Fishes
·
2022
·Vol. 7
·期 5
·235
·
IF 3.17
Hongzhi Zhang,Dan Fang,Jun Mei,Jing Xie,Weiqiang Qiu
Nitrite represents one of the most typical contaminants in aqueous species. The research was conducted to evaluate the impacts of nitrite exposure on the survival, gill morphology, hematological parameters, immune response, and meat flavor of pearl gentian grouper. The fish were exposed to 0, 5, 10, and 20 mg/L of nitrite for 96 h (note: N-0, N-5, N-10, and N-20 indicate nitrite concentrations of 0, 5, 10, and 20 mg/L, respectively). The blood, gills, and muscles were collected from fish to determine hematological parameters, immune response, oxidative stress, and meat flavor after 0, 12, 24, 36, 48, 60, 72, and 96 h of exposure. The data showed that the aspartate aminotransferase (AST), cortisol (COR), malondialdehyde (MDA), alanine aminotransferase (ALT), alkaline phosphatase (AKP), and free amino acids (FAAs) contents were significantly increased, while the glutathione (GSH), immunoglobulin M (IgM), superoxide dismutase (SOD), and lysozyme (LZM) contents were remarkably declined in the N-20 group after 72 h of exposure. In gills, exposure to the higher concentrations of nitrite resulted in the proliferation and hypertrophy of epithelial cells of gill lamellae, as well as an increase in mucous cells. In addition, all fish in the N-10 and N-20 groups died after 96 h of exposure. Our findings suggested that exposure to higher concentrations of nitrite disrupted blood physiology and oxidative stress, leading to dysfunction in the pearl gentian grouper.
研究领域:
水产养殖学
·
环境毒理学
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鱼类生理学
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DOI
高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2024
·Vol. 26
·期 11
·1-14
·
IF 2.1
Ma Yuying,Wu Hai,Jia Min,Zhang Zhijun,Wang Jingwei,Yue Zhenggang,Wu Hong,Yang Tiehong
This investigation is aimed to develop a novel iron supplement, iron oxide nanoparticles modified with Angelica sinensis polysaccharide (IONPs-ASP), for the treatment of iron deficiency anemia (IDA). IONPs-ASP was synthesized using the co-precipitation method and characterized for their structural features, physicochemical properties, and biocompatibility by TEM, SEM, FTIR, etc. The therapeutic effects of IONPs-ASP were assessed in a rat IDA model. IONPs-ASP was administered intravenously, and blood parameters were monitored. In addition, the preliminary safety of IONPs-ASP was evaluated by organ coefficients and histopathological staining. IONPs-ASP was successfully constructed, with a small particle size, core–shell structure, hydrophilicity, and good biocompatibility. Compared to unmodified IONPs, IONPs-ASP showed better stability and dispersion. In the IDA rat model, IONPs-ASP exhibited superior therapeutic efficacy than that of ASP or IONPs monotherapy. Furthermore, no abnormalities were observed in the organ coefficients and tissue section. IONPs-ASP not only has a superior therapeutic effect on IDA but also has the effect of the ASP on supplementing blood. Hence, it may be used as a new iron supplementing agent with double therapeutic efficacy on blood supplementation for the treatment of IDA. Graphical Abstract In this study, we constructed Angelica sinensis polysaccharide (ASP)–modified iron oxide nanoparticles (IONPs) and demonstrated the therapeutic effects of IONPs-ASP on iron deficiency anemia (IDA), which was associated with IONPs supplementation and APS-stimulated hematopoietic cell generation.
研究领域:
纳米技术
·
药理学
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生物医学工程
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血液学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）