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Soft Matter · 2014 ·Vol. 11 ·期 9 ·1767-1777 · IF 4.151

An easy approach for constructing vesicles by using aromatic molecules with β-cyclodextrin

Shangyang Li,Lin Zhang,Bo Wang,Mingfang Ma,Pengyao Xing,Xiaoxiao Chu,Yimeng Zhang,Aiyou Hao

Vesicles were formed in aqueous solution using β-cyclodextrin (β-CD) complexes with a series of ultra-small aromatic molecules. The vesicles are easy to prepare without a complicated synthesis procedure and their structure was identified and characterized using various techniques, including transmission electron microscopy, atomic force microscopy and dynamic laser light scattering. Using the β-CD/L-phenylalanine system as a representative example, the structural factors that caused the self-assembly were revealed using proton nuclear magnetic resonance, Fourier transform infrared spectroscopy and X-ray diffraction. In addition, the vesicular architecture could be endowed with a diverse range of stimuli-responses, as a consequence of the selective addition of various guest molecules. It is anticipated that this novel assembly strategy could be further extended, and that it presents new opportunities for the development of nanocarriers and soft materials.

研究领域: 纳米医学 · 药剂学 · 软物质材料 · 分子自组装 · 药物递送系统
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