Advanced Optical Materials
·
2017
·Vol. 6
·期 4
·1701166
·
IF 6.875
Yanqi Ge,Zhengfeng Zhu,Yanhua Xu,Yunxiang Chen,Si Chen,Zhiming Liang,Yufeng Song,Yousheng Zou,Haibo Zeng,Shixiang Xu,Han Zhang,Dianyuan Fan
2D titanium disulfide (TiS 2 ) is recently found to have strong light absorption properties from visible to infrared (IR) region. This feature is highly attractive for applications in nonlinear photonics; however, the mechanism of broadband light–matter interaction is yet to be determined and nonlinear photonic devices are not developed. Here, for the first time, the experimental evidence supporting the mechanism of the broadband nonlinear photoresponse in ultrathin TiS 2 nanosheets ranging from 400 nm to 1390 nm is reported through laser Z -scan measurements. High-performance nonlinear photonic devices operating in the telecommunication band are also demonstrated. A novel saturable absorber (SA) device is successfully fabricated based on a 2D TiS 2 -decorated fiber, which exhibits outstanding ultrashort pulse generation performance with pulse duration of ≈1.04 ps centered at 1569.5 nm. Furthermore, as a stable all-optical thresholding component, the device can effectively attenuate noise and boost the signal-to-noise ratio of the pulse from 1.90 to 10.68 dB. The findings indicate that TiS 2 -based SA devices can be developed into excellent highly nonlinear photonic devices, which may advance the development of TiS 2 -based optical communication technologies in the future.
研究领域:
光学
·
材料科学
·
光子学
✓ 已验证
DOI
高影响因子
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
·
2025
·Vol. 72
·期 11
·3233-3243
·
IF 4.5
Kun Qian,Chenguo Yao,Yancheng Wang,Qiang Yang,Sizhe Xiang,Qiying Pei,Ting Zhu,Hongmei Liu,Shoulong Dong
Two major reasons why chemotherapy and immunotherapy have limited efficacy in treating gliomas are the blood-brain barrier and the dense, solid structure of the glioma. Pulsed electric fields have been a powerful tool for ablating solid tumors, and narrowing pulse duration can improve the field homogeneity penetrating into the tumor. In this study, we used multicellular tumor spheroids (MCTSs) as a model to explore the potential of ultrashort nanosecond pulses to inhibit tumor cell activity while disrupting their dense drug-resistant barriers. Exposure to ultrashort pulsed electric fields can significantly inhibit the viability of U-87 MG, C6, and GL261 spheroids, as indicated by reduced intracellular ATP content. Meanwhile, the proliferative abilities of tumor cells were suppressed, as evidenced by reduced Ki67 protein expression. In addition, it is notable that, after exposure to electric fields, the volume of spheroids increased dramatically. We hypothesize that ultrashort pulsed electric fields can reduce tumor compactness, thereby facilitating drug delivery for immunotherapy and chemotherapy. Immunofluorescence results showed that the cell-cell junction was broken by ultrashort pulsed electric fields with lower expression of adherens junction protein N-cadherin and tight junction protein ZO-1. It is evidenced that the capability of ultrashort pulsed electric fields to downregulate the intercellular adherence, as well as suppress the epithelial-mesenchymal transition, a key process of metastasis of cancer cells. At last, aqueous fluorescent nanoparticles were applied to simulate the anticancer drug or therapeutic antibodies. Under the supervision of fluorescence microscopy, the degree of nanoparticles penetrating into the spheroids was positively related to the number of ultrashort pulsed electric fields, marked with a higher fluorescent signal from the inner quiescent zone or a necrotic core. In conclusion, we emphasize that ultrashort pulsed electric fields could be promising for downgrading the compactness of glioma tumors, being a powerful assisted therapy for the delivery of anticancer drugs and therapeutic antibodies.
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产品关联
DOI
PubMed
高影响因子
ADVANCED MATERIALS
·
2021
·Vol. 33
·期 17
·2006482
·
IF 30.849
Xu Feng,Yipeng Lun,Xiaofang Jiang,Jianrong Qiu,Huakang Yu,Shifeng Zhou
Nanocrystal-in-glass (NIG) is an exciting class of composites, because it can not only combine the advantages of crystal and glass materials but also potentially generate new physical phenomenon in a cooperative manner. Herein, the nonlinear light–matter interaction processes in a broad range of NIG composites homogeneously embedded with LiNbO 3 are investigated. It is shown that, by rational control of the organization manner of crystal and glass phases, second-harmonic generation (SHG) can be precisely tuned. Importantly, an unusual SHG phenomenon, transverse SHG (TSHG), can be realized in the special region of the microstructure map combined with the features of high loading, nanoscale size, and homogenous distribution of nanocrystals. Furthermore, NIG composites exhibit broadband optical response, allowing TSHG in a wide waveband region to be achieved. Based on the above effects, the applications of the constructed NIG composite for precise measurement of the group velocity and duration of ultrashort optical pulses with femtosecond time scales are demonstrated. Indeed, the findings outline a fundamental principle to design NIG configurations for creating new properties, providing new directions for expanding the scope of NIG functional materials.
研究领域:
材料科学
·
非线性光学
·
光子学
·
纳米复合材料
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）