SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Hang Ao,Hui Feng,Keqing Li,Meizhi Zhao,Zhaosheng Qian,Jianrong Chen
Luminescent materials with aggregation-induced emission (AIE) have been widely used in chemosensors and biosensors based on signal change induced by physical aggregation of AIEgens. In this work, a novel coordinate bonding-induced emission (BIE) phenomenon of gold-glutathione complex was proposed and identified, and this specific coordinate BIE was further utilized to develop signal-enhanced methods for quantification of aluminum species including aluminum cation and polyoxocation AlO 4 Al 12 (OH) 24 (H 2 O) 12 7+ . Gold-glutathione (Au-GSH) complex has shown significant aggregation-induced emission characteristic, and it can sensitively respond to multiple external stimuli such as solvent polarity and pH via an emission-enhancing fashion. It is found that the introduction of aluminum cation to Au-GSH complex is able to more greatly enhance the luminescence through a coordinate bonding-induced emission process, and this BIE behavior is attributed to strong force induced by coordination reaction between glutathione ligands and aluminum cation. In comparison with AIE process, coordinate BIE process was shown to be a more efficient way to enhance the emission. This BIE property of Au-GSH complex was employed to measure aluminum cation and polyoxocation Al 13 with good selectivity. This work provides a new coordinate bonding-induced emission phenomenon, and gives a demonstration of designing chemosensors for metal cations based on coordinate BIE process.
研究领域:
分析化学
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材料科学
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环境化学
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DOI
高影响因子
ORGANIC & BIOMOLECULAR CHEMISTRY
·
2017
·Vol. 15
·期 28
·6006-6013
·
IF 3.564
Liangbin Lin,Xiaoru Lin,Hongyu Guo,Fafu Yang
This study focuses on the construction of novel diphenylacrylonitrile-connected BODIPY dyes with high fluorescence in both solution and an aggregated state by combining DRET and FRET processes in a single donor–acceptor system. The first BODIPY derivatives with one, two, or three AIE-active diphenylacrylonitrile groups were designed and synthesized in moderate yields. Strong fluorescence emissions were observed in the THF solution under excitation at the absorption wavelength of non-emissive diphenylacrylonitrile chromophores, implying the existence of the DRET process between the dark diphenylacrylonitrile donor and the emissive BODIPY acceptor. In the THF/H2O solution, the fluorescence intensity of the novel BODIPY derivatives gradually increased under excitation at the absorption wavelength of diphenylacrylonitrile chromophores, suggesting a FRET process between diphenylacrylonitrile and BODIPY moieties. A greater number of diphenylacrylonitrile units led to higher energy-transfer efficiencies. The pseudo-Stokes shift for both DRET and FRET processes was as large as 190 nm.
研究领域:
化学
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材料科学
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光学
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产品关联
DOI
PubMed
高影响因子
Biosensors-Basel
·
2023
·Vol. 13
·期 3
·351
·
IF 5.4
Lei Liu,Huixing Wang,Husseini Sulemana,Bing Xie,Li Gao
As a biomarker, alpha-fetoprotein (AFP) is valuable for detecting some tumors in men, non-pregnant women, and children. However, the detection sensitivity in some methods needs to be improved. Therefore, developing a simple, reliable, and sensitive detection method for AFP is important for non-malignant diseases. An aptamer binding was developed based on aggregation-induced emission luminogen (AIEgen) nanosphere labeled with Fe3O4@MPTMS@AuNPs. AFP was detected with a sandwich structure of AuNPs magnetic composite particles. An aggregation-induced emission (AIE) molecule and polystyrene (PS) nanosphere complex were assembled, enhancing the fluorescence and improving the sensitivity of detection. The limit of detection (LOD) was at a given level of 1.429 pg/mL, which can best be achieved in serum samples. Finally, the results obtained showed the complex to be promising in practical applications.Keywords:aptamer;AFP;detection;AIE
研究领域:
生物化学
·
医学诊断
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2021
·
IF 6.953
Xiaoyu Xia,Xiaoyi Tan,Chao Wu,Yao Li,Guanghua Zhao,Ming Du
The aggregation-induced emission (AIE) material has been widely used in biological detection due to their unique property of fluorescing in aggregation state. However, the poor dispersion and biocompatibility limit its application in in vivo real-time imaging. Here, a novel strategy is designed to obtain pH-responsive AIE nanomaterials, working through 4-Undecoxy Tetraphenyl Ethylene Methacrylate (PM1) block, with excellent features (dispersion, biocompatibility, self-reconstruction and cancer specific recognition). The recombinant human H-ferritin (rHuHF) was used to prepare rHuHF-PM1 nanocomposites which effectively supported the dispersion and transfer of PM1 in the biological environment, even making it target tumor cells due to the overexpression of ferritin receptors on tumor cells. To simulate the changes of rHuHF in intracellular lysosomes, particle size and fluorescence of rHuHF-PM1 were analyzed, which reflected the loose structural changes of rHuHF nanocages in weak acid system that facilitated the degradation of macromolecular rHuHF in intracellular lysosomes and following release of PM1. The released PM1 molecules aggregated and emitted brilliant blue fluorescence. Several cell lines, Hela, HT-29, HepG2, L-O2 and HUVEC have all been sensitively detected and distinguished. Accordingly, this nanocage has a potential to be applied to disease diagnosis and provides a novel sensing platform for the identification of cancer.
研究领域:
生物纳米技术
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癌症诊断
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分子生物学
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生物医学工程
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DOI
PubMed
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2013
·Vol. 160
·期 3
·H173
·
IF 2.588
Bin Hu,Xiaojing Lv,Jingwei Sun,Mi Ouyang,Zhiyan Fu,Cheng Zhang
In this study, a novel material, Z-2, 3-bis(4-(thiophen-3-yl)-phenyl) –acrylonitrile (Z-TPA), was synthesized and characterized. Optical and electrochromic properties of its homopolymer and copolymer with 3, 4-Ethylenedioxythiophene (EDOT) were investigated in details. UV–vis absorption and fluorescence spectra showed that this material possessed the properties of aggregation-induced emission (AIE) due to the introduction of acrylonitrile, which could show sky-blue emitting at the aggregation state and almost no emitting at the solution state. Both its polymer and copolymer displayed better redox activity. Spectroelectrochemical analysis displayed that the copolymer film exhibited multicolor showing, with a claret red in the fully reduced form and a blue-green color in the fully oxidized. Spectrochronoamperometry data revealed that the copolymer films had fast switching time and high chromatic contrast as compared to the homopolymer P(Z-TPA). What's more, the copolymer film was used to construct a dual type polymer electrochromic device (ECDs) with PEDOT. The performance of ECDs were also investigated.
研究领域:
材料科学
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光学
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电化学
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产品关联
DOI
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 48
·30229-30241
·
IF 3.108
Kai Li,Yang Zhang,Bing Qiao,Furong Tao,Tianduo Li,Yunqiao Ding,Françisco M. Raymo,Yuezhi Cui
Four barbituric derivatives (1–4), were synthesized with obvious aggregation induced emission (AIE) or aggregation induced emission enhancement (AIEE) behaviors. The optical properties in different states and the mechanisms of the enhanced emission of 1–4 were investigated. We found that there were a large number of globular or blocky nanoparticles with average diameters from 229 to 394 nm in tetrahydrofuran (THF)/water solutions when the water fraction (fw) was 90%. The single crystal data of 2 and 4 reveal that multiple intermolecular interactions restrict the intramolecular motions, and promote the formation of a herringbone arrangement (4), thus permitting intense emission in the aggregate state. In addition, the frontier molecular orbital energy and band gap calculated by density functional theory (DFT) are consistent with the experimental results. Compound 4 is cell-permeable: upon entering the live cells, the dye molecules can accumulate in the lysosomes and turn on the fluorescence.
研究领域:
材料科学
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纳米技术
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生物医学工程
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化学
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2022
·Vol. 23
·期 18
·10440
·
IF 6.208
Yingxiang Zhai,Jiguo Zhang,Jian Li,Shouxin Liu,Zhijun Chen,Shujun Li
The potential for leakage of liquid electrolytes from magnesium (Mg) batteries represents a large hurdle to future application. Despite this, there are no efficient sensing technologies to detect the leakage of liquid electrolytes. Here, we developed a sensor using laccaic acid (L-AIEgen), a naturally occurring aggregation-induced emission luminogen (AIEgens) isolated from the beetle Laccifer lacca. L-AIEgen showed good selectivity and sensitivity for Mg2+, a universal component of electrolytes in Mg batteries. Using L-AIEgen, we then produced a smart film (L-AIE-F) that was able to sense leakage of electrolytes from Mg batteries. L-AIE-F showed a strong “turn-on” AIE-active fluorescence at the leakage point of electrolyte from model Mg batteries. To the best of our knowledge, this is the first time that AIE technology has been used to sense the leakage of electrolytes.Keywords:laccaic acid;aggregation-induced emission;smart film;detect of Mg2+
研究领域:
材料科学
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化学
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DOI
PubMed
高影响因子
LIQUID CRYSTALS
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2022
·
IF 2.676
Zengwei Yang,Xinyao Huang,Jianchao Cheng,Hongyu Guo,Fafu Yang
This paper reported the first example of thiophene-containing AIE fluorescence liquid crystals. Thiophene-vinylnitrile Schiff-base derivatives 5 with one alkyl chain and 6 with two alkyl chains were prepared conveniently in yields of 86% and 88%, respectively. They exhibited the smectic phases from 91.5 to 130.6℃ for sample 5 and 71.3 to 120.2℃ for sample 6. They displayed excellent fluorescence in aggregated states of solid film and mesophase. The absolute fluorescence quantum yields in solid film were as high as 0.64 for samples 5 and 0.76 for sample 6, respectively. These results suggested thiophene-vinylnitrile Schiff-base derivatives 5 and 6 were excellent fluorescence liquid crystals and the multiple alkyl chains on thiophene-vinylnitrile Schiff-base derivatives were favourable for the low temperature of mesophase and high fluorescence.
研究领域:
材料化学
·
光学材料
✓ 已验证
DOI
高影响因子
JOURNAL OF FLUORESCENCE
·
2024
·
IF 2.6
Ning Kefan,Ma Xinhuan,Wang Xinyao,Cui Shiqiang,Pu Shouzhi
As a new type of zero-dimensional nanomaterial, carbon dots are widely applied in various fields. However, most of the carbon dots have aggregation fluorescence quenching properties, which limited their practical applications. In this study, a novel sulfur-doped carbon dots (S-CDs) was prepared by solvothermal method. The properties of the S-CDs in ethanol solution and in solid state were investigated respectively. The results showed that the S-CDs have an excited wavelength dependent emission of blue fluorescence in ethanol solution, and have orange fluorescence emission in solid state and composite films, indicating the prepared S-CDs has aggregation-induced emission (AIE) performance. The main reason was that the presence of S-S bonds and the intramolecular rotation of aromatic rings were limited in solid state, resulting in its emission of orange fluorescence. Furthermore, the S-CDs could be applied to identify fingerprints, anti-counterfeiting.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2025
·
IF 4.6
Lingchen Wang,Yue Huang,Linlin Sun,Xiaojuan Gong,Chuan Dong,Shaomin Shuang
Herein, a novel rapid, specific, and sensitive probe for adenosine triphosphate (ATP) detection is developed. We have pioneered the integration of split ATP aptamers with aggregation-induced emission (AIE) via chemical binding to obtain a novel ATP detection probe (TPE probe). Upon the binding of the ATP split aptamer to the target, the intermolecular distance of the AIE molecules decreases, restricting their spatial rotation, which leads to an enhancement of the fluorescence signal, thereby enabling the detection of ATP. This unique design provides the probe with both target-specific recognition capability of the aptamer and sensitive signal-reporting function. Under the optimized experimental conditions, the probe exhibits a linearity range from 1-1000 nM with limit of detection 0.14 nM, displaying a comparative advantage over previously reported methods in terms of sensitivity and selectivity. Additionally, this method demonstrated satisfactory performance for ATP detection in beer samples, with recoveries between 97.5 % to 104.6 %. More importantly, the current research is expected to provide an effective monitoring method for beer quality control.
研究领域:
生物化学
·
分析化学
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产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Sayed Mir Sayed,Xiang-Fei Li,Hao-Ran Jia,Samran Durrani,Fu-Gen Wu,Xiaolin Lu
Lipid droplets (LDs) are spherical dynamic subcellular organelles, and play crucial roles in a number of cellular functions, such as lipid metabolism, protein degradation, membrane formation, energy storage, and signal transduction. It is widely recognized that the dysfunction of LDs can lead to many diseases, and hence it is important to monitor the size, distribution, and movement of LDs in living cells. Herein, we report a dibenzothiopene core-based fluorescent probe named triphenylamine dibenzothiophene-S,S-dioxide (TPA-DBTD), which can exhibit aggregation-induced emission (AIE) characteristic and realize selective and wash-free imaging of LDs in live cells. Most importantly, this probe can efficaciously track the dynamic changes of LDs including lipophagy (an autophagic process that is responsible for the degradation of lipids) in live mammalian cells and stain LDs in fungi. Hence, we believe that TPA-DBTD with high photostability, good biocompatibility, AIE characteristic, and LD staining ability in diverse biological systems (mammalian cells and microorganisms) can find practical applications in the fields of biomedical science, cell biology, and diagnosis of LDs-associated diseases.
研究领域:
生物医学
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细胞生物学
·
诊断学
✓ 已验证
产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2022
·
IF 4.831
Ruihong Yao,Zhijian Li,Panpan Huo,Congcong Gong,Gang Liu,Chunhong Zheng,Shouzhi Pu
In this study, we constructed zinc based metal–organic framework functionalized by L-histidine (His@ZiF-8). The His@ZiF-8 had high porosity, large surface area, abundant carboxyl and amino group, which has been found to greatly enhance the aggregation-induced emission (AIE) of tetracycline (TC). After the His@ZiF-8 enrichment with TC, the TC exhibited strong fluorescence emission peak at 565 nm based on AIE. Under the optimal conditions, the fluorescence intensity of TC exhibited a good linear relationship with TC concentration within 0.1–80 μM with a low limit of detection of 28.6 nM. Antibiotic analogs such as neomycin, chloramphenico, ampicillin, kanamycin, and erythromycin have no obvious interference. In addition, the developed method was successfully used to the detection of TC in milk, river water, and honey.
研究领域:
材料科学
·
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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