Annan Chen,Jin Su,Muran Zhou,Mingpei Cang,Yinjin Li,Yunsong Shi,Zhen Zhang,Yangzhi Zhu,Bin Su,Yang Liu,Zuo-Guang Ye,Yusheng Shi,Jüergen Röedel,Huachen Cui,Haibo Zhang,Kun Zhou,Jian Lu,Chunze Yan
Piezoelectric biomaterials, capable of converting electrical energy to mechanical energy and vice versa, are desirable for implantable devices that can achieve biosensing, tissue regeneration, anti-infection, and tumor treatment. However, their low piezoelectricity, simple geometry, and monotonous functionality remain challenging towards practical applications. Here, we report the design and additive manufacturing of a series of biocompatible piezoelectric lattice materials with bone-mimicking designs and ultrasound-regulated electrical responses. Barium calcium zirconate titanate (BCZT) with a piezoelectric coefficient d 33 up to 580 pC/N was synthesized and used as the parent material of the lattices for additive manufacturing. The as-fabricated BCZT lattices have compressive strength comparable to native trabecular bones, making them promising candidates for implantation and in vivo activation. We show that the lattices allow on-demand activation of anti-tumor or osteogenic functions with programmable non-invasive ultrasound stimuli, both in vitro and in vivo . Our findings provide new insights and a widely applicable strategy for developing versatile, non-invasive, and regulatable biomedical devices via bio-mimicking designs and additive manufacturing.
In this paper, a strategy was developed for fabricating uniform polydimethylsiloxane (PDMS) microcapsules with eccentric and core-centered internal hollow structures, which can be employed as a novel controlled-release system for site-specific drug delivery under ultrasound regulation. This strategy involves the use of a microfluidic device, through which three phases (i.e., an inner water phase containing drug molecules, a middle oil phase of PDMS solution, and an outer water phase) were delivered at independently adjustable flow rates, allowing the formation of water-in-oil-in-water (W/O/W) emulsion droplets in a microfluidic device. After baking the as-prepared microcapsules, microcapsules with different inner hollow cores were obtained. The sizes of the inner hollow structures could be tuned, leading to a series of microcapsules with different densities. The densities of these microcapsules were all lower than that of water, which showed a long gastric residence time. Most interestingly, eccentric hollow microcapsules with well-controlled sizes and shapes were also prepared using this method. The eccentric and core-centered hollow microcapsules demonstrated triggered and controlled the release of encapsulation under ultrasound, for which the release profiles were consistent with the theoretical simulation. The results showed that the microcapsules had all the properties of a floating drug delivery system and controlled release system, and demonstrated great potential to be used for controlled release, in particular, for the delivery of drugs that are absorbed primarily in the upper segments of the gastrointestinal tract.
危险品化学品经营许可证（带存储）