BIOMATERIALS
·
2018
·
IF 8.806
Ruixue Song,Meng Zhang,Yanyan Liu,Zhaowen Cui,Hua Zhang,Zhongmin Tang,Xiaoyan Chen,Haihong Wu,Zhenwei Yao,Mingyuan He,Wenbo Bu
Hypoxia, as an inevitable characteristic of solid tumors, has been regarded as a noticeably causative factor to therapeutic resistance and metastatic variants. Exploring novel theranostics to realize the accurate diagnosis of hypoxia and the simultaneous implementation of effective therapy is a promising prospect for the successful treatment of tumors. In the present study, we designed and synthesized a multifunctional rattle-structured nanotheranostic, with the inner core coated by hollow mesoporous silica for chemical drug Doxorubicin (DOX) storage and hypoxia-sensitive MnO 2 enrichment. In various acidic micro-environments caused by hypoxia, MnO 2 nanosheets could be degraded into manganese ions (Mn 2+ ), which were chelated by the modified Tetraxetanum (DOTA) ligands for real-time T 1 -magnetic resonance imaging (T 1 -MRI), with on-demand DOX release to realize both normoxia and hypoxia-sensitive chemotherapy by overcoming hypoxia. Nanotheranostics integrating hypoxia-driven T 1 -MRI with synergetic chemotherapy have tremendous potential in the intelligent diagnosis, personalized treatment and excellent prognosis of solid tumors in the future.
研究领域:
医学影像学
·
肿瘤学
·
纳米医学
✓ 已验证
DOI
PubMed
高影响因子
Frontiers in Chemistry
·
2021
·
IF 5.221
Zhu Yuwan,Deng Mo,Xu Nannan,Xie Yingjun,Zhang Xuewen
Surgery is the main treatment for liver cancer in clinic owing to its low sensitivity to chemotherapy and radiotherapy, but this results in high mortality, recurrence, and metastasis rates. It is a feasible strategy to construct tumor microenvironments activated by nanotheranostics agents for the diagnosis and therapy of liver cancer. This study reports on a nanotheranostic agent (MONs@PDA-ICG) with manganese oxide nanoflowers (MONs) as core and polydopamine (PDA) as shell loading, with ICG as a photosensitizer and photothermal agent. MONs@PDA-ICG can not only produce ROS to kill cancer cells but also exhibit good photothermal performance for photothermal therapy (PTT). Importantly, O2 generated by MONs decomposition can relieve the tumor hypoxia and further enhance the treatment effects of photodynamic therapy (PDT). In addition, the released Mn2+ ions make MONs@PDA-ICG serve as tumor microenvironments responsive to MRI contrast for highly sensitive and specific liver cancer diagnosis.
研究领域:
肿瘤学
·
纳米医学
·
影像医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2020
·
IF 7.727
Yan Fu,Moon-Sun Jang,Nannan Wang,Yi Li,Te Peng Wu,Jung Hee Lee,Doo Sung Lee,Hong Yu Yang
Multifunctional nanosystems that can transport therapeutic and diagnostic agents into tumor sites and activate their respective functions via tumor-microenvironment recognition are highly desirable for clinical applications. We fabricated pH and redox dual-activatable self-assembled nanotheranostics (named as DA-SNs) via coordination-driven self-assembly of chlorin e6 (Ce6) disulfide-linked pH sensitive polymer ligand, poly (isobutylene- alt -maleic anhydride- graft -methoxy-poly (ethyleneglycol)- graft -imidazole-graft-Cystamine-Ce6) [PIMA-mPEG-API-SS-Ce6], and gadolinium ions (Gd 3+ ). DA-SNs exhibited uniform particle size of ~48 nm, excellent stability, and inherent biosafety. Negatively charged DA-SNs could prolong blood circulation time (t 1/2 = 2.91 h) and improve tumor accumulation. Moreover, DA-SNs could undergo surface charge switch from negative charge to positive one in a slightly acidic tumor extracellular environment (pH 6.8), thus enhancing cellular uptake. After entering tumor cells, fluorescence, photodynamic therapeutic activity, and T 1 MR contrast from DA-SNs could be activated within this intracellular environment with lowered pH and high level of GSH. Importantly, human tumors implanted in mice could be successfully visualized via distinct pH and redox dual-sensitive T 1 MR contrast and fluorescence imaging, indicating that DA-SNs could serve as a dual-modal MR/fluorescence imaging probe for tumor-targeting diagnosis. In addition, DA-SNs exhibited superior photodynamic therapeutic efficiency with negligible side effects. Therefore, this DA-SN shows great promise for synergistic photodynamic therapy and diagnostic imaging.
研究领域:
肿瘤学
·
纳米医学
·
分子影像学
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Yibiao Zou,Fei Sun,Chengmei Liu,Chunhan Yu,Mojue Zhang,Qianyuan He,Yuxuan Xiong,Zushun Xu,Shengli Yang,Guangfu Liao
A simple method is presented for the preparation of novel europium complexes-grafted-oxidative dopamine (ECOD) nanoparticles with uniform sizes (ca. 220 nm), as a high-performance nanotheranostic agent guided by X-ray computed tomography (CT) and photoluminescence (PL). Here, an oxidative dopamine precursor with a rough surface is first prepared by copper (II) ionic catalysis. Then, europium complexes are successfully grafted onto the oxidative dopamine precursor by surface-initiated atom transfer radical polymerization (ATRP). Interestingly, as the additional amount of europium (III) complexes increases, the roughening extent of the ECOD nanoparticles is increased, and the roughening surface expands to a porous network structure. This nanoagent with a rough surface exhibits not only excellent X-ray attenuation properties, but also prominent eminent near-infrared (NIR) absorbance and strong optical imaging efficiency. In addition, ECOD can provide an effective photothermal therapy (PTT) effect, and 39% photothermal conversion efficiency can be achieved. Furthermore, there is no widely detectable toxicity induced in vivo/vitro , and blood circulation can last for a long time in the presence of ECOD nanoparticles, leading to efficient accumulation at the tumor site by a persistently of enhanced permeability and retention (EPR) effect. With the combination of NIR laser irradiation (1.5 W/cm 2 ) for 10 min at 808 nm, effective photothermal ablation of a tumor in vivo can be achieved. Thus, ECOD nanoparticles can be used for effective antitumor treatment and may further exhibit potential as a nanotheranostic agent for clinical diagnosis and treatment.
研究领域:
生物医学工程
·
材料科学
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
DYES AND PIGMENTS
·
2019
·
IF 4.018
Xiaofang Qu,Fuming Yuan,Zhiquan He,Yuhan Mai,Jianmei Gao,Xinmin Li,Dezhi Yang,Yaping Cao,Xiaofei Li,Zeli Yuan
In the fight against cancer, it is urgently necessary to design a single-molecular theranostic agent (SMTA) for simultaneous diagnosis and therapy. However, this goal has not been accomplished. Here, to achieve this ambition, a chemotherapy drug of the aromatic nitrogen mustard class is covalently conjugated onto a small molecule, rhodamine, as an SMTA for the first time. The SMTA can perform multiple functionalities, including mitochondrial-targeted delivery, near-infrared (NIR) fluorescence imaging, NIR photodynamic therapy, and chemotherapy. We verified the synergetic anti-cancer effect through both in vitro and in vivo experiments. Our SMTA may provide a new avenue to explore multiple-functionality anti-cancer agents in theranostics.
研究领域:
生物医学工程
·
肿瘤学
·
药物化学
✓ 已验证
DOI
高影响因子
BIOMATERIALS
·
2012
·
IF 7.404
Shenglin Luo,Xu Tan,Qingrong Qi,Qinyuan Guo,Xinze Ran,Lilong Zhang,Erlong Zhang,Yufeng Liang,Lingling Weng,Hu Zheng,Tianmin Cheng,Yongping Su,Chunmeng Shi
Personalized oncology significantly relies on the development of cancer theranostic agents to integrate cancer therapeutics and diagnostics. Current most common strategy for development of such multifunctional agents requires multistep chemical conjugation with cancer targeted ligands, contrast agents and therapeutic agents. Here we report the chemical synthesis and biological characterization of a new heptamethine dye, termed as IR-808DB, natively with multifunctional characteristics of cancer targeting, near-infrared fluorescence imaging, and efficient anticancer activity . The tumor inhibition effect of IR-808DB is higher than that of cyclophosphamide (CTX) toward a broad spectrum of tumor xenograft models. These findings provide IR-808DB a promising prospect as a new cancer theranostic agent that would enable integration of cancer targeted therapeutics and diagnostics without requirement of multi-component chemical conjugation.
研究领域:
生物化学
·
肿瘤学
·
分子医学
✓ 已验证
DOI
高影响因子
Advanced Healthcare Materials
·
2019
·Vol. 8
·期 10
·1900047
·
IF 6.27
Chaoping Fu,Xiaohui Duan,Minghui Cao,Shuqi Jiang,Xiaohua Ban,Na Guo,Fang Zhang,Jiaji Mao,Ting Huyan,Jun Shen,Li Ming Zhang
Manganese dioxide (MnO 2 )-based nanoparticles are a promising tumor microenvironment-responsive nanotheranostic carrier for targeted magnetic resonance imaging (MRI) and for alleviating tumor hypoxia. However, the complexity and potential toxicity of the present common synthesis methods limit their clinical application. Herein, multifunctional hyaluronic acid-MnO 2 nanoparticles (HA-MnO 2 NPs) are synthesized in a simple way by directly mixing sodium permanganate with HA aqueous solutions, which serve as both a reducing agent and a surface-coating material. The obtained HA-MnO 2 NPs show an improved water-dispersibility, fine colloidal stability, low toxicity, and responsiveness to the tumor microenvironment (high H 2 O 2 and high glutathione, low pH). After intravenous injection, HA-MnO 2 NPs exhibit a high imaging sensitivity for detecting rat intracranial glioma with MRI for a prolonged period of up to 3 d. These nanoparticles also effectively alleviate the tumor hypoxia in a rat model of intracranial glioma. The downregulation of VEGF and HIF-1α expression in intracranial glioma validates the sustained attenuation effect of HA-MnO 2 NPs on tumor hypoxia. These results show that HA-MnO 2 NPs can be used for sensitive, targeted MRI detection of gliomas and simultaneous attenuation of tumor hypoxia.
研究领域:
生物医学工程
·
癌症研究
·
材料科学
·
医学影像
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2020
·Vol. 9
·期 9
·3306-3318
·
IF 6.183
Shuguang Yang,Dejian Li,Liang Chen,Xiaojun Zhou,Liwen Fu,Yanling You,Zhengwei You,Li Kang,Maoquan Li,Chuanglong He
The superior properties of metal organic frameworks (MOF) can provide great opportunities for merging functional nanoparticles to construct smart and versatile cancer theranostic agents. In this study, on the basis of non-mesoporous nanoparticles (molybdenum disulfide, MoS2), the structure of the MOF shell layer with an adjustable structure can be constructed through the natural coordination interaction between polydopamine (PDA) and iron ion, and the tumor cell target ligand was modified on the surface of the nanocomposite after loading the anticancer drug doxorubicin hydrochloride (DOX) to form a multifunctional cancer theranostics nanoplatform (DOX@MoS2-PMA). Benefiting from the excellent properties of MoS2 and MOF, the favorable photothermal properties and pH/near-infrared (NIR) laser-triggered DOX release behavior of composite nanoparticles were demonstrated. Its well-defined nanostructure, adequate colloidal stability, and satisfactory biocompatibility were further evidenced. Furthermore, the selective tumor cell targeting ability of DOX@MoS2-PMA can improve the cellular uptake efficacy and the photothermal-chemotherapy combination therapy can significantly enhance the killing effect on cancer cells both in vitro and in vivo. In addition, fluorescence imaging results show that nanoparticles can efficiently accumulate inside tumors. The photoacoustic (PA) and magnetic resonance (MR) imaging capabilities derived from different components of nanoparticles can perform better imaging effects. To the best of our knowledge, this is the first attempt to merge the performance of MoS2 with MOF for PA/MR dual-modality imaging-guided photothermal-chemotherapy combination therapy. Our work presented herein proves that MOF can be combined with non-mesoporous nanoparticles and exhibits excellent performance, thus opening a new avenue for endowing non-mesoporous nanoparticles with an efficient drug loading capacity and practical applications of MOFs in nanomedicine.
研究领域:
纳米医学
·
癌症研究
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Omega
·
2022
·
IF 4.132
Ting Yan,Gulinigaer Alimu,Lijun Zhu,Huimin Fan,Linxue Zhang,Zhong Du,Rong Ma,Shuang Chen,Nuernisha Alifu,Xueliang Zhang
High treatment accuracy is the key to efficient cancer treatment. Photodynamic therapy (PDT) and photothermal therapy (PTT) are two kinds of popular, precise treatment methods. The combination of photodynamic and photothermal therapy (PDT/PTT) can greatly enhance the precise therapeutic efficacy. In this work, protoporphyrin IX (PpIX) was selected as the PDT agent (photosensitizer), and new indocyanine green (IR-820) was selected as the PTT agent. Further, the two kinds of theranostic agents were encapsulated by biological-membrane-compatible liposomes to form PpIX-IR-820@Lipo nanoparticles (NPs), a new kind of PDT/PTT agent. The PpIX-IR-820@Lipo NPs exhibited good water solubility, a spherical shape, and high fluorescence peak emission in the near-infrared spectral region (700–900 nm, NIR). The cellular toxicity of PpIX-IR-820@Lipo NPs for human cervical cancer cells (HeLa) and human cervical epithelial cells (H8) was detected by the CCK-8 method, and low cytotoxicity was observed for the PpIX-IR-820@Lipo NPs. Then, the excellent cellular uptake of PpIX-IR-820@Lipo NPs was confirmed by laser scanning confocal microscopy. Moreover, the PDT/PTT property of PpIX-IR-820@Lipo NPs was illustrated via 2′,7′-dichlorofluorescin diacetate (DCFH-DA) and annexin V-fluorescein isothiocyanate (annexin V-FITC), as indicator probes. The PDT/PTT synergistic efficiency of PpIX-IR-820@Lipo NPs on HeLa cells was verified, exhibiting a high efficiency of 70.5%. Thus, the novel theranostic PpIX-IR-820@Lipo NPs can be used as a promising PDT/PTT synergistic theranostic nanoplatform in future cervical cancer treatment.
研究领域:
癌症研究
·
纳米技术
·
光疗
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
Acta Biomaterialia
·
2019
·
IF 6.638
Yushen Jin,Yanyan Li,Xin Yang,Jie Tian
Neuroblastoma accounts for 8–10% of malignancies in infants and children. It is urgent to develop an appropriate theranostic agent for effective diagnosis and therapy of neuroblastoma. Herein, we constructed RVG peptide and IRDye800-conjugated bovine serum albumin-coated triangular gadolinium oxide nanoplates (RVG&IRDye800-Gd 2 O 3 TNs) as a targeting MRI agent for the diagnosis of neuroblastoma preoperation and a fluorescence imaging agent for the guidance of the precise excision of the neuroblastoma in surgery. RVG&IRDye800-Gd 2 O 3 TNs have uniform edge length. The RVG&IRDye800-Gd 2 O 3 TNs show remarkably enhanced affinity to both mouse- and human-derived neuroblastoma cells compared with IRDye800-Gd 2 O 3 TNs (3.07-fold and 3.02-fold, respectively). Because of the increased accumulation in tumor cells, RVG&IRDye800-Gd 2 O 3 TNs exhibit signals threefold to fivefold higher than the surrounding normal tissues, which is propitious to the diagnosis of neuroblastoma preoperation and provides real-time visual guidance of the precise excision of the neuroblastoma. Most importantly, with the guidance of the fluorescence imaging agent, the survival rate increased from 0% to 80% 42 days after surgery compared with that in conventional surgery. These findings indicated that the RVG peptide combined with IRDye800-Gd 2 O 3 TNs has the potential to improve the diagnosis and treatment of patients with neuroblastoma. Statement of significance In this study, we prepared RVG peptide and IRDye800-conjugated bovine serum albumin-coated triangular gadolinium oxide nanoplates (RVG&IRDye800-Gd 2 O 3 TNs) as a targeting MRI agent for the diagnosis of neuroblastoma preoperation and a fluorescence imaging agent for the guidance of the precise excision of the neuroblastoma during surgery. Neuroblastoma was accurately located by MRI imaging, and the tumor margin could be real-time monitored through near-infrared fluorescence imaging. The RVG&IRDye800-Gd 2 O 3 TNs exhibit signals threefold to fivefold higher than those in the surrounding normal tissues, which is propitious to the diagnosis of the neuroblastoma preoperation and provides real-time visual guidance of the precise excision of the neuroblastoma. With the guidance of the fluorescence imaging agent in surgery, the survival rate increased from 0% to 80% 42 days after surgery compared with that in conventional surgery.
研究领域:
肿瘤学
·
纳米医学
·
分子影像
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DRUG DELIVERY
·
2022
·
IF 6.819
Zhian Chen,Zhenhao Li,Chuangji Li,Huilin Huang,Yingxin Ren,Zhenyuan Li,Yanfeng Hu,Weihong Guo
Gastric cancer (GC) is a serious disease with high morbidity and mortality rates worldwide. Chemotherapy plays a key role in GC treatment, while inevitable drug resistance and systematic side effects hinder its clinical application. Fenton chemistry-based chemodynamic therapy (CDT) has been used as a strategy for cancer ferroptosis, and the CDT efficiency could be enhanced by photothermal therapy (PTT). With the trend of treatment and diagnosis integration, the combination of magnetic resonance imaging (MRI) and CDT/PTT exhibits enormous progress. Herein, we constructed a platform based on PEGylated manganese-containing polydopamine (PDA) nanoparticles, named as PEG-PDA@Mn (PP@Mn) NPs. The PP@Mn NPs were stable and globular. Furthermore, they demonstrated near-infrared (NIR)-triggered PTT and Fenton-like reaction-based CDT effects and T1-weighted MRI capabilities. According to in vitro studies, the PP@Mn NPs trigger ferroptosis in cancer cells by producing abundant reactive oxygen species (ROS) via a Fenton-like reaction combined with PTT. Furthermore, in vivo studies showed that, under MRI guidance, the PP@Mn NPs combined with the PTT at the tumor region, have CDT anti-tumor effect. In conclusion, the PP@Mn NPs could provide an effective strategy for CDT/PTT synergistic ferroptosis therapy for GC.
研究领域:
癌症治疗
·
纳米技术
·
生物医学工程
·
医学成像
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Junjun Wang,Xiaojiao Zhu,Jie Zhang,Haiyan Wang,Gang Liu,Yingcui Bu,Jianhua Yu,Yupeng Tian,Hongping Zhou
Photodynamic therapy (PDT) takes advantage of reactive oxygen species (ROS) to trigger the apoptosis for cancer therapy. Given that cell apoptosis is a form of programmed cell death involved with multiple suborganelles and cancer cells are more sensitive to ROS than normal cells, early confirmation of the apoptosis induced by ROS would effectively avoid overtreatment. Herein, we highlight an aggregation-induced emission (AIE)-based theranostic agent (TPA3) to in situ dynamically track mitophagy prior to late apoptosis. TPA3 showed high specificity to autophagy vacuoles (AVs), of which appearance is the signature event of mitophagy during early apoptosis and delivered photocytotoxicity to cancer cells and skin cancer tumors in nude mice under irradiation of white light. Furthermore, in situ monitoring of the dynamical mitophagy process involved with mitochondria, AVs, and lysosomes was performed for the first time under confocal microscopy, providing a real-time self-monitoring system for assessing the curative effect prior to late apoptosis. This fluorescence imaging guided PDT witness great advances for applying in the clinical application.
研究领域:
癌症研究
·
生物医学工程
·
诊疗学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）