Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Yahui Song,Jianping Gao,Xiaoyang Xu,Huilin Zhao,Ruinan Xue,Jingkuo Zhou,Wei Hong,Haixia Qiu
Thermal sensitive supramolecular hybrid gels for injectable drug release were prepared by adding different amounts of agar into folic acid (FA) gelator. The gelation temperature was modulated in order to form injectable gel with body temperature (37 °C). Such kind of folic acid-agar (FAG) hybrid gel makes it possible to use supramolecular gel as injectable drug loaded gels for drug release. FT-IR and UV–vis spectra indicate that agar macromolecules involve in the self-assembly process through intermolecular H-bonding and π-π stacking interactions with FA molecules. The SEM and TEM images demonstrate that the fiber diameter of FAG hybrid gel is about 20 nm, much smaller than that of FA gel (40 nm). However, FAG hybrid has a denser nano-fibrous network structure than FA gels. Moreover, FAG hybrid gel is endowed with a more ordered network structure and a little better crystallization capability by adding agar. FAG hybrid gel also shows a shear-thinning behavior but the shear viscosity is about 2 times higher than that of FA gel. Compared with FA gel, the storage (G′) and loss (G″) moduli of the FAG gel are higher, which implies an enhanced gel strength. At the same time, both FA and FAG gels are facilely affected by some external factors such as acid, base and salts. In acidic or basic conditions, the strength became weak and the gelation temperature (Tg) decreased. While, within certain concentrations, the salt (NaCl) increased the gel strength and Tg. FAG gel suffered lower mass loss and owned better stability in different pH solutions compared with pure FA gel. The release behavior of the FA and injectable FAG gels was investigated by using Rhodamine B as a mimic model drug. FAG hybrid gel shows a long release profile and the release time is 3 times longer than that of FA gel, up to 30 h, and the accumulative release amount reaches about 86%. So it is a potential injectable gel for sustained release drug delivery system.
研究领域:
材料科学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Mingfang Ma,Xinran Liu,Liuyang Dong,Ya Huang,Yingle Li,Huiyuan Chen,Ruibin Lan,Aiyou Hao,Zengyang Xie,Wenqing Shang
As a natural cyclic oligosaccharide , β-Cyclodextrin with cavity structure has excellent water solubility and biocompatibility , which makes it highly valuable in the field of supramolecular self-assembly. Although the self-assembly of β-Cyclodextrin into supramolecular gels has been reported by our group, the impact of metal ions on β-Cyclodextrin supramolecular gels has not yet been studied. Herein, a β-Cyclodextrin supramolecular gel was prepared firstly and then the effects of six different metal ions on this gel system were investigated systematically. It was found that tubular stacking induced by hydrogen bond is the main driving force for the self-assembly of β-Cyclodextrin into β-Cyclodextrin supramolecular gels. Moreover, the introduction of metal ions did not hinder the formation of β-Cyclodextrin supramolecular gels. On the contrary, the metal coordination interaction between metal ions and β-Cyclodextrin stabilized the tubular stacking state of β-Cyclodextrin, thereby promoting the formation of β-Cyclodextrin supramolecular gels. This research not only deepens the study of β-Cyclodextrin supramolecular gels but also lays a solid foundation for their application in intelligent materials, drug delivery, and ion channels, among other fields.
研究领域:
材料科学
·
生物化学
·
药物递送
✓ 已验证
产品关联
DOI
高影响因子
Soft Matter
·
2018
·Vol. 14
·期 39
·8044-8050
·
IF 3.709
Yangyang Xu,Suya Fu,Feiyang Liu,Haiyin Yu,Jiangang Gao
Herein, a novel supramolecular gel was fabricated through the bi-component co-assembly strategy of commercially available 10,12-pentacosadiynoic acid (PCDA) and laboratory-synthesized amphiphilic co-gelator N-(2-(1H-imidazol-4-yl)ethyl)stearamide (IMSA), which contains one imidazole head group and a long alkyl chain tail, by synergetic noncovalent interactions. Upon irradiation of normal 254 nm UV light, blue polydiacetylene (PDA) could be obtained by topo-polymerization of the PCDA monomers in the gel phase. This PDA-based supramolecular gel is able to respond to various environmental stimuli and shows a blue-to-red chromatic transition, which could be observed by the naked eye. Specifically, upon exposure to heat, pH, metal cation and organic solvent stimuli, the PDA gel displays thermochromism, halochromism, ionochromism and solvatochromism, respectively. More interestingly, the differences of the above-mentioned stimuli-induced color transition of the blue PDA supramolecular gels could be characterized by UV-Vis absorption spectra and Raman spectra, therefore illuminating a bright application prospect in the area of chemosensing.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TRIBOLOGY INTERNATIONAL
·
2024
·
IF 6.1
Ao Xie,Jiaying Zhang,Hao-Zhe Xu,Xin-Gang Wang,Qiangliang Yu,Wenquan Lv,Meirong Cai,Feng Zhou
This manuscript developed a novel DLC–supramolecular gel (HTG) composite lubrication system to achieve long-life outstanding lubrication under extreme contact stress while avoiding sealing challenges relying on the unique thixotropic properties of the gel. DLC–HTG exhibited ultra-low wear and excellent friction reduction performance under a maximum contact stress of 2.24 GPa. DLC films with designed double transition layers possess high interfacial bond strength and mechanical properties, providing the basis for high wear resistance. The establishment of a robust tribofilm and the confinment effect of HTG on wear debris dominate the achievement of ultra-low wear. This ultra-low wear sliding extends the service life of the lubrication system with the broad implications for mechanical engineering , transportation, and wind power generation .
研究领域:
机械工程
·
材料科学
·
润滑技术
✓ 已验证
产品关联
DOI
高影响因子
Frontiers in Chemistry
·
2024
·
IF 3.8
Yongquan Han,Zhixue Yu,Zijun Guan,Rui Ma,Yuzhou Hu
Supramolecular gel can be used to seal fractures and pores in the formation during oil and gas drilling and production. In this study, a supramolecular gel plugging agent based on hydrophobic association was prepared by free radical polymerization of acrylamide, octadecyl methacrylate, sodium dodecyl sulfate and other monomers by micellar copolymerization. The forming time, rheology, swelling, mechanical properties and plugging properties of supramolecular gels were studied. The experimental results show that the formation time of supramolecular gel plugging agent is controllable, and it has excellent viscoelastic recovery ability in a certain range of shear strain and scanning frequency. When the compression amount is close to 88.3%, the compressive stress reaches 3.82 MPa. Meanwhile, the swelling performance of supramolecular gel was good, and the equilibrium swelling degree reached 22.1% after 188 min swelling in 15% NaCl brine solution. In 1% NaCl solution, the equilibrium swelling degree of supramolecular gel reached 32.5%. In addition, supramolecular gel has strong formation bonding ability, good plugging performance, plugging rate is greater than 95%, can effectively reduce the leakage and improve the plugging effect of low permeability layer. It is of reference and guiding significance for the long-term plugging of heterogeneous and malignant leakage formations.
研究领域:
石油工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2021
·Vol. 11
·期 19
·11519-11528
·
IF 3.361
Lieqiang Liao,Xinjian Jia,Haoxiang Lou,Jinlian Zhong,Huijin Liu,Shunming Ding,Chao Chen,Sanguo Hong,Xuzhong Luo
As one of the most important and fruitful methods, supramolecular self-assembly has a significant advantage in designing and fabricating functional soft materials with various nanostructures. In this research, a low-molecular-weight gelator, N,N′-di(pyridin-4-yl)-pyridine-3,5-dicarboxamide (PDA-N4), was synthesized and used to construct self-assembled gels via a solvent-mediated strategy. It was found that PDA-N4 could form supramolecular gels in mixed solvents of water and DMSO (or DMF) at high water fraction (greater than or equal to 50%). By decreasing the water fraction from 50% to 30%, the gel, suspension and solution phases appeared successively, indicating that self-assembled aggregates could be efficiently modulated via water content in organic solvents. Moreover, the as-prepared PDA-N4 supramolecular gels not only displayed solid-like behavior, and pH- and thermo-reversible characteristics, but also showed a solution–gel–crystal transition with the extension of aging time. Further analyses suggested that both the crystal and gel had similar assembled structures. The intermolecular hydrogen bonding between amide groups and the π–π stacking interactions between pyridine groups played key roles in gel formation. Additionally, the release behavior of vitamin B12 (VB12) from PDA-N4 gel (H2O/DMSO, v/v = 90/10) was evaluated, and the drug controlled release process was consistent with a first-order release mechanism. The human umbilical venous endothelial cell culture results showed that the PDA-N4 xerogel has good cytocompatibility, which implied that the gels have potential biological application in tissue engineering and controlled drug release.
研究领域:
材料科学
·
生物医学工程
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2020
·
IF 3.99
Huiwen He,Junnan Du,Hao Zheng,Meng Ma,Yanqin Shi,Zengliang Gao,Si Chen,Xu Wang
In this study, a series of amino acid grafted inorganic/organic hybrid POSS (Cn@POSS) were designed and synthesized. In order to investigate the surface chain dependent arrangement and self-assembly of POSS in supramolecular self-assembly, the molecular stacking, gelation abilities, thermal stability, morphology and mechanical properties of Cn@POSS gels were evaluated. From the obtained self-assembly mechanism of hybrid POSS, we discovered that the arrangement of hybrid POSS regularly stacking on a hexagonal columnar pathway and assembled into fibrous networks to form the gel in colloid self-assembly. The peripheral segments on the surface of hybrid POSS in a loosely extended state instead the collapse which provide a better position for the closely stacking and oriented aggregation of POSS. As the hierarchical assembled fibrous network, the length of surface chain ( L S ) induced bending of assembled nano-fibers helps the efficient gelation by entanglement of surface chains, but weaken the self-recovery of gels. In contrast, in bulk self-assembly, the stacking of hybrid POSS were obviously affected and perturbed by the length of surface chain, with the shorter L S the closer packing of POSS. This fundamental research helps the understanding of hierarchical self-assembly behaviours of nano-building block POSS in supramolecular gels and inspire the discovering on the applications of POSS based organic-inorganic hybrid molecules in functional soft materials.
研究领域:
材料科学
·
化学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Guiyan Yang,Ruihua Guan,Hengyu Zhen,Kangtai Ou,Jiang Fang,Dian-sen Li,Qiang Fu,Youyi Sun
A new three-dimensional (3D) printing gel is developed to construct hierarchically porous ceramics with adjustable millimeter-, micrometer-, and nanometer-scale size for application in thermal management. Not only does the gel based on supramolecular micelles exhibit excellent DIW 3D printability but also the supramolecular micelles act as templates that can precisely control the structure of micrometer-scale pores. The effect of millimeter- and μmicrometer-scale size on properties of porous ceramics is investigated in detail. The 3D-printed ceramic foam with millimeter-scale pores and smaller micrometer-scale pores shows better thermal insulation and lower compressive strength. For the thermal insulation, the local temperature of a chip exposed to contact heat is only 34.2 °C in the presence of a printed foam cap with a pore size of 41.5 μm, while the local temperature is 54.8 °C in the absence of the printed foam cap. The study provides a new method to construct hierarchically porous alumina ceramics with precisely tunable size, avoiding the issues of subtractive manufacturing and opening up new applications in portable devices or consumer electronics.
研究领域:
材料科学
·
纳米技术
·
先进制造
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Petroleum Science
·
2023
·
IF 5.6
Jing-Bin Yang,Jin-Sheng Sun,Ying-Rui Bai,Kai-He Lv,Jian Li,Mei-Chun Li,Yue-Cheng Zhu
The excellent mechanical properties of supramolecular gel could adapt to the complex reservoir environment and had broad application prospects in the field of oil and gas drilling and production engineering. In this paper, a supramolecular gel based on hydrophobic association and hydrogen bonding was prepared by micellar copolymerization, which could be used to plug fractures and pores in formations. Supramolecular gel was a gel network system with high performance characteristics formed by self-assembly of non-covalent bond interaction. The rheological properties, mechanical mechanics, temperature resistance and swelling ability of supramolecular gel were studied. The results showed that the supramolecular gel had a dense three-dimensional network structure with open and interconnected pore structures, which could exhibit good rheological properties and strong viscoelastic recovery ability. The mechanical properties of the supramolecular gel were excellent, it had a tensile stress of 0.703 MPa and an elongation at break of 1803%. When the compressive strain was 96%, the compressive stress could reach 14.5 MPa. Supramolecular gel also showed good temperature resistance and swelling properties. At the aging temperature of 135 °C, supramolecular gels still maintained good gel strength, and it only took 12 h to reach the equilibrium swelling ratio of 35.87 in 1% NaCl solution. It was also found that supramolecular gel in low concentration saline (1% NaCl solution) showed relatively faster swelling than high concentration saline (25% NaCl solution). The swelling process of the supramolecular gel was non-Fick diffusion (type Ⅱ). This indicated that the organic/inorganic permeability network was well formed. Therefore, the diffusion rate of small molecules could be guaranteed to be equal to the relaxation rate of large molecules before and after the phase transition temperature. In addition to the diffusion of water molecules, the swelling process of the supramolecular gel was also affected by the relaxation of gel network and polymer chain segment, the interaction between water molecules and polymer network and the groups of polymer network and other factors. Supramolecular gel particles could be used as plugging materials for drilling fluids, which had excellent ability to plug formation fractures and pores. The plugging ability of the supramolecular gel was up to 6.7 MPa for 0.5 mm fracture width, and 9.6 MPa for porous media with 5 mD permeability. Compared with HT-PPG gel particles commonly used in oil fields, supramolecular gel particles had better plugging ability on fractures and porous media. The development and application of supramolecular gel had far-reaching significance for promoting the functional application of polymer materials in drilling and production engineering.
研究领域:
石油工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL RESEARCH
·
2023
·
IF 8.3
Zhichun Shi,Xiuqi Huang,Yingnan Zhao,Jun Li,Yan Qing Tian,Piao Piao Zhang,Min Zhu,Ming Zhao
Pentacyclic triterpenes is a natural amphipathic product which possess a rigid backbone and several polar functional groups such as hydroxyl, carbonyl and carboxyl groups . The amphipathic character makes it easy to realize self-assemble into complex nano structure and therefore attract extensive attention due to the simple synthetic processes and renewable raw materials . Hence, a novel Ursolic acid-based hydrogel was prepared successfully via a simple self-assembly of triterpenoid derivative in methanol by capture water molecule in air. The resulting hydrogel show a porous morphology and good elasticity including strong heat resistance . Based on the characteristic above, the hydrogel showed a good iodine adsorption capacity and can removal 75.0% of the iodine from cyclohexane solution and 66.3% from aqueous solution within 36 h. Data analysis indicate that all the iodine adsorption process are dominated by chemisorption and belongs to the multi-site adsorption on heterogenous surfaces. In addition, the obtained hydrogel also possesses a good recyclability which can maintain more than 82% of its capacity after 5 cycles. The simple preparation method and easily available raw materials endow it a great potential in future pollutant treatment.
研究领域:
材料科学
·
环境科学
·
有机化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2021
·
IF 5.097
Yong Yang,Wensheng Liu,Qiankun Zhong,Juzhou Zhang,Bangben Yao,Xiao Lian,Helin Niu
Because of the serious physiological toxicity of methanol, detection of methanol in ethanol medium is tremendously significant. Herein, excellent luminescent lanthanide-based supramolecular metallogels were prepared with the conventional low-molecular-weight-gelator 1,3,5-benzenetricarboxylic acid (BTC) and the lanthanide trivalent cations (Tb3+ and Eu3+), which exhibit distinctive characteristic photoluminescent emission of lanthanides. These metallogels were synthesized depending on the one-step method of a high-concentration reaction synergized with heat-assisted ultrasound. The mechanical characteristics of the supramolecular metallogels were investigated through a rheological study. The scanning electron microscopy study revealed the supramolecular interconnection structure of microcubic blocks formed through irregular self-assembly of nanoplates. The bi-metallogel (Eu/Tb-G) with an obvious brilliant yellow emission signal was favorably fabricated via utilizing the lanthanide co-doping strategy and manifests the characteristic emission bands of lanthanide trivalent ions (Eu3+ and Tb3+) simultaneously. The energy-transfer behavior between Tb3+ and Eu3+ was systematically studied. What is striking is that methanol facilitates the increase of Tb3+ fluorescence intensity without affecting the characteristic emission of Eu3+, and this phenomenon induces a unique emission proportion between Tb3+ and Eu3+ ions. Inspired by this, a self-calibrated fluorescence sensor of methanol is acquired, which adopts the dynamic emission of Tb3+ that can vary continuously and regularly as the target identification detection signal and utilizes the static emission of Eu3+ as the internal reference system. The change of fluorescence lifetime and quantum yield confirmed that this obvious visual optical color signal varying phenomenon can be ascribed to the internal energy-transfer process conversion caused by the unique host–quest interaction between methanol and Eu/Tb-G. In addition, the prepared Eu/Tb-G paper-based sensor has good stimulation response and recyclability to methanol vapor. The above discussion can establish Eu/Tb-G as a ratiometric and colorimetric fluorescent sensor for the detection of methanol and its vapor.
研究领域:
材料科学
·
分析化学
·
生物医学工程
✓ 已验证
DOI
高影响因子
TALANTA
·
2020
·
IF 5.339
Qi Zhou,Xuelin Dong,Binbin Zhang,Shan Lu,Xinwei Zhang,Qin Wang,Yonggui Liao,Yajiang Yang,Hong Wang
The luminescent terbium (Tb 3+ )-loaded supramolecular gels were facilely prepared through the self-assembly of Fmoc-diphenylalanine (FmocPhePhe) at room temperature . Hydroxybenzoic acid (HA, the isomers are denoted as 2-HA, 3-HA, and 4-HA depending upon the positions of hydroxyl groups) was used as a sensitizer to Tb 3+ . The luminescence sensitization of Tb 3+ in the gels was realized by the coordination with hydroxybenzoic acids. The spectra of luminescence, UV–vis, FT-IR, and 1 H NMR verified that this sensitization was attributed to the energy transfer from hydroxybenzoic acids to Tb 3+ . The results of XRD, SEM, and phase transfer temperature further indicated that the initial molecule arrangement of the gels was significantly changed by 2-HA, resulting in more ordered and more compact morphology of the gels. 2-HA exhibited more effective sensitization to Tb 3+ in the gels than 3-HA and 4-HA. It was also found that 2-HA did not affect the self-assembly of FmocPhePhe. Due to the effective fluorescence sensitization by 2-HA, the as-prepared gels can be used for salicylic acid sensing with 6.8 μM of the detection limit. This strategy has been successfully used for the detection of salicylates in pharmaceuticals and cosmetics.
研究领域:
化学
·
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）