Journal of Materials Chemistry C
·
2016
·Vol. 4
·期 38
·9094-9102
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IF 5.066
Ming Li,Hui Zhang,Yan Zhang,Baoshan Hou,Chuangyang Li,Xibin Wang,Ji Zhang,LingHan Xiao,Zhanchen Cui,Yuhui Ao
Novel benzothiadiazole-based second-order nonlinear optical (NLO) chromophores with different push–pull structures were developed. Incorporation of benzothiadiazole (BTD) as a bridge for improving the electro-optic (EO) coefficient (r33) of bulky materials has not been well investigated, despite its extensive application in other photonic materials as electron acceptor. NMR and MS have been used to characterize the structure of synthesized chromophores 5–7. Optical properties have been investigated by UV-vis spectra. Density functional theory calculations have been used to calculate the first-order hyperpolarizability (β) of chromophores r1, 5a, 7a and 5b. Moreover, the poling results of guest–host EO polymers, 5a/PC and 5b/PC, afforded good r33 values of 67 pm V−1 and 45 pm V−1, respectively. All the results demonstrated an improvement in both micro- and macroscopic nonlinearity after incorporation of BTD into chromophores.
研究领域:
材料科学
·
光学
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DOI
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 37
·22855-22859
·
IF 3.108
Junshan Sun,Yinfeng Han
A novel bis(porphyrinato) terbium double-decker complex HTb(DADAPor)2 with a twisted cuboid octupolar molecular symmetry exhibits the largest off-resonant first hyperpolarizability, as evaluated by harmonic light scattering measurements with = 1700 × 10−30 esu.
研究领域:
化学
·
材料科学
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产品关联
DOI
高影响因子
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2025
·
IF 3
Zeng Qingbin,Wang Zhen,Guo Qianni,Song Wei,Zhao Xiuchao,Yang Yuqi,Zhou Xin
Hyperpolarized 129 Xe magnetic resonance imaging (MRI) is a powerful tool for detecting respiratory system diseases. However, 129 Xe is an inert gas and lacks specific detection capability. Entrapping xenon within molecular cages to enable specific detection is a challenging task, and numerous molecular cages have been developed and evaluated to address this challenge. Herein, we report that the aluminum-based metal-organic framework, CAU-1, can effectively entrap xenon for hyperpolarized 129 Xe MRI in aqueous solutions. This platform exhibits high water stability and good dispersibility, and shows excellent xenon entrapment capability, even at a concentration as low as 50 µg/mL. Importantly, it is responsive to pH changes across a range from 6.6 to 5.0, making it promising for monitoring the weakly acidic environment in tumors or metabolic abnormality. Furthermore, the scalable and cost-effective production of this molecular cage will facilitate future advancements in molecular imaging and chemical sensing applications.
研究领域:
医学影像学
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分子生物学
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材料科学
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产品关联
DOI
高影响因子
STAR Protocols
·
2022
·
IF 0
Qingbin Zeng,Qianni Guo,Yaping Yuan,Lei Zhang,Weiping Jiang,Yuqi Yang,Xin Zhou
Summary Due to limited detection sensitivity and contrast limitation, imaging substrates with 129 Xe MRI in living cells is still a challenge. Here, we present an effective protocol to detect and image substrates in human lung cancer cells A549 with hyperpolarized 129 Xe MRI. This protocol was optimized for a cryptophane-based probe sensitive to biothiols and can be expanded to other Xe-based probes to detect potential biomarkers in other mammalian cells. For complete details on the use and execution of this protocol, please refer to Zeng et al. (2021) .
研究领域:
医学成像
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生物医学工程
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分子生物学
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癌症研究
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DOI
PubMed
Nature Communications
·
2025
·Vol. 16
·期 1
·1-13
·
IF 15.7
Zeng Qingbin,Yue Quer,Zhang Ming,Zhou Rui,Wang Zhen,Xiao Zhongyu,Yuan Yaping,Zhao Xiuchao,Jiang Weiping,Zhang Lei,Yang Yuqi,Yang Minghui,Li Haidong,Bouchard Louis-S.,Guo Qianni,Zhou Xin
Fluorescent molecules with specific target moieties are essential for histopathological analysis, but their limited tissue penetration depth makes in vivo, in situ color encoding analysis challenging. Magnetic resonance imaging (MRI) offers deep tissue penetration. When combined with chemical shift-encoded MRI reporters, it enables in vivo chemical shift encoding for biotarget imaging and analysis. These reporters require both strong signal intensity and large chemical shift window. However, conventional proton MRI reporters, with low sensitivity and a small chemical shift window, limit their in vivo applications. Here, we describe a chemical shift-encoded hyperpolarized 129 Xe MRI reporter based on the multivariate metal-organic framework, NiZn-ZIF-8, to overcome these challenges. The proposed NiZn-ZIF-8 gives distinct chemical shifts for dissolved and entrapped 129 Xe without signal interference, enhancing the 129 Xe NMR signal by 210 times compared to dissolved 129 Xe in water and biological media. This enables detection threshold at ≈ 4 fM concentrations, setting a record for the lowest concentration of xenon hosts detected in nanomaterials. Additionally, NiZn-ZIF-8 exhibits good in vivo MRI performance, allowing xenon encoding and distinction in rat lungs. NiZn-ZIF-8 represents a versatile and powerful platform for advanced molecular imaging and in vivo biomedical diagnostics.
研究领域:
医学成像
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纳米材料
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分子成像
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生物医学诊断
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磁共振成像
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产品关联
DOI
PubMed
高影响因子
Cell Metabolism
·
2025
·
IF 30.9
Tingting Zhou,Zhiwei Wang,Xiaowang Lv,Mengting Guo,Ning Zhang,Liangju Liu,Li Geng,Jing Shao,Ka Zhang,Mengru Gao,Aiqin Mao,Yifei Zhu,Fan Yu,Lei Feng,Xiaoyan Wang,Qixiao Zhai,Wei Chen,Xin Ma
Currently, the regulation of specific gut microbial metabolism for the development and/or treatment of hypertension remains largely unexplored. Here, we show that α-lipomycin, produced by Streptomyces aureofaciens ( S. aureofaciens ) Tü117, is upregulated in the serum of high-salt diet (HSD) mice and patients with essential hypertension. α-lipomycin causes vasodilation impairment involving transient receptor potential vanilloid 4 (TRPV4)-mediated nitric oxide and endothelium-derived hyperpolarizing factor pathways in mice. We also find that Lactobacillus plantarum ( L. plantarum ) CCFM639 attenuates the increase in blood pressure (BP) potentially through inhibiting the proliferation of S. aureofaciens Tü117 in mice. An exploratory intervention trial indicates that L. plantarum CCFM639 supplementation reduces BPs in subjects newly diagnosed with pre-hypertension or stage 1 hypertension without antihypertensive medication. Our findings provide evidence for a role of S. aureofaciens Tü117-associated α-lipomycin elevation in the pathogenesis of HSD-induced hypertension, highlighting that targeting gut bacteria serves as a new therapeutic intervention for hypertension.
研究领域:
微生物学
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药理学
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心血管疾病
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产品关联
DOI
PubMed
高影响因子
CRYSTAL GROWTH & DESIGN
·
2025
·
IF 3.4
Yaqi Qin,Xiaoyu Feng,Jinkang Ma,Fanghao Xuan,Kaiwen Hu,Lifeng Cao,Dongwei Zhai,Bing Teng
Two novel chalcone crystals, 5MFTF (C15H11F3O2, P1) and 5MFTN (C14H11NO4, P1), were successfully synthesized by introducing trifluoromethyl and nitro substituents, respectively. Growth of the crystals was carried out by a slow evaporation solution method. The structures of the crystals were successfully verified by the results of 1H NMR, FT-IR, and powder XRD tests. The crystal stacking arrangements of 5MFTF and 5MFTN were characterized via a single-crystal X-ray diffraction (XRD) technique. The second-harmonic generation (SHG) measurements revealed that 5MFTF exhibited an SHG intensity 7.5 times that of potassium dihydrogen phosphate (KDP), while 5MFTN showed a SHG intensity 5.2 times that of KDP. The hyperpolarizability and FMOs were also calculated. In order to reveal the microscopic charge transfer mechanism in crystalline materials (5MFTF and 5MFTN), hole–electron analysis and interfragment charge transfer were calculated. 5MFTN crystal exhibited higher thermal decomposition temperatures compared to the other chalcone crystals (Tm ≈ 207 °C). All of these results indicate that the 5MFTF and 5MFTN crystals are promising for optical applications.
研究领域:
材料科学
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光学材料
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晶体工程
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非线性光学
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有机合成
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DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Jian Li,Xueting Pan,He Li,Xingyu Ren,Tao Tan,Menghan Wang,Junyao Zhu,Yi Yu,Hai Wang,Zhenlin Fan
Epilepsy is one of the most prevalent central nervous system disorders, with antiepileptic drugs (AEDs) as the mainstay of treatment. While effective in reducing seizure frequency in ≈70% of patients, traditional AEDs are limited by blood concentration fluctuations, drug resistance, and cognitive side effects. Neuromodulation, particularly electrical stimulation, has emerged as a promising alternative by reversibly regulating abnormal neural circuits. However, conventional systems require implanted electrodes and external power sources, increasing the risk of trauma and infection. Piezoelectric nanomaterials offer a non-invasive strategy by converting endogenous biomechanical forces or ultrasound stimulation into localized electric currents, inducing neuronal hyperpolarization to suppress excitation. Based on this mechanism, a biomimetic piezoelectric nanoplatform is developed capable of ultrasound-triggered electrical stimulation for targeted neuromodulation without surgical implantation. Additionally, these nanoplatforms can co-deliver AEDs, enabling a dual therapeutic approach that combines localized stimulation with sustained drug release, enhancing efficacy while minimizing systemic exposure. This synergistic integration of ultrasound-responsive piezoelectric nanoplatforms and pharmacotherapy represents a transformative paradigm for safe, effective, and non-invasive epilepsy treatment.
研究领域:
神经病学
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纳米医学
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生物医学工程
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诊疗一体化
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超声治疗
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产品关联
DOI
高影响因子
MOLECULAR PHARMACOLOGY
·
2023
·Vol. 103
·期 4
·241-254
·
IF 3.6
Jian Gao,Hao Yin,Yanqun Dong,Xintong Wang,Yani Liu,KeWei Wang
The uricosuric drug benzbromarone, widely used for treatment of gout, hyperpolarizes the membrane potential of airway smooth muscle cells, but how it works remains unknown. Here we show a novel role of benzbromarone in activation of large conductance calcium-activated K+ channels. Benzbromarone results in dose-dependent activation of macroscopic big potassium (BK) currents about 1.7- to 14.5-fold with an EC50 of 111 μM and shifts the voltage-dependent channel activation to a more hyperpolarizing direction about 10 to 54 mV in whole-cell patch clamp recordings. In single-channel recordings, benzbromarone decreases single BKα channel closed dwell time and increases the channel open probability. Coexpressing β1 subunit also enhances BK activation by benzbromarone with an EC50 of 67 μM and a leftward shift of conductance-voltage (G-V) curve about 44 to 138 mV. Site-directed mutagenesis reveals that a motif of three amino acids 329RKK331 in the cytoplasmic linker between S6 and C-terminal regulator of potassium conductance (RCK) gating ring mediates the pharmacological activation of BK channels by benzbromarone. Further ex vivo assay shows that benzbromarone causes reduction of tracheal strip contraction. Taken together, our findings demonstrate that uricosuric benzbromarone activates BK channels through molecular mechanism of action involving the channel RKK motif of S6-RCK linker. Pharmacological activation of BK channel by benzbromarone causes reduction of tracheal strip contraction, holding a repurposing potential for asthma and pulmonary arterial hypertension or BK channelopathies.
研究领域:
药理学
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肺科学
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细胞生物学
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产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2014
·Vol. 4
·期 91
·50277-50284
·
IF 3.708
Zonghai Shi,Yunshan Zhou,Lijuan Zhang,Cuncun Mu,Haizhou Ren,Daf ul Hassan,Di Yang,Hafiz Muhammad Asif
Three new supramolecular compounds [H2TPP]1.5[SW11VO40]·5CH3CN·4H2O 1, [H2TPP]2[SW10V2O40]·4CH3CN·3H2O 2, and [H2TPP][SW12O40]·4H2O 3 composed of [H2TPP]2+ cation and vanadium substituted Keggin-type polyoxometalate (POM) anion [SW12−nVnO40](2+n)− (n = 0–2) were prepared and characterized. The third-order nonlinear optical (NLO) and optical limiting (OL) properties of resulting hybrids were studied by using an Nd:YAG laser at 532 nm with a pulse duration of τ = 7 ns. The results demonstrate that all of these supramolecular compounds have significant nonlinear reverse saturated absorption, self-defocusing behavior, and good OL performance, especially for compound 1, which has a second hyperpolarizability γ value of 7.05 × 10−29 (esu) and exhibits a comparable OL performance with the most well-known OL materials such as In(Pc*)Cl indicating that they are potentially excellent NLO materials. Remarkably, it was also observed that the degree of vanadium substitution in POM anions corresponding to different onset of reduction potential influences the NLO and OL properties of the resulting compounds: third-order NLO and OL properties of compound 2 are inferior to those of compound 1, and are better than those of compound 3. Both their second hyperpolarizability γ values and the OL performance were observed to be inversely proportional to the HOMO–LUMO gaps of the resulting compounds. The excited charge transfer from porphyrin to POM anions in the supramolecular compounds when exposed to laser irradiation is thought to play key role in the enhancement of NLO and OL response.
研究领域:
材料科学
·
光学
·
化学
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DOI
高影响因子
CELL
·
2025
·
IF 42.5
Daoming Chen,Zhou Yu,Wenbo Wu,Yingxue Du,Qianqian Du,Huanwei Huang,Yaqi Li,Ting Xuan,Ya-Chen Liang,Yang Liu,Zijuan Wang,Rina Su,Yi Zhao,Qi Li,Minmin Luo,Fengchao Wang,Ji Li,Cheng-Ming Chuong,Zhimiao Lin,Ting Chen
Hair loss affects millions globally, significantly impacting quality of life and psychological well-being. Despite its prevalence, effective strategies for promoting human hair growth remain elusive. By investigating congenital generalized hypertrichosis terminalis (CGHT), a rare genetic disorder characterized by excessive hair growth, we discover that chromatin deletions or an inverted duplication disrupt the topologically associating domain (TAD), leading to the upregulation of the potassium channel KCNJ2 in dermal fibroblasts. Mouse genetics demonstrate that KCNJ2-mediated membrane hyperpolarization in dermal fibroblasts promotes hair growth by enhancing fibroblasts Wnt signaling responses, involving a reduction in intracellular calcium levels. Notably, fibroblast membrane potential oscillates during the normal hair cycle, with hyperpolarization specifically associated with the growth phase. Inducing fibroblast membrane depolarization delays the growth phase, while KCNJ2-mediated hyperpolarization rescues hair loss in aging and androgenetic alopecia models. These results uncover a previously unrecognized role of fibroblast bioelectricity in tissue regeneration, offering novel therapeutic avenues for hair loss treatment.
研究领域:
皮肤病学
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分子生物学
·
遗传学
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细胞信号传导
·
再生医学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF INORGANIC BIOCHEMISTRY
·
2021
·
IF 4.155
Kun Chen,Qiang Yu,Yuan Liu,Panchao Yin
Developing strategies against the antibiotic resistance is a major global challenge for public health. Here, we report the synergy of the combination of Preyssler-type polyoxometalates (POMs) ([NaP 5 W 30 O 110 ] 14− or [AgP 5 W 30 O 110 ] 14− ) and ribosome-targeting antibiotics for high antibacterial efficiency with low risk of antibiotic resistance. Due to their ultra-small sizes and active surface ligands, POM anions show strong affinity to bacterial cell membrane and impose hyperpolarization of the bacterial cells as well as the decrease of Mg 2+ influx by blocking Mg 2+ transporters, which finally lead to the structural perturbations of ribosomes and instability of bacterial structures. The bacterial growth can, therefore, be regulated by the presence of POMs: a fraction of Bacillus subtilis shifted to a ‘dormant’, slow-growing cellular state (an extended lag phase) upon the application of subinhibitory concentration of POMs. An approach to combat antibiotic resistant bacteria by applying POMs at their early growth phase followed by antibiotic exposure is validated, and its high efficiency for bacterial control is confirmed.
研究领域:
微生物学
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药学
·
生物技术
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）