Acupuncture and Herbal Medicine
·
2024
·Vol. 4
·期 4
·487
·
IF 0
Wang Zhiyun,Shang Haihua,Gou Wenfeng,Xu Feifei,Hou Yue,Liu Gaiting,Ren Zhonghao,Li Yiliang,Tian Yuhua,Li Wei,Wang Yuefei,Hou Wenbin
Objective: Camellia nitidissima Chi, a Chinese medicine commonly used by ethnic minorities in Guangxi, China, is beneficial for clearing heat, detoxifying, inducing diuresis, and suppressing swelling. It has various pharmacological properties, including antitumor, anti-inflammatory, and antioxidant. However, its potential application in radioprotection remains unclear. In this study, we aimed to determine whether Camellia nitidissima Chi has radioprotective effects against radiation-induced gastrointestinal and hematopoietic damage. Methods: The 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical and 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) techniques were used to assess the ability of Camellia nitidissima Chi to scavenge free radicals. We conducted a 30-day survival rate experiment to evaluate the radioprotective capabilities of Camellia nitidissima Chi. Additionally, we developed models of radiation-induced intestinal and hematopoietic damage. Alterations in the white blood cell (WBC) count, total superoxide dismutase (T-SOD), glutathione (GSH), and protein expression linked to apoptosis were observed. Results: Camellia nitidissima Chi scavenged 84.72% and 93.47% of DPPH and ABTS, had a certain radiation protection potential, and increased the survival rate of mice to over 90%. Moreover, following exposure, Camellia nitidissima Chi enhanced WBC, T-SOD, and GSH levels. Camellia nitidissima Chi increased B-cell lymphoma-extra large (BCL-XL) expression and suppressed Bcl-2 associated X protein (BAX) expression, providing radioprotection to cells. Conclusions: Camellia nitidissima Chi has a strong antioxidant ability; it can improve the survival rate of mice after lethal dose irradiation and protect against radiation-induced hematopoietic and gastrointestinal damage. These findings can serve as a guide for using Chinese medicines for radioprotection.
研究领域:
药理学
·
放射医学
·
民族医药
·
生物学
✓ 已验证
DOI
Nuclear Science and Techniques
·
2018
·Vol. 29
·期 2
·17
·
IF 1.085
Liao Yi-Chuan,Xu Dui-Gong,Zhang Peng-Cheng
Boron carbide/natural rubber latex (B 4 C/NRL) flexible films were prepared via dip-molding with B 4 C content in the range of 5–55 wt% for thermal neutron (0.0253 eV) shielding. B 4 C was well dispersed in NRL according to microscopic observation. Both the inside and outside surfaces of the film were smooth. For B 4 C/NRL flexible films, the minimum elongation at break was greater than 600%, the minimum tensile strength was greater than 12 MPa, and the hardness was in the range of 35–55 HA, which were suitable for preparing flexible wearable products. The attenuation efficiencies of the B 4 C/NRL flexible films for thermal neutrons were also calculated. The B 4 C/NRL flexible films exhibit good attenuation effect for thermal neutrons.
研究领域:
材料科学
·
核工程
·
辐射防护
·
高分子科学
✓ 已验证
DOI
高影响因子
Radiation Detection Technology and Methods
·
2021
·Vol. 5
·期 4
·576-585
·
IF 0
Liu Qiongyao,Ma Zhongjian,Wu Qingbiao,Shi Haoyu,Zhang Gang,Zhang Huijie,Liu Pingcheng,Wang Qingbin
Purpose The high-energy photon source (HEPS) is the first fourth-generation light source under construction in China. It is designed to operate at an average current of 200 mA stored beam current with a top-up model at 6 GeV energy. Considering the linac radiation shielding design, a suitable beam loss scenario, optimized thickness for the bulk shielding and detailed structure design for dumps should be proposed. In this paper, the beam loss scenarios were determined and categorized as normal; the dose limits were presented; using these scenarios and the dose limits, the thickness of the linac tunnel was calculated and detailed designs of the main beam dumps were established. The material selection and size setting of the low-power electron beam dump were discussed. Method The Monte Carlo code is a good choice to simulate the radiation analysis. And the iSHIELD11 was used to verify the simulation calculations. Result and conclusion The designs of the linac bulk shield and dumps satisfied the requirements of radiation protection.
研究领域:
加速器物理
·
辐射防护
·
核工程
✓ 已验证
DOI
危险品化学品经营许可证（带存储）