INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Jingsi Zhang,Xin Chen,Qiping Zhan,Yifan Wang,Keke Meng,Qiuhui Hu,Liyan Zhao
Flammulina velutipes ( F. velutipes ) polysaccharides have been shown to play a crucial role in preventing inflammatory diseases. However, further exploration is needed to understand the specific relationship between their structure and anti-inflammatory activity. In this study, four structurally distinct F. velutipes polysaccharides (FVP2, FVP2U1, FVP2U2, and FVP2U3) were isolated via a previously established ultrasonic degradation model, and the exploration on the impact of chain conformation on their anti-inflammatory activities was focused. The results indicated that FVP2 exhibited a spherical conformation, while FVP2U1 and FVP2U2 displayed flexible chains, and FVP2U3 showed a semi-rigid chain. The study on the impact of four kinds of F. velutipes polysaccharides on inflammatory response in LPS-stimulated RAW264.7 cells revealed that ultrasonic degradation enhanced the anti-inflammatory activity of FVP2. The primary anti-inflammatory mechanism involved the inhibition of NO, TNF-α, IL-1β, and IL-6 release, and reduced transcriptional levels of TLR4, MyD88, NF-κB, and NLRP3. Among the ultrasonically degraded polysaccharides with compliant chain conformations and lower molecular weight demonstrated superior anti-inflammatory activity. These results provide insights into the relationship between molecular weight, chain conformation, and anti-inflammatory activity of F. velutipes polysaccharides, contributing to the potential application of ultrasound in developing highly active anti-inflammatory polysaccharides and related nutritional products.
研究领域:
生物化学
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免疫学
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食品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Cleaner Production
·
2020
·
IF 7.246
Zihan Kang,Ni Qin,Enzhu Lin,Jiang Wu,Baowei Yuan,Dinghua Bao
The piezoelectric Bi 2 WO 6 nanosheets with in-plane spontaneous polarization were synthesized by hydrothermal method . The adsorption and piezocatalytic properties of the synthesized Bi 2 WO 6 nanosheets were investigated upon different variants including synthesis conditions, model dye species, and pH of the dye solution. The materials exhibited positive surface charge and selective adsorption ability for the anionic dye methyl orange (MO) in acidic and neutral conditions. The ultrafast removal of MO ( k obs = 0.718 ppm s −1 ) under ultrasonic vibration was mainly controlled by monolayer adsorption, which followed the pseudo-second-order adsorption kinetics and the Langmuir adsorption isotherm . To eliminate the interference of adsorption, the cationic Rhodamine B (RhB) was adopted as the target pollutant for piezocatalytic experiments. The maximum rate constant of RhB removal (3.9 × 10 −2 min −1 ) was obtained in Bi 2 WO 6 sample with the largest specific surface area of 32.8 cm 2 g −1 . The catalytic nature of the dye degradation phenomenon was confirmed by detection of free radicals and the quenching effect of radical scavengers. The present work demonstrates the potential of Bi 2 WO 6 nanosheets in piezocatalytic applications. Moreover, the synergistic effect of adsorption and piezocatalysis is valuable for in-situ regeneration of the piezoelectric adsorbents.
研究领域:
环境科学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 29
·24549-24556
·
IF 3.289
Rui Zhang,Xiaoyan Hou,Yu Cang,Zhenchuan Yu,Zheqi Shen,Zhiming Zhou,Xuhong Guo,Junwei Wang,Xuedong Zhu
Ultrasonic degradation of polymers is well known already. This article presents an interesting and simple method about ultrasonic degradation of polymer chains which could be amplified by a magnetic field efficiently. A polystyrene-poly acrylic acid (PS-PAA) brush which averaged 238 nm in thickness was employed in the method. After ultrasonic treatment with the frequency at 35 kHz at 303 K for 6 hours, the thickness of PAA chains decreased by 83 nm while it decreased by 180 nm dramatically with the same ultrasonic irradiation coupled with a magnetic field (20 mT). It implied that there was a synergetic effect of ultrasound and magnetic field on the degradation of PAA chains. Increasing the magnetic field intensity or ultrasonic frequency could decrease the residual thickness of PAA chains as well as which could be done by decreasing the temperature. In the experimental range, it's surprising that the thickness of PAA chains decreased from 238 nm to 14 nm after 5 h treatment (20 mT, 53 kHz, 288 K) and the average molecular weight of the PAA chains on the surface of the core decreased from 2.5 × 105 to 1.5 × 104 g mol−1. Different characterizations, such as UV-vis, FTIR, DLS, rheology, KI dosimetry and calorimetry study etc. were employed in this work. Based on the experimental results, a reasonable mechanism was proposed as the magnetic field decreased the viscosity of the brush solution which could enhance the effect of the acoustic cavitation. In all, this work provides a simple and green method on the degradation of polymer brushes and may have applications in material chemistry and environmental engineering in future.
研究领域:
材料化学
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环境工程
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高分子科学
✓ 已验证
产品关联
DOI
高影响因子
ULTRASONICS SONOCHEMISTRY
·
2025
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IF 9.7
Mohammed Mansour,Ramy M. Khoder,Lin Xiang,Lan Lan Zhang,Ahmed Taha,Alsadig Yahya,Ting Wu,Hassan Barakat,Ibrahim Khalifa,Xu Xiaoyun
This study aimed to evaluate the influence of ultrasonic degradation on Houttuynia cordata polysaccharide (HCP) physicochemical properties, structure characterization, and bioactivities. The results indicated that the ultrasonic degradation could significantly decrease HCP’s molecular weight (MW). Total polysaccharide, uronic acid content, solubility, and thermal stability of HCP increased gradually with the increase in ultrasonication power. Fourier transform infrared (FTIR) and Nuclear magnetic resonance spectroscopy (NMR) spectra proved that the primary structure of HCP had not been changed via ultrasonic degradation. Antioxidant and hypoglycemic activity results confirmed that ultrasonication enhanced the ability to scavenge free radicals (DPPH, ABTS, and OH) and improved α-glycosidase and α-amylase inhibition with the increase of ultrasonic power, which was increased in order HCP
研究领域:
食品科学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Wang Liu,Ya-Min Qin,Jin-Yang Shi,De-Ling Wu,Chun-Yang Liu,Juan Liang,Song-Zi Xie
This study aimed to evaluate the influence of ultrasonic degradation on the physicochemical and biological characteristics of Polygonatum cyrtonema polysaccharide (PCP, 8.59 kDa). PCP was subjected to ultrasonic treatment for 8, 16, and 24 h and yielded the degraded fractions PCP-8, PCP-16, and PCP-24 (5.06, 4.13, and 3.69 kDa), respectively. Compared with the intact PCP, PCP-8, PCP-16 and PCP-24 had a reduced particle size (decrements of 28.03 %, 46.15 % and 62.54 %, respectively). Although ultrasonic degradation did not alter the primary structure of PCP, its triple helical and superficial structures were disrupted, with degraded fractions demonstrating reduced thermal stability and apparent viscosities compared with those of the intact PCP. Furthermore, the functional properties of the degraded fractions were different. PCP-16 most favourably affected GLP-1 secretion, while PCP-8 and PCP-24 exhibited the strongest antioxidant and enzyme inhibitory activities, respectively. Hence, controlled ultrasound irradiation is an appealing approach for partially degrading PCP and enhancing its bioactivity as a functional agent.
研究领域:
生物化学
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药理学
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食品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2020
·
IF 9.038
Juanjuan Yao,Huiying Zhang,Longfu Chen,Wei Liu,Naiyun Gao,Shiyi Liu,Xiangyu Chen,Fanghui Rao
The potential risks of sono-induced nitrosation and nitration side reactions and consequent toxic nitrogenous byproducts were first investigated via sono-degradation of diphenylamine (DPhA) in this study. The kinetic models for overall DPhA degradation and the formation of nitrosation byproduct (N-nitrosodiphenylamine, NDPhA) and nitration byproducts (2-nitro-DPhA and 4-nitro-DPhA) were well established and fitted (R 2 > 0.98). Nitrosation contributed much more than nitration (namely, 43.3 – 47.3 times) to the sono-degradation of DPhA. The contribution of sono-induced nitrosation ranged from 0.4 to 56.6% at different conditions. The maximum NDPhA formation rate and the contribution of sono-induced nitrosation were obtained at 600 and 200 kHz, respectively, as ultrasonic frequencies at 200 to 800 kHz. Both NDPhA formation rate and the contribution of sono-induced nitrosation increased with increasing power density, while decreased with increasing initial pH and DPhA concentration. PO 4 3– , HCO 3 – , NH 4 + and Fe 2+ presented negative impacts on sono-induced nitrosation in order of HCO 3 – >> Fe 2+ > PO 4 3– > NH 4 + , while Br – exhibited a promoting effect. The mechanism of NDPhA formation via sono-induced nitrosation was first proposed.
研究领域:
环境科学
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化学工程
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产品关联
DOI
PubMed
高影响因子
Frontiers in Nutrition
·
2022
·
IF 6.59
Li Shiwei,Wang Yingna,Dun Weipeng,Han Wanqing,Xu Chunping,Sun Qi,Wang Zichao
Similar to the enzymatic process, there might also be an active fragment in polysaccharides, how to obtain is important for investigating the bioactivity and pharmacological mechanism of polysaccharides. Presently, a Gynostemma pentaphyllum endophytic fungus Chaetomium globosum CGMCC 6882 polysaccharide [Genistein Combined Polysaccharide (GCP)] was degraded by ultrasonic treatment, two polysaccharide fragments of GCP-F1 and GCP-F2 were obtained. Physicochemical results showed that GCP-F1 and GCP-F2 had the same monosaccharide composition of arabinose, galactose, glucose, xylose, mannose, and glucuronic acid as compared to GCP with slightly different molar ratios. However, weight-average molecular weights of GCP-F1 and GCP-F2 decreased from 8.093 × 104 Da (GCP) to 3.158 × 104 Da and 1.027 × 104 Da, respectively. In vitro scavenging assays illustrated that GCP-F1 and GCP-F2 had higher antioxidant activity against 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical, superoxide anions, and hydroxyl radical than GCP, the order was GCP < GCP-F1 < GCP-F2. Meanwhile, antibacterial tests showed that ultrasonic degradation increased the antibacterial activity of GCP-F1 as compared to GCP, but GCP-F2 almost lost its antibacterial activity with further ultrasound treatment. Changes in the antioxidant and antibacterial activities of GCP-F1 and GCP-F2 might be related to the variation of their molecular weights.
研究领域:
生物化学
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药理学
·
微生物学
✓ 已验证
DOI
PubMed
高影响因子
ULTRASONICS SONOCHEMISTRY
·
2021
·
IF 7.491
Yu-qiong Gao,Jin-qiang Zhou,Yan-yan Rao,Han Ning,Jia Zhang,Jun Shi,Nai-yun Gao
The present study comparatively investigated the ultrasonic degradation of ketoprofen (KET) and paracetamol (PCT) in water. Ultrasonic irradiation at 555 kHz achieved rapid degradation of KET and PCT in water, the removal efficiencies of KET (2.5–80 μM) and PCT (2.5–80 μM) reached 87.7%-100% and 50.6%-86.9%, respectively, after 10 min of reaction under an ultrasonic power of 60 W. The degradation behaviors of both KET and PCT followed the Langmuir-Hinshelwood model. KET was eliminated faster than PCT because of its higher hydrophobicity. Acidic media favored ultrasonic degradation of KET and PCT. Organic compounds in water matrices exerted a great negative effect on the ultrasonic degradation rates of KET and PCT major by competing with target compounds with the generated radicals at the bubble/water interfacial region. The effects of anions were species dependent. The introduction of ClO 4 − and Cl − enhanced KET and PCT degradation to different extents, while the introduction of HCO 3 − posed a negative effect on both KET and PCT. KET and PCT degradation are accompanied by the generation of several transform intermediates, as identified via LC/MS/MS analysis, and corresponding reaction pathways have been proposed. A human umbilical vein endothelial cell (HUVEC) toxicity evaluation indicated that ultrasonic treatment was capable of controlling the toxicity of KET or PCT degradation. Of note, the enhanced formation of disinfection byproducts (DBPs), i.e., trichloromethane (TCM) and trichloronitromethane (TCNM), was found due to chlorination after ultrasonic treatment for both KET and PCT.
研究领域:
环境科学
·
毒理学
·
水处理技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
WATER RESEARCH
·
2019
·
IF 7.913
Xiaohui Lu,Jingnan Zhao,Qun Wang,Da Wang,Haodan Xu,Jun Ma,Wei Qiu,Tao Hu
In this paper, the kinetics of bisphenol S (BPS) degradation in the presence of peroxydisulfate (PDS) or dissolved oxygen (DO) in ultrasound (US) system were investigated. For PDS (US/PDS), increased PDS concentration result in faster BPS degradation, but the enhancement was not remarkable with multiplying PDS dosages. Therefore, heterogeneous PDS activation model based on a Langmuir-type adsorption mechanism was proposed to explain the trait of BPS abatement. The equilibrium constant of PDS (K PDS ) was calculated to be 2.91 × 10 −4 /μM, which was much lower than that of BPS, suggesting that PDS was hard to adsorb on the gas-liquid interface of the cavitation bubble following by activation. Besides, the formation of •OH and SO 4 •− in US/PDS system was reinvestigated. The result showed that SO 4 •− rather than •OH was the predominant radical, which was quite different from previous study. Dissolved oxygen largely improve the degradation of BPS in US system and •OH rather than O 2 •− was proved to be the main reactive oxygen species (ROS). The improvement of •OH generation possibly caused by the reaction of DO with •H so that it cannot recombine with •OH. The transformation of the BPS in US system mainly included BPS radical polymerization, hydroxylation and hydrolysis. Frustratingly, the acute toxicity assay of Vibrio fischeri suggests that the degradation products of BPS are more toxic. These results will improve the understanding on the activation mechanisms of PDS and the role of dissolved oxygen play in US. Further investigations may need to explore other treatment ways of BPS and evaluate the acute toxicity of degradation products.
研究领域:
环境科学
·
化学
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL TECHNOLOGY
·
2017
·
IF 1.751
Yang Hu,Guan Wang,Mingzhi Huang,Kairong Lin,Yuqiang Yi,Zhanqiang Fang,Pengjun Li,Kangming Wang
Metronidazole (MNZ), one of the most commonly used nitroimidazole antibiotics in the world, poses a serious threat to human life and health. In this study, an enhanced sono-Fenton process for the degradation of MNZ is presented. The catalytic capacity of nano-Fe3O4 in systems comprising ultrasound + Fe3O4 + H2O2, and the influential parameters such as H2O2, nano-Fe3O4 doses and pH for the Sono-Fenton process, was investigated. The results showed that the nano-Fe3O4 particles appeared to be roughly spherical in shape, with an average size of 10–20 nm. It was found that •OH radicals were rapidly generated due to the catalytic activity of the nano-Fe3O4. MNZ could be degraded within a wide pH range, from 3 to 9, and the degradation efficiencies were considerably enhanced by ultrasound. When the MNZ concentration was fixed at 20 mg/L, the nano-Fe3O4 dosage at 500 mg/L, the pH at 3 and the reaction temperature at 30°C, the removal efficiencies of MNZ were above 98% after 5 h. It is indicated that Fe3O4 magnetic nanoparticles were synthesized as heterogeneous catalysts to effectively degrade MNZ, and the observed stability and recyclability demonstrated that nano-Fe3O4 was promising for the treatment of wastewater contaminated with antibiotics.
研究领域:
环境科学
·
纳米技术
·
催化化学
·
水污染控制
·
药物降解
·
环境工程
✓ 已验证
DOI
高影响因子
Food Bioscience
·
2025
·
IF 5.9
Huadan Zhang,Congcong Sun,Kailin Li,Xianliang Luo,Zebin Guo,Song Miao,Baodong Zheng
Fucoidan, a marine-derived sulfated polysaccharide, possesses a diverse range of bioactive properties. This study aimed to evaluate the physicochemical characteristics and anti-inflammatory activity of Laminaria japonica fucoidan (LJF) and degradation fractions (DLJF-Ts) obtained through ultrasonic-assisted H 2 O 2 /Vitamin C (VC) treatment (1, 3, and 6 h). The molecular weights of LJF, DLJF-1, DLJF-3, and DLJF-6 were 225, 101, 45, and 31 kDa, respectively. The fucose was the major monosaccharide, and structural analysis demonstrated that the main functional groups were unchanged, while their sheets changed from larger to smaller. Meanwhile, the DLJF-3 showed the superior effects of in vitro antioxidant and anti-inflammatory. Furthermore, after 48 h of colitis mice fecal fermentation, the DLJF-3 was metabolized by gut microbiota, leading to a marked elevation in short-chain fatty acids. The content of Bacteroides increased and the Desulfovibrio reduced significantly. Overall, the obtained results revealed that DLJF-3, as the anti-inflammatory agent, could be used for the development of functional foods and healthcare products.
研究领域:
海洋生物技术
·
食品科学
·
药理学
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免疫学
·
微生物学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Water Process Engineering
·
2024
·
IF 6.3
Yu-qiong Gao,Ke-xuan Li,Qian Zeng,Fu-xiang Tian,Ze-ning Fan,Gang-yi Xing,Nai-yun Gao
Pharmaceuticals and personal care products (PPCPs) and their disinfection by-product (DBPs) formation during the disinfection process have raised widespread concerns. In this study, the effects of common anions on the sonochemical degradation of two model PPCPs, sulfamethoxazole (SMX) and naproxen (NPX), and their DBPs formation potentials were comparatively explored. The degradation processes followed the heterogeneous kinetic models, indicating PPCPs degradation mainly occurred at the bubble/water interface via radical oxidation. Acidic conditions enhanced sonochemical degradation. Cl − and HCO 3 − have minimal effect, with HCO 3 − moderately enhancing SMX degradation, while Br − notably increased degradation of both PPCPs. Ultrasonic pretreatment reduced trichloromethane (TCM) formation but raised nitrogenous disinfection by-products (N-DBPs) level due to the formed intermediates. Cl − has little effect on DBPs formation, while HCO 3 − obviously diminished N-DBPs formation from both PPCPs. The increase of Br − concentration increased the formation of brominated DBPs (Br-DBPs), while the formation of chlorinated DBPs were inhibited both in direct chlorination and ultrasonic pretreatment followed by postchlorination. Ultrasonic pretreatment also elevated Br incorporation and utilization factors of trihalomethanes (THMs). Of note, although ultrasonic treatment can effectively degrade PPCPs in real environmental matrices, the increase in trichloronitromethane (TCNM) formation potential should be carefully monitored.
研究领域:
环境科学
·
水处理工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）