Suhao Wang,Lixuan Li,Shun Zhang,Qianqian Jiang,Pengxian Li,Chengjun Wang,Rui Xiao,Xiao-Ming Li,Jizhou Song
Electrophysiology and optogenetics are pivotal in neuroscience for probing and modulating neural activities, playing a vital role in unraveling the complexities of brain functionality. Despite their importance, the efficacy of existing devices is hampered by insufficient functional integration, pronounced foreign body reactions, and physical constraints that impede natural animal behaviors. Here, we develop a multifunctional, ultraflexible neural probe designed for simultaneous electrophysiological monitoring and optical neural modulation, along with mechanical properties that are conducive to flexibility and compliance. By integrating a wireless neural signal acquisition and stimulation circuit, we achieved wireless recording of brain signals in mice and wireless optogenetic control over their locomotor behavior. The multifunctional ultraflexible probe presented in this study holds substantial promise for closed-loop brain-machine interfaces and deepening our understanding of neural circuit functions. This innovative approach addresses the aforementioned limitations by a comprehensive solution for in vivo neural interrogation and manipulation, marking a significant advancement in the tools available for neuroscience research.
Jian Wang,Xinxing Zeng,Fude Nie,Renming Pan,Jie Chen,Yaofeng Mao,Haifu Wang,Xingquan Zhang,Jun Wang
Transient microchips have attracted considerable attention in the field of information security and privacy protection due to their self-destruction capability. Metastable intermolecular composites (MICs) are appealing for such applications due to their high energy density and rapid reaction kinetics, which meet the demands for miniaturization and fast response in transient microchips. However, weak interfacial interactions in conventional MICs limit the contact between components, hindering both microchip integration and ignition reliability. Herein, a hydrogen-bond assembly strategy is proposed to fabricate BC/GO/Al/CuO energetic films with exceptional flexibility and superior combustion performance. Dopamine modification introduces abundant hydroxyl groups onto the MIC particle surfaces, enabling the formation of a continuous hydrogen-bond network with binder bacterial cellulose (BC) binder and functional additive graphene oxide (GO).The integrated transient microchips retain structural integrity after 25 drop tests from 50 cm height, and the BC/GO/Al/CuO films are reliably ignited using a 3 V/3 A power supply, inducing complete destruction to the silicon substrate. This work demonstrates a novel strategy for creating highly flexible and reactive energetic films, showing great promise for application in advanced transient microchips.
危险品化学品经营许可证（带存储）