PHYSICAL CHEMISTRY CHEMICAL PHYSICS
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2017
·Vol. 20
·期 4
·2205-2210
·
IF 4.123
Rui-Ling Zhang,Yang Yang,Song-Qiu Yang,Ke-Li Han
Host–guest charge transfer (HGCT) plays a key role in applications from solar energy conversion to photocatalysis. Herein, a HGCT system, a pillared Pt(II) metallacage with encapsulated coronene was synthesized and the ultrafast excited-state dynamics were investigated by combination of femtosecond transient absorption spectroscopy, nanosecond transient emission spectrocopy and quantum chemistry calculations. Two significant ultrafast dynamic processes were unveiled: (i) charge transfer from a singlet local excited (1LE) state associated with the coronene moiety to a 1HGCT state with τ = 9.5 ps; and (ii) triplet–triplet energy transfer from a high 3HGCT state to a 3LE state with τ = 139.5 ps. The resulting long-lived species, the lowest 3LE and 3HGCT states eventually decay to the ground state in microsecond time scales of 5.2 and 43.4 μs respectively. Moreover, a clear mechanism depicting the main excited-state decay pathways connecting the initial photoexcited transients with the resulting species was proposed.
研究领域:
化学
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光化学
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理论计算
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMISTRY OF MATERIALS
·
2023
·
IF 8.6
Kai Yang,Shuo Ma,Youping Wu,Biao Zhao,Jianping Deng
Utilizing achiral fluorophores to fabricate circularly polarized luminescence (CPL) materials is of significant importance in both fundamental research and practical applications; chirality transfer has become an indispensable process in routine efforts reported so far. However, this may restrict or even become a bottleneck in further advancing CPL materials starting from achiral fluorophores. Inspired by biological light-harvesting architectural systems, we attempt to establish a new strategy, i.e., circularly polarized fluorescence energy transfer (CPF-ET) to explore multicolor CPL films in the absence of chirality transfer. CPL has been successfully realized through both radiative energy transfer and nonradiative energy transfer. The material systems consist of chiral fluorescent helical polyacetylene working as a circularly fluorescence polarized energy donor and achiral fluorophores as an energy acceptor. Achiral acceptors absorb circularly polarized fluorescence energy from the donor and hence emit the corresponding CPL; accordingly, chirality transfer is no longer an indispensable condition, and the sense of the CPL emission of the achiral fluorophores is controlled by the chiral fluorescent polymer. Moreover, multicolor CPL films can be simply prepared by employing varying achiral fluorophores. This work provides a facile and versatile platform for achieving CPL by taking advantage of achiral fluorophores.
研究领域:
材料科学
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光学
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化学
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生物物理学
✓ 已验证
产品关联
DOI
高影响因子
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2022
·Vol. 24
·期 33
·19799-19805
·
IF 3.945
Jing Wang,Shuping Xu,Xiangxin Xue,Lina Zhao,Weiqing Xu
The charge transfer (CT) interactions play a vital role in tuning the luminescence of organic crystals. The enhanced energy transfer (ET) effect in rare earth (RE) ions is a significant method to achieve long-lifetime fluorescence. These studies are of great significance in the fields of photoelectric functional materials. However, the effect of CT interactions on the process of ET from the cocrystal ligand group to RE ions is unknown. In this work, we have doped Eu3+ ions, Tb3+ ions and Eu3+/Tb3+ mixed ions on the surfaces of Phen–TCNB (Phen = 1,10-phenanthroline, and TCNB = 1,2,4,5-tetracyanobenzene) to construct organic cocrystal-type core–shell structures by the epitaxial growth method. The core–shell structures exhibited multiple photoluminescence depending on the types and proportions of RE3+ ions that are doped on the surfaces of the cocrystals. Experimental and theoretical investigations prove that the ET enhancements from ligand groups to Eu3+ ions originate from appropriate energy differences between the lowest triplet states of Phen–TCNB and the lowest excited state of RE3+ ions. In contrast, the reduced Tb3+ 5D4 lifetime is caused by the energy back transfer process since the energy difference becomes small. These results reveal that the multiple luminescences of the cocrystal-type core–shell structures can be adjusted by the CT and ET, and this study provides a new strategy for developing novel optoelectronic materials.
研究领域:
材料科学
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光学
✓ 已验证
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
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2025
·
IF 21.1
Qiming Song,Zifan Li,Qun Peng,Xinwen Ou,Kun Zhao,Zhimin Dong,Liqun Ye,Chenchen Liu,Yunhai Liu,Jun He,Lai-Hon Chung,Bin Han
Photocatalytic O 2 activation, which produces miscellaneous reactive oxygen species (ROSs) via electron or energy transfer, is crucial for various chemical and biological processes. Unfortunately, controlling the exciton behaviors to flexibly regulate the generation of ROSs has rarely been explored and the underlying regulatory mechanisms remain poorly understood. Here, via linkage orientation engineering of covalent organic frameworks (COFs), we showcase a facile strategy for the flexible regulation between 1 O 2 and H 2 O 2 generation in photocatalytic O 2 activation. Imine-based COFs equipped with donor (D)-N=C-acceptor (A) chain (TFPT COFs) exerts effective H 2 O 2 production via electron transfer, while its structurally isomeric COFs with reversed imine orientation (TAPT COFs) tends to singlet oxygen ( 1 O 2 ) photosynthesis via energy transfer, attaining high efficiency for pollutant removal. Based on the results from ultrafast spectroscopy and theoretical calculations, when the N atom of the imine linkage is close to the electron acceptor, it diminishes the surface potential difference and increases the exciton binding energy; this favors the activation of the spin-triplet state excitons via an energy transfer process. Conversely, a strong built-in electric field is created when this N atom is adjacent to the electron donor, which encourages the dissociation of excitons into carriers and their subsequent separation.
研究领域:
化学
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材料科学
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生物学
✓ 已验证
产品关联
DOI
高影响因子
PHARMACOLOGICAL RESEARCH
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2020
·
IF 5.893
Yong Xia,Fuyan Xu,Meiping Xiong,Hao Yang,Wentao Lin,Yao Xie,Huizhi Xi,Qiang Xue,Tinghong Ye,Luoting Yu
Targeted therapies and immunotherapy have brought substantial benefits to patients with melanoma . However, brain metastases remain the biggest threat to the survival and quality of life of melanoma patients. One of the major challenges to an effective therapy is the inability of drugs to penetrate the blood-brain barrier (BBB). Anti-schizophrenic drugs can cross the BBB, and many of them have demonstrated anti-cancer effects. Repurposing existing drugs for new clinical indications is an alluring strategy for anticancer drug discovery . Herein, we applied this strategy and screened a small collection of existing anti-schizophrenic drugs to use as anti-melanoma agents. Among them, trifluoperazine dihydrochloride (TFP) exhibited promising potencies for suppressing the growth and metastasis of melanoma, both in vitro and in vivo . TFP obviously suppressed the viability of melanoma cells within the micromolar range and inhibited the growth of melanoma in the subcutaneous mice models. Notably, intraperitoneal (i.p.) administration of TFP (40 mg/kg/day) obviously inhibited the growth of intra-carotid-injection established melanoma brain metastasis and extended the survival of brain metastasis-bearing mice. Moreover, TFP significantly suppressed lung metastasis and bone metastasis of melanoma in preclinical metastasis models. Mechanistically, TFP caused G0/G1 cell cycle arrest and mitochondrial-dependent intrinsic apoptosis of melanoma cells. In addition, TFP treatment increased the expression of microtubule associated protein 1 light chain 3 beta-II (LC3B-II) and p62 in vitro , suggesting an inhibition of autophagic flux. TFP decreased LysoTracker Red uptake after treatment, indicating impaired acidification of lysosomes. Moreover, the colocalization of LC3 with lysosomal-associated membrane protein 1 (LAMP1), a lysosome marker, was also suppressed after TFP treatment, suggesting that TFP might block the fusion of autophagosomes with lysosomes, which led to autophagosome accumulation. Taken together, our data highlight the potential of repurposing TFP as a new adjuvant drug for treating melanoma patients with brain, lung, and bone metastases.
研究领域:
肿瘤学
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药理学
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分子生物学
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癌症研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING
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2024
·
IF 4.2
Jiandong Hao,Ling Li,Bin Zhang,Ningqiang Shi,Tingwei Yan,Jinchang Meng
We used dry-wet transfer to prepare boron nitride nanoribbons (BNNRs) film. The effects that the different BNNRs film areas by dry transfer, the different areas and thicknesses of BNNRs film by wet transfer on BNNRs deep ultraviolet (DUV) detector were investigated, respectively. There is an excellent capability of detection and sensing for dry transfer DUV detector. The photocurrent rises with the area of the film. The maximum photocurrent ( I phmax ) is 34 pA at 1.64 mW/cm 2 (0.3 × 0.7 cm 2 , 30 mg). Rise and fall time are around 0.38s/0.41s. The responsivity and detectivity are 0.23μA/W and 5.57 × 10 7 (0.41 mW/cm 2 , V bias = 10V). The direct transfer of the MCE filter membrane by wet transfer can control the size and thickness of the film. The I phmax becomes larger with the thickness of the BNNRs film ( I phmax : 171 pA). And the time response is about 0.73s/0.72s, the responsivity and detectivity are up to 0.71μA/W and 1.72 × 10 8 (0.41 mW/cm 2 , V bias = 10V). However, it does not have a better ability to sense the DUV light than dry transfer. Therefore, different transfer methods can be applied to various requirements. This provides a good prospect for the high-performance DUV detectors.
研究领域:
材料科学
·
光学工程
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED MATERIALS
·
2019
·Vol. 32
·期 2
·1905696
·
IF 25.809
Jinhui Nie,Zewei Ren,Liang Xu,Shiquan Lin,Fei Zhan,Xiangyu Chen,Zhong Lin Wang
As a well-known phenomenon, contact electrification (CE) has been studied for decades. Although recent studies have proven that CE between two solids is primarily due to electron transfer, the mechanism for CE between liquid and solid remains controversial. The CE process between different liquids and polytetrafluoroethylene (PTFE) film is systematically studied to clarify the electrification mechanism of the solid–liquid interface. The CE between deionized water and PTFE can produce a surface charges density in the scale of 1 nC cm −2 , which is ten times higher than the calculation based on the pure ion-transfer model. Hence, electron transfer is likely the dominating effect for this liquid–solid electrification process. Meanwhile, as ion concentration increases, the ion adsorption on the PTFE hinders electron transfer and results in the suppression of the transferred charge amount. Furthermore, there is an obvious charge transfer between oil and PTFE, which further confirms the presence of electron transfer between liquid and solid, simply because there are no ions in oil droplets. It is demonstrated that electron transfer plays the dominant role during CE between liquids and solids, which directly impacts the traditional understanding of the formation of an electric double layer (EDL) at a liquid–solid interface in physical chemistry.
研究领域:
物理化学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MOLECULAR CARCINOGENESIS
·
2025
·
IF 3.2
Minling Lu,Ting Wan,Qianling Huang,Jingjing Yao,Yaqiu Zheng,Shaofang Yu,Xiaomin Zhu,Xiaoyi Zeng,Zhongqiu Liu,Yuan Zheng,Linlin Lu
Brain metastasis (BM), most vital and common metastasis phenotype occurs during tumorigenesis, the incidence of which varied remarkedly in various cancers. Overwhelming evidence suggested blood–brain barrier (BBB) can attenuate the anti-BM efficacy of chemotherapies via hindering their penetration. This study aimed to investigate the preferential cancer type that is more prone to BM, and bioactive compound that suppress BM through penetrating BBB. By intracardiac injection of lung cancer cells, breast cancer cells and melanoma cells, BM models were established. By two cycles of primary-isolation and incubation of H446-luc cells to improve the incidence of BM. Artemisinin (ART) and its derivatives were evaluated to suppress BM in vitro and in vivo. Compared to lung cancer-driven BM (66.67%), the incidence of BM in breast cancer (16.67%–33.33%) and melanoma (33.33%) were extremely low. The incidence of BM in lung cancer increased from 66.67 (1st generation) to 80% (2nd generation). Compared to other ingredients, artesunate (ARTS) exerted a more significant inhibitory effect on cell proliferation, especially in lung cancer cells. Simultaneously, ARTS suppressed lung cancer migration via decreasing N-cadherin and Snail, and enhancing E-cadherin. Most importantly, we found that ARTS could strikingly suppress tumor growth in brain with high concentration, implying that ARTS might penetrate BBB and accumulate in brain tissue to hinder lung cancer-driven BM. Our findings not only suggest lung cancer exhibited tumor specificity in cancer-driven BM model, but also provide ARTS as a promising candidate for clinical treatment of lung cancer-relayed BM.
研究领域:
肿瘤学
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药理学
·
神经科学
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分子生物学
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癌症研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2019
·
IF 5.589
Rui Wang,Ting Tang,Guining Lu,Zhiqiang Zheng,Kaibo Huang,Huafeng Li,Xueqin Tao,Hua Yin,Zhenqing Shi,Zhang Lin,Fengchang Wu,Zhi Dang
This study investigated the relative significance of electron transfer (e-transfer) and H-atom transfer (H-transfer) in a nanoscale zerovalent iron (n-ZVI) system and six n-ZVI-based bimetallic systems (Fe/Cu, Fe/Ni, Fe/Pd, Fe/Ag, Fe/Pt, and Fe/Au) through a case study of the debromination of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47). The results revealed that the reactivities of these bimetallic particles to BDE-47 decreased in the following order: Fe/Pd > Fe/Ag > Fe/Cu > Fe/Ni > Fe/Au > Fe/Pt ≈ n-ZVI. Debromination of BDE-47 in metal-H 2 systems suggested that Ni, Pd, Pt, Cu and Au can utilize H 2 to debrominate BDE-47. In the H-transfer process, BDE-47 preferentially debrominated the para‑ bromine substituent to generate BDE-17, whereas in the e-transfer process, BDE-47 preferentially debrominate ortho‑ bromine substituent to generate BDE-28. The debromination pathways of BDE-47 in bimetallic and NaBH 4 -metal systems suggested that Fe/Ni, Fe/Pd and Fe/Pt debrominate polybrominated diphenyl ethers (PBDEs) through a H-transfer dominant mechanism, while Fe/Ag debrominate PBDEs through an e-transfer dominant mechanism. In the cases of Fe/Cu and Fe/Au, the e-transfer and H-transfer may be equally involved in the debromination of PBDEs. These results greatly improve our understanding of the relative significance of e-transfer and H-transfer in the dehalogenation of halogenated aromatic compounds (HACs) in various n-ZVI-based bimetallic systems.
研究领域:
环境科学
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Nano
·
2020
·
IF 14.588
Yue Tan,Kui He,Bing Tang,Huarui Chen,Zhipeng Zhao,Chengqian Zhang,Li Lin,Jinbin Liu
The nanoprobes for identification of cancer metastases in the mononuclear phagocyte system (MPS) organs are of significant importance but are limited due to the long-standing challenge of low tumor-targeting specificity with inadequate targeting efficiency and high nonspecific accumulation. Here, we report a surface regulation strategy that integrates the tumor-acidity-activated charge-reversal behavior and precise control in both hydrodynamic diameter (HD) and surface charge on ultrasmall luminescent gold nanoparticles (AuNPs) to achieve significantly high tumor-targeting specificity. The precise regulation of AuNPs to a rational HD and surface charge could rapidly and selectively recognize small metastatic tumors (∼1 mm) in liver and lung with high signal-to-noise ratios of 4.6 and 4.5, respectively. These results help further understand the in vivo transport of nanoprobes and provide guidance for design of translatable nanosized nanomedicines in cancer metastasis theranostics.
研究领域:
纳米医学
·
肿瘤学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nano Energy
·
2018
·
IF 13.12
Ping Chen,Yan Meng,Mahshid Ahmadi,Qiming Peng,Chunhong Gao,Long Xu,Ming Shao,Zuhong Xiong,Bin Hu
“Ruddlesden-Popper” perovskites with multiple quantum wells (MQWs) layered structure are extremely attractive for light-emitting diodes (LEDs) due to their effective energy confinement and high device stability properties. Two important processes of energy transfer (ET) and charge transfer (CT) are responsible for the effective energy confinement in MQWs. At present stage, the ET mechanism has been widely accepted as the main origin of high efficiency in MQWs. However, the high dielectric constant (ε) of hybrid perovskites should significantly limit the ET process, because the ET rate is inversely proportional to the ε. Therefore, the detailed contribution of CT mechanism, especially under electrical excitation, should be carefully considered. Herein, we report a high quality quasi-2D perovskite film of PA 2 (CsPbBr 3 ) n-1 PbBr 4 MQWs through a simple solution process, with highly-dense and smooth morphology, and a high photoluminescence (PL) quantum efficiency. Then, the PL and transient PL spectra were measured under electrical injection in a hole-only and electron-only devices, respectively, to verify the CT mechanism. Furthermore, the photo-excitation intensity dependent PL spectra reveal that the CT mechanism is more important than ET mechanism for the electroluminescence of PA 2 (CsPbBr 3 ) n-1 PbBr 4 perovskite LEDs (PeLEDs), resulting in a pure cyan emission at ~ 505 nm and maximal external quantum efficiency up to 3.6%, representing one of the best results in reported blue PeLEDs.
研究领域:
材料科学
·
光电技术
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2021
·
IF 4.539
Wenjun Hu,Qi Qi,Haiyan Hu,Changhai Wang,Qing Zhang,Zekang Zhang,Yueying Zhao,Xianglong Yu,Mingxue Guo,Shouying Du,Yang Lu
Tumor metastasis is the main reason for the high mortality rate of breast cancer patients and lymph node metastasis is the primary means of tumor spreading. Liposomes loaded with bufalin (BF), a steroidal inhibitor of various inflammatory signaling pathways in cancer, and superparamagnetic Fe 3 O 4 nanoparticles were developed to inhibit lymphatic metastasis in breast cancer. Fe 3 O 4 functioned as both a magnetic targeting and photothermal agent. In vivo studies using a mouse model of lymph metastatic breast cancer demonstrated that BF-Fe 3 O 4 -L(liposomes), administered by iv injection, accumulated in sentinel lymph nodes (SLNs) with high efficiency under magnetic direction and exhibited significant photothermal character under near-infrared (NIR) light irradiation. The combination of targeted delivery, photothermal and chemotherapeutic properties resulted in a 91% tumor inhibition rate in SLNs compared with untreated (PBS) controls and 81% lower incidence of pulmonary metastases formation. These findings reveal the significant potential of BF- Fe 3 O 4 -Ls for delivering -targeted, chemo-photothermal therapy in the treatment of metastasic cancer.
研究领域:
肿瘤学
·
纳米医学
·
药理学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）