Nature Communications
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2025
·Vol. 16
·期 1
·1-13
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IF 15.7
Zhao Erzhuo,Zhang Yixin,Zhan Juhong,Xia Guangsen,Yu Gang,Wang Yujue
The recently developed porous solid electrolyte (PSE) reactor for electrosynthesis of hydrogen peroxide (H 2 O 2 ) has attracted significant global interest. However, scaling up the PSE reactor for practical applications poses challenges, particularly due to performance decline in enlarged reactors. Here we systematically investigate how factors such as material selection, assembly parameters, flow field patterns, and operating conditions influence H 2 O 2 electrosynthesis in the PSE reactor. Our findings reveal that the performance decline during reactor scale-up is primarily caused by the uneven flow field in the PSE layer. Based on these insights, we optimize the reactor design and develop a 12-unit modular electrode stack PSE reactor with a total electrode area of 1200 cm 2 . The scaled-up reactor maintains efficient H 2 O 2 electrosynthesis without significant performance decline. It operates stably for over 400 h and can produce up to 2.5 kg pure H 2 O 2 (~83 kg 3% H 2 O 2 solutions) per day with considerably lower energy costs (0.2‒0.8 USD/kg H 2 O 2 ) than the market prices of H 2 O 2 stocks. This work represents a crucial advancement in the development of PSE reactor technology for practical H 2 O 2 electrosynthesis.
研究领域:
化学工程
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电化学
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环境科学
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产品关联
DOI
PubMed
高影响因子
POLYMER ENGINEERING AND SCIENCE
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2025
·
IF 3.2
Jiawei Liu,Tongjia Zhang,Lixin Song,Guangyuan Zhou,Honghua Wang
Incorporating reactive groups that can participate in epoxy cross-linking into traditional thermoplastic toughening agents enhances the interfacial compatibility between thermoplastic and thermosetting resins, thereby improving the impact toughness of the system. In this study, hydroxyl end groups were integrated into phenolphthalein polyether ketone (PEKC) molecular chains to engage in the cross-linking reaction during epoxy curing, significantly enhancing the toughening effect on the epoxy system. The results indicate that hydroxyl-terminated phenolphthalein polyether ketone (PEKC-OH) of various molecular weights can enhance the impact strength of the epoxy system (E51/MTHPA). Among these, the PEKC-OH-2 resin exhibited the optimal toughening effect at an addition level of 10 phr, increasing the impact strength from 11.85 to 23.46 kJ/m 2 , representing a 98% improvement, without compromising the operating temperature and mechanical properties of the epoxy system. Additionally, kilogram-scale toughening agent resins were produced through scale-up experiments of PEKC-OH-2 in a 50-L polymerization reactor, validating its applicability for industrial epoxy toughening. In summary, the PEKC-OH synthesized in this study serves as an efficient reactive thermoplastic toughening agent, offering ease of preparation, industrial producibility, and considerable application potential. Highlights Novel hydroxyl-terminated phenolphthalein polyether ketone (PEKC-OH). Reactive hydroxyl end groups improved compatibility with epoxy resin. PEKC-OH formed an interpenetrating network with epoxy, boosting impact toughness. Scaled-up of PEKC-OH-2 in a 50-L reactor for industrial production. PEKC-OH is feasible to prepare and has great application prospect.
研究领域:
材料科学
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化学工程
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DOI
高影响因子
Nanomaterials
·
2024
·Vol. 14
·期 9
·805
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IF 4.4
Deyue Xiao,Peng He,Haolong Zheng,Shujing Yang,Siwei Yang,Guqiao Ding
Graphene has achieved mass production via various preparative routes and demonstrated its uniqueness in many application fields for its intrinsically high electron mobility and thermal conductivity. However, graphene faces limitations in assembling macroscopic structures because of its hydrophobic property. Therefore, balancing high crystal quality and good aqueous dispersibility is of great importance in practical applications. Herein, we propose a tape-wrapping strategy to electrochemically fabricate water-dispersible graphene (w-Gr) with both excellent dispersibility (~4.5 mg/mL, stable over 2 months), and well-preserved crystalline structure. A large production rate (4.5 mg/min, six times faster than previous electrochemical methods), high yield (65.4% ≤5 atomic layers) and good processability are demonstrated. A mechanism investigation indicates that the rational design of anode configuration to ensure proper oxidation, deep exfoliation and unobstructed mass transfer is responsible for the high efficiency of this strategy. This simple yet efficient electrochemical method is expected to promote the scalable preparation and applications of graphene.
研究领域:
材料科学
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化学工程
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DOI
PubMed
高影响因子
Nanomaterials
·
2022
·Vol. 12
·期 6
·1018
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IF 5.719
Jianming Yu,Lijie Yang,Jing Jiang,Xunyi Dong,Zhiyang Cui,Chao Wang,Zhenda Lu
Silver nanowires (Ag NWs) have shown great potential in next-generation flexible displays, due to their superior electronic, optical, and mechanical properties. However, as with most nanomaterials, a limited production capacity and poor reproduction quality, based on the batch reaction, largely hinder their application. Here, we applied continuous-flow synthesis for the scalable and high-quality production of Ag NWs, and built a pilot-scale line for kilogram-level per day production. In addition, we found that trace quantities of water could generate sufficient vapor as a spacer under high temperature to efficiently prevent the back-flow or mixed-flow of the reaction solution. With an optimized synthetic formula, a mass production of pure Ag NWs of 36.5 g/h was achieved by a multiple-channel, continuous-flow reactor.Keywords:continuous-flow synthesis;silver nanowires;flow chemistry;pilot-scale synthesis
研究领域:
材料科学
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化学工程
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DOI
PubMed
高影响因子
LANGMUIR
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2024
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IF 3.7
Jiayu Li,Haoxu Zhan,Bingjun Su,Yiqun Yao,Yiran He,Wu Zhang,Zeqiang Zhong,Lei Li,Dongyan Zhang,Hao Yang,Chao Li
Sodium manganese hexacyanoferrate, also called Prussian white (PW), has attracted much attention as a promising cathode material for Na-ion batteries due to its high-voltage platform and inexpensive elemental composition. However, their parasitic vacancies and water molecules often deteriorate the electrochemical performance. Proper regulation of such defects in scale-up preparation is still a challenge. In this work, PW was prepared via aqueous precipitation assisted by manganese oxalate in a 10 L reactor. High-quality Na2.32Mn[Fe(CN)6]0.95□0.05·1.97 H2O was obtained and exhibited a specific capacity of 148 mAh g–1. The phase transition from monoclinic to rhombohedral during long-term cycling for such an ultra-Na-rich cathode has been first reported. In addition, the vacuum drying temperature was further discussed, and 150 °C is more suitable for achieving the balance between dehydration and electrical properties.
研究领域:
材料科学
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电化学
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DOI
PubMed
高影响因子
CHINESE JOURNAL OF CHEMICAL ENGINEERING
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2022
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IF 3.898
Ye Yuan,Yurui Pan,Menglong Sheng,Guangyu Xing,Ming Wang,Jixiao Wang,Zhi Wang
Membrane technology features inspiring excellence from numerous separation technologies for CO 2 capture from post-combustion gas. Polyvinylamine (PVAm)-based facilitated transport membranes show significantly high separation performance, which has been proven promising for industrial scale-up. However, commercialized PVAm with low molecular weight and excessive crystallinity is not available to prepare high-performance membranes. Herein, the synthesis process of PVAm was optimized by regulating polymerization and acidic hydrolytic conditions. The membranes based on PVAm with a molecular weight of 154 kDa and crystallinity of 11.37% display high CO 2 permeance of 726 GPU and CO 2 /N 2 selectivity of 55 at a feed gas pressure of 0.50 MPa. Furthermore, we established a PVAm synthesis reactor with an annual PVAm solution (1%(mass)) capacity of over 7000 kg and realized the scaled-up manufacture of both PVAm and composite membranes.
研究领域:
材料科学
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环境工程
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DOI
高影响因子
Frontiers in Bioengineering and Biotechnology
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2025
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IF 4.8
Yaping Ma,Minchang Liu,Ruifang Gu,Rongya Zhang,Xiaomei Ji,Juan Zhang,Wu Wen,Zheng Peng
Introduction: Laccase exhibits significant applications in food additives, wastewater treatment, and biomass processing. Fungal laccase exhibits high activity, good stability, and excellent performance. However, scale-up production of high-yield laccase from fungi is challenging. This study aimed to identify crucial factors affecting enzyme production and analyze the enzymatic properties of laccase during fermentation.Methods: A laccase-producing white-rot fungus was used for fermentation process optimization in 200 L and 1200 L fermenters. The Plackett–Burman design revealed three significant influencing factors: temperature, aeration ratio, and agitation speed. The steepest ascent experiment was used to approximate the maximum response region, followed by the establishment of a regression model between experimental factors and laccase activity using the Box–Behnken response surface methodology and optimal fermentation condition selection.Results: The optimal conditions for laccase production by Ganoderma lucidum fermentation were 30°C temperature, 0.66 aeration ratio, and 100 rpm agitation speed, achieving a maximum laccase activity of 214,185.2 U/L. Dissolved oxygen (DO) was a crucial factor for high laccase yield, and its maintenance at a high level in the fermentation system significantly enhanced the enzyme activity. Fermentation batches with varying laccase production levels exhibited a trend of decreasing pH and a subsequent increase in the mid-to-late fermentation stages. With decreased pH, the DO level started declining; when DO stabilized, the pH started to rebound, coinciding with the peak laccase activity, indicating a signal of fermentation endpoint in industrial production.Discussion: This study provides valuable theoretical and data support for the industrial production of laccase by fungi through optimized fermentation processes.
研究领域:
生物技术
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微生物学
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生化工程
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工业生物技术
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DOI
PubMed
高影响因子
WATER RESEARCH
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2020
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IF 9.13
Longqian Xu,Yunfeng Mao,Yang Zong,Deli Wu
Salt removal from seawater/wastewater using flow-electrode capacitive deionization (FCDI) is of particular interest, but scale-up desalination is limited by low water production, high energy consumption and complex cell configuration. In this study, an innovative FCDI system is described that uses integrated desalination modules equipped with membrane-current collector (MCC) assembly, and thereby named as MCC-FCDI system. A single desalination module design provides an average salt removal rate ( ASRR , 0.3 – 0.44 µmol/(cm 2 ·min)) close to that of the classic FCDI system (with a graphite current collector design), but the design requires a much lower infrastructure investment, device size and energy cost. More importantly, our design enables simultaneous operation of multiple modules in the shared flow-electrode tank, easily realizing scale-up desalination. Evidence is provided by the results of the multi-module operation: multi-modules isolated closed-cycle (MICC) and multi-modules short-circuited closed-cycle (MSCC). For instance, the MICC configuration showing nearly twice the desalination performance over ~ 50 h of operation compared to that of the single ICC operation. The results indicated that in addition to making the device suitable for practical application, the Ti-mesh MCC with a woven network enables the flow electrode to achieve substantial ion adsorption capacity due to the efficient update of fresh carbon particles. In short, the results of this study showed that MCC-FCDI is a promising desalination system for scale-up applications, providing a new reference and guidance for device design.
研究领域:
环境工程
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材料科学
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水处理技术
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DOI
PubMed
高影响因子
Journal of the Taiwan Institute of Chemical Engineers
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2021
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IF 5.876
Zhiquan Chen,Lei Ni,Peihong Wu,Juncheng Jiang,Yuan Yu,Qingwei Song,Gang Fu
Background Metal foam has been demonstrated numerous advantages in fine chemistry when used as catalyst support. In this research, a novel strategy for the fabrication of copper tungstate (CuWO 4 ) foam as heterogeneous catalysis to conduct dimethyl sulfoxide (DMSO) oxidation reaction in a scale-up microreactor was proposed. Methods A series of three-dimensional skeleton CuWO 4 foams were prepared by a continuous sintering approach. The obtained CuWO 4 catalysis inherited the porous structure from the copper foam and had a high loading density of CuWO 4 crystal particles. Afterwards, DMSO oxidation was employed as a probe reaction to explore the catalytic performance of CuWO 4 foam. Significant findings CuWO 4 foam showed prefect catalytic activity in a scale-up microreactor. The average crystallite size of CuWO 4 were increased from 52.8 to 57.7 nm with extension of sintering time. Under the optimum condition (residence time was 40 min, CuWO 4 catalyst was CuWO 4 F-5 and reaction temperature was 80 o C), a high dimethyl sulfone yield of 65.4% was obtained. The yield of MSM reached nearly 65.3% in the run time of 1 h and showed a value of 50.4% even in the run time of 4 h. Higher reaction contact surface and larger crystal particles of CuWO 4 foam are conducive to enhancing the catalytic performance of CuWO 4 foam. This research indicates the potential opportunity to apply CuWO 4 foam in a scale-up microreactor.
研究领域:
化学工程
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催化材料
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DOI
高影响因子
Materials Today Energy
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2021
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IF 7.311
Qiushi Sun,Xiao Chen,Jian Xie,Changhai Shen,Yuan Jin,Cheng Huang,Xiongwen Xu,Jian Tu,Bo Wang,Tiejun Zhu,Xinbing Zhao,Jipeng Cheng
A solid-state lithium metal battery has been considered as a promising next-generation energy storage system for its high safety. Great challenges remain for the scale-up fabrication of solid-state Li batteries with the current manufacturing facility used for liquid Li-ion batteries. In this work, a scale-up route is employed to fabricate quasi-solid-state Li batteries by cathode-supported coating of a solid electrolyte combined with in-situ polymerization for interfacial modification. A Li 1.3 Al 0.3 Ti 1.7 (PO 4 ) 3 (LATP) layer with a polyvinylidene fluoride (PVDF) binder is coated on the LiCoO 2 cathode as the solid electrolyte. A iquid electrolyte containing a poly(ethylene glycol) methyl ether acrylate (PEGMEA) monomer is injected during the battery fabrication process followed by in-situ polymerization. The in-situ formed gel electrolyte acts as a soft interface to enhance the contact between the electrode and the solid electrolyte. A coin-type quasi-solid-state Li||LiCoO 2 battery delivers a high capacity of 122 mAh g −1 and retains 81% of its initial capacity after 100 cycles at 0.5 C and 60 °C. A pouch-type Li||LiCoO 2 battery is also fabricated using a commercial LiCoO 2 electrode and shows a satisfactory safety performance and stable cycling at 0.5 C.
研究领域:
材料科学
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能源技术
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Peng Liu,Lu Huang,Chenglong Qin,Chengxiang Gui,Yanlin Ge,Wei Liu,Zhichun Liu
Photocatalytic hydrogen production from solar energy is considered as one of the most cost-effective approaches to carbon neutrality. However, the geographic mismatch between liquid water and solar resources poses great challenges to its large-scale and low-cost practical application. An ingenious water self-replenishing photocatalytic system consisting of a porous photocatalytic layer with Pt/TiO 2 as catalyst and a hygroscopic hydrogel is reported herein. The hygroscopic hydrogel can harvest moisture from the atmosphere in dark and provide sufficient vapor for hydrogen production in porous photocatalytic layer under solar irradiation, ensuring a hydrogen production of 21.67 mmol m −2 h −1 . A large-scale prototype with reaction area of 24 cm × 24 cm demonstrates a stable H 2 production of 3673.9 mL m −2 day −1 under natural sunlight and is regenerated by atmospheric water harvesting at night. This work provides a new strategy for large-scale hydrogen production from the gaseous water in the air.
研究领域:
材料科学
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能源科学
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环境科学
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2022
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IF 6.51
Ji Wang,Wei He,Lei Cheng,Hao Zhang,Yang Wang,Chao Liu,Shuo Dong,Wenhui Zha,Xianghe Kong,Chen Yao,Xinsong Li
Dimeric artesunate phospholipid (ART-GPC), an amphiphilic derivative of artemisinin dimer reported in our previous work, can be applied to treat malaria effectively. The objective of this study is to develop a facile method for the industrial production of ART-GPC liposomes . Conventional methods including thin film hydration (TFH), ethanol injection (EI), and freeze drying (FD) were used to prepare ART-GPC liposomes, and the resultants presented poor physicochemical properties. Fortunately, a modified thin film hydration method (MTFH) by forming thin film of ART-GPC composed of fine lipid bilayer structure in the vials showed promise for the liposomes production. A quality design strategy (solvents, pressure, hydration time, and temperature) was performed to obtain optimal physicochemical characteristics and production conditions. Thereafter, ART-GPC liposomes are produced under GMP conditions with the size of 176.32 nm, PDI of 0.17, zeta potential of −25.79 mV, and osmotic pressure of 297.33 mOsm/kg, confirming the scalability and reproductivity of the MTFH technology. It is the first report that the MTFH method allows liposomes to be preserved in a dry film state and in-situ hydrated in injection vials with excellent performance. Conclusively, the MTFH method is a promising technology for the large-scale production of ART-GPC liposomes.
研究领域:
药剂学
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生物医学工程
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药物化学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）