Advanced Science
·
2022
·Vol. 9
·期 22
·2201844
·
IF 17.521
Zong-Tao Li,Hong-Wei Zhang,Jia-Sheng Li,Kai Cao,Ziming Chen,Liang Xu,Xin-Rui Ding,Bin-Hai Yu,Yong Tang,Jian-Zhen Ou,Hao-Chung Kuo,Hin-Lap Yip
Tandem structures with different subpixels are promising for perovskite-based multicolor electroluminescence (EL) devices in ultra-high-resolution full-color displays; however, realizing excellent luminance- and color-independent tunability considering the low brightness and stability of blue perovskite light-emitting diodes (PeLEDs) remains a challenge. Herein, a bright and stable blue gallium nitride (GaN) LED is utilized for vertical integration with a green MAPbBr 3 PeLED, successfully achieving a Pe-GaN tandem LED with independently tunable luminance and color. The electronic and photonic co-excitation (EPCE) effect is found to suppress the radiative recombination and current injection of PeLEDs, leading to degraded luminance and current efficiency under direct current modulation. Accordingly, the pulse-width modulation is introduced to the tandem device with a negligible EPCE effect, and the average hybrid current efficiency is significantly improved by 139.5%, finally achieving a record tunable luminance (average tuning range of 16631 cd m −2 at an arbitrary color from blue to green) for perovskite-based multi-color LEDs. The reported excellent independent tunability can be the starting point for perovskite-based multicolor EL devices, enabling the combination with matured semiconductor technologies to facilitate their commercialization in advanced display applications with ultra-high resolution.
研究领域:
材料科学
·
光电技术
·
显示技术
✓ 已验证
DOI
高影响因子
Journal of Energy Chemistry
·
2024
·
IF 14
Meng-Chen Huang,Chao-Hua Xue,Zhongxue Bai,Jun Cheng,Yong-Gang Wu,Chao-Qun Ma,Li Wan,Long Xie,Hui-Di Wang,Bing-Ying Liu,Xiao-Jing Guo
All-season thermal management with zero energy consumption and emissions is more crucial to global decarbonization over traditional energy-intensive cooling/heating systems. However, the static single thermal management for cooling or heating fails to self-regulate the temperature in dynamic seasonal temperature condition. Herein, inspired by the dual-temperature regulation function of the fur color changes on the backs and abdomens of penguins, a smart thermal management composite hydrogel (PNA@H-PM Gel) system was subtly created though an “on-demand” dual-layer structure design strategy. The PNA@H-PM Gel system features synchronous solar and thermal radiation modulation as well as tunable phase transition temperatures to meet the variable seasonal thermal requirements and energy-saving demands via self-adaptive radiative cooling and solar heating regulation. Furthermore, this system demonstrates superb modulations of both the solar reflectance (Δ R = 0.74) and thermal emissivity (Δ E = 0.52) in response to ambient temperature changes, highlighting efficient temperature regulation with average radiative cooling and solar heating effects of 9.6 °C in summer and 6.1 °C in winter, respectively. Moreover, compared to standard building baselines, the PNA@H-PM Gel presents a more substantial energy-saving cooling/heating potentials for energy-efficient buildings across various regions and climates. This novel solution, inspired by penguins in the real world, will offer a fresh approach for producing intelligent, energy-saving thermal management materials, and serve for temperature regulation under dynamic climate conditions and even throughout all seasons.
研究领域:
材料科学
·
生物仿生学
·
能源工程
✓ 已验证
产品关联
DOI
高影响因子
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
·
2022
·Vol. 106
·期 19
·6551-6566
·
IF 5.56
Khan Sabir,Xu Xueqi,Song Jialei,Wu Panpan,Liu Xiaobin,Liu Jing,Chen Ketao,Xu Zhenyue,Wu Hang,Zhang Buchang
Abstract TetR family transcriptional regulators (TFRs) are widespread in actinomycetes, which exhibit diverse regulatory modes in antibiotic biosynthesis. Nitrogen regulators play vital roles in modulation of primary and secondary metabolism. However, crosstalk between TFR and nitrogen regulator has rarely been reported in actinomycetes. Herein, we demonstrated that a novel TFR, SACE_4839, was negatively correlated with erythromycin yield in Saccharopolyspora erythraea A226. SACE_4839 indirectly suppressed erythromycin synthetic gene eryAI and resistance gene ermE and directly inhibited its adjacent gene SACE_4838 encoding a homologue of nitrogen metabolite repression (NMR) regulator NmrA (herein named NmrR). The SACE_4839-binding sites within SACE_4839-nmrR intergenic region were identified. NmrR positively controlled erythromycin biosynthesis by indirectly stimulating eryAI and ermE and directly repressing SACE_4839 . NmrR was found to affect growth viability under the nitrogen source supply. Furthermore, NmrR directly repressed glutamine and glutamate utilization-related genes SACE_1623 , SACE_5070 and SACE_5979 but activated nitrate utilization-associated genes SACE_1163 , SACE_4070 and SACE_4912 as well as nitrite utilization-associated genes SACE_1476 and SACE_4514 . This is the first reported NmrA homolog for modulating antibiotic biosynthesis and nitrogen metabolism in actinomycetes. Moreover, combinatorial engineering of SACE_4839 and nmrR in the high-yield S. erythraea WB resulted in a 68.8% increase in erythromycin A production. This investigation deepens the understanding of complicated regulatory network for erythromycin biosynthesis. Key points
SACE_4839 and NmrR had opposite contributions to erythromycin biosynthesis.
NmrR was first identified as a homolog of another nitrogen regulator NmrA.
Cross regulation between SACE_4839 and NmrR was revealed.
研究领域:
微生物学
·
分子生物学
·
生物技术
✓ 已验证
DOI
PubMed
高影响因子
CHINESE MEDICAL JOURNAL
·
2025
·
IF 7.3
Li Na,Mao Jingwei,Tang Haiying,Tan Xiaoyan,Bi Jian,Wu Hao,Chen Xiuli,Wang Yingde
Background: Regulatory dendritic cell (DCreg) subset exhibits a unique capacity for inducing immune tolerance among the variety subsets of dendritic cells (DCs) within gut-associated lymphoid tissues (GALTs). Fms-like tyrosine kinase 3 ligand (FLT3L) is involved in the differentiation of DCregs and the subsequent expansion of regulatory T-cells (Tregs) mediated by DCregs, though the precise mechanism remains poorly understood. This study aimed to explore the expansion mechanism of Treg induced by DCreg and the role of FLT3L in this process. Methods: DCregs were distinguished from other DC subsets isolated from GALTs of BALB/c mice through a mixed lymphocyte reaction assay. The functions and mechanisms by which FLT3L promoted Treg expansion via DCregs were investigated in vitro through co-culture experiments involving DCregs and either CD4 + CD25 − T-cells or CD4 + CD25 + T-cells. Additionally, an in vivo experiment was conducted using a dextran sulfate sodium (DSS)-induced colitis model in mice. Results: CD103 + CD11b + DC exhibited DCreg-like functionality and was identified as DCreg for subsequent investigation. Analysis of Foxp3 + Treg percentages within a co-culture system of CD4 + CD25 − T-cells and DCregs, with or without FLT3L, demonstrated the involvement of the FLT3/FLT3L axis in driving the differentiation of precursor T-cells into Foxp3 + Tregs induced by DCregs. Cell migration and co-culture assays revealed that the FLT3/FLT3L axis enhanced DCreg migration toward Tregs via the Rho pathway. Additionally, it was observed that DCregs could promote Treg proliferation through the Notch pathway, as inhibition of Notch signaling by DAPT (N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester) suppressed Treg expansion within the co-culture system of DCregs and CD4 + T-cells or CD4 + CD25 + T-cells. Furthermore, the FLT3/FLT3L axis influenced JAG1 expression in DCregs, indirectly modulating Treg expansion. In vivo experiments further established that FLT3L promoted DCreg expansion and restored Treg balance in DSS-induced colitis models, thereby ameliorating colitis symptoms in mice. Conclusion: The FLT3/FLT3L axis is integral to the maintenance of DCreg function in Treg expansion.
研究领域:
免疫学
·
分子生物学
·
医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2023
·Vol. 170
·期 12
·126503
·
IF 3.9
Mengtao Sun,Likun Wang,Guohua Shi,Qiying Liu,Gang Xu,Yong Liu,Gaorong Han
Dual-band electrochromic (EC) smart windows, capable of selectively regulating visible (VIS) and near-infrared (NIR) light, are one of the most attractive candidates for significantly reducing the energy consumption of buildings. Niobium-tungsten bimetallic oxides exhibit a fast ion exchange rate and high cycle stability in the electrochemical field because of various structural chemistry in the pseudobinary system Nb2O5/WO3, showing excellent dual-band EC potential. Herein, we employ a facile hydrothermal technique to synthesize Nb18W16O93 (NWO) films with low temperature and facile procedure. The obtained NWO films exhibit impressive dual-band electrochromic performances, including high optical regulation (radiation blocking rates of 33.1% and 77.5% in the VIS and NIR band) and short coloring/bleaching time (12 s/2.6 s at 633 nm and 6.5 s/6.1 s at 1600 nm). These results demonstrate that NWO is a high-performance dual-band EC material and provide a practical strategy to synthesize the NWO electrodes with nanorod stacking architectures in a facile and low-cost way.
研究领域:
材料科学
·
电化学
✓ 已验证
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2023
·
IF 19
Hulin Zhang,Xiang Zhang,Wenhai Sun,Mingjun Chen,Yingjun Xiao,Zhenmin Ding,Dukang Yan,Jianbo Deng,Zitong Li,Jiupeng Zhao,Yao Li
Smart windows that incorporate photothermal modulators (PMs) can independently regulate solar transmittance and infrared (IR) emissivity to improve building comfort and reduce energy consumption. Herein, a novel all-solid-state variable IR emissivity device (VED) is first designed and fabricated with a high visible irradiation transmittance ( T ′ vis = 0.79) and solar irradiation transmittance ( T ′ sol = 0.75) using an ITO/SiO 2 /ITO Fabry–Perot cavity structure. The VED exhibits different IR emissivity (ɛ) values at positive (ɛ P = 0.80) and negative (ɛ N = 0.38) bias, allowing for dynamic regulation of radiation by controlling the electrical conductivity of the indium tin oxide (ITO) layer. Furthermore, an all-solid-state PM with a structure of ITO/SiO 2 /ITO/Glass/ITO/NiO/ZrO 2 /Li/WO 3 /ITO, which is capable of independently regulating solar transmittance (Δ T' sol = 0.31) and IR emissivity (Δɛ 2.5–25 µm = 0.42), is fabricated. The multi-mode smart window incorporating PMs can achieve “bright,” “dark,” “warm,” and “cool” modes, making them suitable for deployment in diverse climate zones. The innovative smart window holds a massive potential for use in reducing building energy consumption.
研究领域:
材料科学
·
能源技术
·
建筑环境工程
✓ 已验证
产品关联
DOI
高影响因子
Acta Pharmaceutica Sinica B
·
2023
·
IF 14.5
Siqin He,Lulu Wang,Dongxu Wu,Fan Tong,Huan Zhao,Hanmei Li,Tao Gong,Huile Gao,Yang Zhou
A major challenge facing photodynamic therapy (PDT) is that the activity of the immune-induced infiltrating CD8 + T cells is subject to the regulatory T lymphocytes (Tregs), leaving the tumor at risk of recurrence and metastasis after the initial ablation. To augment the antitumor response and reprogram the immunosuppressive tumor microenvironment (TME), a supramolecular photodynamic nanoparticle (DACss) is constructed by the host-guest interaction between demethylcantharidin-conjugated β -cyclodextrin (DMC-CD) and amantadine-terminated disulfide-conjugated FFVLGGGC peptide with chlorin e6 decoration (Ad-ss-pep-Ce6) to achieve intelligent delivery of photosensitizer and immunomodulator for breast cancer treatment. The acid-labile β -carboxamide bond of DMC-CD is hydrolyzed in response to the acidic TME, resulting in the localized release of DMC and subsequent inhibition of Tregs. The guest molecule Ad-ss-pep-Ce6 can be cleaved by a high level of intracellular GSH, reducing photosensitizer toxicity and increasing photosensitizer retention in the tumor. With a significant increase in the CTL/Treg ratio, the combination of Ce6-based PDT and DMC-mediated immunomodulation adequately achieved spatiotemporal regulation and remodeling of the TME, as well as improved primary tumor and in situ lung metastasis suppression with the aid of PD-1 antibody.
研究领域:
肿瘤学
·
药剂学
·
免疫学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2020
·Vol. 36
·期 2
·301-306
·
IF 1.063
Liu Shuo,Yang Mingjie,Guo Weiwei
Metal-organic frameworks(MOFs)-based nanozyme plays an important role in biosensing, therapy and catalysis. In this study, the effects of single-stranded DNA(ssDNA) with programmable sequences and its complementary DNA(TDNA) on the intrinsic peroxidase-like activity of hemin loaded MOFs(UiO-66- 2 ), denoted as hemin@UiO-66-NH 2 , were investigated. The hemin@UiO-66- 2 exhibited improved catalytic activity compared with free hemin. However, the catalytic activity is inhibited in the presence of ssDNA, as ssDNA can be adsorbed by MOFs and therefore protected the active sites from contact with substrates. Upon the addition of the T DNA , double-stranded DNA(dsDNA) was formed and detached from the MOFs, resulting in the recovery of catalytic activity. Sequentially adding ssDNA or its complementary DNA strands can achieve the reversible regulation of the catalytic activity of MOFs nanozymes. Moreover, the DNA hybridization-based regulation was further applied to a cascaded catalytic system composed of the nanozyme, hemin@UiO-66-NH 2 , and glucose oxidase. These nanozyme based programmable and reversibly regulated catalytic systems may have potential applications in future smart biosensing and catalysis systems.
研究领域:
生物化学
·
纳米医学
·
催化科学
✓ 已验证
DOI
高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Leixia Mei,Haihong Yang,Weimiao Dong,Min Liu,Jun Han
The abnormal levels of pH and oxygen (O2) in the wound microenvironment impeded wound healing, and their regulation remains a challenge. Thus, a wound dressing with pH and O2-regulating capacity is urgently desired. Here, we designed and prepared a fluorinated peptide hydrogel wound dressing to regulate the pH and O2 microenvironment of the wound site. Fluorinated peptides with the (naphthalene-2-ly)-Gly-5fPhe-5fPhe-Tyr-Arg-Gly-Asp sequence (F5–Pep) could self-assemble to a nanofiber network in a weak acidic buffer (pH = 6.0), which is similar to the pH of human skin. The F5–Pep hydrogel can maintain pH levels at 6.0–7.3 for 24 h and continuously release O2 for 4 h. The blood coagulation and hemostasis assay showed that the F5–Pep hydrogel significantly accelerated blood clotting speed in vitro and rapidly controlled hemorrhage in a mouse liver hemorrhage model. In vitro cell migration assays and in vivo animal experiments confirmed that the F5–Pep hydrogel can promote cell migration and wound healing. In summary, this work might provide an effective treatment strategy for wounds and develop advanced wound-healing materials.
研究领域:
材料科学
·
生物医学工程
·
伤口愈合
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Yang Liu,Qunfeng Chen,Gengmei Liu,Tao Tao,Haodong Sun,Zhenhui Lin,Lihui Chen,Qingxian Miao,Jianguo Li
Dynamic transparent-opaque transition behavior endows the stimuli-chromic materials with the solar modulation capability. However, these materials commonly involve the high manufacturing cost and complexity, the additional consumption of electric energy for solar modulation, or the weak effectiveness of light management. Herein, we develop a low-cost yet broadband light management sodium carboxymethyl cellulose-caging-poly(N-isopropylacrylamide) thermochromic composite (i.e., CMC/PNIPAM), where the nanoscale-skeleton CMC molecules well cage the PNIPAM molecules, which enables the homogeneous dispersion and sufficient distribution of the PNIPAM nanogels in the system. The CMC/PNIPAM features the excellent solar-modulation capability (including optical transmittance modulation of 68.17% and infrared transmittance modulation of 48.50%) and a low phase temperature of 30 °C, as well as the long-term stability of dynamic transparent-opaque transition. Such merits of the broadband light management, low cost, simply fabrication as well as scaling up, make the CMC/PNIPAM function as a promising candidate for the energy-saving buildings and construction.
研究领域:
材料科学
·
能源工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Optical Materials
·
2025
·
IF 7.2
Zhixuan Zhang,Dongsheng Zhuang,Yutong Niu,Junyi Wang,Hongliang Zhang,Wei Cheng
It is reported that by introducing structural water into amorphous tungsten oxide and using multivalent Al 3+ as electrolyte ions, the tungsten oxide hydrate films exhibit dramatically enhanced dual-band EC performance. The structural water triggers the surface reduction of tungsten at a relatively low reduction potential, which governs the selective regulation of NIR light. The fast electrochemical kinetics and negligible structural destruction during the surface redox process enable fast and ultrastable NIR regulation. Increasing the reduction potentials, the Al 3+ intercalates into the lattice, accompanied by injection of electrons, resulting in the formation of polaron absorbing visible light. The high charges and small radius of Al 3+ , and the enlarged ion diffusion channels by structural water synergistically facilitate the ion insertion/extraction, leading to enhanced EC performance in the visible light region. The tungsten oxide hydrate film is used as a working electrode to pair with an electrocatalytic counter electrode, with the presence of redox couples in Al 3+ based electrolyte, to form a full EC device that exhibits NIR selectivity of 0.66, and cycling stability of 20 000 cycles in NIR region and 8000 cycles in visible region, which enables to design and fabricate large-size high-performance dual-band EC smart window for controllable management of solar heat and light.
研究领域:
材料科学
·
能源技术
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Tiankai Bai,Zhilong Shi,Shuguang Bao,Xiaorong Hou,Yuping Zhao,Wai L.W. Leung,Yuhui Li,Sirigunqiqige Pan,Ying Xin,Ye Luo,Xiaohe Xiao,Laxinamujila Bai,Huifang Li
Radix Fici Hirtae (RFH), a traditional Chinese medication, is said to be useful in controlling immunity. However, it remained unclear whether its polysaccharides components are associated with these immunomodulatory properties. Herein, two polysaccharides, designated RFHP-1 and RFHP-2, were isolated from RFH using water-soluble alcohol precipitation and column chromatography. Structural characterization by monosaccharide content analysis, methylation, and nuclear magnetic resonance spectroscopy (NMR) revealed that the main chain of RFHP-1 was formed by the interconnection of →4)-α-D-Glc p -(1→, →3,6)-β-D-Glc p -(1→, →3)-β-D-Glc p -(1→, and →4,6)-α-D-Glc p -(1→, and the main chain of RFHP-2 was formed by the interconnection of →4)-α-D-Glc p -(1→, →3,6)-β-D-Gal p -(1→, →3)-β-D-Gal p -(1→, →4,6)-α-D-Glc p -(1→ and →6)-β-D-Gal p -(1→. Both RFHP-1 and RFHP-2 raised the CD4/CD8 ratio and improved the expression of immune factors in immunocompromised mice. By activating the NF-κB pathway (promote phosphorylation of p65 and IκB), RFHP-1 and RFHP-2 both promoted release cytokines (NO, TNF-a, IL-6, and IFN-γ) at RAW 264.7 macrophages. The results of molecular docking (−8.4 kcal/mol vs. -6.0 kcal/mol) and isothermal titration calorimetry (ITC) (−7.75 kcal/mol vs. -7.46 kcal/mol) demonstrated that RFHP-1 exhibited stronger binding affinity with MD2, suggesting greater immunoactivating potential. These findings indicate that RFHP polysaccharides, particularly RFHP-1, may serve as promising candidates for development as dietary supplements for individuals with compromised immune systems.
研究领域:
中药学
·
免疫学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）