Small
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2023
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IF 13.3
You Huang,Ke Chen,Ling Liu,Huizhen Ma,Xiaoning Zhang,Kexin Tan,Yuan Li,Ying Liu,Changlong Liu,Hao Wang,Xiao-Dong Zhang
Near-infrared-II (NIR-II) imaging has shown great potential for monitoring the pathological progression and deep tissue imaging but is limited to present unmet NIR-II agent. Present fluorophores show a promising prospect for NIR-II imaging, but brightness and photostability are still highly challenging during real-time monitoring. In this work, atom-engineered NIR-II Au 24 Cd 1 clusters with ultrahigh brightness, stability, and photostability are developed via single atomic Cd doping. Single atom Cd substitutions contribute to Cd 4d state in HOMO and redistribution of energy level near the gap, exhibiting 56-fold fluorescence enhancement of Au 24 Cd 1 clusters. Meanwhile, single atomic Cd reinforces Cd Au bond energy, formation energy, and stabilized cluster structure, leading to persistent stability for up to 1 month without decay, as well as excellent photostability of 1 h without photobleaching, much longer than clinically approved indocyanine green (<5 min). In vivo imaging shows gold clusters can monitor acute kidney injury (AKI) even after 72 h of injury, enabling evaluating progression at a very long window. Meanwhile, the bioactive gold clusters can alleviate AKI-induced oxidative stress damage and acute neuroinflammation. Single atom-engineered gold clusters exhibit molecular tracking and diagnostic prospect in kidney-related diseases.
研究领域:
生物医学工程
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纳米技术
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分子成像
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肾脏病理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Sustainable Chemistry & Engineering
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2022
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IF 9.224
Shuyang Bao,Yueyuan Liang,Liansheng Wang,Luhan Wang,Li Xu,Yu Wang,Xiaojuan Liang,Weidong Xiang
Solid laser lighting with high photoelectric conversion efficiency and compact size has been increasingly vital in lighting applications. Extensive research has been conducted to obtain high-quality color converters for application to high-power and high-luminance laser lighting. Currently, Y3Al5O12:Ce3+ phosphor in glass (Ce:PiG) and Y3Al5O12:Ce3+ phosphor-in-glass film (Ce:PiF) possessing high efficiency, low cost, easy fabrication, and controllable chromaticity are becoming the most mainstream research directions. In this study, by modifying the glass particle size and sintering temperature, investigating the relevant host glass, and so forth, high-performance Ce:PiG was developed through a one-step co-sintering technology. It possesses a high internal quantum efficiency, approaching 100% of the original phosphors (92.5%). The luminous efficacy (LE) of the Ce:PiG was 240 lm/W at 2.18 W/mm2 under 450 nm blue laser diode (LD) excitation, which is the best result yet reported. Furthermore, to enhance the laser saturation threshold, the fabricated Ce:PiF relying on a sapphire substrate can withstand an 8 W/mm2 blue incident power density. The obtained sample can even reach an LE of 251.5 lm/W, which is an obvious improvement to Ce:PiG. In addition, the result, an LD module combined with the sample that meets the standard white light source, indicates that this work has good prospects for white laser lighting.
研究领域:
光电技术
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材料科学
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照明工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
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2024
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IF 8.3
Caixia Qi,Lin Shen,Jin Li,Xun Sun,Lehui Song,Jiadong Chen,Yixuan Wu,Jaebum Choo,Lingxin Chen
Near-infrared (NIR) surface-enhanced resonance Raman (SERRS) nanoprobes have found wide applications in biomedicine; however, almost all of these nanoprobes are fluorescent because the resonant Raman dyes used cannot be fully quenched onto the underlying plasmonic nanoparticles. Therefore, suppressing the fluorescence backgrounds in resonant Raman spectroscopy imaging is extremely important. In this work, we use a black hole quencher, IQ1, as a Raman dye to develop absolutely nonfluorescent NIR resonant SERRS NPs. Ultrafast spectroscopy clarifies that the nonfluorescent mechanism of the dyes is attributed to the ultrafast internal conversion at the subpicosecond scale, which quenches the fluorescence of excited states. The resultant nanoprobes exhibit zero fluorescent background, femtomolar-level sensitivity (100 fM) as well as superb photostability (τ = 10006 s) without fluorescence photobleaching, outperforming that of fluorescent counterparts. More importantly, the SERRS NPs show a synergistic photothermal effect originating from the dye molecule-plasmon interactions, achieving a high photothermal conversion efficiency of 64.94%. Featuring these excellent properties, these SERRS NPs allow for longitudinally photostable cellular imaging and enhanced photothermal elimination of cancer cells. To the best of our knowledge, this is the first example of absolutely nonfluorescent NIR SERRS NPs, opening up promising applications for improved phototheranostics.
研究领域:
生物医学工程
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纳米技术
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光学光谱学
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癌症治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）