
·Vol. 21
·期 3
·299
·
IF 2.465
Bo Jin,Rongzong Zheng,Rufang Peng,Shijin Chu
Five new bis(3-hydroxy-4-pyridinone) tetradentate chelators were synthesized in this study. The structures of these tetradentate chelators were characterized by1H-NMR,13C-NMR, FT-IR, UV-vis, and mass spectral analyses. The binding abilities of these tetradentate chelators for uranyl ion at pH 7.4 were also determined by UV spectrophotometry in aqueous media. Results showed that the efficiencies of these chelating agents are dependent on the linker length. Ligand4bis the best chelator and suitable for further studies.Keywords:chelating agent;3-hydroxy-4-pyridinone;uranium;tetradentate chelator
研究领域:
化学
·
环境科学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF PHARMACEUTICAL SCIENCES
·
2024
·
IF 3.7
Yuanfeng Wei,Xin Chen,Runxue Ding,Jingwen Zhang,Hui Chen,Junxiao Zhu,Jianjun Zhang,Peiya Shen
Different from salt, metal chelate is a novel state of drug constructed by more separate coordinate bonds to form a chelating circle. Due to their composition similarity, it is hard to distinguish them except identifying ionic bond (i.e., salt) or coordinate bond (i.e., chelate) in the single crystal structure. In this study, sodium chelate (CDCC No: 1865670) and lithium salt (CDCC No: 2161617) of puerarin (PUE) was prepared. In addition to difference in single crystal structure, it was found that they showed totally different phase solubility behaviors: lithium salt demonstrated a typical inverse proportion curve as other common salts, while sodium chelate exhibited disordered scatters. However, when incorporating the unit PUE-Na complex in solution state and complexation constant K 11 in chemical equation, the scatters in phase solubility diagram of chelate could be well fitted and the value of K 11 was dramatically higher with orders of magnitude than the dissociation constant K c ; while processing phase solubility curve of lithium salt by incorporating complex item, it could not well match the curve at all. PUE sodium chelate is more likely to be a weak electrolyte with partial dissociation, while PUE lithium salt acted as a strong electrolyte with complete dissociation. The phase solubility test would be served as a surrogate tool for differentiation of chelates from salts when single crystal was not available.
研究领域:
药学
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2016
·
IF 2.653
Huan Wu,Yanmei Zhao,Xuanping Tan,Xiaoqing Zeng,Yuan Guo,Jidong Yang
A convenient fluorescence quenching method for determination of Quizalofop-p-ethyl(Qpe) was proposed in this paper. Eosin Y(EY) is a red dye with strong green fluorescence (λex/λem = 519/540 nm). The interaction between EY, Pd(II) and Qpe was investigated by fluorescence spectroscopy, resonance Rayleigh scattering(RRS) and UV–Vis absorption. Based on changes in spectrum, Pd(II) associated with Qpe giving a positively charged chelate firstly, then reacted with EY through electrostatic and hydrophobic interaction formed ternary chelate could be demonstrated. Under optimum conditions, the fluorescence intensity of EY could be quenched by Qpe in the presence of Pd(II) and the RRS intensity had a remarkable enhancement, which was directly proportional to the Qpe concentration within a certain concentration range, respectively. Based on the fluorescence quenching of EY-Pd(II) system by Qpe, a novel, convenient and specific method for Qpe determination was developed. To our knowledge, this is the first fluorescence method for determination of Qpe was reported. The detection limit for Qpe was 20.3 ng/mL and the quantitative determination range was 0.04–1.0 μg/mL. The method was highly sensitive and had larger detection range compared to other methods. The influence of coexisting substances was investigated with good anti -interference ability. The new analytical method has been applied to determine of Qpe in real samples with satisfactory results.
研究领域:
分析化学
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环境科学
✓ 已验证
DOI
高影响因子
BIOMATERIALS
·
2025
·
IF 12.9
Yuping Zhang,Jianqi Deng,Mingbin Lang,Gang Shu,Jinbin Pan,Cai Zhang,Ran Cheng,Shao-Kai Sun
High atomic number elements-based X-ray computed tomography (CT) contrast agents offer a promising solution to address the inherent deficiencies of FDA-approved iodine contrast agents. However, they face substantial challenges in balancing imaging performance, safety, and large-scale production for clinical translation. Herein, inspired by the history of clinical gadolinium- and iodine-based contrast agents, we report a large-scale approach for synthesizing non-ionic bismuth (Bi) chelate for high-performance CT imaging in vivo . Bi-HPDO3A can be easily obtained from low-cost precursor within 4 steps at 6 g-scale. The non-ionic macrocyclic structure endows it with low osmolality, low viscosity, high stability, good renal clearable capability and biocompatibility. Additionally, Bi-HPDO3A realizes superior imaging performance across various in vivo applications, including gastrointestinal imaging, renal imaging, and computed tomography angiography (CTA). Especially, Bi-HPDO3A exhibits superior spectral imaging capability owing to the high K-edge of element Bi, achieving metal artifact-free CTA in vivo . The proposed Bi-HPDO3A that balances overall performance can serve as a high-performance CT contrast agent with potential for clinical translation.
研究领域:
医学影像学
·
放射医学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
·
2011
·
IF 2.234
Zhenhu Cao,Yan Zhang,Pingan Song,Yuanzheng Cai,Qi Guo,Zhengping Fang,Mao Peng
A novel metal chelate complex containing phosphorus, nitrogen and zinc (II) ion was synthesized and used as the flame retardant of low density polyethylene (LDPE). The zinc chelate complex was synthesized by reacting zinc acetate with the ligand of tetraethyl (1,2-phenylenebis(azanediyl)) bis (2-hydroxylphenylmethylene) diphosphonate (TEPAPM). The chemical structure of the target Zn-TEPAPM was confirmed by FTIR, 1 H NMR, 13 C NMR and 31 P NMR spectra. The flame retardancy and thermal behavior of LDPE containing various amount of Zn-TEPAPM were investigated by limiting oxygen index test, thermogravimetric (TG) analysis and cone calorimetry . The results show that Zn-TEPAPM can greatly increase the thermal stability, the char formation and smoke suppression ability of LDPE. The TG curves show that even when the filler content of Zn-TEPAPM is as low as 1 wt% in LDPE, the onset degradation temperature of LDPE is increased from 429 °C to 442 °C, and the maximum degradation temperature is increased from 469 °C to 488 °C. Also, a reduction of 32% for the peak heat release rate (PHRR) is obtained in the cone test. Moreover, Zn-TEPAPM is demonstrated to be a very effective synergist of ammonium polyphosphate (APP). When 1 wt% of Zn-TEPAPM was introduced into the LDPE/APP (mass ratio 80/19) blend, the PHRR value is reduced by 32%, compared with that of LDPE/APP blend without Zn-TEPAPM, and the char layer becomes more compact and intact.
研究领域:
高分子化学
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材料科学
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阻燃技术
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化学工程
✓ 已验证
DOI
高影响因子
Inorganic Chemistry Frontiers
·
2024
·Vol. 11
·期 11
·3168-3177
·
IF 6.1
Qi Zhang,Ruibing Lv,Ying Wang,Zhenghang Luo,Pengyang Pan,Tingwei Wang,Quancheng Liu
Laser-sensitive primary explosives (LSPEs) have long been a focus of attention as the material foundation for safer and more efficient laser-initiation technology. However, LSPEs often have poor safety due to their structural characteristics, which greatly limits the development and application of laser initiating technology. In this work, we introduced the concept of multidentate chelates into LSPEs and innovatively propose the concept of energetic quadridentate chelates. To achieve this highly creative idea, we synthesized an energetic flexible chelating ligand, namely, 1,2-bis(3-nitroamino-1,2,4-triazol-5-yl)ethane (BNATE), and prepared a novel metal quadridentate chelate, namely, [Cu(BNATE)·2H2O] (1), by chelating it with Cu2+. Through a series of tests, including X-ray single-crystal diffraction analysis, thermogravimetric analysis, and differential scanning calorimetry (TG-DSC), and evaluation of the safety and detonation performance, it was proven that this compound adhered to the high stability characteristics of the chelate, and its safety and detonation performance were superior to previous LSPEs. Moreover, through laser-initiation experiments, it was determined that the compound had excellent photosensitivity and a lower laser-initiation threshold. To explain the reason why the chelate structure is specifically sensitive to a laser, diffuse reflection ultraviolet and TD-DFT simulations were conducted, which not only demonstrated experimentally that chelation had a good enhancement effect on the laser photosensitivity but also confirmed the mode of electron transfer in the quadridentate chelate structure.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2010
·
IF 1.566
Hongqi Chen,Cailing Zhou,Lun Wang,Jingguo Chen,Bo Ling,Jie Fu
The sensitized fluorescence intensity of the terbium (III) ion can be notably enhanced in the presence of sodium hexametaphosphate (SHMP). Based on this, water-soluble Tb-SHMP chelate complexes were synthesized in aqueous solutions, and characterized by spectrofluorometry. 6-Mercapto-5-triazole[4,3-b]-S-tetrazine was generated by the quantitative reaction of HCHO with 4-amino-3-hydrazino-5-mercapto-1,2,4-triazole under alkaline conditions at room temperature . The spectral overlap between the emission of Tb-SHMP chelate complexes and absorption of 6-mercapto-5-triazole[4,3-b]-S-tetrazine meets the prerequisite for fluorescence energy transfer . Based on this, a novel efficient fluorescence energy transfer system between Tb-SHMP chelate complexes as donor and 6-mercapto-5-triazole[4,3-b]-S-tetrazine as acceptor was developed for the determination of HCHO in aqueous solutions. Under the optimal experimental conditions, this method is capable of detecting HCHO concentrations from 2.06 × 10 −5 to 6.18 × 10 −3 mg mL −1 and the limit of detection was 7.11 × 10 −6 mg mL −1 . Compared with other general methods for the determination of HCHO, the proposed method improved the sensitivity and selectivity. Moreover, the proposed method was successfully applied to the determination of HCHO in water samples.
研究领域:
分析化学
·
环境科学
✓ 已验证
DOI
高影响因子
Asian Journal of Pharmaceutical Sciences
·
2025
·
IF 11.9
Haiqing Zhong,Xufang Ying,Xiaoyan Bao,Linjie Wu,Yiying Lu,Qi Dai,Qiyao Yang,Xin Tan,Donghang Xu,Jianqing Gao,Min Han
An increasing number of studies have focused on depleting lactate and modulating the tumor lactic microenvironment to interfere with tumor progression, particularly in breast cancer. Lactate accumulation in tumors contributes to a highly acidic microenvironment that promotes cancer cell survival and resistance to therapies. However, existing lactate depletion agents, primarily enzymes and macromolecules, fall short of clinical applications in terms of poor stability and solitary lactate depletion without interfering with the transport process. Consequently, the development of stable molecules that deplete lactate and interfere with lactate transport is critically needed. Therefore, in this study, chlorin e6 (Ce6)-gadolinium chloride-flavin adenine dinucleotide (FAD)/tamoxifen molecular chelates were prepared. The chelates fully interfered with lactate transport, depleted lactate in the tumor microenvironment, mitigated photodynamic therapy resistance, and realized synergistic photodynamic-hormonal therapy. FAD has promising capabilities in regulating lactate levels and mitigating acidic microenvironments. However, a strategy for depleting lactate by chelating the coenzyme FAD to form nanoparticles has not yet been reported. Tamoxifen disrupts tumor development and interferes with lactate transport by binding to estrogen receptor and inhibiting the expression of monocarboxylate transporter expression. In addition, coupling with Gd 3+ increased the solubility of Ce6, thus improving the photodynamic therapy effectiveness. This innovative strategy improves therapeutic efficacy and offers a promising approach for breast cancer treatment by improving therapeutic efficacy.
研究领域:
肿瘤学
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生物化学
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医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Pharmaceuticals
·
2024
·Vol. 17
·期 12
·1717
·
IF 4.3
Olga Yu. Selyutina,Maya A. Ul’yanova,Olga A. Chinak,Viktor A. Timoshnikov,Lidiya G. Fedenok,Alexander A. Stepanov,Vadim V. Yanshole,Leonid V. Kulik,Sergey F. Vasilevsky,Nikolay E. Polyakov,George J. Kontoghiorghes
Background/Objectives:Some specific anthraquinone derivatives (AQs) are known to be used widely as effective chemotherapeutic agents in the treatment of cancer. However, their fundamental shortcoming is the high rate of cardiotoxicity observed in treated patients, which is thought to be caused by the increase in production of reactive oxygen species (ROS) catalyzed by iron and copper. The development of improved AQs and other anticancer drugs with enhanced efficacy but reduced toxicity remains a high priority. The aim of this study was to evaluate the cytotoxic and ROS production effects of chelate iron and copper complexes of two novel AQs, namely 4-hydroxynaphto[2,3-h]cinnoline-7,12-dione (Q2) and 3-(hydroxymethyl)naphto[2,3-h]cinnoline-4,7,12(1H)-trione (Q3).Methods: The chelation ability of Q2 and Q3 was studied using NMR and UV–Vis spectroscopy. Cytotoxicity studies were carried out using the MTT assay. The influence of chelation on ROS production was studied using NMR spectroscopy in linoleic acid micelles.Results: It was found that only Q3 forms complexes with Fe(III) and Cu(II) ions, whereas Q2 does not demonstrate chelating properties. A cytotoxicity study revealed that Fe[Q3]3significantly decreased the viability of lung cancer A549 cells, while Q3 and Cu[Q3]2did not demonstrate cytotoxic properties in this cell line. Furthermore, the presence of Q3 lowered the rate of iron-induced lipid peroxidation in linoleic acid micelles. By contrast, Q2 did not influence the rate of lipid peroxidation, probably due to the absence of effective metal chelating ability.Conclusions:The high cytotoxic effects observed with the iron complex of Q3 against cancer cells in combination with a reduced rate of iron induced lipid peroxidation in the presence of Q3, make Q3 and its iron complex promising for further evaluation and use as chemotherapeutic agents in cancer.
研究领域:
药理学
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肿瘤学
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
·
2024
·
IF 2.6
Shuaishuai Wei,Jiaying Huo,Jia Lin,Ziwei Zhang,Shijian Dong,Lulu Ma,Shugang Li
Summary In this study, a method to produce iron-chelating peptides derived from egg yolk proteins was developed and optimised. The egg yolk proteins were enzymolysed and ultrafiltered to prepare egg yolk peptide (EYP), and then the EYP was chelated with Fe to produce egg yolk peptide-Fe (EYP-Fe). The optimised mass ratio of peptide to iron, pH, temperature and reaction time were found at 8:1, pH 8.0, 40 °C and 30 min, respectively. The mean particle size of EYP-Fe was 389.2 ± 2.61 nm, and the chelating ratio was 95.38 ± 1.93%. The measurements of FTIR, X-ray photoelectron spectroscopy (XPS) and NMR showed that ferrous ions mainly combined with the amino and carboxyl of EYP to form EYP-Fe. In vitro stability studies have shown that the iron release rate of the EYP-Fe is maintained at around 5% under alkaline conditions, and there is no significant difference in iron release rate under conditions of 30 °C–80 °C; besides, it has a lower iron release rate (18%) in gastrointestinal digestion compared to FeSO 4 (97.93%), indicating that the EYP-Fe has good heat tolerance, alkalinity and digestion tolerance. The above results provide a scientific basis for the use of EYP-Fe derived from egg yolk protein as a potential alternative to iron supplements.
研究领域:
食品科学
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营养学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Food Measurement and Characterization
·
2025
·
IF 3.3
Pan Xiaoya,Wang Hongyue,Guo Keshuang,Zhang Tong,Li Xinnan,Zhang Xiangrong
The study aimed to prepare the chelate of L-theanine (LT) with zinc (Zn) and evaluate its stability, antioxidant and antidiabetic activity. The chelation mechanism between Zn 2+ and LT was investigated by ultraviolet-visible, Fourier transform infrared, scanning electron microscopy/energy dispersive spectrometer and 1 H nuclear magnetic resonance spectroscopy. L-theanine-Zn chelate (LT-Zn) was obtained using LT to Zn citrate in a mass ratio of 3:1 at pH 6 and 70 °C for 180 min with the chelation efficiency of 61.86 ± 1.26%. The results revealed the amino nitrogen atoms and carboxyl oxygen atoms in LT chelated with Zn ions, and the mass of the chelate was confirmed by liquid chromatography with tandem mass spectrometry. Scanning electron microscopy with the element analyzed by energy dispersive spectroscopy showed that the morphology of LT-Zn consisted of irregular granular particles with rough surface. The LT-Zn exhibited higher solubility and improved stability under 100 °C, various pH condition and different concentrations of glucose and NaCl ( p < 0.05) than that of sulfate Zn and Zn gluconate. Compared to sulfate Zn and Zn gluconate, the LT-Zn showed better stability during simulated gastrointestinal digestion. The chelate also exhibited antioxidant activity, as well as an inhibitory effect on α-glucosidase and α-amylase. Overall, the study provided a novel approach to prepare Zn nutraceuticals with antioxidant and antidiabetic properties.
研究领域:
食品科学
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营养学
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生物化学
✓ 已验证
产品关联
DOI
高影响因子
COLLOID AND POLYMER SCIENCE
·
2014
·Vol. 292
·期 6
·1385-1393
·
IF 2.41
Li Qiu-Ping,Yan Bing
The luminescent nanoparticles were prepared by encapsulating the [LnL 4 ] − (Ln = Eu, Tb; L = BTFA, HFAA, TTFA, TFAA) complexes anion into the silicon framework. We firstly synthesized a series of novel siloxy-bearing lanthanide complex precursor, and then encapsulated them into the silica sphere by a modified Stöber process. As a result, four europium and two terbium tetrakis β-diketonate complexes functionalized silica sphere nanoparticles were obtained and characterized in detail using Fourier transform infrared spectra, X-ray diffraction, scanning electronic microscope, thermogravimetric analysis, luminescence excitation and emission spectroscopy, luminescence lifetime measurements, and diffuse reflectance UV–Vis spectroscopy. The result shows that these luminescent nanoparticles maintain the distinctive luminescence character of lanthanide chelate including broad excitation spectra, line-like emission spectra, high quantum efficiency, and long luminescent lifetime, which makes them great potential application in the synthesis of luminescent nanoparticle.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）