LANGMUIR
·
2013
·
IF 4.187
Gaoling Yang,Haizheng Zhong,Ruibin Liu,Yongfang Li,Bingsuo Zou
The ability to tune the size, shape, and properties of supraparticles is of great importance for fundamental study as well as their promising applications. We previously developed a method to synthesize monodisperse ZnSe supraparticles via “in situ aggregation” of ZnSe nanoparticles through a simple hot-injection method. In the present work, we show that the “in situ aggregation” strategy can be extended to tune the shapes of ZnSe supraparticles, and introduce novel functional magnetic and luminescence properties. Shape control is manipulated with oleic acid as ligands, which balances the attractive interparticles van der Waals forces and steric repulsive forces from the ligands. With the increase of oleic acid concentration, a morphology change from microspheres to asymmetrical multimer and three-dimensional nanoflowers was observed. “Doping” preformed Fe3O4 nanoparticles into ZnSe supraparticles endow them with magnetic properties. The magnetism of these Fe3O4@ZnSe supraparticles depends on the dosage of dopant. Doping of preformed CdS nanocrystals was also studied, resulting in emissive hybrid CdS@ZnSe supraparticles with diameters of 50–100 nm. It is noted that the doping of Fe3O4 and CdS nanoparticles show differing morphologies. The differences can be explained by variance in the lattice mismatches which leads to differing potentials for crystal growth.
研究领域:
材料科学
·
纳米技术
·
化学
✓ 已验证
DOI
高影响因子
Nanoscale Advances
·
2019
·Vol. 1
·期 10
·4137-4147
·
IF 0
Xiaoya Yu,Xiao Liu,Wanchuan Ding,Jun Wang,Gang Ruan
Recently, supraparticle protein–nanoparticle co-assemblies (or ‘supraparticle co-assemblies’ for short) have attracted considerable interest due to their fundamental and technological value. However, it remains challenging to form supraparticle co-assemblies with high stability. Here, we show that using hydrophobic interaction, instead of the previously used electrostatic and van der Waals interactions, as the primary driving force can lead to instant formation of exceptionally stable supraparticle co-assemblies with minimal external energy input. Our formation method of supraparticle co-assemblies simply involves mixing globular proteins (e.g., bovine serum albumin) with hydrophobic nanoparticles (e.g., hydrophobic magnetic nanoparticles and hydrophobic quantum dots) without significant energy input (e.g., sonication or stirring). Upon mixing of hydrophobic nanoparticles and proteins, the formation of supraparticle co-assemblies only takes <1 minute. Further incubation of the mixture for several hours results in a gradual increase of the size uniformity of supraparticle co-assemblies. The formed supraparticle co-assemblies have been colloidally stable for 6 months and counting, and can withstand harsh environments such as basic and acidic pH, high temperature, high dilution, and serum. Co-encapsulation of different sizes/types of nanoparticles is found to be feasible and the co-encapsulation number ratio of different nanoparticles is well-controlled by the feeding ratio. Proof-of-concept studies show the potential of the supraparticle co-assemblies for biological imaging, delivery, and modulation. The combination of very rapid formation, minimal energy consumption, highly stable products, and inexpensive raw materials of this hydrophobic interaction-driven process meets many of the main goals of ‘ideal’ nano-manufacturing. Thus, this process could serve as the foundation of ideal manufacturing of supraparticle co-assemblies.
研究领域:
材料科学
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生物医学工程
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
Cell Reports Physical Science
·
2023
·
IF 8.9
Qi Pan,Jie Fu,Sijin Liu,Jungui Zhou,Bo Ma,Shuhua Chen,Yinghua Qiu,Yi Lin,Yiqi Hu,Di Yang,Jinxing Chen,Man-Keung Fung,Yunjun Wang,Qiao Zhang,Lu Wang,Muhan Cao
The commercial application of all-inorganic perovskite (CsPbX 3 ) nanocrystals (NCs) in displays is mainly limited by low-yield and high-cost colloidal synthesis, poor stability, and unsatisfactory green emission wavelength. Here we report a simple and effective strategy that generates encapsulated CsPbX 3 @cyanuric acid (CA) super-particles (SPs) to overcome these obstacles. Because of the improved light conversion efficiency and suppressed reabsorption losses, these SPs exhibit excellent optical properties with high photoluminescence quantum yield (PLQY) of ∼90% and PL emission located at 525 nm, satisfying the high-standard benchmark Rec. 2020. Moreover, CA can greatly protect the perovskite NCs from environmental stimuli due to the trap-free bandgap of the perovskite and increased defect formation energy. By employing perovskite SPs in the display, a wide color gamut covering 94% of Rec. 2020 can be realized. This work enriches the family of perovskite NCs for high-quality displays, which will contribute to the prosperity of perovskite in the near future.
研究领域:
材料科学
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光学工程
·
显示技术
✓ 已验证
DOI
高影响因子
TALANTA
·
2020
·
IF 5.339
Ting Zhang,Lingli Lei,Meiling Tian,Junjie Ren,Zhisong Lu,Yang Liu,Yingshuai Liu
An ultrasensitive lateral flow immunoassay (LFIA) strip has been developed based on a multifunctional photothermal contrast Fe 3 O 4 @Au supraparticle (Fe 3 O 4 @Au SP) for quantitative Ochratoxin A (OTA) detection. The Fe 3 O 4 @Au SP composite not only shows a better photothermal effect over Fe 3 O 4 and gold nanoparticles , but possesses magnetic property and excellent ability to directly adsorb protein (antibody). Under 808 nm irradiation, photothermal images of the test strips are recorded by a portable Infrared thermal camera. A quantitative analysis is easily achieved based on the thermal changes, which are proportional to the concentrations of analytes. Under an optimal condition, a wide linear detection range from 1 pg mL⁻ 1 to 1μgmL⁻ 1 and a limit of detection (LOD) at 0.12 pg mL⁻ 1 have been achieved with OTA as a model analytes. The practical application potential has also been validated by detection of OTA in spiked corn , peanut, and soybean extractives with overall recoveries ranging from 98.6% to 115% and coefficient of variations (CVs) between 6.06% and 12.73%. The photothermal LFIA renders a rapid, sensitive, and quantitative bio-/chemo-sensing platform with only a portable laser source and a thermal camera.
研究领域:
生物医学工程
·
食品安全检测
✓ 已验证
DOI
高影响因子
ACS Omega
·
2023
·
IF 4.1
Nan Zhao,Qirui Sun,Lening Zhang,Hao Jin,Mengsi Zhang,Shuwei Liu,Hua Xin
In clinical practice, the incidence and mortality of non-small cell lung cancer are increasing year by year, which is a serious threat to the health of patients. Once the optimal surgical window is missed, the toxic side effects of chemotherapy have to be confronted. With the rapid development of nanotechnology in recent years, medical science and health have been greatly impacted. Therefore, in this manuscript, we design and prepare chemotherapeutic drug vinorelbine (VRL)-loaded polydopamine (PDA) shell-coated Fe3O4 superparticles, and further graft the targeted ligand RGD onto their surface. Because of the introduction of the PDA shell, the toxicity of the prepared Fe3O4@PDA/VRL-RGD SPs is greatly reduced. At the same time, due to the existence of Fe3O4, the Fe3O4@PDA/VRL-RGD SPs also have MRI contrast capability. Under the dual-targeting effect of RGD peptide and external magnetic field, Fe3O4@PDA/VRL-RGD SPs can accumulate into tumors effectively. The accumulated superparticles in the tumor sites can not only effectively identify and mark the location and boundary of the tumor under MRI, guideing the application of near-infrared laser, but also release the loaded VRL under the stimulation of the acidic microenvironment of the tumor to play the role of chemotherapy. On further combination with photothermal therapy under laser irradiation, A549 tumors are completely eliminated without recurrence. Our proposed RGD/magnetic field dual-targeting strategy can effectively improve the bioavailability of nanomaterials and contribute to better imaging and therapeutic effects, which has a promising application prospect in the future.
研究领域:
纳米技术
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癌症研究
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生物医学工程
·
分子生物学
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诊疗学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Xiaohui Wang,Zhipeng Li,Yadan Ding,Kexin Wang,Zhenkai Xing,Xue Sun,Wanqiu Guo,Xia Hong,Xiaojuan Zhu,Yichun Liu
It is challenging and urgent in neurosurgery to improve therapeutic effect of the most common and lethal malignant glioma in central nervous system. The superadditive therapeutic effect of photothermal therapy and photodynamic therapy holds great promise. Herein, a highly efficient photothermal-photodynamic therapy nanoplatform was developed on the basis of Fe 3 O 4 -IR806 superparticles. The introduction of the near-infrared (NIR) dye IR806 and the fabrication of the self-assembled structure of the superparticles warrant 3.5 times increase in the photothermal conversion efficiency compared with the Fe 3 O 4 nanoparticles . The Fe 3 O 4 -IR806 superparticles generated reactive oxygen species (ROS) with the NIR light irradiation by virtue of the dye IR806. Both in vitro and in vivo experiments demonstrated that the Fe 3 O 4 -IR806 superparticles exhibited negligible toxicity. The Fe 3 O 4 -IR806 superparticles efficiently inhibited the cultured glioma cells via photothermal ablation and ROS cytotoxicity in vitro, as well as suppressed the bearing glioma growth in vivo with the NIR light induction. Our results highlight the promise of the Fe 3 O 4 -IR806 superparticles for improved photothermal-photodynamic therapy of cancer.
研究领域:
神经外科
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癌症治疗
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纳米技术
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry A
·
2022
·Vol. 10
·期 28
·15116-15126
·
IF 14.511
Yue Hu,Yuqi Wang,Zhou Fang,Xinyi Wan,Mengyang Dong,Zhizhen Ye,Xinsheng Peng
Developing efficient water adsorbents for atmospheric water harvesting in desert regions still remains a challenge due to the lack of useful strategies to enhance low-pressure water uptakes and adsorption–desorption kinetics. Herein we demonstrate a simple and efficient polyvinylpyrrolidone (PVP) assisted self-assembly strategy for the fabrication of core–shell MOF-801@MIL-101(Cr) (M-8010) supraparticles. The water uptake capacity of the prepared supraparticles is about 225% and 390% higher than that of pure MOF-801 and MIL-101 at 8% RH, respectively, benefiting from the synergistic effect between the preconcentration functions of shell MOF-801 and the high storage capacity of core MIL-101. Fast water capture and release kinetics of M-8010 supraparticles is also achieved. Their water collection rate is estimated to be about 0.253 Lwater/kgadsorbents per day under 10–20% RH, demonstrating that the M-8010 supraparticles are a great potential and stable adsorbent for water harvesting under extremely arid environments. This work may pave a new way to design MOF@MOF supraparticles for high-performance water harvesters in desert areas.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2024
·
IF 5.3
Zixing Xu,Huoyue Lin,Jie Dai,Xiaowei Wen,Xiaoya Yu,Can Xu,Gang Ruan
Two frequent problems hindering clinical translation of nanomedicine are low drug loading and low colloidal stability. Previous efforts to achieve ultrahigh drug loading (>30 %) introduce new hurdles, including lower colloidal stability and others, for clinical translation. Herein, we report a new class of drug nano-carriers based on our recent finding in protein-nanoparticle co-assembly supraparticle (PNCAS), with both ultrahigh drug loading (58 % for doxorubicin, i.e., DOX) and ultrahigh colloidal stability (no significant change in hydrodynamic size after one year). We further show that our PNCAS-based drug nano-carrier possesses a built-in environment-responsive drug release feature: once in lysosomes, the loaded drug molecules are released instantly (<1 min) and completely (∼100 %). Our PNCAS-based drug delivery system is spontaneously formed by simple mixing of hydrophobic nanoparticles, albumin and drugs. Several issues related to industrial production are studied. The ultrahigh drug loading and stability of DOX-loaded PNCAS enabled the delivery of an exceptionally high dose of DOX into a mouse model of breast cancer, yielding high efficacy and no observed toxicity. With further developments, our PNCAS-based delivery systems could serve as a platform technology to meet the multiple requirements of clinical translation of nanomedicines.
研究领域:
药学
·
纳米技术
·
药物递送系统
·
癌症研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2019
·Vol. 7
·期 47
·15042-15048
·
IF 6.641
Jingjing Liu,Mengqi Xiao,Chaoran Li,Hai Li,Zhiyi Wu,Qishan Zhu,Rujun Tang,Ao Bo Xu,Le He
Self-assembly of non-spherical building blocks offers a potential route to photonic crystal supraparticles (PCSs) with novel structures and optical properties. However, experimental fabrications of anisotropic-particle-based PCSs have rarely been demonstrated owing to the requirement of additional control over the particle orientation during the assembly process. Here, we develop a spatially confined magnetic assembly strategy for the tailored assembly of ellipsoidal particles into PCSs with unusual non-close-packed structures. Detailed studies reveal that the transition of these metastable structures into close-packed structures is kinetically inhibited during the drying process owing to the synergy of spatial confinement and magnetic alignment. Unlike conventional PCSs, the nanoellipsoid-based PCSs exhibit anisotropic optical properties and multiple magneto-optical responses. The present work not only provides a model system for studying colloidal assembly under spatially confined conditions but also greatly extends the family of PCSs with interesting structures and properties, bringing new opportunities for applications in various areas.
研究领域:
材料科学
·
纳米技术
·
光学
·
胶体化学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 2
·1-8
·
IF 5.479
Wang Kexin,Ding Yadan,Hong Xia,Liu Yichun
A reliable, rapid and ultrasensitive immunoassay is described for determination of immunoglobulin G (IgG). It is making use of biofunctional magnetite (Fe 3 O 4 ) superparticles coated with SiO 2 and serving as an infrared (IR) probe. The unique IR fingerprint signals originating from the transverse and longitudinal phonon modes, respectively, of the asymmetric stretching of the Si–O–Si bridges display a satisfactory resistance to optical interference from the environment. The adoption of Fe 3 O 4 superparticles instead of Fe 3 O 4 nanoparticles as the magnetic core warrants a controllable structure and a strong magnetic response. This facilitates the efficient purification of the probes and the alleviation of the interfacial resistance between the liquid-solid interfaces by using a magnet. The gold-coated substrate was used to immobilize goat-anti-human IgG. The analyte (human IgG) was incubated with the IR probes, and then captured by the substrate immobilized antibody with the assistance of an external magnetic field. The integral area of the IR absorption band between 1250 cm −1 – 900 cm −1 was chosen for quantitative assay. The limit of detection is 95 fM, which is two orders of magnitude better than that without the magnetic field. The assay time was shortened from 2 h to 1 min. High selectivity, specificity, and long-term stability of the immunoassay were achieved. The performance of the assay when analyzing blood samples confirmed the practicability of the method.
Schematic presentation of the infrared (IR) immunoassay based on Fe 3 O 4 superparticle@SiO 2 nanocomposites. The assistance of an external magnetic field reduces the incubation time and improves the detection sensitivity.
研究领域:
分析化学
·
纳米技术
·
生物传感器
·
医学诊断
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）