Nanomaterials
·
2022
·Vol. 12
·期 22
·3934
·
IF 5.719
Xiaoni Shi,Kun Yang,Hetao Song,Zhidong Teng,Yun Zhang,Weihao Ding,Aofei Wang,Shuzhen Tan,Hu Dong,Shiqi Sun,Yonghao Hu,Huichen Guo
The successful development of foot-and-mouth disease virus-like particles (FMD-VLPs) has opened a new direction for researching a novel subunit vaccine for foot-and-mouth disease (FMD). Therefore, it is urgent to develop an adjuvant that is highly effective and safe to facilitate a better immune response to be pair with the FMD-VLP vaccine. In this research, we prepared a new nano-emulsion adjuvant based on squalane (SNA) containing CpG using the pseudo-ternary phase diagram method and the phase transformation method. The SNA consisted of Span85, Tween60, squalane, polyethene glycol-400 (PEG400) and CpG aqueous solution. The average particle diameter of the SNA was about 95 nm, and it exhibited good resistance to centrifugation, thermal stability, and biocompatibility. Then, SNA was emulsified as an adjuvant to prepare foot-and-mouth disease virus-like particles vaccine,BALB/cmice and guinea pigs were immunized, and we evaluated the immunization effect. The immunization results in mice showed that the SNA-VLPs vaccine significantly increased specific antibody levels in mice within 4 weeks, including higher levels of IgG1 and IgG2a. In addition, it increased the levels of IFN-γ and IL-1β in the immune serum of mice. Meanwhile, guinea pig-specific and neutralizing antibodies were considerably increased within 4 weeks when SNA was used as an adjuvant, thereby facilitating the proliferation of splenic lymphocytes. More importantly, in guinea pigs immunized with one dose of SNA-VLPs, challenged with FMDV 28 days after immunization, the protection rate can reach 83.3%, which is as high as in the ISA-206 control group. In conclusion, the novel squalane nano-emulsion adjuvant is an effective adjuvant for the FMD-VLPs vaccine, indicating a promising adjuvant for the future development of a novel FMD-VLPs vaccine.Keywords:nano-emulsion;adjuvants;FMD virus-like particles;squalane;immune responses
研究领域:
病毒学
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免疫学
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药学
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DOI
PubMed
高影响因子
JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2025
·
IF 8.4
Ruizhe Chen,Leilei Cheng,Wenbo Zhang,Jing Gu,Haoran Yuan,Yong Chen
The catalytic pyrolysis of polyethylene for aromatic production is a promising method for waste plastic disposal and resource recovery. This study investigated the nature of metal species and the distribution of acidic sites in low-density polyethylene (LDPE) scission-aromatization reactions using metal-loaded zeolite catalysts. Under the influence of the 1.0Zn/MOR40 catalyst, LDPE achieved a maximum aromatic selectivity of 45.71 % at 500 °C, based on the total product composition. The results indicated that catalysts with a lower Brønsted acid site to Lewis acid site ratio (BAS/LAS) and a higher concentration of [ZnOH] + species favored the reaction, promoting the generation of olefin intermediates and aromatics while suppressing polycyclic aromatic hydrocarbons (PAHs) formation. However, there was an optimal range for the BAS/LAS ratio and [ZnOH] + species concentration. Reaction results involving squalene and triacontane demonstrated that excessive dehydrogenation of reactants and insufficient BAS could hinder the progression of aromatization reactions, resulting in an increased proportion of PAHs. This study provides a comprehensive understanding of the balance between the synergistic and antagonistic effects of metal-acid sites on the aromatization process.
研究领域:
化学工程
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催化
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高分子科学
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材料科学
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环境科学
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DOI
PubMed
高影响因子
Materials Today Communications
·
2024
·
IF 3.7
Ruifa Wu,Xuanyu Zhang,Ming Deng,Mi Zhou,Kaikai Jin,Wei Xu,Ruifeng Li,Kai Kang,Chaoyu Xiang
Zirconia nanoparticles (ZrO 2 NPs) are considered promising functional materials due to their high refractive index , thermal stability, and relatively wide bandgap. They can be particularly valuable when blended with monomer resins to create transparent composite materials with tunable refractive indices. However, the challenge of synthesizing uniformly sized and transparently dispersible ZrO 2 NPs in organic resin monomers has been an ongoing research problem. In this study, we proposed an improved method based on an existing synthesis route for the production of ZrO 2 NPs. We employed a sol-gel approach and introduced a simple yet effective strategy to synthesize ZrO 2 NPs. Using high-boiling non-coordinating solvent squalane to adjust the concentration of oil amine ligands in the solution, helped to balance the nucleation and growth of ZrO 2 , thereby improving the size uniformity of ZrO 2 NPs. In addition, the addition of sodium hydroxide (NaOH) to the reaction system effectively promoted the crystal growth of ZrO 2 without affecting its crystal structure and crystallinity . Simultaneously, this addition significantly reduced the content of surface oleylamine (OAm) ligands. Finally, ZrO 2 was modified using 2-Ethylhexanoic acid (EHA) and 3-methacryloxypropyltrimethoxysilane (KH-570), achieving successful transparent dispersion within the high refractive index acrylic monomer , benzyl acrylate (BZA). In-situ polymerization was used with a UV initiator to produce a refractive index continuously tunable BZA/ZrO 2 composite film .
研究领域:
材料科学
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纳米技术
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化学工程
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DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
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2024
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IF 5.4
Wanling Chen,Nanxi Xiang,Jiahong Huang,Huixian Xu,Zhenyuan Wang,Bo Ruan,Jichuan Zhang,Chengyu Wu,Jiaheng Zhang,YanZhen Liang
Collagen-based skincare products can replenish collagen in the skin; however, collagen cannot easily penetrate the dermis, limiting its effectiveness. Therefore, nanomaterials that can enable collagen to effectively penetrate the dermis are urgently needed. This study aimed to determine the potential role of the supramolecular collagen nanoparticles, namely, lactoferrin, recombinant human collagen, and palmitoyl tripeptide-5, in improving the effectiveness of skincare products. Lactoferrin and recombinant collagen served as carriers encapsulating palmitoyl tripeptide-5, with an encapsulation rate of 94.18%. The supramolecular collagen nanoparticles demonstrated good stability after 1 month. Transdermal efficiency was improved by 69.90%, allowing the nanoparticles to penetrate deeply into the dermis. Within 28 days of use, the moisture content of the stratum corneum increased by 10.51%, facial elasticity improved by 8.15%, skin firmness increased by 12.53%, facial melanin index decreased by 1.84%, and individual type angle increased by 19.10%. Within 14 days, there was a 24.69% reduction in eye bag wrinkles and a 37.61% reduction in nasolabial wrinkles. Wrinkle lengths decreased by 10.22% and 21.57%, and areas decreased by 34.41% and 27.92%, respectively. The supramolecular collagen nanoparticles displayed multiple skincare benefits, including moisturizing, whitening, wrinkle reduction, and firming. In conclusion, the supramolecular collagen nanoparticles are promising candidates for cosmetic products.
研究领域:
化妆品
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纳米技术
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皮肤病学
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DOI
PubMed
高影响因子
Advanced Science
·
2024
·Vol. 11
·期 28
·2401636
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IF 14.3
Mengjiao Liu,Xin Zhang,Yue Xin,Dongxu Guo,Guangkai Hu,Yifei Ma,Bin Yu,Tao Huang,Chengchang Ji,Meifang Zhu,Hao Yu
Triboelectric nanogenerators (TENGs), a promising strategy for harvesting distributed low-quality power sources, face inevitable bottlenecks regarding long-term abrasion and poor durability. Herein, both issues are addressed by selecting an earthworm-inspired self-replenishing bionic film (ERB) as the tribo-material of sliding-freestanding TENGs (SF-TENGs), it consists of an interconnected 3D porous network structure capable of storing and releasing lubricant under cyclic mechanical stimuli. Thanks to the superiority of self-replenishing property, there is no need for periodic replenishment and accurate content control of lubricant over the interfacial-lubricating SF-TENGs based on dense tribo-layers. Additionally, an SF-TENG based on ERB film (ERB-TENG) demonstrates remarkable output stability with only a slight attenuation of 1% after continuous operation for 100 000 cycles. Moreover, the ERB-TENG displays a distinguished anti-wear property, exhibiting no distinct abrasion with an ultra-low coefficient of friction (0.077) and maintaining output stability over a prolonged period of 35 days. Furthermore, integration with an energy management circuit enables the ERB-TENG to achieve a 39-fold boost in charging speed. This work proposes a creative approach to enhance the durability and extend the lifespan of TENG devices, which is also successfully applied to wind energy harvesting and intelligent sports monitoring.
研究领域:
纳米技术
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材料科学
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能量收集
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机械工程
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体育科技
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DOI
PubMed
高影响因子
ACS Catalysis
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2026
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IF 13.6
Xiaoru Wang,Zhanwu Lei,Jicong Yan,Penglong Wang,Ruifeng Chong,Fuping Tian,Tao Hu,Ruiguo Cao,Xiang Wang
Developing non-noble metal catalysts for hydrocracking polyolefins is a promising yet formidable challenge for upcycling waste plastics in practice. Herein, we report a NiW/WOx (2 < x < 3) catalyst, which accomplishes polyolefin hydrocracking at 250 °C, yielding a liquid product of about 73 wt % and a gaseous product of about 22 wt %. The liquid fraction primarily consists of hydrocarbons in the C4–C25 range, with more than 77% falling within the jet-fuel-range components (C8–C16). The gas product is dominated by branched C3–C6 hydrocarbons, characteristic of liquefied petroleum gas (LPG), with negligible carbon loss, such as methane and ethane.A sequence change from inactive to active, and back to inactive in polyolefin hydrocracking was found accompanying the reconstruction of the surface structure of the catalyst from Ni-doped WO3 to NiW alloy nanoparticles supported on WOx (NiW/WOx), and then to WO2-encapsulated NiW (NiW@WO2). The coexposure of NiW alloy nanoparticles and WOx is further demonstrated to be necessary for fulfilling the bifunctionality of the catalyst in hydrogen dissociation and C–C bond cleavage in polyolefin hydrocracking, and the absence of either will deactivate the catalyst.
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DOI
高影响因子
Nature Communications
·
2026
·
IF 18.1
Tu Weilin,Chu Mingyu,Yan Tianran,Zhang Qingqing,Wang Xianpeng,Zhang Liang,Cao Muhan,Zhang Qiao,Zhu Mingshan,Zhan Mingxiu,Chen Jinxing
The compositional heterogeneity of post-consumer plastic waste, exemplified by prevalent polyethylene (PE)/polypropylene (PP) mixtures (>50% of the plastic market), severely complicates recycling. Kinetic disparities between PE and PP during chemical recycling create significant conversion gradients, limiting valued product yield and process viability. Here, leveraging strong interfacial coupling between ruthenium oxides and rutile TiO 2 , we construct highly active, epitaxial RuO x sites enabling efficient one-pot co-conversion of PE/PP mixtures with a high liquid yield of 95.02%, while maintaining a low 0.62% gas yield. Compared to conventional Ru nanoparticles, the epitaxial RuO x structure provides additional dehydrogenation sites for PP activation, which promotes carbon–metal back-donation to weaken C–C bonds, thus exhibiting comparable activation capabilities toward both 3 C– 2 C bond in PP and 2 C– 2 C bond in PE. This unique epitaxial catalyst enables highly efficient co-hydrogenolysis of mixed polyolefins, establishing a practical approach for their upcycling.
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DOI
高影响因子
RSC Advances
·
2026
·Vol. 16
·期 8
·6865-6875
·
IF 6.1
Minjia Yuan,Zhihui Zheng,Yan Yu,Yi Wang,Wenxing Wang,Qi Li,Xiaomin Li,Dongyuan Zhao
To address the growing demand for advanced oil-control materials in cosmetics, this study developed novel flower-like mesoporous silica nanoparticles (FLS) with topology-enhanced oil–adsorption properties. Using a biphasic microemulsion synthesis strategy, FLS with petal-like surface topology, radial pore channels, and excellent colloidal stability were successfully prepared. Compared with conventional mesoporous silica nanoparticles (MSN) with small mesopores (2–3 nm) synthesized via the classical Stöber method, FLS exhibited significantly superior oil-absorption capacity across a wide range of oils, with maximum uptake nearly twice that of MSN. Notably, FLS showed exceptional adsorption efficiency for large-molecular-weight oils, demonstrating an approximately 226.3% increase over MSN in adsorbing PDMS-15000 w. This remarkable enhancement is attributed to the unique flower-like topology, which provides large open concave structures for instantaneous oil wetting and straight, radially aligned mesochannels for rapid oil transport and maximized pore utilization. In vivo human skin tests further confirmed the cosmetic efficacy of FLS. Collectively, these findings position FLS as a next-generation oil-control material and highlight topology-enhanced oil adsorption as a novel design strategy for advanced adsorbents.
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PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Dengliang Cai,Guangxin Zhao,Wenan Tie,Ting Lei,Jiachun Feng
Polypropylene (PP) combines excellent mechanical properties with cost-effectiveness, yet its practical applications are hindered by poor thermo-oxidative resistance and slow crystallization kinetics. While conventional antioxidants and nucleating agents can mitigate these issues, increasing safety concerns over synthetic additives have spurred interest in natural alternatives. However, natural antioxidants such as vitamin E (VE) often exhibit inadequate stabilization at low loadings, and few industrially available biobased nucleating agents were developed. Here, we reported that myo-inositol (Ins), a bioderived compound, acted as a dual-functional additive, simultaneously improving both the thermo-oxidative stability and crystallization behavior of VE-containing PP. Incorporating 0.2 wt % Ins into PP stabilized with 0.1 wt % VE dramatically extended the oxidation induction time from 7.5 to 45.3 min, indicating strong synergistic antioxidant activity. Furthermore, Ins enhanced crystallization kinetics, increasing the peak crystallization temperature by 5.4 °C (10 °C/min cooling rate) and reducing the half-crystallization time by 69% during isothermal crystallization at 120 °C compared to VE-only PP. The dual role of Ins was attributed to its function as a metal chelator and a heterogeneous nucleation agent, offering a sustainable strategy for high-performance PP modification.
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DOI
高影响因子
Advanced Materials Technologies
·
2025
·
IF 6.2
Junjin Duan,Yanqin Huang,Fuqing Wei,Jiachun Feng
To meet the growing demand for flexible wearable devices in the information era, the development of cost-effective, easy-processable, and mechanically sound flexible luminescent materials is pivotal but remains challenging. Here, a facile one-step melt mixing strategy is reported to prepare the reprocessable polyethylene with high stable fluorescence (f-PE) using low-density polyethylene (LDPE) and high-dosages of benzoyl peroxide (BPO) as raw materials. Typically, after 30 min mixing 50 g LDPE with 1 g BPO in a 110-rpm mixer, the resulting f-PE exhibited high fluorescent brightness and remarkable fluorescent stability. In addition to good fluorescent and mechanical properties, f-PE also demonstrated excellent processability and can be processed using conventional melt processing methods for normal PE. Based on the results, the extended through-space n-π*/π-π* interactions resulting from the high-content BPO-induced extensive grafting of oxygen-containing functional groups on the main chain is proposed, as well as the chain scissions and rearrangement under strong melt shearing, may be main factors to contribute f-PE with luminescent and processable properties. Thanks to advantages such as cost-effective raw materials, and scalable and solvent-free production, the f-PE and its preparation technique show great potential for flexible wearable applications, bringing new opportunities for functionalizing traditional versatile PE.
研究领域:
材料科学
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高分子化学
·
光学材料
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产品关联
DOI
高影响因子
JOURNAL OF SURFACTANTS AND DETERGENTS
·
2020
·Vol. 23
·期 5
·937-943
·
IF 1.654
Shuai Kong,Chong Shen,Yulu Luo,Qin Meng
Surfactants are one of the important ingredients of cosmetics. However, their penetration and penetration-promoting behavior in the skin has not been well understood. Aiming to explore the surfactant penetration in skin, a novel fluorescent surfactant F-C16, based on sodium fluorescein, was synthesized in this paper. F-C16 has a fluorescence maxima ( λ em ) of around 530 nm, and its fluorescence increased with the polarity of solvent. It possesses good emulsifying properties and low cytotoxicity. Hence, it can be used as a quickly detected indicator for surfactants in cosmetics. As demonstrated by this fluorescent surfactant, it was found that the surfactants can penetrate well into skin and cells. It seems that surfactants in cosmetics can enter the cells and reach the dermal layer of skin.
研究领域:
化妆品科学
·
药学
·
材料科学
·
生物医学工程
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产品关联
DOI
高影响因子
ChemSusChem
·
2022
·Vol. 16
·期 3
·e202202035
·
IF 9.14
Bowen Du,Xiao Chen,Yu Ling,Tiantian Niu,Weixiang Guan,Jipeng Meng,Haoquan Hu,Chi-Wing Tsang,Changhai Liang
Graphical Break it down : Catalytic hydrogenolysis-isomerization of nondegradable polyolefin plastics to high-value gasoline, diesel, and light lubricants with highly branched chains is achieved over Rh/Nb 2 O 5 bifunctional catalyst under relatively mild conditions. Preliminary economic analysis shows that this technology is economically feasible and has great potential in accelerating the transition to a circular plastics economy. Upcycling of waste polyolefin plastics still meets with economic and technological challenges in practice. In this work, the catalytic hydrogenolysis-isomerization of nondegradable polyolefin plastic waste to high-value gasoline, diesel, and light lubricants with highly branched chain is achieved over a bifunctional Rh/Nb 2 O 5 catalyst under relatively mild conditions. Owing to the high efficiency of metallic Rh active sites, the dehydrogenation/hydrogenation of long carbon chains of polyolefins is enhanced. With the assistance of strong Brønsted acidity of Nb 2 O 5 , the cleavage of C−C bonds, skeletal rearrangements, as well as the β-scission of alkylcarbenium ions occurs, which boosts the one-step solvent-free catalytic hydrogenolysis and isomerization of polyolefins. In addition, the preliminary economic analysis shows that this technology is economical, feasible, and has great potential in accelerating the transition to a circular plastics economy for sustainable development.
研究领域:
化学工程
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环境科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）