RSC Advances
·
2019
·Vol. 9
·期 59
·34652-34657
·
IF 3.049
Shengling Li,Duanlin Cao,Zhiyong Hu,Zhichun Li,Xianjiao Meng,Xinghua Han,Wenbing Ma
In this study, a highly selective chemosensor ML based on a BODIPY fluorescent chromophore was synthesized for sequential recognition of Cu2+ and HSO3− in a CH3OH/H2O (99 : 1 v/v) system, which contained three recognition sites and its structure characterized by 1H NMR, 13C NMR and ESI-HR-MS. The sensor ML showed an obvious “on–off” fluorescence quenching response toward Cu2+ and the ML-Cu2+ complex showed an “off–on” fluorescence enhancement response toward HSO3−. The detection limit of the sensor ML was 0.36 μM to Cu2+ and 1.4 μM to HSO3−. In addition, the sensor ML showed a 1 : 3 binding stoichiometry to Cu2+ and the recovery rate of ML-Cu2+ complex identifying HSO3− could be over 70%. Sensor ML showed remarkable detection ability in a pH range of 4–8.
研究领域:
分析化学
·
生物化学
✓ 已验证
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2017
·
IF 6.32
Kai-Yue Tan,Chun-Yan Li,Yong-Fei Li,Junjie Fei,Bin Yang,Ya-Jun Fu,Fang Li
Adenosine triphosphate (ATP) is mainly produced in the mitochondrion and used as a universal energy source for various cellular events. Various fluorescent probes for ATP have been established successfully, but most of them are not appropriate for monitoring the fluctuation of the mitochondrial ATP level. Herein, a fluorescent probe named Mito-Rh is first synthesized and used to recognize ATP in mitochondrion. In the probe, rhodamine, diethylenetriamine, and triphenylphosphonium are selected as fluorophore, reaction site, and mitochondrion-targeting group, respectively. Probe Mito-Rh shows high sensitivity to ATP with 81-fold fluorescence enhancement, and the detection range (0.1–10 mM) can match the concentration level of ATP in the mitochondrion. Moreover, Mito-Rh provides excellent selectivity toward ATP over other biological anions (ADP, AMP, GTP, CTP, UTP) owing to a concurrent effect of dual recognition sites (hydrogen bond and π–π stacking). In particular, the probe can localize in mitochondrion specifically and demonstrates utility in the real-time detection of mitochondrial ATP concentration changes.
研究领域:
细胞生物学
·
生物化学
✓ 已验证
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2020
·
IF 5.774
Chao Yu,Jian Lu,Zhiqiang Hou,Zhongfei Ma,Xinyu Lin,Zeqing Dong,Wendong Xing,Yongsheng Yan,Yilin Wu
Exposure and distribution of recognition sites are critical for membrane separation materials to enhance adsorption and separation efficiency toward rubidium ion. Herein, we prepared the rubidium (Rb) ion separation membranes (Rb-ISMs) through a delayed phase inversion method taking advantage of the different polarities between ethanol and water. Fabrication process was conducted through immersion of a poly (vinylidene fluoride)/graphene oxide (PVDF/GO) casting solution into coagulating bath containing 18-crown-6 (18C6) grafted mesoporous silica, ethanol and water. After phase inversion process, the as-prepared adsorbent materials were immobilized on membrane surface by strong electrostatic interaction force. The method could effectively avoid the embedding and aggregation recognition sites, and the coagulating bath only required the ethanol and water that was relatively healthy and environmental. The Rb-ISMs prepared at optimal conditions showed enhanced rebinding capacity (49.344 mg g −1 ) towards Rb ± , with a superior rebinding selectivity (11.8, 6.82, 9.08 for Rb ± /Ca 2+ , Rb ± /Cs ± , Rb ± /Mg 2+ , respectively). Importantly, Rb-ISMs showed remarkable perm-selectivity and regeneration performance, which further demonstrated its potentials in the rapid and effective separation field of Rb ions.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
Zidan Luo,Mengfei Tian,Naveed Ahmad,Yuxin Xie,Chunguo Xu,Jie Liu,Chunjian Zhao,Chunying Li
Chlorogenic acid (CGA), known as an important natural antioxidative compound in Ficus carica L, has valuable application prospects on health food, functional food, nutrition and dietary formulations. In this study, a surface multiple imprinting layers membrane (SMILM) was developed and applied to separate CGA from F. carica . Two different imprinting layers were integrated onto the membrane surface in sequence. The first imprinting layer was formed by dopamine polymerization and the second imprinting layer was fabricated by atom transfer radical polymerization (ATRP) and boronate affinity. The prepared SMILM with well-oriented multiple recognition sites exhibited high adsorption capacity (52.08 mg·g −1 in 60 min) for CGA and specific selectivity with imprinting factor ( IF ) of 3.06. Furthermore, the recognition mechanism of SMILM was clarified by molecular simulation and NMR. The SMILM was successfully applied to separate CGA from the fruits, peels and leaves of F. carica with recoveries of 90.22, 83.31 and 84.95 %, respectively.
研究领域:
植物化学
·
分离技术
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材料科学
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产品关联
DOI
PubMed
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2012
·Vol. 404
·期 1
·79-88
·
IF 3.778
Lu Fuguang,Yang Jinlong,Sun Min,Fan Lulu,Qiu Huamin,Li Xiangjun,Luo Chuannan
This paper reports the preparation of dapsone (DDS) imprinted polymer layer-coated silica submicron particles (SiO 2 ) combined with chemiluminescence (CL) toward analysis of tracing DDS in practical samples. To induce the selective occurrence of surface polymerization, the amino groups were first grafted at the surface of SiO 2 by the (3-aminopropyl)triethoxysilane (APTES). The molecularly imprinted polymers (MIP) were coated at the surface of modified SiO 2 by the graft copolymerization. After the removal of templates, recognition sites of DDS were exposed in the polymer layers. The DDS-imprinted products were characterized by FT-IR, SEM, TEM, dynamic adsorption, and static adsorption tests. The proximity between the thickness of MIP layer and the spatial size of DDS indicated that the imprinted sites almost situated at the surface of MIP, leading to rapid adsorption saturation within 90 min. The apparent maximum binding amount of MIP toward DDS was evaluated as 14.98 mg·g −1 , which was much higher than that of non-molecularly imprinted polymers. The CL sensor provided a wide linear range for DDS within 1.0 × 10 −6 to 1.0 × 10 −4 mol·L −1 with a detection limit of 5.27 × 10 -7 mol·L −1 and the relative standard deviation of 1.8 % ( n = 11) by determinations of 5.0 × 10 −6 mol·L −1 DDS. This method was applied to determine DDS in urine samples and satisfactory results were obtained.
Determination of dapsone in flow injection chemiluminescence sensor
研究领域:
分析化学
·
药物分析
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Zhaokun Yang,Huajun Jin,Ang Yu,Zhangyong Yu,Dongjian Shi,Shengrong Yan,Liyan Qin,Shirong Liu,Mingqing Chen
In comparison with molecularly imprinted photonic hydrogel (MIPH) with specific molecular recognition sites inside matrix, surface molecularly imprinted photonic hydrogel (S-MIPH) is more competitive as a molecular sensor due to presence of molecular recognition sites distributed on surface of hydrogel wall. Nevertheless, the construction of S-MIPH sensors is still challenging owing to the absence of interaction between traditional colloids and imprinted molecules. Here we report the construction of S-MIPH sensors by using poly (styrene-acrylic acid) colloids with abundant carboxyl group that are capable of binding imprinted molecules readily through hydrogen interaction. Benefit from this novel motif, S-MIPH sensors can be readily constructed by self-assembly of poly (styrene-acrylic acid) colloids binding imprinted molecules, the polymerization of precursor solution, as well as finally removal of colloids and imprinted molecules. The self-assembly of poly (styrene-acrylic acid) colloids binding imprinted molecules was investigated in detail. The as-prepared sensor delivers high sensitivity (as low as 10 −9 mol L −1 ), rapid response speed (< 60 s), and good selectivity owing to the 3D macroporous structure and specific molecular recognition sites that are well distributed on surface of hydrogel wall. Additionally, the developed sensors show good sensing performance even in commercial milk, showing great potential for real application.
研究领域:
生物化学
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材料科学
·
传感器技术
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Shucheng Liu,Jinyu Li,Zhi Hu,Xuan Zhang,Ru Feng,Yue Wang,Ruiheng Lu,Yuheng Li,Xingchen Yan
Green and sustainable recovery of high-value natural flavonoids in agricultural wastes could not only improve natural resource utilization, but also could effectively reduce environmental pollution. Recently, great efforts have been made for research on the development of magnetic imprinted composite adsorbent, but the simultaneous promotion of stable selectivity and high adsorption amounts still faces its challenges. Inspired by “Sandwich-like” transport channels with proper steric and specific affinity sites, herein we designed a new kind of surface-imprinted magnetic colloidal nanocrystal clusters (MCNCs) with dual recognition sites (MCNCs@DR-MIPs) via sequential surface imprinted strategy. A two-step sequential surface-initiated atom transfer radical polymerization (SI-ATRP) was employed to construct the double imprinted sites, which can significantly improve the adsorption selectivity and adsorption amounts. In this design, the metal ion Zn(II) and the low pKa boronic acid APBA (1-allylpyridine-3-boronic acid, pKa = 7.4) could effectively tune the appropriate yolk-shell confinement sites, the obtained artificial double imprinted binding sites establishes the promising chemical environment for selective separation. As expected, the adsorption equilibrium experiments exhibited adsorption kinetics (180 min) and the maximum equilibrium binding capacity (34.60 µmol g −1 ). In virtue of unique advantages of magnetic separation materials, this novel absorbent exhibited a green and environmentally friendly enrichment process for naringin (NRG). Meanwhile, MCNCs@DR-MIPs showed excellent selectivity (imprinted factor 2.15) and regeneration properties (only decreased by 8.22 % after 7 cycles) for NRG . Additionally, the commercially available NRG could be effectively extracted and concentrated to 94.78 %. This study offers a sustainable effective strategy for flavonoids purification of magnetic separation materials and promotes advance the other natural compounds from agricultural wastes.
研究领域:
材料科学
·
环境科学
·
天然产物化学
✓ 已验证
产品关联
DOI
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2018
·
IF 2.975
Zehu Wang,Teng Qiu,Longhai Guo,Jun Ye,Lifan He,Xiaoyu Li
In this work, we demonstrate a miniemulsion polymerization strategy to synthesize molecularly imprinted polymer (MIP) submicron particles. Bisphenol A (BPA), an endocrine disrupting chemical , is chosen as the template molecule. The template was dissolved in the mixture of the functional monomer and crosslinking agent. The monomer mixture was emulsified into miniemulsion with the droplet diameter of about 100 nm via sonication . The specific sites were immobilized into polymer particles through the radical polymerization in the droplets. After the extraction of the template, MIP particles were obtained with an average diameter of 138 nm. The formation of recognition sites on the particles was validated by the excellent binding capability towards BPA in the selective and competitive binding experiments. Benefited from the small particle sizes and large surface areas, the MIP particles exhibit accelerated adsorption kinetics . The particles with submicron sizes, excellent BPA recognition accuracy and rebinding efficiency would be attractive in environmental and analytic fields for BPA decontamination .
研究领域:
环境科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2018
·
IF 4.439
Yu Xi,Manhong Huang,Xubiao Luo
It is therefore difficult to develop anionic imprinted polymers due to its intrinsic properties of anionic templates, which have much smaller charge size ratio, species diversity, and irregular geometry than cationic templates. Moreover, its synthesis is not suitable for traditional apolar media. Hence, well-defined recognition cavities formed by coordination are almost impossible for anion imprinted polymers. Synthesized anion imprinted polymers (IIP) by electrostatic attraction of positive and negative charges to enhance the stability of anion and functional monomer in the pre-polymerization process were proposed. Speciation of phosphate and surface potential at different pH on IIP have effect on phosphate capture were investigated. The resultant IIP has a high 78.88 mg g −1 at 35 °C while non-anion imprinted polymers (NIP) has only 33.35 mg g −1 adsorption capacity. In coexist experiments, all the selectivity coefficients ( α ) of IIP are greater than 1.8, and selectivity would rise with anion concentration increased. All these shows IIP possessed outstanding selectivity and specificity to phosphate. Adsorption energy E , and ΔH 0 of IIP are 14.26 kJ mol −1 and 36.32 kJ mol −1 , respectively. It indicated that phosphate adsorbed to IIP is ion exchange reaction. It is further verified by FTIR and XPS that recognition sites of anion imprinted polymers are N + of AMD and P–O − in H 2 PO 4 − . They moved to imprinted cavities and form N + –O − , N H hydrogen bonded, which also contribute to adsorption.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2018
·
IF 6.434
Jian Lu,Yilin Wu,Xinyu Lin,Jia Gao,Hongjun Dong,Li Chen,Yingying Qin,Liang Wang,Yongsheng Yan
The increasing amount of europium in aqueous environment from rare earth industry has become a serious environmental challenge. Significant efforts have been focused on ion-imprinting membranes (IIMs) for selective separation of ions from analogues. Based on ion-imprinting technique, we have developed Eu 3+ -imprinted nanocomposite membranes (Eu-IIMs) for selectively separating Eu 3+ from La 3+ , Gd 3+ and Sm 3+ . Polydopamine (pDA) was previously synthesized on basal membranes to augment the interfacial adhesion. Grapheme oxide (GO) and modified silicon dioxide (kSiO 2 ) were synergistically stacked on pDA-modified substrates to form hydrophilic nanocomposite membranes. Ag nanoparticles were modified on the surface to enhance anti-fouling performance. The temperature-controlled selective recognition sites were formed using N-isopropylacrylamide (NIPAm) and acrylamide (Am) as functional monomers as well as europium ions as templates by RAFT (reversible addition-fragmentation chain transfer) method. Large enhanced Eu 3+ -rebinding capacity (101.14 mg g −1 ), adsorptive selectivity (1.82, 1.57, 1.45 for Eu 3+ /La 3+ , Eu 3+ /Gd 3+ , Eu 3+ /Sm 3+ ) and permselectivity (3.82, 3.47, 3.34 for La 3+ /Eu 3+ , Gd 3+ /Eu 3+ , Sm 3+ /Eu 3+ ) were achieved on Eu-IIMs with superior regeneration performance. Additionally, the negligible damage of the membranes after buried for 20 d indicated the superior anti-fouling property of the Eu-IIMs. The ion-imprinted nanocomposite membranes synthesized in this work have shown great potentials for selective separation of rare earth ions.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Yuan Ma,Haowen Wu,Qian Zhao,Hongxing Shi,Xin Wen,Hongfeng Wang,Yanhong Wang,Jiying Men
To address the efficacy differences and side effects of amlodipine (ADP) enantiomers, this study innovatively developed a surface molecularly imprinted membrane (S-ADP@SNP-SMIM) for the specific recognition and selective separation of S-ADP. The membrane was constructed via synchronous grafting polymerization and cross-linked imprinting on the SiO 2 -NH 2 /PSF composite membrane substrate, utilizing methacrylic acid (MAA) and N,N’-methylene bisacrylamide (MBA) as the functional monomer and cross-linking agent, respectively. The imprinted membrane achieved efficient recognition of S-ADP through hydrogen bonding and ionic interactions, with a selectivity coefficient reached 4.18. The cumulative release amount of S-ADP through S-ADP@SNP-SMIM reached 1608.76 μg/cm 2 within 24 h, significantly higher than that of R-ADP (139.97 μg/cm 2 ). In addition, leveraging the selective release properties of the imprinted membrane, a transdermal preparation was developed using 0.7 % carbomer as the matrix, 4 mg/mL racemic ADP solution as the drug-loading system, and a combined osmotic enhancer of 1 % oleic acid and azone. The cumulative transdermal transported volume of S-ADP in this transdermal preparation reached 1884.45 μg/cm 2 within 24 h, while that of R-ADP was only 176.47 μg/cm 2 , highlighting the regulatory role of imprinted recognition sites in selective transport. This study presented a surface molecularly imprinted membrane strategy that achieved precise separation of the superior isomer S-ADP, resolving enantiomeric efficacy disparities in amlodipine. This approach provided a dual-functional platform for establishing a universal framework for enantiomer-selective delivery systems of chiral drugs and mitigating clinical side effects.
研究领域:
药学
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2022
·
IF 7.336
Shuangchao Sheng,Zheng Zhang,Meng Wang,Xin He,Caiyun Jiang,Yuping Wang
Because of the tenacious vitality of tetracycline, it would also cause toxic effects on surface water at low concentrations. Therefore, it was critical to design the material as a platform with specific selective sensing functions and promote removal. A MIL-125(Ti)-derived cake-like TiO 2 with recognition sites (MT450) were successfully compounded by a simple mixed-solvent thermal method and using calcination method. MT450 not only inherited the large specific surface area of MIL-125(Ti), but also had excellent photoelectrochemical properties and introduced numerous recognition sites to give it the ability to quickly and specifically recognize and bind antibiotics, and improved the selectivity and sensitivity of photoelectrochemical detection effect. The results showed that MT450/ITO modified electrode was explored as novel photoelectrochemical sensor, which presented remarkable performance for tetracycline detection in a wide linear range from 0.005 to 50 μM and the LOD was estimated as 2.83 nM. Because the imprinted cavity made the affinity between tetracycline and MT450 greater, and was profit to the opening of the electron/hole transfer channel. The proposed strategy showed that the Ti-MOFs derived material with imprinted cavities can be evaluated the selective detection of photoelectrochemistry. Furthermore, the selective effects of the molecularly imprinted materials were evaluated by photocatalytic degradation of pollutants experiment.
研究领域:
材料科学
·
环境科学
·
分析化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）