Journal of Cleaner Production
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2022
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IF 11.072
Yingjie Xu,Hongying Xia,Qi Zhang,Wuchen Cai,Guiyu Jiang,Libo Zhang
Germanium-containing dust as an intermediate by-product in the process of zinc hydrometallurgy , which often contains a large number of heavy metal substances. Due to the constraints of economic benefits and process technology, green and efficient treatment of germanium-containing dust is always a great challenge. In this work, XRD , ICP-OES, XPS , SEM and other characterization methods were used to analyze the existing state and quantity of main substances in germanium-containing dust. It was found that the occurrence state of germanium was closely related to sphalerite . At the same time, longer reaction time would lead to continuous hydrolysis of silicate, which would eventually affect the recovery of zinc, germanium and lead and the fixation of toxic substances. Therefore, the ultrasonic enhanced ammonium persulfate oxidation process was proposed to control the waste of resources and environmental pollution caused by the accumulation of germanium-containing dust. The final results showed that more than 95% of zinc and 89% of germanium were efficiently recovered, and heavy metals such as arsenic and cadmium were fixed in the liquid, and then concentrated in the purification and impurity removal stage. The residue after reaction is high-grade lead sulfate residue, which can be returned to the lead smelting system for recycling. In summary, the ultrasonic-enhanced ammonium persulfate process eventually makes all substances in germanium-containing dust harmless and resource treatment.
研究领域:
冶金学
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环境科学
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DOI
高影响因子
Small
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2023
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IF 13.3
Ruoxi Zhao,Haixia Zhu,Lili Feng,Yanlin Zhu,Bin Liu,Chenghao Yu,Shili Gai,Piaoping Yang
Increasing the yield of reactive oxygen species (ROS) to enhance oxidative stress in cells is an eternal goal in cancer therapy. In this study, BiVO 4 artificial nanozyme is developed with adjustable vanadium vacancy for ultrasound (US) enhanced piezoelectric/sonodynamic therapy. Under US excitation, the vanadium vacancy-rich BiVO 4 nanosheets (abbreviated V v -r BiVO 4 NSs) facilitate the generation of a large number of electrons to improve the ROS yield. Meanwhile, the mechanical strain imposed by US irradiation makes the V v -r BiVO 4 NSs display a typical piezoelectric response, which tilts the conduction band to be more negative and the valance band more positive than the redox potentials of O 2 /O 2 •− and H 2 O/·OH, boosting the efficiency of ROS generation. Both density functional theory calculations and experiments confirm that the introduction of cationic vacancy can improve the sonodynamic effect. As expected, V v -r BiVO 4 NSs have better peroxidase enzyme catalytic and glutathione depletion activities, resulting in increased intracellular oxidative stress. This triple amplification strategy of oxidative stress induced by US substantially inhibits the growth of cancer cells. The work may open an avenue to achieve a synergetic therapy by introducing cationic vacancy, broadening the biomedical use of piezoelectric materials.
研究领域:
生物医学工程
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材料科学
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肿瘤学
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DOI
PubMed
高影响因子
Advanced Science
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2025
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IF 14.1
Lichao Zhu,Zhisheng Guo,Yu Luo,Haiyan Huang,Kexin Zhang,Bingbing Duan,Renmiao Peng,Haochen Yao,Chao Liang,Kaiyang Wang
The spatiotemporal sequential treatment strategy of promoting rapid separation of charge carriers, amplifying oxidative stress, increasing the low content of intracellular Cu, enhancing cuproptosis, and cascading activation of immunotherapy is considered one of the most effective techniques for improving the comprehensive therapy of tumors. Herein, copper tungstate (CuWO₄, CWO) nanoparticles with ultrasmall bandgap (1.71 eV) is developed as both piezoelectric-catalysis agents and copper nanocarriers for synergistic sono-enhanced cuproptosis. Owing to the unique bandgap microstructure, exposure to ultrasound (US) significantly increase the generation of reactive oxygen species (ROS) and the release of Cu 2+ from CWO. Additionally, ≈60% of glutathione (GSH) and nicotinamide adenine dinucleotide phosphate (NADPH) are consumed in situ, leading to oxidative stress, ferroptosis, and cuproptosis in cancer cells. This cascading approach induces substantial mitochondrial dysfunction and the release of damage-associated molecular patterns (DAMPs), which promotes immunogenic cell death (ICD) and augments antitumor immunity. Both in vitro and in vivo studies have shown that this sono-enhanced cuproptosis-based therapy could effectively suppress tumor growth. Overall, this study investigates a novel Structure-Function therapeutic approach that combines piezoelectric catalysis, ferroptosis, cuproptosis, and cascade activation of immune regulation, opening up new possibilities for addressing the challenges associated with conventional cuproptosis therapy.
研究领域:
肿瘤学
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生物材料学
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免疫学
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DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2024
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IF 8.1
Dongbo Wang,Jingting Sang,Mingyang Wang,Dawei Luo,Dandan Han,Bowen Zhang,Jingtao Wang,Junbo Gong
Stereoselective recognition using “tailor-made” chiral ionic liquids (CILs) is an effective approach to obtaining enantiopure compounds through crystallization resolution. In this study, CILs were used as additives to stereoselectively inhibit the nucleation and growth of unwanted enantiomers via a conformational matching mechanism. Interestingly, a cosolvency phenomenon was found in the threonine-CILs-ethanol solvent system. Based on this, an enhanced stereoselective crystallization resolution strategy that combines ultrasound and cosolvency was proposed. The goal of this strategy was to improve the crystallization yield and enantiomeric purity. The results showed that the crystallization resolution yield of the cosolvency system was 33.43%, higher than that of the pure water system (13.56%). More importantly, the introduction of ultrasonic enhancement further increased the crystallization resolution yield to 39.45%. This work will facilitate the exploration of the unlimited potential of utilizing the cosolvency phenomenon and ultrasonic enhancement for crystallization resolution.
研究领域:
化学
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材料科学
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DOI
高影响因子
MATERIALS SCIENCE & ENGINEERING R-REPORTS
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2024
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IF 31.6
Jun Li,Xiangmei Liu,Chaofeng Wang,Yufeng Zheng,Zhenduo Cui,Zhaoyang Li,Shengli Zhu,Hui Jiang,Yu Zhang,Paul K. Chu,Shuilin Wu
The deep-seated drug-resistant bacterial infection is one of the most noticeable public-health threat owing to poor drug therapeutic effect, high recurrence, and devastating complication. Herein, we propose a bactericidal strategy of bio-heterointerface charging through ultrasound-boosted bacterial extracellular and intracellular electron transfer for eradicating implant-related drug-resistant bacterial infection, where a TiO 2 -modified porphyrin-based two-dimensional metal-organic framework (2DMOF-TiO 2 ) is selected as a sonosensitizer. The ultrasound-boosted extracellular and intracellular electron transfer between methicillin-resistant Staphylococcus aureus and 2DMOF-TiO 2 induces rapid reactive oxygen species (ROS) burst surrounding bacterial outer and inner, contributing to intracellular oxidation, membrane potential decrease (∼5 mV), membrane disruption, and pyrimidine metabolism disorder, thus causing bacterial death. The in vivo results of 2DMOF-TiO 2 implant exhibit rapid sonocatalytic anti-infection and enhanced osseointegration at bone-implant interface. This platform may inspire the universal thinking about ultrasound-boosted extracellular and intracellular electron-transfer-induced ROS and provide a superior therapeutic candidate for various deep-seated infectious diseases.
研究领域:
微生物学
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生物医学工程
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传染病学
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材料科学
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产品关联
DOI
高影响因子
Nature Communications
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2025
·Vol. 16
·期 1
·1-23
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IF 15.7
Wang Yandong,Li Haodong,Lin Junyang,Li Yutang,Zhang Keqin,Li Hui,Fu Qiang,Jiang Yanyan
Conventional immunotherapy exhibits low response rates due to the immunosuppressive tumor microenvironment (TME). To overcome this limitation, this study introduces ZFPG nanoparticles (ZFPG NPs) with ZnFe 2 O 4 @Pt cores and glucose oxidase (GOx) shells. The ZFPG NPs possess five-enzyme activities, good sonosensitivity, and remarkable magnetic targeting properties, which facilitate sono-metallo-immunotherapy for prostate cancer treatment in male mice. Specifically, the magnetic targeting ability effectively improves their accumulation in tumors while still showing enrichment in the liver and kidneys. The multienzyme cascade catalysis and sonosensitivity of these NPs effectively deplete glutathione and glucose, and enhance the generation and utilization of H 2 O 2 , thereby inducing multiple ROS bursts. Furthermore, these comprehensive effects up-regulate the HMOX1 to promote the Fe 2+ and lipid peroxides accumulation, thereby inducing immunogenic ferroptosis. This strategy facilitates anti-tumor immunity by ameliorating the immunosuppressive TME and inhibiting lung metastatic progression. This joint warfare strategy offers a powerful solution to address conventional immunotherapy limitations.
研究领域:
纳米技术
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癌症免疫治疗
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生物医学工程
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分子生物学
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肿瘤学
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产品关联
DOI
PubMed
高影响因子
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