Arabian Journal of Chemistry
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2024
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IF 5.3
Jianan Li,Haoran Bi
Occupational exposure to herbicides is an important factor for the development of Parkinson's disease (PD). Atrazine (ATR) and simazine (SIM) are dopamine neurotoxins that can cause PD-like symptoms, but the mechanism is unknown. We analyzed the differentially expressed genes (DEGs) in the substantia nigra of PD patients and controls by using the PD dataset GSE20333 from the Gene Expression Omnibus (GEO) database. The potential intersectional targets of ATR and SIM combined exposure induced PD were screened by network pharmacology. The intersection targets were used for enrichment analysis and to construct protein–protein interaction networks. The binding potentials between hub targets and triazine herbicides were validated using molecular docking, and the cellular exposure models were also constructed to validate the screened results. We identified 934 genes that showed differential expression between individuals with PD and healthy controls. Using network pharmacology, we further refined our search to 151 targets of herbicides known to contribute to PD, and identified eight potential core targets: CDK2, CYCS, FOS, LCK, NTRK2, PDGFRB, PGR, and VEGFA. Finally, molecular docking and molecular biological detection results showed that ATR and SIM each exhibit strong binding affinity to CDK2, CYCS and PGR, both ATR and SIM exposure alone or in combination can affect the expression of core targets. Our study indicates that combined exposure to ATR and SIM may play a critical role in the development of PD and offers a new perspective on occupational prevention and treatment strategies.
研究领域:
神经科学
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毒理学
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分子生物学
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DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2020
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IF 3.232
Nisar Hussain,Hongbin Pu,Abid Hussain,Da-Wen Sun
Existing approaches for the screening of unsafe materials in food matrices are time-consuming, tiresome and destructive in nature. Therefore, in the current study, a surface-enhanced Raman spectroscopy (SERS) method based on octanethiol-functionalized core-shell nanoparticles (Oct/Au@AgNPs) was established for rapid detection of ziram in apple and pear fruits. The morphology of substrate was evaluated using high-resolution TEM images and superimposed HAADF-STEM-EDS elemental mapping images, which confirmed that Au@AgNPs having gold (Au) core size of 28 nm in diameter and silver (Ag) shell of 5.5 nm in thickness were successfully grafted with octanethiol. The SERS method with the sensitive nanoparticles could detect ziram of up to 0.015 and 0.016 ppm in apple and pear with high coefficients of determination (R 2 ) of 0.9987 and 0.9993, respectively. Furthermore, satisfactory recoveries (80–106%) were also accomplished for the fungicide in real samples. This work demonstrated that the functionalized silver-coated gold nanoparticles were easy to prepare and could be used as sensitive SERS platforms for monitoring of other agrochemicals in foods.
研究领域:
分析化学
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食品科学
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纳米技术
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DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
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2023
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IF 6.2
Zihang Zeng,Xujun Wang,Tianhui Yang,Yuanyuan Li,Xiaofeng Liu,Peng Zhang,Bo Feng,Taiping Qing
Designing highly active nanozymes for bioanalysis and environmental sensing remains a challenge. In this study, transition metal, palladium (Pd) and iron (Fe), doped germanium oxide (GeO 2 ) nanozyme was designed and optimized. Compared with the pristine GeO 2 nanozyme, the transition metal doped GeO 2 nanozyme have lower Michaelis-Menten constants and higher catalytic activity , indicating that the Pd and Fe doped GeO 2 nanozyme not only enhance their affinity for the substrate but also improve its catalytic activity. In addition, a colorimetric sensor based on the GeO 2 @Pd–H 2 O 2 -TMB system was constructed for the visual detection of simazine in water samples due to the good affinity between TMB and simazine. This sensor has good selectivity and sensitivity with a detection limit of 6.21 μM because of the highest catalytic performance of GeO 2 @Pd nanozyme. This study broadens the application of nanozymes in environmental field and other nanozymes can also be enhanced in activity by simple transition metal doping.
研究领域:
生物分析
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环境传感
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纳米技术
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催化
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2023
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IF 15.1
Bingyang Liu,Yu Wang,Xue Hao,Xuetao Liang,Qi Yang
In this work, a carbon-based catalyst Fe/Co@C with MOF as a self-sacrificing template was prepared by high-temperature roasting of FeCo-MIL101, which was applied to activate PMS for the degradation of chlorotriazine herbicides (ATZ and SIM) showing excellent performance. Characterization analysis revealed that Fe/Co@C possesses a certain graphene structure and has a saturation magnetization rate of 0.87 emu/g, which can be separated from the solution easily and quickly. The degradation of ATZ and SIM was enhanced by introducing chloride ions into the system, and 100 mmol/L Cl - could lead to the complete removal of ATZ and SIM in 6 min, while improving the interfacial electron transfer of Fe/Co@C/PMS. In combination with quenching experiments, ESR test results and DFT calculations, two important roles of chlorine radicals in the reaction are proposed: (1) direct electron transfer and (2) indirect promotion of 1 O 2 generation through the production of HOCl. In addition, the testing of the influencing factors of the catalyst in the system (catalyst dosing, PMS dosing, pH, temperature), the testing of coexisting anions in the aqueous matrix, and the reusability all showed satisfactory performance. Finally, the degradation mechanisms of ATZ and SIM were proposed in combination with GC–MS determination of contaminant intermediates and analysis of their toxicity.
研究领域:
环境科学
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催化
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水处理
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化学工程
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2016
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IF 4.758
Jin Zhang,Chaoying Wang,Yanhui Niu,Shijie Li,Rongqin Luo
A novel electrochemical sensor based on molecularly imprinted polymer membranes (MIPM) as biomimetic molecular recognition element involved in o -aminothiophenol functionalized Au nanoparticles (ATP@AuNPs) modified gold electrode was constructed for sensitive and selective detection of herbicide simazine (SMZ). The nano-scaled MIPM, with high specific surface area, was prepared by self-assembly of o -aminothiophenol (ATP) and electrodeposition of ATP@AuNPs in the presence of template SMZ. Cathodic current of SMZ was measured by cyclic voltammetry and the results exhibited that the proposed sensor possess a high electrocatalytic activity at a negative potential and a fast rebinding dynamics towards the reduction of SMZ in 0.01 M H 2 SO 4 solution (pH 1.7). Linear dependency of peak current on SMZ concentrations was observed from 0.03 to 140 μM and detection limit was estimated to be 0.013 μM (3S/N). The enhancement of sensitivity was attributed to the presence of gold nanoparticles (AuNPs) which decreased the electron-transfer impedance and increased imprinting sites, lead to the superior enrichment effect of the trace amount of SMZ in aqueous solvent. The developed SMZ imprinted sensor exhibited excellent long-term stability and acceptable repeatability. In addition, the proposed method was successfully applied to measure SMZ in several real samples with the spiked recoveries changing from 91.4% to 96.8%, showing a promising potential in practical application.
研究领域:
分析化学
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环境科学
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纳米技术
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电化学
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产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
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2026
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IF 4.9
Junzhi Ni,Dian Lei
Chitosan/thiourea nanoprobes enabled selective chlorpyrifos sensing. • Heteroatom-rich carbon surfaces supported molecular recognition. • Static quenching dominated with partial inner-filter contribution. • Detection was linear from 0.06 to 50 μg L⁻¹. • Real samples showed 91.3-97.1% recovery and HPLC-UV agreement. Pesticide residues in soil-water-plant interfaces pose persistent risks to ecosystem recovery, yet rapid sensing platforms that combine sustainable material design, structural interpretability, and matrix-tolerant analytical performance remain limited. Herein, biopolymer-derived fluorescent nanoprobes were engineered from chitosan and thiourea through controlled hydrothermal conversion for selective chlorpyrifos monitoring in restoration-relevant environmental matrices. The nanoprobes exhibited quasi-spherical morphology with an average diameter of 8.5 ± 2.1 nm, amorphous/turbostratic carbon organization, defect-rich aromatic domains, and oxygen-, nitrogen-, and sulfur-containing surface functionalities. These structural features generated blue fluorescence at 445 nm under 340 nm excitation, a quantum yield of 16.8%, nanosecond lifetime behavior, and excellent stability over a wide pH range, ionic strength, storage, and irradiation conditions. Chlorpyrifos recognition was mediated by cooperative hydrogen bonding, donor-acceptor interaction, electrostatic/dipole-assisted association, and π-associated contact between the pesticide molecule and the heteroatom-rich nanoprobe surface. The sensing platform showed concentration-dependent fluorescence quenching over 0.06-50 μg L⁻¹, with a detection limit of 0.018 μg L⁻¹, a quantification limit of 0.060 μg L⁻¹, and 95% signal stabilization within 108 s. Mechanistic analysis indicated dominant static quenching with a partial inner-filter contribution. In forest topsoil extract, runoff water, and plant-surface washings, recoveries ranged from 91.3% to 97.1%, and fluorescence-derived concentrations agreed closely with HPLC-UV validation. These results establish chitosan-derived fluorescent nanoprobes as structurally defined, photophysically stable, and environmentally applicable sensing materials for rapid chlorpyrifos residue monitoring.
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高影响因子
Environmental Science-Nano
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2025
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IF 5.1
Bingqian Jing,Yuanyuan Li,Xiaofeng Liu,Zihang Zeng,Zan Long,Bingni Jia,Bo Feng,Peng Zhang,Taiping Qing
The widespread use of triazine pesticides in agricultural practices raises concerns regarding their potential harm to both humans and the environment, given their known carcinogenic and neurotoxic effects. Triazine pesticides exhibit various toxic effects on organisms, posing a significant challenge in accurately distinguishing them due to their analogous structures. Herein, we functionalized platinum nanoparticles (Pt NPs) and constructed a three-channel sensing array by modulating their oxidase-like activities through various ligands on the surface of Pt NPs. Triazine pesticides can inhibit the activity of functionalized Pt NPs, allowing the substrate TMB to show different degrees of color development reaction, which provides a solid basis for the construction of sensing arrays by platinum nanozymes. The proposed platinum nanozyme sensing array showed good performance for the identification of five kinds of triazine pesticides (atrazine, simazine, metribuzin, metamitron, and terbutryn) across a wide range of concentrations (0.5-100 µg/mL) through statistical classification using advanced algorithms like linear discriminant analysis (LDA) and hierarchical cluster analysis (HCA). Importantly, the sensing array exhibited good anti-interference ability and achieved accurate discrimination of structurally similar triazine pesticides in real water samples. This study provided a simple and effective method for the identification of triazine pesticides, with potential for discriminating other related pollutants such as antibiotics and biotoxins for environmental monitoring and food safety.
研究领域:
环境科学
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分析化学
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生物医学工程
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产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
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2025
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IF 5.1
Junjie Qi,Wenhui Hao,Jingkun Li,Yuqi Wan,Guoyong Jiang,Yukihiro Ozaki,Fuwei Pi
Phoxim is a broad-spectrum organophosphorus pesticide widely used in the world; however, its neurotoxicity and potential risk pose a significant threat to human health and ecosystems. To address this issue, based on the same metal clusters and similar topologies, a MOF-on-MOF composite strategy, i.e., PCN222(Fe)@NU-1000, was developed for rapid evaluation of phoxim via ratiometric fluorescence and colorimetric dual-signal output. Herein, the inner core, PCN222(Fe), imparts peroxidase-like catalytic activity enabling colorimetric detection based on the 3,3′,5,5′-tetramethylbenzidine (TMB) and the solution decolourisation caused by acetylcholinesterase (AChE) products, while the outer shell, NU-1000, provides a strong fluorescence emission at 461 nm. This core-shell structure also facilitates fluorescence resonance energy transfer (FRET), whereby phoxim selectively quenches the fluorescence of NU-1000 without affecting PCN222(Fe), enabling ratiometric fluorescence sensing. This integrated dual-signal system-comprising ratiometric fluorescence and enzyme-mimetic colorimetry-ensures signal cross-verification and improved detection accuracy. The fluorescence mode exhibits a quantification range of 5.0 ng/mL to 4.0 μg/mL with a detection limit of 4.0 ng/mL, while the colorimetric mode shows a linear range from 2.5 ng/mL to 25.0 ng/mL and a detection limit of 1.76 ng/mL. Furthermore, the method accurately evaluates phoxim levels in fruits and vegetables such as apples and celery, achieving recoveries ranging from 95 % to 115 % and a relative standard deviation (RSD) of less than 9 %. This MOF-on-MOF dual-signal sensing strategy is designed to be simple, user-friendly, and highly reliable, providing significant value for the development of rapid and sensitive approaches in food and environmental science.
研究领域:
分析化学
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材料科学
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环境科学
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食品科学
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纳米技术
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传感器技术
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产品关联
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2024
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IF 3.8
Rui Shi,Yipeng Huang,Guihua Ruan,Zhengyi Chen,Yanqun Yang,Zhuqiang Wu
The distinctive morphology of dendritic mesoporous silica nanoparticles (DMSN) has recently attracted considerable attention in scientific community. However, synthesis of DMSN with well-defined structure and uniform size for ultrafast extraction of trace herbicide residues from environmental and food samples remains to be a compelling challenge. In this study, sulfhydryl functionalized dendritic mesoporous silica (SH-DMSN) was synthesized and the SH-DMSN showcases monodisperse microspheres with flower shape and precisely tailored and controllable pore sizes. This distinctive structural configuration accelerates mass transfer within the silica layer, resulting in heightened adsorption efficiencies. Furthermore, the particle sizes (455, 765, and 808) of the adsorbent can be meticulously fine-tuned by introducing distinct templates. Specifically, when the particle size is 765 nm, the optimized SH-DMSN exhibits a substantial specific surface area (691.32 m²/g), outstanding adsorption efficiencies (>90 %), remarkably swift adsorption and desorption kinetics (2 min and 3 min, respectively), and exceptional stability. The superior adsorption capabilities of this novel adsorbent, ranging from 481.65 to 1021.7 µg/g for organochlorine herbicides containing amide groups, can be attributed to the interplay of S-π interactions, halogen bonding, and electrostatic attraction interaction. These interactions involve the lone pair electrons of sulfhydryl and silanol groups with the π-electrons, halogen atoms and amide groups in herbicide molecules. This study not only offers a new perspective on advancing the practical utilization of dendritic mesoporous silica but also provides a pragmatic strategy for the separation and analysis of herbicides in diverse sample matrices.
研究领域:
材料科学
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环境科学
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分析化学
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL POLLUTION
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2024
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IF 7.6
Zihang Zeng,Bingni Jia,Xiaofeng Liu,Lixiang Chen,Peng Zhang,Taiping Qing,Bo Feng
The presence of microplastics in the ecological environment, serving as carriers for other organic pollutants , has garnered widespread attention. These microplastics exposed in the environment may undergo various aging processes. However, there is still a lack of information regarding how these aged microplastics impact the environmental behavior and ecological toxicity of pollutants. In this study, we modified polystyrene microplastics by simulating the aging behavior that may occur under environmental exposure, and then explored the adsorption behavior and adsorption mechanism of microplastics before and after aging for typical triazine herbicides. It was shown that all aging treatments of polystyrene increased the adsorption of herbicides, the composite aged microplastics had the strongest adsorption capacity and the fastest adsorption rate, and of the three herbicides, metribuzin was adsorbed the most by microplastics. The interactions between microplastics and herbicides involved mechanisms such as hydrophobic interactions, surface adsorption, the effect of π-π interactions, and the formation of hydrogen bonds . Further studies confirmed that microplastics adsorbed with herbicides cause greater biotoxicity to E. coli . These findings elucidate the interactions between microplastics before and after aging and triazine herbicides. Acting as carriers, they alter the environmental behavior and ecological toxicity of organic pollutants, providing theoretical support for assessing the ecological risk of microplastics in water environments.
研究领域:
环境科学
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生态学
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产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
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2024
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IF 4.9
Guangping Xia,Yipeng Huang,Shi Yu,Bingmei Lai,Zhenyu Li,Guihua Ruan
The escalating use of herbicides containing chlorophenyl and acylamino (HCAs) in agriculture has intensified concerns regarding their environmental impact, underscoring the need for efficient and eco-friendly methods for their extraction and detection. This study introduces the synthesis of a novel N/S rich covalent organic framework (COF), DFT-TPB-COF, using 2,5-diformylthiophene and 1,3,5-tri(4-aminophenyl) benzene as building blocks. The as-synthesized COF is uniform, spherical and monodisperse, making it an ideal candidate as packed materials in solid-phase extraction column for HCAs extraction from complex environmental samples. The DFT-TPB-COFs show adsorption capabilities ranging from 2.52 to 30.34 mg g −1 for six HCAs, facilitated by π-π interactions, p-π interactions, hydrogen bonding, electrostatic interactions, and hydrophobic interactions. The adsorption–desorption process is rapid (10 min). Additionally, the presence of other types of herbicides showed little interference in the adsorption efficiency of DFT-TPB-COF for HCAs. A sensitive and reliable method combining the DFT-TPB-COFs-filled SPE column with HPLC-UV was developed for detection of six HCAs in various environmental water and soil samples. The method exhibited excellent linearity (1–200.0 ng mL −1 ) and low limits of detection (0.3–0.9 ng mL −1 ) for HCAs. This study not only demonstrates the potential of DFT-TPB-COFs as a suitable packed material in solid-phase extraction column, but also opens avenues for the practical application of COFs in the adsorption of organic pollutants.
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
LANGMUIR
·
2026
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IF 3.9
Xiaowen Huang,Zhuqiang Wu,Yipeng Huang,Guihua Ruan,Ningli Tang
Flower-shaped covalent organic frameworks (COFs) with hierarchically porous structures are highly desirable for rapid and high-efficiency adsorption applications, yet precisely controlling the morphology of COFs to uniform and monodisperse flower shapes under mild conditions remains a significant challenge. Herein, tetrafluoro-p-benzoaldehyde and 4,4′,4″-(1,3,5-triazine-2,4,6-triyl)triphenylamine were used as building blocks for the controllable synthesis of hydrangea-shaped COFs at room temperature by solvent regulation. The use of aprotic solvents facilitated the formation of spherical COFs; however, the addition of a suitable fraction of nonpolar mesitylene in dioxane led to the formation of hydrangea-shaped COFs. The as-synthesized COFs were demonstrated to be good adsorbents for triazine and amide herbicides, benefiting from the hydrangea-shaped structure and rich triazine, imine, and tetrafluorobenzene groups for hydrogen bonding and reinforced π–π interactions. Coupling hydrangea-shaped COFs-based solid-phase extraction with high-performance liquid chromatography, analyses of five herbicides were realized in a wide linear range (1–100 μg/L) and low limits of detection (0.50–0.70 μg/kg). In addition, the relative recoveries of the analytes from spiked soil samples ranged from 85.48% to 103.64% with relative standard deviations less than 3.16%. This study elucidates the effects of solvent properties on the morphologies of COFs and provides inspiration for rational design and controllable synthesis of COFs with well-defined structures and functional groups by facile solvent regulation at room temperature to realize high sorption performances.
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PubMed
高影响因子
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