Polymers
·
2018
·Vol. 10
·期 2
·190
·
IF 2.935
Sa Liu,Chunting Zhong,Weiwei Wang,Yongguang Jia,Lin Wang,Li Ren
As a drug carrier, polyrotaxane (PR) has been used for targeted delivery and sustained release of drugs, whereas silver sulfadiazine (SD-Ag) is an emerging antibiotic agent. PR was synthesized by the use of α-cyclodextrin (CD) and poly(ethylene glycol) (PEG), and a specific antibacterial material (PR-(SD-Ag)) was then prepared by loading SD-Ag onto PR with different mass ratios. The loading capacity and the encapsulation efficiency were 90% at a mass ratio of 1:1 of PR and SD-Ag. SD-Ag was released stably and slowly within 6 d in vitro, and its cumulative release reached more than 85%. The mechanism of PR loading SD-Ag might be that SD-Ag attached to the edge of α-CD through hydrogen bonding. PR-(SD-Ag) showed a higher light stability than SD-Ag and held excellent antibacterial properties againstEscherichia coli(E. coli) andStaphylococcus aureus(S. aureus).Keywords:polyrotaxane;silver sulfadiazine;mechanism;antibacterial
研究领域:
药学
·
材料科学
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DOI
PubMed
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2017
·Vol. 314
·期 3
·1607-1618
·
IF 1.282
Liu Huijun,Qi Caixia,Feng Zhiyuan,Lei Lanlin,Deng Shanxia
The adsorption of thorium(IV) was studied using a novel supramolecular polyrotaxane based on β-cyclodextrin derivatives. The effects of pH, contact time, Th(IV) initial concentration and adsorbents dosage on the adsorption of thorium(IV) by polyrotaxane were optimized using Box–Behnken design of response surface methodology. Analysis of variance and correlation coefficients showed that the predicted model was consistent with the experimental data well. The adsorption best fitted to the Langmuir model indicated that the adsorption process happened on homogeneous surface. The thermodynamic parameters (∆ G
0 < 0, ∆ H
0 > 0, ∆ S
0 > 0) demonstrated that the adsorption of Th(IV) ions onto polyrotaxane was spontaneous and endothermic.
研究领域:
环境科学
·
化学工程
·
材料科学
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DOI
高影响因子
RSC Advances
·
2014
·Vol. 4
·期 100
·56791-56797
·
IF 3.708
Yulin Cui,Mei Tan,Aidi Zhu,Mingyu Guo
Strain hardening and high resilience are two unique mechanical characteristics of many soft biological hydrogels. However, these properties, especially the strain hardening behaviour, are generally not seen in synthetic polymer hydrogels. Here, hydrogels are prepared by free-radical copolymerization of acrylamide and chain-extended vinyl-modified pseudo-polyrotaxane, which acts as a multifunctional crosslinker. The reactive pseudo-polyrotaxane is based on a β-cyclodextrin monomer and amine-terminated PEG–PPG–PEG (Pluronic F127). The obtained hydrogels can be stretched from 10 to more than 26 times their original length before breaking and withstand a compression strain of 95% and even 98% without fracture. Tensile stretching tests show obvious strain hardening behaviours in high stretching and compression deformation regimes. The strain hardening behaviour in stretching deformation is considered to be the orientation and aggregation of the movable crosslinkers along the axial polymer backbone. Moreover, the formation of a second supramolecular network due to the chain-extension effect may also be responsible for it. Highly resilient behaviours with almost no hysteresis and residual strains are also observed even with a maximum strain of λ = 12 because of the inherent freely movable character of the crosslinkers.
研究领域:
材料科学
·
生物医学工程
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DOI
高影响因子
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
·
2019
·Vol. 96
·期 1
·69-79
·
IF 1.429
Duan Nannan,Ye Lin,Zhang Ai-ying,Feng Zeng-guo
Abstract A series of PPR-based multiblock copolymers were prepared by using a PPR self-assembled from a distal 2-bromoisobutyryl end-capped ferrocenyl containing derivative Br-TEG-Fc-TEG-Br with 4 β-CDs as initiator to initiate the in situ ATRP of NIPAAm in aqueous solution at room temperature. After the ATRP, about 2 β-CDs were resided on the polymeric backbone through a 7 day dialysing purification, but those β-CDs were all slipped off the polymeric chain through a further 7 day dialysing treatment. It suggested that the resulting multiblock copolymers are really the PPR-based instead of the PR-based ones showing an impeded dethreading behavior of β-CDs and the PNIPAAm blocks attached are not bulky enough as polymeric stoppers to end-cap the β-CD-TEG-Fc-TEG PPRs into the PR-based multiblock copolymers. Graphic abstract A series of PPR-based multiblock copolymers were prepared by using a PPR self-assembled from Br-TEG-Fc-TEG-Br with 4 β-CDs as initiator to initiate the aqueous ATRP of NIPAAm. After the polymerization there are about 2 β-CDs still entrapped on the polymeric chain through a 7 day dialyzing purification. Those threaded β-CDs are all slipped off the polymeric backbone through a further 7 day dialyzing treatment.
研究领域:
高分子化学
·
材料科学
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DOI
高影响因子
Polymer Chemistry
·
2015
·Vol. 6
·期 11
·2098-2107
·
IF 5.52
Yang Kang,Xiao-Mei Zhang,Sheng Zhang,Li-Sheng Ding,Bang-Jing Li
Self-assembly of stimuli-responsive polymeric nanoparticles have attracted great attention in recent years due to their prospective biological applications. This paper developed a novel pH-sensitive amphiphilic dendritic polyrotaxane drug-polymer conjugate by covalently linking doxorubicin (DOX) and dendritic polyrotaxane via a pH-responsible hydrazone bond with 1.84 wt% (weight percent) of DOX. The drug-polymer conjugate was amphiphilic and could be self-assembled to micelles (PR-g-DOX micelles) in an aqueous solution. The globular morphology and compact micelles with a diameter of around 110 nm were observed by SEM and TEM. Moreover, the micelles showed a significantly faster DOX release at mildly acidic pH of 6.0 and 5.0 and almost no burst release at the physiological pH of 7.4. Notably, it was confirmed that this micelle could efficiently deliver DOX to the nuclei of the tumor cells, which led to a much greater cytotoxic effects in the A549 cancer cells than the parent DOX. In vivo results revealed better drug tolerability of PR-g-DOX micelles and a higher in vivo efficacy without any increase in the toxicity of the PR-g-DOX micelles. Furthermore, the maximum tolerated dose (MTD) results showed that PR-g-DOX micelles showed an excellent safety profile with a two-fold higher MTD (10 mg kg−1 DOX) than that of free DOX (5 mg kg−1 DOX). We are convinced that the PR-g-DOX micelle has tremendous potentials for targeted cancer therapy.
研究领域:
药学
·
生物医学工程
·
肿瘤学
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DOI
高影响因子
MACROMOLECULAR RAPID COMMUNICATIONS
·
2015
·Vol. 36
·期 15
·1402-1408
·
IF 4.941
Rui Qi,Yong Jin,Xinfeng Cheng,Baozhu Fan,Tongbing Sun,Shaojun Peng,Hanping Li
A novel rod-containing block copolymer is constructed by supramacromolecular self-assembly of α-cyclodextrin and a triblock copolymer with methoxy polyethylene glycol as the flanking chains and the midterm block alternately connected by 2,2-dimethylolbutyric acid and isophorone diisocyanate. The assembled rod-containing block copolymer shows an exciting phenomenon of concentration- and pH-dependent morphological switching of well-defined nanostructures. In the solutions at pH 9.2, spherical micelles, rod-like micelles, and hydrogel are observed successively with an increase of the concentration. Notably, the rod-like micelles are composed of spherical segments due to the combination of the crystalline cores of the spherical micelles. In addition, 1D nanostructures with different curvatures from linear rod-like micelles (pH 9.2) to ring-shaped micelles (pH 7.5) can be obtained by controlling the pH values of the assembled systems.
研究领域:
高分子化学
·
材料科学
·
超分子化学
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DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2019
·
IF 3.973
Sisi Ma,Ligang Lin,Qi Wang,Yuhui Zhang,Honglei Zhang,Yixin Gao,Lin Xu,Fusheng Pan,Yuzhong Zhang
A simple and effective strategy to simultaneously enhance the permeability and antifouling properties of ethylene vinyl alcohol (EVAL) membrane was developed based on the bioinspired natural cleaner, cilia. Taking clue from the self-cleaning effect of cilia, supramolecular polyrotaxanes (PRs) with sliding and rotating cyclic molecules along linear chains were synthesized using azide-alkyne click chemistry. Cilia-like PRs were incorporated into EVAL matrix in the fabrication of modified EVAL membranes. Cilia-like structures protruding from the membrane surface have been observed by SEM, TEM and AFM. By imitating natural ciliary movements, these structures provided a proactive self-cleaning system to remove the foulants. The introduction of cilia-like PRs enhanced the surface roughness and hydrophilicity, and significantly enhanced permeability by 55.3% compared to raw EVAL membrane. Moreover, the membrane modified with cilia-like PRs showed an excellent antifouling property with a lower water flux decline (12.6%) and higher water flux recovery (94%) in dynamic fouling tests. Furthermore, this modified membrane develops the scope of bioinspired membranes, inspiring more attractive potential applications in self-cleaning materials, dynamic membranes and supramolecular machines.
研究领域:
材料科学
·
环境工程
·
生物启发设计
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产品关联
DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2013
·
IF 2.206
Xiaofeng Wang,Weiyi Xing,Bibo Wang,Panyue Wen,Lei Song,Yuan Hu,Ping Zhang
Polypseudorotaxane (PPR) prepared by the inclusion complex between beta-cyclodextrin (β-CD) and poly(propylene glycol) (PPG) was chosen as a ‘‘green’’ carbon source in intumescent flame retardants (IFRs) and exhibited more effective carbonization and higher degree of graphitic network than that of free β-CD. Its combination with ammonium polyphosphate (APP) and melamine (MA) presented the most excellent char-forming ability whether in nitrogen or in air atmosphere. After blending IFRs into polylactic acid (PLA), the thermal stability was characterized by thermogravimetric analysis (TGA), and their flammability was assessed by limited oxygen index (LOI), vertical combustion, and cone calorimeter. The higher LOI% value and lower total heat release (THR) of PLA2 (which contains 20 wt % APP/MA/PPR mixtures) revealed that it presented more excellent flame retardance. Besides, the results of scanning electron microscopy (SEM) exhibited the existence of more bubbles in the char residue of PLA2.
研究领域:
材料科学
·
化学工程
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产品关联
DOI
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2020
·Vol. 221
·期 18
·2000157
·
IF 2.335
Ming Gao,Hang Lu,Rong-Hao Song,Lin Ye,Ai-Ying Zhang,Zeng-Guo Feng
To highlight whether γ-cyclodextrins (CDs) facilitate propargylamine monosubstituted β-CDs (PA-β-CDs) as end stoppers to get threaded onto a distal azide terminated poly(2-hydroxyethylmethacrylate) (PHEMA) homopolymer (PH-46-2N 3 ) to create linear and hyperbranched polyrotaxanes (PRs) via the in situ copper-catalyzed azide/alkyne cycloaddition (CuAAC), PH-46-2N 3 is self-assembled with a varying amount of γ-CDs in water and then subjected the CuAAC with PA-β-CDs to end-cap the resulting γ-CD-PHEMA polypseudorotaxanes (PPRs) into the γ-CD-PHEMA PRs. It demonstrates that γ-CDs cannot promote PA-β-CDs to be entrapped on the PHEMA chain most likely due to their different cavity size and molecular framework and linear PRs are always formed with up to 29% γ-CD coverage ratio along the PHEMA axis thereof.
研究领域:
高分子化学
·
超分子化学
·
材料科学
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产品关联
DOI
高影响因子
Journal of Functional Biomaterials
·
2023
·Vol. 14
·期 7
·360
·
IF 4.8
Lulu Wang,Yuehai Peng,Wenfang Liu,Li Ren
Corneal disease has become the second leading cause of blindness in the world. Corneal transplantation is currently considered to be one of the common treatments for vision loss. This paper presents a novel approach utilizing dual-crosslinked membranes composed of polyrotaxane multiple aldehydes (PRAs), 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC), and N-hydroxysuccinimide (NHS) in the development process. Collagen was crosslinked, respectively, by EDC/NHS and PRAs to form stable amide bonds and imine groups. Through the formation of a double interpenetrating network, dual-crosslinked (Col-EDC-PRA) membranes exhibited enhanced resistance to collagenase degradation and superior mechanical properties compared to membranes crosslinked with a single crosslinker. Furthermore, Col-EDC-PRA membranes display favorable light transmittance and water content characteristics. Cell experiments showed that Col-EDC-PRA membranes were noncytotoxic and were not significantly different from other membranes. In a rabbit keratoplasty model, corneal stromal repair occurred at 5 months, evidenced by the presence of stromal cells and neo-stroma, as depicted in hematoxylin–eosin-stained histologic sections and optical coherence tomography images of the anterior segment. Moreover, there was no inflammation and corneal neovascularization, as well as no corneal rejection reaction in the surgical area. Overall, the results demonstrated that the dual-crosslinked membranes served effectively for corneal tissue regeneration after corneal defect.Keywords:collagen membrane;corneal repair;corneal regeneration
研究领域:
生物医学工程
·
眼科研究
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DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2015
·Vol. 3
·期 26
·5277-5283
·
IF 4.726
Shuling Yu,Jintao Yuan,Jiahua Shi,Xiaojiao Ruan,Yali Wang,Shufang Gao,Yu Du
A small, nano-sized, water-soluble polyrotaxane (PR) was synthesized using a highly efficient one-pot synthesis strategy in a homogeneous water system, formed from β-cyclodextrin-(COOH)2, poly(propylene glycol)bis(2-aminopropyl ether) (PPG, 2 kDa) and a mono-(6-azido-6-desoxy)-β-cyclodextrin stopper via room temperature click chemistry. β-cyclodextrin-(COOH)2 and PR were characterized by one- and two-dimensional NMR as well as by high resolution transmission electron microscopy (HR-TEM). The number of carboxyl groups in one PR was determined by 1H NMR. Two-dimensional diffusion-ordered NMR spectroscopy (2D DOSY) and nuclear Overhauser enhancement spectroscopy (2D NOESY) show that β-cyclodextrin-(COOH)2 and PPG successfully formed an inclusion complex. HR-TEM revealed the morphology of water-soluble PR as a spherical nanoparticle with a size of approximately 3.5 nm ± 1.5 nm. PR was labeled with rhodamine to assess its biocompatibility and cell membrane penetrability in vitro. The in vivo real-time fluorescent imaging biodistribution experiments indicated that water-soluble PR can actively target tumor sites using an enhanced permeability and retention (EPR) effect, with a significantly prolonged blood circulation time in tumor-bearing mice.
研究领域:
材料科学
·
生物医学工程
·
纳米医学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2022
·
IF 10.53
Liang Ren,Jianxin Chen,Qing Lu,Jian Han,Jinsheng Liang,Hong Wu
Nanofiltration membranes with high permeability and antifouling ability is favor of efficient and sustainable separation. However, simultaneous enhancement of above performances faces formidable challenges. Herein, we present a facile method to obtain ultrapermeable antifouling nanofiltration membranes via surface binding binary complex of dihydroxyl viologen (HV 2+ ) axis molecule and cucurbit[n]uril (CB[n]) on the freshly prepared polyamide (PA) thin-film composite membranes in a rotaxane manner. CB[n]-rotaxanes feature three-dimensional hydrophilic structure and create heterogeneous channel in PA selective layer, which favors water transport resistance decrease. Meanwhile, CB[n]-rotaxanes as host molecules enhance superficial grafting ability of membranes towards guest-labelled antifouling materials through supramolecular recognition. Inspiringly, adopting stimuli-responsive guest, such as azobenzene , endows grafted antifouling layer with photo-activated regeneration capability, which further improves fouling reversibility of membranes. The optimal membrane exhibits a 3-fold increase of permeance, maintained Na 2 SO 4 rejection and enhanced antifouling properties compared to the pristine, which overmatches most of the state-of-the-art nanofiltration membranes. The proposed construction strategy may pave a novel avenue to develop ultrapermeable antifouling membranes for treating complex wastewater.
研究领域:
材料科学
·
环境工程
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）