INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2025
·Vol. 26
·期 9
·4266
·
IF 4.9
Fumin Xue,Xinyue Yuan,Xingyi Li,Shimin Fang,Yan Cheng
Improving the stability of drugs in the solid state, as well as improving their solubility and poor bioavailability, is highly physiologically relevant. In this study, we focused on enhancing the solubility of hypoxanthine (HYP) through salt formation resulting from the preparation of hypoxanthine–maleic acid salt (HYP-MAL). Single crystals were obtained through solvent evaporation methods, and DSC, TGA, PXRD, FT-IR, and1H NMR spectra were used to characterize the samples. The salt system had higher solubility properties than HYP, with an equilibrium solubility in water that was roughly 2.4 times greater than that of HYP, but the salt’s equilibrium solubility increased when the pH shifted from 7.4 to 1.2; additionally, from 0 to 10 min, the powder dissolution rate was 1.8 times that of HYP, resulting in increased bioavailability. The anti-obesity impact of HYP-MAL salt on obese mice was investigated, providing important insights for the development of future weight-loss medications.
研究领域:
药学
·
生物化学
·
药物开发
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF STRUCTURAL CHEMISTRY
·
2025
·Vol. 66
·期 1
·1-15
·
IF 1.4
Ma X.,Yang Y.,Zhou J.,Li Z.,Hong X.,Jin S.,Wang D.
Preparation, X-ray crystal structure, Fourier transform infrared (FTIR) spectroscopy, and elemental analysis of complexes 1 , 2 from the pyridine and the mono- and dicarboxylic acids are reported. XRD and FTIR analysis demonstrate that both belong to the organic salt. The salt 1 crystallizes in the triclinic, space group \(P\bar{1}\) , with a = 7.271(3) Å, b = 9.548(4) Å, c = 14.698(7) Å, α = 78.435(6)°, β = 85.975(7)°, γ = 71.492(6)°, V = 948.0(8) Å 3 , Z = 2. The salt 2 crystallizes in the orthorhombic, space group P 2 1 2 1 2 1 , with a = 7.9476(6) Å, b = 11.6756(9) Å, c = 25.686(2) Å, α = β = γ = 90°, V = 2383.4(3) Å 3 , Z = 4. In this study, the pyridine at 1 , 2 were both involved in the classical ionic N–H⋯O H-bonds. The O–H⋯O H-bonds were also present in both salts. Apart from the classical H-bonds, the auxiliary interactions of CH⋯O, CH 3 –O, CH 3 –CH 3, CH–π, and O–π also helped the stabilization and expansion of the whole high-dimensional (3D) packings. Hirshfeld surface analysis provides additional views into the prevalence of the various short contacts in the crystal structure. On account of the subtle balance of the various nonbonding associations the synthons \(R_{2}^{2}\) (7), \(R_{2}^{2}\) (10), \(R_{3}^{2}\) (8), \(R_{3}^{2}\) (10), \(R_{3}^{3}\) (9), \(R_{3}^{3}\) (19), \(R_{4}^{3}\) (15), \(R_{4}^{4}\) (17), \(R_{5}^{4}\) (12) and \(R_{6}^{4}\) (18) were noted at the salts. For the combination of the classical H-bonds plus the various non-covalent contacts, the salts adopted the 3D net. In conclusion, we have shown that 3D structures can be constructed by the collective non-covalent interactions.
研究领域:
化学
·
晶体学
·
材料科学
✓ 已验证
DOI
高影响因子
Advanced Energy Materials
·
2023
·Vol. 14
·期 4
·2303020
·
IF 27.8
Simin Chai,Yue Zhong,Yijiang Wang,Qiong He,Alireza Azizi,Leyuan Chen,Xueting Ren,Weifeng Wei,Shuquan Liang,Zhi Chang,Anqiang Pan
Ion electrokinetic regulation in gel polymer electrolytes (GPEs) is of great significance in alleviating dendrite growth and electrode corrosion of metallic lithium in lithium metal batteries (LMBs). Herein, a supramolecular LiPAAOB salt-assisted GPEs (3D-DIS-1.25% GPEs) is synthesized to improve the ionic electrodynamics of LMBs. The LiPAAOB conductor salt provides sufficient Li + ions while simultaneously facilitating LiTFSI dissociation. Theses dissociated Li + ions can be further anchored firmly by enriched affinitive sites (─C═O, ─C─O) induced in 3D composite polymer skeleton (PALC). Due to the strong hydrogen-bonding interactions between PALC and LiPAAOB/LiTFSI, a stable coordination structure is thereby constructed in 3D-DIS-1.25% GPEs, which then facilitates Li + ions to transport rapidly along polymer chains. Consequently, the electrochemical stable window and ionic conductivity of the 3D-DIS-1.25% GPEs are increased to as high as 5.3 V and 1.34 mS cm −1 , respectively. The Li + /e − double conducting interfaces in situ formed on Li metal anode and active particles in cathodes can effectively inhibit dendrite growth and electrode corrosion. As a result, both Li||3D-DIS-1.25% GPEs||Li symmetrical battery and flexible 3D-DIS-1.25% GPEs-based pouch cell with high LFP loading operate stably even under folded and curly state, indicating the application possibility of using 3D-DIS-1.25% GPEs in constructing various flexible high-energy-density batteries.
研究领域:
材料科学
·
电化学
·
能源存储
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）