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MOLECULES · 2018 ·Vol. 23 ·期 9 ·2234 · IF 3.098

Imidazolium Chloride: An Efficient Catalyst for Transamidation of Primary Amines

Qingqiang Tian,Zongjie Gan,Xuetong Wang,Dan Li,Wen Luo,Huajun Wang,Zeshu Dai,Jianyong Yuan

A highly efficient and convenient protocol of imidazolium chloride (30 mol %) catalyzed amidation of amines with moderate to excellent yields was reported. The protocol shows broad substrate scope for aromatic, aliphatic, and heterocyclic primary amines.Keywords:imidazolium chloride;catalyst;primary amines;transamidation

研究领域: 有机化学 · 催化反应

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Molecular Catalysis · 2024 · IF 3.9

Sustainable Aerobic Transamidation and Esterification of N-Heteroaryl Amides by Heterogeneous Copper Catalyst

Narina Wang,Chaolumen Bai,Xiaomin Ge,Dan Liu,Agula Bao,Tegshi Muschin,Yong-Sheng Bao

Transamidation of secondary amides via heterogeneous strategy has remained an unsolved problem. Here we report a novel and efficient approach for transamidation and esterification of ubiquitous N -heteroaryl amides with various amines and alcohols that exploits an engineered heterogeneous supported copper nanoparticles catalyst. This method overcomes the difficulty of heterogeneous catalysts, which can only achieve transamidation of primary amide driven by the emission of ammonia gas. A broad diversity of N -heteroaryl amides containing quinolin-2-yl, isoquinolin-1-yl, pyrazin-2-yl and pyridin-2-yl directing groups convert into corresponding α-ketoamides and α-ketoesters using needle-shape copper nanoparticles supported on γ-Al 2 O 3 as heterogeneous catalyst. This environmentally benign, catalyst recyclable and easy-to-handle catalysis methodology will have great application prospects in the pharmaceutical synthesis and biological or chemical industry.

CAS / MDL: 64-17-5 7447-39-4 16940-66-2

研究领域: 有机化学 · 药物合成 · 环境科学

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Imidazolium Chloride: An Efficient Catalyst for Transamidation of Primary Amines

Sustainable Aerobic Transamidation and Esterification of N-Heteroaryl Amides by Heterogeneous Copper Catalyst