Advanced Healthcare Materials
·
2021
·Vol. 11
·期 4
·2101855
·
IF 9.933
Jieqi Xie,Yuejun Yao,Shuqin Wang,Linge Fan,Jie Ding,Yun Gao,Shifen Li,Liyin Shen,Yang Zhu,Changyou Gao
Excessive reactive oxygen species (ROS) generated after myocardial infarction (MI) result in the oxidative injury in myocardium. Implantation of antioxidant biomaterials, without the use of any type of drugs, is very appealing for clinical translation, leading to the great demand of novel biomaterials with high efficiency of ROS elimination. In this study, a segmented polyurethane (PFTU) with a high density of ROS-scavenging backbone units is synthesized by the reaction of poly(thioketal) dithiol (PTK) and poly(propylene fumarate) diol (PPF) (soft segments), thioketal diamine (chain extender), and 1,6-hexamethylene diisocyanate (HDI). Its chemical structure is verified by gel permeation chromatography (GPC), 1 H nuclear magnetic resonance ( 1 H NMR) spectroscopy, and Fourier transform infrared (FTIR) spectroscopy. The electrospun composite PFTU/gelatin (PFTU/Gt) fibrous patches show good antioxidation capacity and ROS-responsive degradation in vitro. Implantation of the PFTU/gelatin patches on the heart tissue surface in MI rats consistently decreases the ROS level, membrane peroxidation, and cell apoptosis at the earlier stage, which are not observed in the non-ROS-responsive polyurethane patch. Inflammation and fibrosis are also reduced in the PFTU/gelatin-treated hearts, resulting in the reduced left ventricular remodeling and better cardiac functions postimplantation for 28 d.
研究领域:
材料科学
·
心脏病学
·
生物材料工程
·
再生医学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2018
·
IF 4.841
Jia Nan Zhang,Bo Zhi Chen,Mohammad Ashfaq,Xiao Peng Zhang,Xin Dong Guo
Hyaluronic acid (HA) has many applications in human medicine and cosmetic industry. This study describes the fabrication and evaluation of cross-linked HA (cHA) based microneedles (HA-cHA-MNs) for anti-ageing treatment. The results suggested that the increasing content of cHA gel particles decrease the mechanical properties of MNs. The in-vitro degradation profile and in-vivo epidermal expansion in mice were also carried out. The data suggested that the proportion of cHA particles decreased the rate of MNs degradation. The prepared HA-cHA-MNs have prolonged effectiveness with high swelling retention time or epidermal expansion time in mice up to 6 days or more.
研究领域:
生物医学工程
·
药剂学
·
皮肤科学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2025
·
IF 5.2
Lujie Zhang,Qinghua Song,Peijing Yang,Zhanqiang Liu
Microneedle (MN) technology is a promising minimally invasive tool for interstitial skin fluid (ISF) extraction. Hydrogel MN patches enable efficient ISF extraction. However, the traditional polydimethylsiloxane (PDMS) photopolymerization method has limitations in morphology control, accuracy, and susceptibility to process parameter interference, affecting MN strength and functional consistency. To address these challenges, we propose a composite hydrogel MN patch based on Digital Light Processing (DLP) 3D bioprinting of hyaluronic acid methacryloyl (HAMA)/gelatin methacryloyl (GelMA) for high-efficiency ISF transdermal extraction. The structure and performance of the MNs were improved by optimizing the bio-ink ratio and printing parameters. Adjusting the ratio of GelMA and HAMA improved the cross-linking structure, optimizing the mechanical properties and swelling performance of the composite hydrogel. Optimizing the light intensity and exposure time ensured consistent MN morphology, resulting in well-defined and evenly distributed needle tips. Controlled UV exposure avoided defects such as uneven cross-linking or brittleness. The results showed that when the HAMA-to-GelMA ratio was 8:2, the light intensity was 9 mW/cm 2 , and the exposure time was 6 s, the MN patches demonstrated excellent microstructures and mechanical properties, with each MN enduring over 1.28 N and achieving a swelling rate above 1200 %. In vitro experiments verified effective penetration and ISF extraction, obtaining 8.5 mg of PBS in 1 min and successfully quantifying glucose concentration. In summary, this study establishes a robust MN patch with superior swelling performance and enhanced ISF extraction efficiency and provides a promising platform for minimally invasive diagnosis and real-time health monitoring.
研究领域:
生物医学工程
·
材料科学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Haoyu Wang,Ping Han,Ying Yu,Shaolong Han,Yue Qiao,Yuehan Li,Bin Sun,Zheng Gu
Conductive hydrogels have been extensively investigated and demonstrate promising applications in wearable and flexible sensors. However, their broader implementation in this field is hindered by the insufficient strain sensitivity, susceptibility to mechanical damage with limited self-recovery, and inadequate adhesion to human skin. Herein, we present a multifunctional MXene/TA@CNC electronic hydrogel patch (MTC e-patch) by integrating highly conductive two-dimensional (2D) transition metal carbides (MXene) and tannic acid-coated carboxylated cellulose nanocrystals (TA@CNC) with polyvinyl alcohol and borax. And dynamic three-dimensional (3D) network is formed through synergistic dynamic hydrogen bonding and dynamic borate ester linkages. The incorporation of TA@CNC effectively prevents the oxidation of MXene, thereby extending the operational lifespan of hydrogels. The flexible covalent crosslinked network, combined with the rigidity of TA@CNC, imparts the MTC e-patch with excellent electrical conductivity (1.62 S/m), superior mechanical strength (≈1.35 MPa, 930 %), robust adhesiveness (≈28 kPa), and high self-healing capability (92 %). The rapid (161 ms) and sensitive (Gauge factor = 4.39) sensing performance of the developed wearable sensor enables the precise detection of subtle human motions, such as swallowing, throat vibrations during speech, and pen strokes during writing. Even when damaged, the sensor continues to provide stable signal output, demonstrating significant potential for applications in smart wearables, electronic skins, and human–machine interfaces.
研究领域:
材料科学
·
柔性电子
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Peihe Wang,Hongyan Ding,Xiaofeng Li,Yangchengyi Liu,Yi Sun,Yujing Li,Guozhuang Xu,Shangda Chen,Xiufeng Wang
The slippage of moisture-sensitive materials from substrates during bending or stretching is a common issue that causes baseline drift and even failure of the flexible humidity sensors, which are essential components of wearable electronic devices. In this study, we report a stretchable, self-adhesive, and transparent humidity-sensing electronic patch comprising liquid metal particle electrodes with a stretchable serpentine structure and a humidity-sensing layer made of Ti3C2Tx MXene/carboxymethyl cellulose. This patch is constructed on a soft–hard integrated heterostructure substrate and demonstrates stable humidity-sensitive response performance at 100% tensile strain, along with autonomous adhesion to human skin. Additionally, it exhibits maximum response (1145.4%) at 90% relative humidity (RH), fast response and recovery time (1.4/5.9 s), elevated sensitivity (64.63%/% RH), and preserved humidity sensing under deformation, as well as easy scalability for multiplexed detection. We further illustrate the patch’s potential applications in healthcare and environmental monitoring through a non-contact security door control system and wind monitor system. Our proposed strain-isolation strategy can be extended to other rigid conductive materials and stretchable substrates, providing a feasible mechanism for producing stretchable electronic skin patches.
研究领域:
材料科学
·
柔性电子
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Applied Materials Today
·
2025
·
IF 6.9
Yisheng Hu,Ya Wang,Yuqing Cai,Xiaodong Xu,Liping Zhao,Jing Zhang
Melanoma is a leading cause of cancer-related deaths. Surgical excision, the standard treatment, often results in incomplete removal and recurrence. A double-layered microneedle patch was developed for chemo-photothermal treatment of melanoma. The patch, based on zwitterionic poly(sulfobetaine methacrylate) (SBMA), includes a slow-degrading hair particles/curcumin (HMP/Cur) layer and a fast-dissolving ZIF-8/doxorubicin/ Panax notoginseng polysaccharide (ZIF-8@DOX/PNPS) layer, with an asiaticoside/ HMP (AS-HMP) substrate. Prepared via a three-step casting process, the microneedles exhibit excellent photothermal properties and tumor synergism under near-infrared (NIR) light. Upon skin insertion, the fast-dissolving layer releases ZIF-8@DOX within 5 min, which then releases DOX in the tumor's acidic environment. The HMP/Cur layer heats to 56.52 °C within 60 s under NIR, aiding in tumor elimination. In addition, the AS-HMP layer covers the wound and promotes tissue regeneration and collagen deposition, enhancing skin regeneration. The double-layered microneedles platform can simultaneously eliminate the tumor and accelerate wounding healing, making it a promising for clinical melanoma therapy.
研究领域:
肿瘤学
·
生物医学工程
·
药剂学
✓ 已验证
产品关联
DOI
高影响因子
Drug Delivery and Translational Research
·
2025
·
IF 5.5
Zhao Erman,Tang Xiuling,Zhao Minggao,Yang Le
Wound healing for various diseases and wounds such as diabetes and burns remains a major biomedical challenge. Conventional monotherapy is ineffective, and the efficacy of drug delivery is limited by the depth of drug penetration. In this study, we develop a novel, multifunctional, dissolvable hyaluronic acid (HA) microneedle patch (MN-LTT). Microneedling is biocompatible and delivers the drug in a painless and non-invasive manner. Lidocaine and thrombin are mixed with HA hydrogel and loaded onto the needle tips of the MN-LTT, which facilitates wound repair by continuously delivering the drug deep into the dermis for rapid analgesia and hemostasis. In addition, the backing layer of the MN-LTT is composed of tetracycline hydrochloride and HA hydrogel, and its excellent antimicrobial properties further accelerate wound healing. In a mouse full-thickness skin wound model, MN-LTT accelerated cell proliferation and granulation tissue growth, reduced inflammatory-factor levels, and restored collagen deposition, resulting in complete wound healing within seven days. Thus, the proposed microneedle delivery system achieved rapid hemostatic, analgesic, and bactericidal effects, providing a safer and more effective strategy for wound healing. These features make the multifunctional HA microneedle patch potentially valuable for clinical applications. Graphical This self-assembled multifunctional microneedle (MN-LTT) can deliver drugs into the wound tissue in a painless and minimally invasive manner, quickly achieving the functions of hemostasis, analgesia, and antibacterial effects to jointly promote wound healing. In addition, the rapid degradation of MN-LTT can avoid secondary damage to the wound during dressing changes. This combined therapy is a potential strategy for achieving high-quality wound healing
研究领域:
生物医学工程
·
药剂学
·
组织修复与再生
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Pengxiang Si,Mingrui Liang,Jihua Zou,Yu Kuang,Juntao Zhang,Qingsha S. Cheng,Yiqian Kong,Yuxin Cai,Guozhi Huang,Yun Wu,Zhu Long,Boxin Zhao,Dan Zhang
Bio-integrated electronic devices are skin-mounted accurate tools for acquiring biological signals. The knee joint is one of the most important joints for human movement, playing a crucial role in functions such as walking, standing, sitting and containing important physiological health information about orthopedic disease diagnosis, prevention, and rehabilitation. However, it is still challenging to precisely and directly monitor joint rotation via skin-mounted bio-integrated electronic devices because joints are hidden inside the skin. In this study, we design a reusable, sustainable, battery-free, wireless, and flexible antenna sticker to adhere to the skin that can directly measure knee joint rotation degree. The antenna sticker is adhered to the lower leg and powered by electromagnetic radiation from a radio frequency identification (RFID) reader. When rotating the knee, the distance between the antenna sticker and the reader changes, leading to an alteration in the received signal strength indicator (RSSI). Meanwhile, the 3D optical motion capture system collects joint rotation data as a “gold standard”. After matching two series of real-time data using the Gaussian method, one RSSI can represent one specific joint rotation degree. The antenna sticker is stable at a variety of humidity and temperatures. The antenna sticker shows great potential to sense joint rotation and human motions. The scientific insights and engineering principles revealed in this antenna sticker will be applicable to a broad range of applications including skin-mounted epidermal electronics and wearable devices.
研究领域:
生物医学工程
·
电子皮肤
·
无线通信
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Wenjing Wang,Rui Feng,Kaiyue Wei,Jiashuo Xu,Wenhui Dong,Jiao Li,Jianan Sun,Sai Wang,Xiangzhao Mao
Excessive histamine in spoiled seafood poses considerable health hazards to consumers, yet its detection is challenging due to complicated sample preparation and detection methodologies. Herein, an integrated colorimetric platform containing Poly (vinyl alcohol) (PVA)/ hyaluronic acid (HA) microneedle patchs-assisted extraction and aptasensor-based detection was reported. The developed PVA/HA microneedle patches facilitated on-site histamine extraction from seafood through a two-minute press-and-peel procedure. To enhance detection efficacy, strategies for generating high-affinity aptamers with specific terminal-fixed structures and constructing AuNPs@FeP-chitosan oligosaccharide (COS) nanozyme boosting catalytic efficiency were proposed. Utilizing the aptamer HIS3-T2 in conjunction with the nanozyme, a colorimetric aptasensor was developed. Integrated with the patches, the aptasensor achieved high sensitivity and selectivity, detecting histamine within a range of 2~800 nM with a limit of detection (LOD) of 1.89 nM. Validated on real-world salmon and shrimp samples, this integrated system promises rapid and accurate histamine monitoring, offering great reference for similar applications in food quality control.
研究领域:
生物传感技术
·
食品安全
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Composites and Hybrid Materials
·
2025
·Vol. 8
·期 2
·1-17
·
IF 21.8
Mbituyimana Bricard,Fu Lina,Wang Hao,Qi Fuyu,Jiang Yuchi,Meng Fanbo,Wu Min,Shi Zhijun,Yang Guang
Androgenetic alopecia (AGA) is the most common type of hair loss frequently observed in clinics. Right now, there are no effective treatments for AGA. Here, we developed a biodegradable microneedle (MN) patch made of polylactic-co-glycolic acid (PLGA) loaded with glutamic acid (GA) that improves sustainable drug release and effective hair regeneration treatment. Once the patch has penetrated the skin, the GA-loaded MNs (GA-MNs) are quickly separated from their base and enter the skin. These MNs then serve as drug storage tanks inside the skin, releasing the therapeutics gradually for over 4 weeks. The sustained release of GA from long-acting biodegradable needles could lead to endocytosis by dermal papilla cells (DPCs), promoting the proliferation of cells. Compared with topical minoxidil, which requires daily treatment, animal studies have shown that GA-MNs can increase hair regeneration more effectively with lower dose frequency; the number of hair follicles in the GA-MNs group reached 83.68 ± 4.52%, which was significantly higher than that of the minoxidil group (56.93 ± 3.21%). This transdermal technology of biodegradable MNs shows considerable promise in clinical applications and offers a straightforward, safe, and effective therapy approach for clinical hair regeneration treatment.
研究领域:
生物医学工程
·
皮肤病学
·
药物递送系统
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Xiaoxuan Zhang,Guopu Chen,Lingyu Sun,Fangfu Ye,Xian Shen,Yuanjin Zhao
Microneedles are providing an emerging strategy for promoting wound healing. Attempts to develop this technology tend to impart them with additional functions. Herein, inspired by the claws of eagles, we present a liquid metal (LM)-encapsulated microneedle patch by employing a top-down multiple-mold-guided photolithography method for incisional wound healing. The microneedle patch is composed of two tilted hydrogel parts and ventilatory gauze as the connection. Such microneedle tips form a claw-like clamping structure, enabling the patch to stick to the skin, fix the wounded area and avoid secondary dehiscence. As the embedded W-patterned LM connects the tips of each microneedle part and links the microneedle part to an external power source, the microneedle patch can provide a stable spatial electric field around the wounds, guide cell migration and accelerate wound healing. It is demonstrated that the microneedle patch can perform well in treating wounded SD rats. These results indicate that the present microneedle patch is practically valuable and may find various applications in wound-healing related biomedical fields.
研究领域:
生物医学工程
·
材料科学
·
医学
✓ 已验证
产品关联
DOI
高影响因子
Pharmaceutics
·
2022
·Vol. 14
·期 10
·2158
·
IF 6.525
Degong Yang,Xuejun Chen,Ziqing Li,Chunrong Yang
Ionic liquids (ILs) have been proven to be an efficient technology for enhancing drug skin permeability. However, the question of whether the two components of ILs are released synchronously in transdermal preparations has remained unclear. Thus, this study aimed to investigate the release characteristics of two components of ILs and their underlying molecular mechanism. The ILs containing flurbiprofen (FLU) and lidocaine (LID) were synthesized and characterized. The four typical acrylates pressure sensitive adhesives (PSAs) with different functional groups were synthesized and characterized. The effects of PSAs on the release characteristics of two components of ILs were investigated by drug release tests and verified by skin permeation experiments. The action mechanisms were revealed by FTIR, Raman, dielectric spectrum, and molecular docking. The results showed that the average release amount of FLU (0.29 μmol/cm2) and LID (0.11 μmol/cm2) of ILs in the four PSAs was significantly different (p< 0.05), which illustrated that the two components did not release synchronously. The PSA−none and PSA−OH with low permittivity (7.37, 9.82) interacted with drugs mainly by dipole-dipole interactions and hydrogen bonds. The PSA−COOH and PSA−CONH2with high permittivity (11.19, 15.32) interacted with drugs mainly by ionic bonds and ionic hydrogen bonds. Thus, this study provides scientific guidance for the application of ILs in transdermal preparations.Keywords:transdermal patch;ionic liquids;release characteristics;hydrogen bond;ionic hydrogen bond
研究领域:
药剂学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）