Journal of Materials Chemistry C
·
2020
·Vol. 8
·期 40
·14100-14108
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IF 7.059
Zhihao Zhou,Xiaodong Yi,Puxian Xiong,Xingyi Xu,Zhijun Ma,Mingying Peng
Near-infrared (NIR) persistent luminescence (PersL) materials have recently evoked considerable interest in the field of biomedicine, but the choices of efficient emitters for NIR PersL phosphors are rather limited. Herein, we report a new class of Fe3+-activated NIR PersL phosphor based on the LiGaO2 host, which exhibits an intense NIR PersL at around 748 nm and possesses an ultra-long PersL time of much longer than 26 h. The optical properties of this phosphor as well as the trapping and de-trapping processes, the trap characteristics, and the underlying PersL mechanism are comprehensively studied by means of photoluminescence (PL), PersL, electron paramagnetic resonance (EPR), thermoluminescence (TL), and X-ray photoelectron spectroscopies (XPS). It was found that the NIR PersL in this material is closely related to the oxygen vacancies. Furthermore, the penetration experiments and cytotoxicity tests of the biological tissue show that this material has great potential for bioimaging applications. Our achievement in the case of nontoxic Fe3+-activated LiGaO2 phosphors lays the foundation for the future design of Cr3+-free PersL phosphors with efficient NIR PersL towards versatile bioapplications.
研究领域:
材料科学
·
生物医学
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DOI
高影响因子
ACS Applied Electronic Materials
·
2021
·
IF 3.314
Junqing Xiahou,Qi Zhu,Lin Zhu,Siyuan Li,Ji-Guang Li
Modern engineering fields put forward requirements for optical temperature sensors, which need natural-light excitation/storage and near-infrared (NIR) afterglow emission for some special conditions. Here, NIR persistent luminescent phosphors of ZnGa2–x(Mg/Ge)xO4:Cr3+ (x = 0–1.25) have been synthesized. The incorporation of Mg2+/Ge4+ ions in ZnGa2O4:Cr3+ resulted in more defect clusters of “MgGa′–GeGa•” and “ZnGa′–GeGa•” and interstitial oxygens (OInt). Increasing the calcination temperature and Mg2+/Ge4+ doping both contributed to the generation of OInt. Higher efficiency of visible light excitation was observed, mainly due to the defect clusters and OInt. The samples exhibited a bright NIR emission at 695 nm by exposure to UV or visible light, and the NIR signal can last longer than 1 h after the stoppage of excitation. Incorporation of Mg2+/Ge4+ and increasing the calcination temperature both resulted in a deeper trap depth. However, the density of trapped charge carriers takes the dominant role in the persistent luminescence. Therefore, the x = 0.25 sample, having the most trapped charge carriers, exhibits the best afterglow performance. The prepared phosphor exhibited a temperature-dependent persistent luminescence behavior, which can charge natural light and release NIR light repeatedly many times, indicating that they are the potential natural-light rechargeable materials for temperature sensing.
研究领域:
材料科学
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光学工程
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产品关联
DOI
高影响因子
RSC Advances
·
2018
·Vol. 8
·期 20
·10954-10963
·
IF 2.936
Ting Song,Meng Zhang,Yuxue Liu,Jian Yang,Zheng Gong,Hong Yan,Hancheng Zhu,Duanting Yan,Chunguang Liu,Changshan Xu
Spinel-phase Zn2Ga2.98Ge0.75–xSnxO8:Cr0.023+ (ZGGSO:Cr3+) nanoparticles with various Sn4+ concentrations were prepared by a hydrothermal method in combination with a post-annealing in vacuum at high temperature. For these nanoparticles, the observed near infrared (NIR) persistent luminescence peaked at ∼697 nm and originates from the 2E, 4T2 (4F) → 4A2 transitions of Cr3+ and the afterglow time exceeds 800 min. For both the interior and surface Cr3+ ions in the ZGGSO host, it can be found that the increased energy transfer from Cr3+ to the deep trap (anti-site defects, ) after the substitution of Ge4+ by Sn4+ plays a key role in enhancing the persistent luminescence of the ZGGSO:Cr3+ nanoparticles. Strikingly, this energy transfer process can be controlled through the variations in the crystal field strength and the trap depths. Our results suggest that not only Sn4+ substitution can improve in vivo bioimaging but also the existence of deep traps in ZGGSO:Cr3+ nanoparticles is helpful for retracing in vivo bioimaging at any time.
研究领域:
材料科学
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生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2025
·
IF 9.6
Yanping Xie,Yunfei Zhu,Ya Wen,Siqi Hu,Ju Jiao,Yue Wu,Lijun Jiang,Bruno Viana,Ka-Leung Wong,Jing Wang,Rui Zou
Epstein–Barr virus (EBV) is a well-recognized oncogenic virus that promotes several lymphoid and epithelial cancers. The Epstein–Barr nuclear antigen 1 (EBNA1), which is known to be expressed in all EBV-positive cancers, plays a vital role in viral genome replication and maintenance and is therefore emerged as an attractive target for clinical intervention. Several EBNA1 inhibitors have shown potency in the growth inhibition of EBV-positive cancers, yet low bioavailability and in vivo unmonitored nature hamper their further implementation. Here a novel EBNA1 nano-inhibitor based on EBNA1-specific peptide inhibitor (P4) functionalized ZnGa 2 O 4 :Cr 3+ ultra-small near-infrared persistent luminescent (NIR-PL) nanoparticles (ZGOC-P4) is developed. Owing to the specific binding to EBNA1, ZGOC-P4 nano-inhibitor can quickly achieve nuclear internalization in EBV-positive nasopharyngeal carcinoma (NPC) cells (C666-1) and selectively inhibit their growth. In sharp contrast, ZGOC-P4 nano-inhibitor shows no inhibition effect on EBV-negative NPC cells (HK-1). Moreover, the results indicate that the well-designed nano-inhibitor enables efficient tumor-targeting accumulation in NPC xenograft model under the monitoring of autofluorescence interference-free NIR-PL imaging in vivo and suppresses EBV-associated tumor growth with an inhibition rate of 61.6%. This work highlights the potency of ZGOC-P4 on NPC treatment and may provide new sight into future research on EBV-associated diseases.
研究领域:
生物医学工程
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肿瘤学
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病毒学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Hongbin Chen,Bin Zheng,Chao Liang,Li Zhao,Ying Zhang,Huizhuo Pan,Wanying Ji,Xiaoqun Gong,Hanjie Wang,Jin Chang
The photothermal therapy agents induced by 808 nm near infrared light laser have good potential for photothermal therapy (PTT) in vivo, with the advantages of harmless treatment, minimally invasion, high efficiency and deep tissue penetration. For the traditional photothermal therapy agents, however, it was impossible to track them in vivo because of the low signal-to-noise ratio, so we cannot conduct the extra near infrared light laser to radiate tumors sites accurately. Herein, we introduce a new complex: indocyanine green (ICG), near-infrared persistent luminescence (PL) phosphors ZnGa 2 O 4 :Cr 3 + (ZGC) and mesoporous silica nanoparticles (MSNs) (ICG@mZGC nanoparticles) were assembled for long-lasting optical imaging to guide PTT. The results revealed that the novel nanoparticle, ICG@mZGC, could lower signal-to-noise ratio, enable highly sensitive optical detection during optical imaging-guided PTT and perform a good effect of photothermal therapy in vivo, and thus providing possibilities for mZGC to improve the localization precision of tumor sites in photothermal therapy in the body.
研究领域:
生物医学工程
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纳米医学
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光学成像
✓ 已验证
DOI
高影响因子
Nanoscale
·
2017
·Vol. 9
·期 20
·6846-6853
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IF 7.367
Zhihao Zhou,Wei Zheng,Jintao Kong,Yan Liu,Ping Huang,Shanyong Zhou,Zhuo Chen,Jianlin Shi,Xueyuan Chen
Persistent luminescence nanoparticles (PLNPs) have shown great promise in the field of biomedicine, but are currently limited by the challenge in the synthesis of high-quality PLNPs with bright persistent luminescence and a long afterglow time. Herein, we report a facile strategy for the synthesis of monodisperse, rechargeable and LED-activated ZnGa2O4 : Cr3+ near-infrared (NIR) PLNPs based on a modified solvothermal liquid–solid-solution method. The as-synthesized PLNPs are not only flexible for bioconjugation, but could also circumvent the limitation of the weak persistent luminescence and short afterglow time that most PLNPs confronted owing to their rechargeable capability. It was unraveled that both thermal activation and quantum tunneling mechanisms contributed to the afterglow decay of the PLNPs, and the quantum tunneling was found to dictate the LED-activated afterglow intensity and lasting time. Furthermore, by utilizing the superior excitation-free persistent luminescence, we demonstrated for the first time the application of biotinylated ZnGa2O4 : Cr3+ PLNPs as background-free luminescent nano-bioprobes for sensitive and specific detection of avidin in a heterogeneous assay with a limit of detection down to ∼150 pM, thus revealing the great potential of these NIR PLNPs in ultrasensitive biodetection and bioimaging.
研究领域:
材料科学
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生物医学工程
·
分析化学
✓ 已验证
DOI
PubMed
高影响因子
ACS Nano
·
2024
·
IF 15.8
Xiaofang Luo,Junpeng Shi,Ruoping Wang,Longlong Cao,Yan Gao,Jinyuan Wang,Maochun Hong,Xia Sun,Yun Zhang
Atherosclerosis (AS) is a crucial contributor to various cardiovascular diseases (CVDs), which seriously threaten human life and health. Early and accurate recognition of AS plaques is essential for the prevention and treatment of CVD. Herein, we introduce an AS-targeting nanoprobe based on near-infrared (NIR) persistent luminescence nanoparticles (PLNPs), developing a highly sensitive NIR persistent luminescence (PersL) AS plaque imaging technique and successfully realizing early AS plaque detection. The nanoprobe exhibits good monodispersity and regular spherical morphology and also owns exceptional NIR PersL performance upon repetitive irradiation by biological window light. The surface-conjugated antibody (anti-osteopontin) endowed nanoprobe excellent targeting ability to foam cells within plaques. After intravenously injected nanoprobe into AS model mice, the highly sensitive PersL imaging technique can accurately detect AS plaques prior to ultrasonography (US) and magnetic resonance imaging (MRI). Specifically, the NIR PersL imaging reveals AS plaques at the earliest within 2 weeks, with higher signal-to-background ratio (SBR) up to 5.72. Based on this technique, the nanoprobe has great potential for applications in the prevention and treatment of CVD, the study of AS pathogenesis, and the screening of anti-AS drugs.
研究领域:
医学影像学
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心血管疾病研究
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生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Shengqiang Liu,Ning Mao,Zhen Song,Quanlin Liu
Near-infrared (NIR)-persistent luminescence (PersL) materials are of promising applications in labeling, tracing, bio-imaging, and so forth, featuring distinctive self-sustained NIR light emitting. The PersL radiation spectrum, PersL duration, and charging efficiency are recognized as the key enablers for high-performance NIR PersL materials. Here, we have designed and developed a series of broad-band NIR superlong PersL phosphors (Sr,Ba) (Ga,In)12O19:Cr3+ with efficient UV-red light charging capacity. Typical SrGa10.49In1.5O19:0.01Cr3+ presents intensive NIR PersL from 650 to 1000 nm peaking at ∼770 nm, with a PersL duration of 360 h. This material can be efficiently and repeatedly charged by solar radiation in various outdoor environments. Our work further identifies that this NIR PersL material is advantageous for labeling and tracing as a secret NIR additive and in situ bio-imaging as an optical probe under high tissue penetration red light excitation.
研究领域:
材料科学
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生物医学工程
·
光学
✓ 已验证
DOI
高影响因子
JOURNAL OF LUMINESCENCE
·
2018
·
IF 2.732
Xia Sun,Junpeng Shi,Shenghui Zheng,Jinlei Li,Shougang Wang,Hongwu Zhang
Inflammation is implicated in many human diseases, thus the diagnosis of inflammation is very important for the early treatment of diseases associated with inflammation. However, the high-sensitivity diagnosis of inflammation remains difficult. Near-infrared (NIR) persistent luminescence nanoparticles (PLNPs) were considered one of the most promising candidates for high-sensitivity bioimaging due to being free of autofluorescence. In this study, we synthesized PLNPs Zn 1.1 Ga 1.8 Ge 0.1 O 4 :Cr 3+ (ZGG) which demonstrated low cytotoxicity, excellent NIR persistent luminescence. We conducted the visualization of inflammation using these nanoparticles. The results indicated that the surface states of the ZGG influenced the progression of macrophage phagocytosis in vitro . ZGG-NH 2 demonstrated higher levels of internalization compared with ZGG-OH and ZGG-PEG. However, in contrast to the in vitro results, ZGG-PEG exhibited a greater ability to facilitate the visualization of inflammation in vivo . The long chains of PEG on the ZGG-PEG surfaces resulted in a lower reticuloendothelial system capture rate compared with both ZGG-OH and ZGG-NH 2 . A higher concentration of the ZGG-PEG would cycle through the inflammation site, thereby inducing a high level of ZGG-PEG retention and thus yielding the strongest luminescent signal. Taken together, the results of this study demonstrate a simple and novel method for high-sensitivity visualization of inflammation in vivo .
研究领域:
生物医学工程
·
分子影像学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Bo-Mei Liu,Rui Zou,Sun-Qi Lou,Yi-Fan Gao,Li Ma,Ka-Leung Wong,Jing Wang
X-ray-stimulated near-infrared persistent luminescence nanoparticles (NIR-PLNPs) offer attractive capabilities for autofluorescence free deep-seated imaging and depth-independent treatment, but still suffer from adverse effects caused by high-dose X-ray irradiation (>5 Gy). From the viewpoint of two centers of NIR-PLNPs, i.e., X-ray photon absorption center and defects center, we here propose a top-down composition design strategy for the development of low dose X-ray-stimulated NIR-PLNPs with improved X-ray photon absorption efficiency and optimized persistent luminescence (PersL) performance. Successfully, hypersensitive X-ray-stimulated NIR-PLNPs LaGaO 3 :Sb 3+ ,Cr 3+ with a super-long PersL emission (>500 h) at ∼750 nm are prepared. The nature of high Z atomic constituents of the host LaGaO 3 endows these NIR-PLNPs with strong X-ray absorption capacity. Simply by codoping with size-mismatched ions Sb 3+ , the concentration of oxygen vacancies in the host is rationally optimized, leading to the enhanced NIR PersL performance of Cr 3+ ions. In vivo bioimaging demonstrates that the designed X-ray-stimulated NIR-PLNPs LaGaO 3 :Sb 3+ ,Cr 3+ can be readily reactivated under X-ray irradiation with even a lower dose to 0.37 Gy, showing the advantages of these nanoparticles on deep-seated imaging and treatment. More importantly, we anticipate that our proposed top-down composition design strategy can be applied to develop much low dose X-ray-stimulated NIR-PLNPs in the future.
研究领域:
材料科学
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医学影像学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
·
2019
·Vol. 103
·期 2
·267-273
·
IF 1.65
Wang Chengcheng,Zheng Shenghui,Zou Xiaoyan,Sun Xia,Zhang Hongwu
The development of nanotechnology has drawn increased attention to the risks of nanoparticles (NPs). In this work, the near-infrared persistent luminescence imaging technique was used to track the biodistribution of NPs in vivo in zebrafish. Zebrafish were used as a vertebrate animal model to show NPs distribution and the effects of exposure. ZnGa 2 O 4 :Cr (ZGOC) was chosen as the probe in this work. In continuous exposure experiments, the results showed more particles accumulated in the intestines than in the gills in both groups. In both the gills and abdomen, the NPs contents were greater in the ZGOC–NH 2 -treated groups than in the ZGOC groups, and the NPs caused damage to the gills and intestines. Removal exposure experiments indicated that ZGOC and ZGOC–NH 2 could be excreted from the body. The metabolism, excretion of NPs, the quantification and monitoring of NPs behavior in biological systems should be examined in further studies.
研究领域:
环境科学
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毒理学
·
纳米生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Yan Gao,Junpeng Shi,Xia Sun,Chen Wu,Longlong Cao,Xiaofang Luo,Jinyuan Wang,Xiao Zhang,Yun Zhang
Fluorescent immunochromatographic test strips are critical for highly sensitive, rapid detection. However, their sensitivity for detecting trace biomarkers is often affected by autofluorescence and photon absorption of the samples (nitrocellulose membrane substrates and blood chromophores). Here, we report for the first time an immunochromatographic test strip based on near-infrared (NIR) persistent luminescence nanoparticles (PLNPs) for the highly sensitive detection of the biomarker N-terminal pro-brain natriuretic peptide (NT-proBNP). NIR PLNPs exhibit long NIR persistent luminescence (PersL) properties after excitation, allowing separation of excitation and detection, thereby eliminating sample autofluorescence interference. In addition, the PersL in the NIR region greatly reduces the absorption of photons by the sample, further improving the detection sensitivity. After optimization, the test strips can detect NT-proBNP at levels as low as 15.28 pg/mL, which covers the required clinical detection range. The assay demonstrated a recovery rate of 94–101% in human serum samples, and the inter and intrabatch coefficients of variation were less than 15%. The concentrations of NT-proBNP measured in clinical samples correlated well with those of the Roche electrochemiluminescence immunoassay, which is widely used in clinical practice. This NIR PersL immunochromatographic test strip has potential applications in the highly sensitive and immediate detection of trace biomarkers.
研究领域:
生物医学工程
·
临床检验
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）