Advanced Science
·
2024
·Vol. 11
·期 41
·2405544
·
IF 14.3
Kejun Wang,Siyuan Chen,Guanyu Bao,Tao Sun,Junqiu Zhang,Daobing Chen,Lining Sun,Zhiwu Han,Chao Liu,Qian Wang
Numerous plants evolve ingeniously microcantilever-based hairs to ultra-sensitively detect out-of-plane quasi-static tactile loads, providing a natural blueprint for upgrading the industrial static mode microcantilever sensors, but how do the biological sensory hairs work mechanically? Here, the action potential-producing trigger hairs of carnivorous Venus flytraps ( Dionaea muscipula ) are investigated in detail from biomechanical perspective. Under tiny mechanical stimulation, the deformable trigger hair, composed of distal stiff lever and proximal flexible podium, will lead to rapid trap closure and prey capture. The multiple features determining the sensitivity such as conical morphology, multi-scale functional structures, kidney-shaped sensory cells, and combined deformation under tiny mechanical stimulation are comprehensively researched. Based on materials mechanics, finite element simulation, and bio-inspired original artificial sensors, it is verified that the omnidirectional ultra-sensitivity of trigger hair is attributed to the stiff-flexible coupling of material, the double stress concentration, the circular distribution of sensory cells, and the positive local buckling. Also, the balance strategy of slender hair between sensitivity and structural stability (i.e., avoiding disastrous collapse) is detailed revealed. The unique basic biomechanical mechanism underlying trigger hairs is essential for significantly enhancing the performance of the traditional industrial static mode microcantilever sensors, and ensure the stability of arbitrary load perception.
研究领域:
植物学
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生物力学
·
传感器技术
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产品关联
DOI
PubMed
高影响因子
ACS Nano
·
2023
·
IF 17.1
Kai Tao,Jiahao Yu,Jiyuan Zhang,Aocheng Bao,Haowen Hu,Tao Ye,Qiongling Ding,Yaozheng Wang,Haobin Lin,Jin Wu,Honglong Chang,Haixia Zhang,Weizheng Yuan
There is huge demand for recreating human skin with the functions of epidermis and dermis for interactions with the physical world. Herein, a biomimetic, ultrasensitive, and multifunctional hydrogel-based electronic skin (BHES) was proposed. Its epidermis function was mimicked using poly(ethylene terephthalate) with nanoscale wrinkles, enabling accurate identification of materials through the capabilities to gain/lose electrons during contact electrification. Internal mechanoreceptor was mimicked by interdigital silver electrodes with stick–slip sensing capabilities to identify textures/roughness. The dermis function was mimicked by patterned microcone hydrogel, achieving pressure sensors with high sensitivity (17.32 mV/Pa), large pressure range (20–5000 Pa), low detection limit, and fast response (10 ms)/recovery time (17 ms). Assisted by deep learning, this BHES achieved high accuracy and minimized interference in identifying materials (95.00% for 10 materials) and textures (97.20% for four roughness cases). By integrating signal acquisition/processing circuits, a wearable drone control system was demonstrated with three-degree-of-freedom movement and enormous potentials for soft robots, self-powered human–machine interaction interfaces of digital twins.
研究领域:
材料科学
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生物医学工程
·
人工智能
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2022
·
IF 5.546
Xinyue Deng,Shuai Xie,Wentang Wang,Chunhui Luo,Faliang Luo
Bearing several merits including resemblance to tissues, tunable conductivity, and mechanical flexibility, conductive hydrogels have been widely applied in wearable sensors, implantable bioelectronics, artificial skins, etc. However, the fragile nature, lack of self-healing capability, and insufficient sensitivities at low strains of traditional conductive hydrogels cannot meet the increasing demands of flexible electronics. Here, carbon nanotubes (CNTs) were dispersed in water with the assistance of bis benzyl-modified polyethylene glycol (B-PEG 181 ), which served as additional cross-linkers to prepare hydrogel by introducing acrylamide (AM) and N , N’ -methylene bisacrylamide (MBAA). The synergy of physical entanglements and π-π interactions led to extreme stretchability (0∼132 mm/mm) and self-healable capability. In addition, the introduction of CNTs and lithium chloride endowed the hydrogel with ultra-high sensitivity (GF = 122.7, at 6.0∼8.0 mm/mm strain), superior to present sensors. Consequently, the obtained sensor could detect various human motions. It is envisioned that the remarkable performances empower the obtained gel promising applications in strain sensors, human-machine interfaces, and soft robots.
研究领域:
材料科学
·
生物医学工程
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DOI
高影响因子
Advanced Fiber Materials
·
2023
·Vol. 5
·期 4
·1392-1403
·
IF 16.1
Ma Chao,Wang Meng,Wang Kai,Uzabakiriho Pierre Claver,Chen Xi,Zhao Gang
High-performance wearable sensors that detect complex, multidimensional signals are indispensable in practical applications. Most existing sensors can only detect axial deformations or single stimuli, dramatically limiting their application fields. In this study, anisotropic strain and deformation-insensitive pressure sensors were effectively constructed based on a rigid-flexible synergistic stretchable substrate. Furthermore, we developed a three-dimensional integrated sensor with highly directional selective sensing through reasonable design and assembly. This integrated sensor recognizes the amplitude and direction of strain in the plane with a maximum gauge factor of 635 and an unprecedented selectivity of 13.99. Additionally, this device can also monitor the pressure outside the plane with a sensitivity of 0.277 kPa −1 . We further investigated the working mechanism of sensor anisotropy and confirmed the application of the sensor in detecting complex multifreedom human joint movements. This research discovery provides new ideas and methods for developing multidimensional sensors, which is essential for broadening the application field of wearable electronic products. Graphical Abstract
研究领域:
材料科学
·
传感器技术
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
CHEMISTRY OF MATERIALS
·
2021
·
IF 9.811
Ling Cai,Guangxue Chen,Junfei Tian,Bin Su,Minghui He
Ionic skin with a high performance has been extensively explored due to its ability to convert external stimuli into obvious electrical signals for wearable electronics and intelligent detection. However, due to the unmatched Young’s moduli between the elastic substrate and the conductive layer, rapidly manufacturing durable ionic skin with ultrasensitivity over a wide range of pressures is still a great challenge. Here, we report a new strategy of 3D printing polymerizable deep eutectic solvent (PDES) for the manufacture of highly sensitive bioinspired ionic skin over a wide range of pressures via photopolymerization shrinkage formed submicrometer-scale protrusions on bioinspired skin structures. The 3D patterned poly(PDES) ionic skin (interlocked pyramid type with submicrometer protrusions) can realize “all-in-one” ability with high transparency, compressibility, and intrinsic conductivity, displaying ultrabroad range pressures (0.6 Pa–2 MPa) with superhigh sensitivity (348.28 KPa–1) and high electrical durability (at 0.35 MPa for 45 000 cycles). Furthermore, these excellent abilities allow as-prepared ionic skins to serve as visually detected pressure sensors for precision instruments, providing great potential in flexible wearable monitoring equipment and human-computer interaction.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2024
·
IF 5.8
Shu He,Zeng Liu,Hongli Fang,Xinyu Wei,Zhiyue Cui,Wen Gu,Wei Shao
Hydrogels are extensively utilized as strain sensors in the domain of wearable devices. However, balancing mechanical properties, adhesion, and self-healing capabilities in hydrogel sensors has consistently been a research challenge. In this study, a novel P(AA-AMPS)/PEI hydrogel was synthesized through a straightforward one-step radical polymerization with acrylic acid (AA) and 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) as monomers, polyethyleneimine (PEI) and AlCl 3 as physical crosslinkers to effectively solve the above challenge. The P(AA-AMPS)/PEI hydrogel demonstrated good mechanical properties with a tensile strength of 42.54 kPa, a high self-adhesion strength to pigskin up to 37.48 kPa, and rapid self-healing efficiency of 100 % after 1 h. The P(AA-AMPS)/PEI hydrogel sensor exhibited good stability, precision, and dependability in real-time monitoring of both subtle and large human movements due to the ultra-high sensitivity (GF values were 5.92, 13.82, and 20.89 within the strain ranges of 0–300 %, 300–600 %, and 600–850 %). It must be noted that the sensing performance of the healed P(AA-AMPS)/PEI hydrogel remained unchanged. The developed hydrogel sensor exhibited promising applications in wearable devices, electronic skin, and human–machine interaction.
研究领域:
材料科学
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生物医学工程
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传感器技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2022
·
IF 14.224
Xiao-Yu Tian,Meng-Wei Sun,Guo-Yu Wen,Min Cao,Da-Wei Pan,Rui Xie,Xiao-Jie Ju,Zhuang Liu,Wei Wang,Liang-Yin Chu
Ultrasensitive real-time detection of trace Pb 2+ in continuous flow is vital to effectively and timely eliminate the potential hazards to ecosystem health and sustainability. This work reports on a micro-structured smart hydrogel grating with ultra-sensitivity, high selectivity , good transparency and mechanical property for real-time detection of Pb 2+ in continuous flow. The hydrogel grating possesses uniform surface relief microstructures with periodic nano-height ridges made of poly(acrylamide- co -benzo-18-crown-6-acrylamide) networks that crosslinked by tetra-arm star poly(ethylene glycol)acrylamide. The hydrogel grating with good optical transparency and mechanical property can change its height via selective host-guest complexation with Pb 2+ to output a changed diffraction efficiency. Meanwhile, the periodic nano-ridges with large specific area benefit the contact with Pb 2+ for fast Pb 2+ -induced height change. Thus, with such rationally designed molecular structures and surface relief microstructures, the hydrogel grating integrated in a glass-based mini-chip allows real-time detection of Pb 2+ in continuous flow with ultra-sensitivity and high selectivity. The hydrogel grating detector can achieve ultralow detection limit (10 −9 M Pb 2+ ), fast response (2 min), and selective detection of Pb 2+ from dozens of interfering ions even with high concentrations. This high-performance hydrogel grating detector is general and can be extended to detect many analytes due to the wide choice of responsive hydrogels, thus opening new areas for creating advanced smart detectors in analytical science.
研究领域:
分析化学
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环境科学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2021
·Vol. 413
·期 20
·4939-4945
·
IF 4.157
Guan Shulin,Yue Jing,Sun Weihan,Xu Weiqing,Liang Chongyang,Xu Shuping
A highly sensitive trypsin sensing system in serum was developed by using an anodic alumina oxide (AAO)-based, trypsin substrate-decorated hybrid ion permeation membrane. Owing to the trypsin-triggered peptide hydrolyzation reaction, the surface electrical feature of the peptide-decorated hybrid ion membrane changed. The electric double layer effect reduces the effective ion current diameter in the AAO nano unit, so that the ion current rectification ratio will be enhanced, realizing the quantitative detection of trypsin. The lowest detection concentration can be achieved as low as 0.1 pM. This method is no need for sample pre-preparation, easy to operate, highly sensitive, and also applicable to other enzyme evaluation systems by changing corresponding substrates. This study provides a new idea for selective measurements of proteases in complex biological samples. Graphical abstract
研究领域:
生物化学
·
医学检测
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Zhencai Qu,Chang-an Xu,Xiaobin Li,Yifei Wu,Kunxin Wang,Xiaole Zheng,Xiaohua Cui,Xiankun Wu,Jun Shi,Kun Wu
Design and exploitation of smart fire-warning devices with ultrasensitive response capability are always an urgent need for effective fire protection. Herein, a nano-filler (BP-MoS 2 ) is prepared by ball milling black phosphorene and molybdenum disulfide and added into the graphene oxide (GO) film to fabricate a multifunctional film with high fire resistance and rapid response ability. When the addition of BP-MoS 2 is 20.0 wt%, the GO/BP-MoS 2 20.0 shows an excellent flame retardancy. The residual char rate is improved from 46.60% to 66.65%, and its peak of heat release rate (pHRR) value has reduced from 599.92 W g −1 to 274.00 W g −1 , resulting in a 54.33% decrease, which is attributed to the ultra-fast catalytic char formation and synergistic flame retardancy of BP and MoS 2 . Meanwhile, the composite film can still maintain the original shape within 15 s of ignition. More interestingly, when encountering a flame attack, it reveals an ultra-fast fire warning response (about 1 s), which is attributed to the fast carbonization after contacting with flame. Such approach offers a novel perspective for the preparation of intelligent fire alarm devices with ultra-fast response ability.
研究领域:
材料科学
·
消防安全工程
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Science China-Materials
·
2022
·Vol. 65
·期 8
·2289-2297
·
IF 8.64
Yang Yizhuo,Tang Wenjie,Wang Jinyi,Liu Ruiqing,Yang Ping,Chen Shisheng,Yuan Yuehui,Xu Jingfeng,Ren Xueyang,Yu Shancheng,Wu Hao,Zhou Yunfan,Zhai Leili,Shao Xiaodong,Chen Zenan,Hu Benhui
Recently, rapid advances in flexible strain sensors have broadened their application scenario in monitoring of various mechanophysiological signals. Among various strain sensors, the crack-based strain sensors have drawn increasing attention in monitoring subtle mechanical deformation due to their high sensitivity. However, early generation and rapid propagation of cracks in the conductive sensing layer result in a narrow working range, limiting their application in monitoring large biomechanical signals. Herein, we developed a stress-deconcentrated ultrasensitive strain (SDUS) sensor with ultrahigh sensitivity (gauge factor up to 2.3 × 10 6 ) and a wide working range (0%–50%) via incorporating notch-insensitive elastic substrate and micro-crack-tunable conductive layer. Furthermore, the highly elastic amine-based polymer-modified polydimethylsiloxane substrate without obvious hysteresis endows our SDUS sensor with a rapid response time (2.33 ms) to external stimuli. The accurate detection of the radial pulse, joint motion, and vocal cord vibration proves the capability of SDUS sensor for healthcare monitoring and human-machine communications.
研究领域:
材料科学
·
生物医学工程
·
柔性电子
✓ 已验证
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2022
·
IF 14.224
Long Ma,Jiajing Wang,Yaru Li,Dan Liao,Wenlu Zhang,Xiao Han,Shuli Man
Rapid, sensitive and specific detection of bacteria is of great importance. Herein, we developed a versatile biosensing platform for ultrasensitive detection of pathogenic bacteria, termed as SCENT-Cas (Silver nanoCluster Empowered Nucleic acids Test using CRISPR/Cas12a). Simply, the species-specific invA gene of Salmonella typhimurium (S. typhi) was isothermally amplified using LAMP, which subsequently triggered the trans -cleavage of CRISPR/Cas12a. The trans -cleavage degraded any single-stranded DNA (ssDNA) non-specifically. A DNA-templated AgNCs probe was then employed, in which green fluorescence emissive AgNCs effectively converted to red fluorescence emissive AgNCs when placed in close vicinity to a pre-designed converter ssDNA. As such, the trans -cleavage was utilized for shredding converter ssDNA, enabling the green-to-red fluorescent change to form a ratiometric biosensing platform. With this strategy, target nucleic acid was dexterously converted into ratiometric fluorescence that was recorded to detect as low as 1 CFU/mL S. typhi with a dynamic range from 1 to 10 8 CFU/mL. To our knowledge, this is the first report regarding the use of ratiometric fluorescence in CRISPR/Cas-based detection, which minimizes interference and improves reliability. Lastly, this proposed strategy was challenged by detecting S. typhi contamination in real food samples. Our work enriches CRISPR/Cas toolbox in biosensing by providing a desirable method for bacterial detection.
研究领域:
生物传感器
·
分子生物学
·
纳米技术
·
食品安全
✓ 已验证
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2021
·
IF 7.514
Zhijun Liu,Li Wang,Pengfei Liu,Kairen Zhao,Shuying Ye,Guoxi Liang
Hydrogen peroxide (H 2 O 2 ) is usually used as a fungicide in food, it is carcinogenic, accelerates aging or inducing toxic effects such as cardiovascular disease. Herein, to meet the demand for effective and fast detection of H 2 O 2 in food, a novel non-enzymatic electrochemiluminescence (ECL) sensor based on single-stranded DNA (ssDNA)/g-C 3 N 4 nanosheets (NS) was established. The ssDNA/g-C 3 N 4 NS hybrid was prepared by simple mixing g-C 3 N 4 NS and ssDNA solution together. The prepared ssDNA/g-C 3 N 4 NS exhibited improved peroxidase-like activity and was modified on a glassy carbon electrode to catalyze the ECL reaction of luminol-H 2 O 2 to amplify the luminescence signal. Under the optimized conditions, the proposed sensor exhibits high sensitivity with a limit of detection (LOD) as low as 33 aM H 2 O 2 , which is much lower than the vast majority of reported methods. This method enables the reliable responding to H 2 O 2 from the milk samples within 1 min.
研究领域:
分析化学
·
食品科学
·
纳米技术
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）