ADVANCED MATERIALS
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2020
·Vol. 32
·期 52
·2005394
·
IF 27.398
Hanxu Chen,Feika Bian,Lingyu Sun,Dagan Zhang,Luoran Shang,Yuanjin Zhao
Blood purification by adsorption of excessive biomolecules is vital for maintaining human health. Here, inspired by kidney self-purification, which removes a number of biomolecules with different sizes simultaneously, hierarchical molecular-imprinted inverse opal particles integrated with a herringbone microfluidic chip for efficient biomolecules cleaning are presented. The particle possesses combinative porous structure with both surface and interior imprints for the specific recognition of small molecules and biomacromolecules. Additionally, the presence of the herringbone mixer largely improve the adsorption efficiency due to enhanced mixing. Moreover, the inverse opal framework of the particles give rise to optical sensing ability for self-reporting of the adsorption states. These features, together with its reusability, biosafety, and biocompatibility, make the platform highly promising for clinical blood purification and artificial kidney construction.
研究领域:
生物医学工程
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材料科学
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医学
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DOI
高影响因子
BIOMACROMOLECULES
·
2025
·
IF 5.4
Xuanru Wei,Hengfeng Zhu,Dichan Hong,Xiangxian Li,Zhuqun Shi,Quanling Yang
Conventional hemoperfusion adsorbents suffer from inefficiency and poor biocompatibility. Cellulose, a natural polysaccharide with biocompatible, biodegradable, and nontoxic properties, was combined with graphene oxide (GO) to fabricate composite beads (TGO) for blood purification. GO synthesized via a modified Hummers method was complexed with 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibrils (TOCNs). Increasing GO content (2–20 wt %) enhanced TGO’s specific surface area (256.4–289.0 m2 g–1) while retaining an ∼10 nm pore size. TGO demonstrated exceptional adsorption capacities: bilirubin (418.4 mg g–1), creatinine (23.5 mg g–1), uric acid (146.6 mg g–1), and Cu2+ (171.9 mg g–1). The beads exhibited excellent hemocompatibility (hemolysis rate <5%) and prolonged recalcification time (585 ± 5.2 s). Notably, TGO restored blood bilirubin levels to normal within 30 min, highlighting its potential for blood purification.
研究领域:
生物材料学
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医学工程
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吸附技术
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Xiangxian Li,Hengfeng Zhu,Xuanru Wei,Quanling Yang,Chuanxi Xiong,Zhuqun Shi
Activated carbon is extensively utilized in blood purification applications. However, its performance has been significantly limited by their poor blood compatibility. In this work, 2,2,6,6-tetramethylpiperidinyl-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCN) and activated carbon (AC) were used to form composite beads by the drop curing method to improve hemocompatibility. The TOCN/AC composite beads had porous surface and exhibited extraordinary adsorption properties. The beads had a high adsorption capacity for creatinine with the optimal adsorption capacity of 83.33 mg g −1 . And the equilibrium adsorption of bilirubin, uric acid and Cu 2+ by TOCN/AC beads was as high as 159.80 mg g −1 , 114.61 mg g −1 and 154.0 mg g −1 , respectively, with a mass ratio of TOCN to AC of 1:4. It is also observed that the adsorption behavior of TOCN/AC beads on creatinine was consistent with the second-order kinetics and Langmuir isothermal model. The hemolysis rate of TOCN/AC was 1.21 %, indicating that TOCN/AC beads had good blood compatibility. The clearance of creatinine toxin in blood by TOCN/AC beads was as high as 87 % within 90 min. Overall, our produced composite beads had great potential for application in the field of blood purification.
研究领域:
材料科学
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医学工程
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生物医学
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产品关联
DOI
PubMed
高影响因子
Journal of the Iranian Chemical Society
·
2021
·Vol. 18
·期 8
·2123-2133
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IF 2.019
Kang Huiting,An Kai,Guan Lianxiong,Tian Dating
Magnetic molecularly imprinted polymers (MIPs) for urea were prepared using konjac glucomannan (KGM) as the substrate, methacrylic acid as the graft comonomer, ethylene glycol dimethacrylate as the cross-linker, urea as the template molecule, and Fe 3 O 4 NPs as the magnetic ingredient. The resultant MIPs were characterized by Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, X-ray diffraction, transmission electron microscopy, thermogravimetric analysis, vibrating sample magnetometry, and Brunauer–Emmett–Teller spectroscopy. The MIPs possessed high superparamagnetism with core–shell structures, which could be easily separated from the mixture by an external magnetic field. The MIPs could specifically recognize urea, and the recognition capacity and adsorption performance remained almost unchanged after three cycles of adsorption and elution. The adsorption kinetics of MIPs on urea could be described by the second-order kinetic model. The maximum adsorption capacity of MIPs on urea was 16.80 mg/g, and the adsorption isotherms of MIPs on urea followed the Langmuir model. In addition, in vitro adsorption experiments through simulated body fluids showed that the MIPs had good adsorption capacity for urea. The product is expected to be used as a novel adsorption material for blood purification.
研究领域:
生物材料
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医学工程
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产品关联
DOI
高影响因子
Artificial Cells Nanomedicine and Biotechnology
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2018
·
IF 3.026
Wenhui Zong,Jian Chen,Wenyan Han,Guanghui Cheng,Jie Chen,Yue Wang,Weichao Wang,Lailiang Ou,Yaoting Yu,Jie Shen
A novel polyvinyl alcohol-amino multi-walled carbon nanotube (PVA-AMWCNT) nanocomposite microsphere was prepared successfully for the first time and used for endotoxin removal. The resulting AMWCNT modified PVA microsphere was characterized by SEM, Raman spectrum and fluorescence image, which indicated AMWCNT was dispersed into the macropores of PVA microsphere uniformly. The PVA-AMWCNT microspheres showed better adsorption capability and faster adsorption equilibrium for endotoxin in aqueous solution when compared to the PVA microsphere with polymyxin B (PMB) as ligand. More noteworthy, the PVA based microspheres had little nonspecific adsorption in simulated serum. Therefore, PVA-AMWCNT nanocomposite microsphere with an excellent haemocompatibility has a great potential application in clinical blood purification.
研究领域:
材料科学
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生物医学工程
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医学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
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2019
·
IF 7.015
Caini Liu,Wenyi Wang,Yanling Li,Fangyan Cui,Chengcheng Xie,Liuyong Zhu,Bojin Shan
Hybrid ultrafiltration membranes of poly(vinylidene fluoride) (PVDF) and poly(ethylene glycol)-multi-walled carbon nanotubes (PMWCNTs) have been prepared via phase inversion method. Compared with pristine PVDF membranes, PMWCNT/PVDF hybrid membranes showed a significant higher water flux (384 L m −2 h −1 ), more stable rejection rate of bovine serum albumin (BSA) and better antifouling properties because of better hydrophilicity. Besides, the antifouling properties of PMWCNT/PVDF hybrid membranes can be further reduced applying a weak electric field (direct current, about 2 V cm −1 ). More important, PMWCNTs/PVDF membrane exhibited the lowest hemolysis ratio of 0.4% ever reported, which has improved the hemocompatibility and safety of blood. Moreover, after the introduction of weak electric field, the adhesion of red blood cells is minimized. This study shows that the novel PMWCNT/PVDF hybrid membranes have excellent antifouling ability and hemocompatibility which opens up a new field for the application of PVDF membranes.
研究领域:
材料科学
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生物医学工程
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膜技术
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产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2018
·
IF 5.091
Xueyi Guo,Weijia Wang,Xiuhong Yuan,Ying Yang,Qinghua Tian,Yang Xiang,Yan Sun,Zhiming Bai
Magnetic nano capture agent (MNCA)-based magnetic separation is considered as a promising approach to rapidly isolate heavy metals from blood. Limited removal efficiency and potential biosafety risks are the major challenges for the clinical use of MNCA-based magnetic separation. Here, we report a highly-efficient MNCA-based magnetic separation of heavy metals from blood in continuous multi-stage adsorption mode. The interactions between MNCA and blood components ( e.g. blood cells and plasma proteins) and the MNCA-induced cellular immune responses are studied in detail. The distribution and redistribution of heavy metals in blood are quantitatively analyzed. It demonstrates that concentration dependent redistribution can increase the contact between heavy metals and MNCA, leading to improvement on heavy metal removal efficiency. The removal performance is tested in batch mode and in continuous mode. Results show that 97.97% of Pb and 96.53% of Cd are removed from blood in 120 min using continuous multi-stage adsorption mode, and the residual concentrations of Pb and Cd in blood decrease from 400 μg L −1 to 8.11 μg L −1 and 13.84 μg L −1 , respectively. This study paves an effective way for heavy metal intoxication therapy by MNCA-based magnetic separation.
研究领域:
环境科学
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生物医学工程
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纳米技术
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毒理学
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产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Yaotao Cai,Zixi Zheng,Yanan Huang,Jintao Xu,Jianming Pan
Hemoperfusion is a common treatment for lead poisoning, where hemoperfusion adsorbents are used to remove lead ions from blood. However, traditional hemoperfusion adsorbents often suffer from limited efficiency and poor biocompatibility, reducing their effectiveness for human use. To address these limitations, we developed a novel photothermal nanomotor adsorbent through a controllable sequential super-assembly strategy. Gold nanoparticles (Au NPs) were incorporated into the nanochannels of halloysite nanotubes (HNTs), followed by modification of the outer HNT surface with polydopamine (PDA) and 2,3-dimercaptosuccinic acid (DMSA), forming Au@HNTs@PDA-DMSA. This nanomotor adsorbent leverages the photothermal properties of Au NPs to achieve self-propulsion via thermophoresis under near-infrared (NIR) light irradiation. The performance of this nanomotor was evaluated for Pb(II) removal in both aqueous solutions and human blood samples, reaching adsorption equilibrium within 20 min and a maximum capacity of 45.980 mg/g. The adsorption kinetics followed a pseudo-second-order model with a high fitting coefficient (R 2 = 0.999), and the Langmuir model fit better than the Freundlich model, indicating monolayer adsorption. Notably, when driven by 808 nm NIR light at 1.0 W cm −2 , the Au@HNTs@PDA-DMSA nanomotors showed a significantly enhanced adsorption capacity of 151.769 mg/g, improving blood lead removal efficiency by 1.80 times compared to non-irradiated conditions. Furthermore, the addition of sulfhydryl and carboxyl groups from DMSA provided more active sites, leading to a 9.76-fold increase in lead removal compared to passive adsorbents using HNTs. In vitro tests confirmed the excellent biocompatibility and biosafety of the nanomotor adsorbent, achieving a blood lead removal rate of 91.25 %. This advancement overcomes the limitations of traditional lead adsorbents, offering a promising solution for more effective lead detoxification in clinical and environmental settings.
研究领域:
生物医学工程
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环境科学
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纳米技术
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产品关联
DOI
高影响因子
BIOMACROMOLECULES
·
2016
·
IF 5.583
Xuelian Huang,Rui Wang,Ting Lu,Dongxu Zhou,Weifeng Zhao,Shudong Sun,Changsheng Zhao
The aim of this study was to create heparin-like chitosan hydrogels (HLCHs) for blood purification. Herein, we prepared two heparin-like chitosans (HLCSs) with various carboxymethyl and sulfate groups, followed by a cross-linking reaction with glutaraldehyde. The synthetic chitosan derivatives were characterized by X-ray photoelectron spectroscopy, gel permeation chromatography, FTIR and NMR. The average sulfonation degrees of two HLCSs were 0.69 and 0.94 per sugar unit, respectively. The swelling ratio of the HLCH could reach up to 4800%, and the HLCHs remained a well-defined shape and stable below 170 °C. Moreover, the activated partial thromboplastin time and thrombin time results indicated that both of the HLCSs and their hydrogels exhibited excellent thrombus inhibition property. Furthermore, the contact activation and complement activation results also proved that the hydrogels possessed good blood compatibility and had the potential to be used as blood-contacting materials.
研究领域:
生物材料
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生物医学工程
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血液学
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产品关联
DOI
PubMed
高影响因子
Frontiers in Chemistry
·
2022
·
IF 5.545
Liu Yunhong,Peng Xinyan
In artificial liver blood purification system, highly efficient removal of multiple toxic metabolites from whole blood by hemoperfusion still remains a challenge in the clinical field, due to the limited unspecific absorptive capacity and low biocompatibility of adsorbents. In this work, a new pyridinyl-modified hypercrosslinked polystyrene (HCP) adsorbent, named HCP(St-DVB-VP), was constructed directly through a Friedel-Crafts post-crosslinking reaction using a small-molecule crosslinking agent for the first time. The preparation method provides in this study can avert the problem posed by the use of the toxic carcinogenic chloromethyl ether reagent in the traditional HCP resin synthesis process. The results indicated that HCP(St-DVB-VP) had a highly porous structure with a specific surface area of 761 m2 g−1. Notably, the adsorbent demonstrated excellent adsorptive properties towards both protein-bound toxins (bilirubin) and medium- and large-sized molecular toxins (PTH, IL-6) in vitro experiments simultaneously. More importantly, the obtained adsorbent showed acceptable hemocompatibility. Taken together, the low-cost and ecofriendly fabrication method, broad-spectrum adsorption performance and hemocompatibility makes the HCP(St-DVB-VP) promising for whole blood perfusion in artificial liver blood purification in clinical practice.
研究领域:
材料科学
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生物医学工程
·
化学工程
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DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2021
·
IF 7.328
Yunhong Liu,Xinyan Peng,Zhudong Hu,Mingguang Yu,Jijun Fu,Yugang Huang
Protein-bound uremic toxins (PBUTs), the presence of which in the blood is an important risk factor for the progression of chronic kidney disease (CKD), have not been cleared efficiently via traditional hemodialysis methods until now. In this study, biosafe and efficient nitrogen-containing porous carbon adsorbent (NPCA) beads for the clearance of PBUTs were prepared from porous acrylonitrile/divinylbenzene cross-linked copolymer beads followed by pyrolysis. The resulting NPCA beads were characterized via SEM, XPS and nitrogen adsorption/desorption tests. The results demonstrated that the NPCA beads possessed a mesoporous/microporous hierarchical structure with rich nitrogen functional groups on their surfaces and realized efficient PBUTs adsorption in human plasma. More importantly, the efficacy of PBUTs removal was substantially higher than those of commercial adsorbents that are commonly used in clinical uremia treatments. The NPCA beads also exhibited satisfactory removal efficacy towards middle-molecular-weight uremic toxins. The PBUTs removal mechanism of the NPCA beads is ascribed to effective competition between nitrogen-containing NPCA and proteins for PBUT binding. According to hemocompatibility assays, the NPCA beads possessed satisfactory in vitro hemocompatibility. This nitrogen-containing porous carbon adsorbent is an attractive and promising material for blood purification applications in the treatment of clinical uremia.
研究领域:
材料科学
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生物医学工程
·
肾病学
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DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2020
·
IF 3.573
Jue Zhang,Bingqing Yan,Chao He,Yuanyuan Hao,Shudong Sun,Weifeng Zhao,Changsheng Zhao
Chronic kidney disease has attracted great attention as a public health disease and is mainly caused by the retention of uremic toxins in the body. Urea is a kind of representative toxin with high solubility and cannot be removed easily; in fact, no suitable absorbers have been found to remove urea by physical adsorption. Herein, we prepare urease-immobilized magnetic graphene oxide as a recyclable nanocatalyst for effective urea removal in blood purification, which shows great removal ability toward urea (2194 ± 110 mg/g). The clearance ratio is over 80% even for a high concentration urea solution of 80 mg/mL, and it is 77% for collected dialysate from a clinic. The nanocatalyst exhibits good reusability and storage stability. Furthermore, a series of blood-related tests indicate that the prepared nanocatalyst has good blood compatibility. Thus, the urease-immobilized recyclable nanocatalyst has great potential for effective and safe urea removal in blood purification.
研究领域:
生物医学工程
·
纳米技术
·
材料科学
·
医疗器械
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）