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ACS Applied Materials & Interfaces · 2022 · IF 10.383

A Trilayered Composite Fabric with Directional Water Transport and Resistance to Blood Penetration for Medical Protective Clothing

Yanyan Lin,Chao Wang,Dongyang Miao,Ningbo Cheng,Na Meng,Aijaz Ahmed Babar,Xianfeng Wang,Bin Ding,Jianyong Yu

Functional textiles with enhanced moisture management can facilitate sweat transport away from the skin to improve personal comfort. However, porous materials exhibit low capability of preventing the intrusion of external liquids, becoming a bottleneck in the design of medical protective clothing. Herein, a trilayered composite fabric based on a gradient wettability structure is demonstrated for directional water transport and resistance to blood penetration. The proposed fabric shows distinct advantages, including a high water breakthrough pressure of 2.43 kPa from the external side, an outstanding positive water transport index (1522%), and an antiblood penetration resistance of 2.71 kPa. Moreover, the fabric shows improved comfort with a high moisture transmission (320 g m–2 h–1) and desired water evaporation rate (0.36 g h–1). This work addressed the concern of directional water transport and resistance to blood penetration while providing a comfortable wearing microenvironment, leading to a promising research direction for multifunctional medical textiles.

CAS / MDL: 77-86-1
研究领域: 纺织材料科学 · 医学防护材料 · 功能材料
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Advanced Healthcare Materials · 2024 · IF 10

Hemostatic Dressing Immobilized with ε-poly-L-lysine and Alginate Coated Mesoporous Bioactive Glass Prevents Blood Permeation by Pseudo-Dewetting Behavior

Zilin Wu,Yilin Ding,Zhihao Qin,Zhipeng Sun,Zetao Wang,Xiaodong Cao

The integration of hemostats with cotton fabrics is recognized as an effective approach to improve the hemostatic performance of dressings. However, concerns regarding the uncontrollable absorption of blood by hydrophilic dressings and the risk of distal thrombosis from shed hemostatic agents are increasingly scrutinized. To address these issues, this work develops an advanced dressing (AQG) with immobilized nano-scale mesoporous bioactive glass (MBG) to safely and durably augment hemostasis. The doubly immobilized MBGs, pre-coated with ε-poly-L-lysine and alginate, demonstrate less than 1% detachment after ultrasonic washing. Notably, this MBG layer significantly promotes the adhesion, aggregation, and activation of red blood cells and platelets, adhered five times more red blood cells and 29 times more platelets than raw dressing, respectively. Specially, with the rapid formation of protein corona and amplification of thrombin, dense fibrin network is built on MBG layer and then blocked blood permeation transversely and longitudinally, showing an autophobic pseudo-dewetting behavior and allowing AQG to concentrate blood in situ and culminate in faster hemostasis with lower blood loss. Furthermore, the potent antibacterial properties of AQG extend its potential for broader application in daily care and clinical setting.

研究领域: 生物材料 · 止血 · 伤口愈合 · 纳米技术 · 生物医学工程
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