CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Ping Ye,Heng Ding,Bo Yang,Weimiao Wang,Xiaodong Li,Zhiqiang Qiao,Rui Li,Guangcheng Yang,Guoqing Lv
The ignition strategy of energetic materials using low-energy near-infrared (NIR) laser has garnered significant attention due to its enhanced safety and reliability. This study explores the use of a relatively photosensitive but mechanical insensitive energetic material, DATNBI, to facilitate the self-assembly of nano-CL-20 crystals into polycrystalline particles though solvothermal induction, yielding a rough structure conducive to NIR laser ignition. The findings demonstrate that by adjusting the content of DATNBI, it is possible to achieve micro-nano controllable spherical CL-20/DATNBI (C/D) particles, with CL-20 as the primary component and DATNBI as the auxiliary component. The incorporation of DATNBI and the rough surface structure enhance the light absorption of C/D particles in the NIR band. Additionally, the unique synergistic effect between CL-20 and DATNBI during thermal decomposition further promotes NIR laser ignition. As expected, the C/D particles achieved self-sustained combustion and exhibited excellent combustion performance under a 1064 nm laser, which is challenging to be achieved with raw CL-20 or raw DATNBI. Furthermore, the relatively insensitive DATNBI and spherical structure reduced the impact sensitivity of the C/D particles. This multifunctional material strategy, integrating energy, safety, environment-friendliness, and laser ignition performance, offers a novel approach for laser ignition of energetic materials.
研究领域:
化学
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材料科学
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能源与燃料
✓ 已验证
产品关联
DOI
高影响因子
Heliyon
·
2024
·
IF 3.4
Yan Zhang,Hua Wei,Pingguang Zhu,Xiaojuan Hao,Jing Chen,Haina Zhang
The adhesion of bacteria to the surface leads to formation of biofilms causing numerous infection problems in implanting medical devices or interventional therapy. Traditional treatment for such problems is generally to administrate patients with antibiotics or antifungal agent. Alternatively, devices are taken out of the body to mechanically destroy the biofilm and re-used by surgery. In this study, a straightforward method was developed to remove biofilms using a MXene-based photothermal hydrogel. The hydrogel consists of dynamic crosslinking network formed by Schiff-base reaction between aldehyde-containing xyloglucan (OXG) and amine-containing MXene (NH 2 -MXene), which showed efficient killing of both gram-positive Staphylococcus aureus ( S. aureus ) and gram-negative Escherichia coli ( E. coli ) bacteria upon near-infrared (NIR) laser irradiation. The NH 2 -MXene/OXG nanocomposite hydrogel showed a high photothermal antibacterial efficiency and stable photothermal conversion, demonstrated by efficient removal of biofilms ex vivo .
研究领域:
生物医学工程
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材料科学
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微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
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2024
·
IF 6.5
Guolin Zheng,Yifan Cui,Zhe Jiang,Wenda Wang,Man Zhou,Yuanyuan Yu,Ping Wang,Qiang Wang
To our knowledge, surface hydrophobicity is normally fabricated by hydrophobic or fluorinated materials; however, it can be predicted. So, it is exciting and high value that using a single hydrophilic material directly obtains a hydrophobic surface , which may be a promising and significant aspect and a great challenge in surface and interface science . Herein, the copper sulfide (CuS) nanoflowers were in-situ deposited on the cotton fabric after cotton fabric was incubated with copper(II) chloride dihydrate and thioacetamide stirring for 3 h at 80 °C, labelled as Cot@PTA@CuS. Then, Cot@PTA@CuS was treated by near infrared (NIR) laser irradiation at 808 nm, recorded as Cot@PTA@CuS-NIR. Interestingly, Cot@PTA@CuS-NIR exhibits good hydrophobicity with WCAs of 136.5 ± 3.5° and hydrophobic stability within 30 min. Notably, the hydrophobicity of Cot@PTA@CuS-NIR is created without using the lower surface free energy materials, possessing significant progressiveness compared with conventional surface hydrophobicity fabricated by hydrophobic or fluorinated materials. The X-ray diffraction (XRD) and X-ray photoelectron spectra (XPS) demonstrate the formation of cuprous oxide (Cu 2 O) after NIR laser irradiation. Subsequently, the polydimethylsiloxane (PDMS) was selected to encapsulate CuS nanoflowers with improving the stability of CuS nanoflowers and obtaining superhydrophobicity, recorded as Cot@PTA@CuS-NIR@PDMS, achieving the results of killing two birds with one stone. Cot@PTA@CuS-NIR@PDMS also has an excellent photothermal effect and UV resistance. Finally, Cot@PTA@CuS-NIR@PDMS was used for efficient oil/water separation. Overall, this work renders a novel, feasible, and facile idea for gaining surface hydrophobicity by hydrophilic CuS nanoflowers with NIR laser irradiation, inspiring more scholars to create surface hydrophobicity by hydrophilic materials.
研究领域:
材料科学
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界面科学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry C
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2024
·
IF 5.7
Ximei An,Ling Gao,Jingrui Guo,Fan Meng,Huiwang Lian,Shaoan Zhang,Janak L. Pathak,Yang Li,Shizhen Zhang
In vivo wound healing stands as a transformative paradigm in the field of tissue repair and regeneration, yet still suffers from a pivotal limitation of inferior penetration depth along with the thermal tissue damage side-effect of photopolymerization hydrogels under conditions of suboptimal light and power. Herein, we propose an upconversion-photopolymerization-driven strategy and synthesize injectable NaYF4:Yb3+,Tm3+@NaYF4:Nd3+,Yb3+ + GelMa (UC-YT@NY + GelMa) hydrogel hybrids to respond to in vivo wound healing. The use of a near-infrared laser with a wavelength of 808 nm, a power density of 1.27 W cm−2 and an irradiation time of 8 minutes resulted in a hydrogel photopolymerization efficiency of up to 96.3%. A comparison with the use of a 980 nm laser under the same conditions shows that our process not only has excellent photopolymerization performance, but also significantly reduces the photothermal effect. Our biocompatible hydrogel hybrids facilitate deep-penetration wound healing at a depth of 3 mm in a mouse model and achieve complete healing in 7 days. This novel interventional therapy provides precise spatiotemporal control over therapeutic agent release, offering high-quality deep-tissue wound healing.
研究领域:
生物医学工程
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材料科学
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组织工程
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Renpeng Yang,Xiaogang Yu,Chengxiong Wei,Chengwei Wu,Wei Zhang
The poor photothermal performance of Fe 3 O 4 magnetic particles under 808 nm near-infrared laser inevitably limits their application in the field of photothermal therapy for tumor. Herein, Fe 3 O 4 clusters with a mean size of 239.1 nm were synthesized by solvothermal method and thermal treatment at 400℃. Compared with the reported Fe 3 O 4 materials, the developed clusters exhibit high extinction coefficient of 7.88 L/(g∙cm) and the highest photothermal conversion efficiency of 51.1 %, for which thermal treatment plays a key role. Due to the introduction of thermal treatment, the increased grain size and decreased grain distance can enhance the Fe 3+ magnetic coupling and thus improve the extinction ability, while the defects caused by high temperature can trigger more electron traps to promote electron non-radiative relaxation and translate into more thermal energy. The measurements of coercivity (10.6 Oe to 67.3 Oe), blocking temperature (382.3 K to over 400 K) and Urbach energy (0.461 eV to 0.692 eV) before and after thermal treatment support this explanation. The in vitro and in vivo photothermal experiments show that the Fe 3 O 4 clusters can kill tumor cells and inhibit tumor growth through the conversion of laser energy into thermal energy.
研究领域:
材料科学
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医学
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肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
Frontiers in Materials
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2021
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IF 3.515
Zhao Qian,Yu Zhenglei,Liang Yunhong,Ren Lei,Ren Luquan
Near infrared laser- (NIR-) driven intelligent hydrogel actuator systems including printable N-isopropylacrylamide- (NIPAm-) nanosized synthetic hectorite clay-nanofibrillated cellulose (NFC) hydrogels and NIPAm-4-hydroxybutyl acrylate- (4HBA-) NFC hydrogels with a high response rate were prepared via three-dimensional (3D) printing and hydrothermal synthesis, respectively. The addition of NFC was beneficial to the improvement in rheology. The 3D printed intelligent hydrogel actuators with a structure pattern of Model I and Model II exhibited the saddle and inverted saddle deformations, respectively, to prove the validity of 3D printing. In order to improve the response rate and enrich movement patterns, the hydrothermal synthesized intelligent hydrogel actuators were prepared on the base of the 3D printed intelligent hydrogel compositions. The addition of NFC maintained the controllable NIR response. Based on a wedge-shaped design, the hydrothermal synthesized intelligent hydrogel pushed the resin ball with weight of 130 mg forward 8 mm in 39 s. By changing the torque values of a hydrogel in a different direction, the actuator realized controllable continuous rollover movement. Attributed to the longilineal shape, the intelligent hydrogel actuator reached an effective displacement of 20 mm in 10 s via a forward movement. The characteristics and structure design of a hydrogel material significantly realized multiple controllable functional four-dimensional (4D) printed deformations and movements. The combination of advantages of the 3D printed and hydrothermal synthesized intelligent hydrogels provided a new direction of development and abundant material candidates for the practical applications of 4D printing in soft robot, information sensing, and health engineering.
研究领域:
材料科学
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生物工程
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软体机器人
✓ 已验证
产品关联
DOI
高影响因子
Research
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2022
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IF 11.036
Xin Wang,Zhongju Ye,Shen Lin,Lin Wei,Lehui Xiao
Self-propelled nanomotors have shown enormous potential in biomedical applications. Herein, we report on a nanozyme-powered cup-shaped nanomotor for active cellular targeting and synergistic photodynamic/thermal therapy under near-infrared (NIR) laser irradiation. The nanomotor is constructed by the asymmetric decoration of platinum nanoparticles (PtNPs) at the bottom of gold nanocups (GNCs). PtNPs with robust peroxidase- (POD-) like activity are employed not only as propelling elements for nanomotors but also as continuous O2 generators to promote photodynamic therapy via catalyzing endogenous H2O2 decomposition. Owing to the Janus structure, asymmetric propulsion force is generated to trigger the short-ranged directional diffusion, facilitating broader diffusion areas and more efficient cellular searching and uptake. This cascade strategy combines key capabilities, i.e., endogenous substrate-based self-propulsion, active cellular targeting, and enhanced dual-modal therapy, in one multifunctional nanomotor, which is crucial in advancing self-propelled nanomotors towards eventual therapeutic agents.
研究领域:
生物医学工程
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纳米医学
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肿瘤治疗
✓ 已验证
DOI
高影响因子
Journal of Nanomaterials
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2019
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IF 2.233
Bing Liu,Jian Zhou,Bin Zhang,Jing Qu
Photothermal therapy is a promising approach for cancer treatment. In our study, we investigate the photothermal effect of different concentrations of the Ag@Fe3O4 nanoparticles on apoptosis and proliferation in the human epithelial ovarian cancer cells SKOV3. Ovarian cancer cells SKOV3 were treated with the Ag@Fe3O4 nanoparticles under an 808 nm near-infrared (NIR) laser irradiation at different concentrations. The cell proliferation was measured by the cell counting kit-8 (CCK-8) assay. The results show that the Ag@Fe3O4 nanoparticles with NIR laser irradiation could markedly inhibit the proliferation of the ovarian cancer cells SKOV3 independent of a concentration-time manner. Meanwhile, the cell morphology was also seriously damaged under the treatment of high-concentration nanoparticles. However, Ag@Fe3O4 nanoparticles have almost no obvious effect on the growth of SKOV3 cells without NIR laser illumination treatment. Therefore, it is reasonable to believe that the Ag@Fe3O4 nanoparticles have promising applications in photothermal treatment of cancer cells.
研究领域:
生物医学
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肿瘤学
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纳米医学
✓ 已验证
DOI
高影响因子
Advanced Science
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2021
·Vol. 8
·期 16
·2100228
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IF 16.806
Jun Wang,Tingting Li,Jen-Shyang Ni,Heng Guo,Tianyi Kang,Zeshun Li,Menglei Zha,Songbo Lu,Chen Zhang,Weizhi Qi,Lei Xi,Kai Li
Precise and efficient delivery of nanomedicine to the target site has remained as a major roadblock in advanced cancer treatment. Here, a novel photoacoustic force (PAF)-guided nanotherapeutic system is reported based on a near-infrared (NIR)-absorbing semiconducting polymer (SP), showing significantly improved tumor accumulation and deep tissue penetration for enhanced phototherapeutic efficacy. The accumulation of nanoparticles in 4T1 tumor-bearing mice induced by the PAF strategy displays a fivefold enhancement in comparison with that of the traditional passive targeting pathway, in a significantly shortened time (45 min vs 24 h) with an enhanced penetration depth in tumors. Additionally, a tumor-bearing mouse model is rationally designed to unveil the mechanism, indicating that the nanoparticles enter solid tumors through enhanced transportation across blood vessel barriers via both inter-endothelial gaps and active trans-endothelial pathways. This process is specifically driven by PAF generated from the nanoparticles under NIR laser irradiation. The study thus demonstrates a new nanotherapeutic strategy with low dose, enhanced delivery efficiency in tumor, and boosted therapeutic efficacy, opening new doors for designing novel nanocarriers.
研究领域:
生物医学工程
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癌症治疗
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纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
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2024
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IF 2.7
Lin Mei,Zhimin Liu,Yanmei Shi,Xiangyun Zhang
Near-infrared laser-activated gold nanorods (AuNRs) with excellent photothermal property and tunable surface functionalization are considered as an ideal platform for biomedical applications. However, bare AuNRs have cytotoxicity against normal cells and are prone to agglomeration during laser irradiation. Herein, multivalent polymer-functionalized AuNRs (AuNRs@pDMAEMA-C 4 ) was constructed as a highly stable and biocompatible photothermal agent for enhanced antibacterial therapy. The functionalized polymer was synthetized via the reversible addition-fragmentation chain transfer polymerization and subsequently quaternized. Moreover, positively charged AuNRs@pDMAEMA-C 4 can easily capture the bacterial surface via electrostatic interactions. The integration of photothermal therapy of AuNRs and chemotherapy of functionalized polymer can achieve enhanced antibacterial effects. Under 808 nm laser irradiation, AuNRs@pDMAEMA-C 4 possessed excellent photothermal conversion capability and can kill gram-positive and gram-negative bacteria. Study of the antibacterial mechanism indicated that the antibacterial action of the prepared photothermal antibacterial agent can cause serious damage of the bacterial outer membranes, result in cytoplasm leakage and bacterial death. The nanocomposites combining with near-infrared laser irradiation can facilitate rapid healing of bacteria-infected wound by rat model of wound infection and histological analysis of the wound tissues. These results suggest that the surface functionalization can be used as potential strategy to fabricate light-activated therapeutic agent for biomedical applications.
研究领域:
生物医学工程
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材料科学
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微生物学
✓ 已验证
产品关联
DOI
高影响因子
Journal of the Mechanical Behavior of Biomedical Materials
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2017
·
IF 3.11
Qian Zhao,Yunhong Liang,Lei Ren,Feng Qiu,Zhihui Zhang,Luquan Ren
A hydrogel material system which was fit for molding and 3D printing was developed to fabricate bilayer hydrogel actuators with controllable temperature and near infrared laser responses. Polymerization on interface boundary of layered structure enhanced the bonding strength of hydrogel actuators. By utilizing anisotropic of microstructure along with thickness direction, bilayer hydrogel actuators fabricated via molding realized intelligent bending/shrinking responses, which guided the preparation of hydrogel ink for 3D printing. In-situ free radical polymerization under vacuum realized the solidification of printed hydrogel actuators with graphene oxide . Based on anisotropic swelling/deswelling behaviors of precise structure fabricated via 3D printing, the printed bilayer hydrogel actuators achieved temperature and near infrared laser responsive deformation. Changes of programmable printing path effectively resulted in corresponding deformation patterns. Combination of advantages of molding and 3D printing can promote the design and fabrication of hydrogel actuators with high mechanical strength, response speed and deformation ability.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Jianping Sheng,Ling Zhang,Liu Deng,Yajing Han,Liqiang Wang,Haichuan He,You-Nian Liu
Tungsten oxide is a promising nanodrug in phototherapy via transforming light energy to reactive oxygen species and heat. Nevertheless, the phototherapeutic activity of the tungsten oxide nanomaterials is generally activated under 980 nm laser, which is close to the absorption of normal tissue, resulting in unfavorable heating effect on normal tissues. Therefore, the tungsten oxide nanomaterials which can be excited under 808 nm are highly required to avoid overheating and obtain deep tissue penetration of near-infrared (NIR) laser. Here, we successfully synthesized a novel dopamine enveloped tungsten oxide nanodots (WO 3−x /Dpa-Mel NPs) via facile one-step solvothermal route, using dopamine as the template and reductant in triethylene glycol solvent. Under the 808 nm laser irradiation, the as-obtained WO 3−x /Dpa-Mel NPs exhibit excellent photodynamic activity and stability. Meanwhile, the WO 3−x /Dpa-Mel NPs also possess high photothermal conversion property. Thus, the photothermal therapy (PTT) and photodynamic therapy (PDT) can be triggered simultaneously under single 808 nm laser irradiation. Additionally, the inherited good biocompatibility and dispersity in aqueous solution from dopamine hydrochloride (Dpa-Mel) also make the WO 3−x /Dpa-Mel NPs more suitable for in vivo application. The as-obtained WO 3−x /Dpa-Mel NPs exhibit an excellent synergistic phototherapy effect on solid tumor ablation in vivo without damaging healthy tissues under single 808 nm NIR light irradiation, indicating WO 3−x /Dpa-Mel NPs can serve as a multifunctional therapeutic nanoplatform to realize the synergistic cancer therapy.
研究领域:
生物医学工程
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纳米医学
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）