Journal of Materials Chemistry A
·
2020
·Vol. 8
·期 36
·19022-19027
·
IF 11.301
Hui Ma,Haoge Cheng,Xinlei Ma,Sen Wang,Zhuqing Zhou,Yuqiao Chai,Ruoqi Chen,Xinyue Zhang,Yonglin He,Yapei Wang,Yan Li,Xusheng Wang,Rui Li,Ning Ma,Mianqi Xue
Charge/light-related advancements have greatly pushed the development of modern technology, and the relationship between charge and light is worth exploring. While research into the applications of light and charge flow (photoelectric current) is in full swing, studies on the reaction between light and electrostatic charge have made little progress on rare ways to realize photo-stimulated discharge. Herein, we link electrostatic charge and light using a bridge of intense heat, which is produced from the efficient photothermal conversion of Ti3C2Tx MXene. The in situ photothermal conversion and selective thermally stimulated discharge are successfully combined, then novel light-induced electrostatic lithography can be realized on both polymethyl methacrylate glasses and nanofilms. In this process the surface temperature of Ti3C2Tx film can be as high as 300 °C using 808 nm near-infrared irradiation at a power density of 1.7 W cm−2. The combination of light and electrostatic charge is also successfully applied to electrostatic printing and chemical reactions.
研究领域:
材料科学
·
光子学
·
纳米技术
✓ 已验证
DOI
高影响因子
ADVANCED ENGINEERING MATERIALS
·
2024
·Vol. 26
·期 12
·2400189
·
IF 3.4
Bo Wang,Sen Chen,Weichen Feng,Xiaohui Shan,Xiyu Zhu,Ruizhi Yuan,Yingjie Cao,Linlin Fan,Bo Yuan,Hongzhang Wang,Gang Zhou,Jing Liu
The misuse of antibiotics has led to antibiotic-resistant “superbugs,” prompting the exploration of alternative antibacterial strategies. This study focuses on the promising avenue of photothermal therapy (PTT). Despite numerous advantages, the clinical applicability of PTT as a sole sterilization strategy is hindered by the necessity for higher temperatures, potentially causing harm to healthy tissues. To overcome this challenge, this study introduces antimicrobial peptides (AMPs) to modify the surface of gallium-based liquid metal (LM) nano-antimicrobial agents, thereby enhancing their photothermal antibacterial effects within a lower temperature range. First, a novel LM composite nanomaterial, LM@AMP nanoparticles, is synthesized through a sonication process involving 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)], AMP, and LM in an aqueous solution. Herein, AMPs not only contribute to the structural stability of LM nanoparticles but also enhance their selective interaction with bacterial cell membranes. Then, a thorough characterization of LM@AMP nanoparticles is performed, encompassing analyses through electron microscopy, determination of particle size, and assessment of zeta potential. Moreover, the exceptional photothermal properties exhibited by these nanoparticles are validated. Finally, this investigation demonstrates that LM@AMP nanoparticles selectively target bacterial cell membranes, showcasing efficient bactericidal effects (near 100%) at relatively low temperatures under near-infrared irradiation.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
·
微生物学
✓ 已验证
产品关联
DOI
高影响因子
BIOMATERIALS
·
2019
·
IF 10.273
Tong Chen,Dong Cen,Zhaohui Ren,Yifan Wang,Xiujun Cai,Jie Huang,Lucy Di Silvio,Xiang Li,Gaorong Han
An unpredicted side effect of photothermal therapy (PTT) is agitated by hyperthermia which results in damage to healthy tissue. Developing PTT platforms, enabling effective tumor ablation under mild irradiation conditions, is of wide interest, but challenging. Here, we investigated bismuth crystals embedded silica ( [email protected] 2 ) nanoparticles , loaded with an autophagy inhibitor (chloroquine, CQ). It was found that SiO 2 effectively prevented the oxidization of Bi nanocrystals in the physiological environment and could serve as a scatter layer to improve NIR absorption, enabling a high photothermal conversion efficiency (~43%) and excellent photostability. Furthermore, the findings indicated that CQ molecules, delivered intracellularly by the particles, significantly weakened the degradation of autolysosomes by lysosome within the tumor cells, thus inducing suppression effect to autophagy and resistance to photothermia. Both in vitro and in vivo anti-tumor effects were consequently promoted owing to the combined effects enabled by [email protected] 2 -CQ nanoparticles under mild NIR irradiation conditions. This study demonstrates a potential new PTT platform with superior therapeutic efficacy.
研究领域:
癌症治疗
·
材料科学
·
纳米医学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Colloid and Interface Science Communications
·
2023
·
IF 4.5
Chengyang Ban,Hanzhu Shi,Qiong Ding,Bin Wu,Ru Xia,Jiasheng Qian,Ming Cao
In this study, Fe/ABTS/PVP nanocomplexes (named FAPs) as photothermal-reinforced catalytic antibacterial agents were prepared using the coordination-induced assembly of Fe (III), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and polyvinylpyrrolidone (PVP). The redox pairs of Fe(II)/Fe(III) in FAPs can catalyze the H 2 O 2 to hydroxyl radicals (•OH) through Fenton reactions, thereby killing effect on bacteria. The photothermal effect of ABTS •+ in FAPs stimulated by near infrared (NIR) irradiation can further improve the catalytic effect, thereby generating more •OH and achieving better antibacterial activity. What's more, the reduction reaction between glutathione (GSH) and ABTS •+ results in the depletion of the GSH level, the redox pair of Fe(II)/Fe(III) is also beneficial in the consumption of GSH. This dual depletion of GSH further expands the intracellular oxidative stress. Thus, the integrated function of photothermal effect, catalytic property, and dual depletion of GSH by FAPs provides a new strategy for fighting against bacterial infections.
研究领域:
纳米技术
·
材料科学
·
生物医学工程
·
抗菌研究
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2022
·
IF 9.965
Yujie Gao,Yuanhao Dong,Shuting Yang,Anchun Mo,Xin Zeng,Qianming Chen,Qiang Peng
Developing antibiotics-independent antibacterial materials is of great importance for combating drug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). MXene (transition metal carbides and nitrides), a class of novel 2D nanomaterials , has shown great potentials in biomedical areas. However, the effect of MXene size on its properties and bioactivity is still unknown. Herein, we report for the first time that the antibacterial photothermal therapy efficacy of Ti 3 C 2 T x MXene nanosheets is size-dependent. Three MXene suspensions with small size of 196 nm (MX-s), medium size of 347 nm (MX-m) and large size of 497 nm (MX-l) were prepared via ultrasonication. Upon NIR irradiation for 5 min, the temperature of MXene suspensions (10 μg/mL) increased to 64, 60 and 56 °C for MX-s, MX-m and MX-l, respectively. Accordingly, the viability loss of MRSA induced by MX-s, MX-m and MX-l under NIR was 93%, 69% and 56%, respectively. The in vivo study in the MRSA-infected mouse model showed that the photothermal therapy efficacy of MX-s was comparable to that of the positive control vancomycin . This is the first report on the size-dependent photothermal effect and photothermal antibacterial activity of MXene, which may guide the development of MXene-based therapeutics in the future. In addition, the drug-free antibacterial therapy has great implications for the treatment of antibiotics-resistant bacteria infections.
研究领域:
生物医学工程
·
纳米技术
·
抗菌治疗
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2023
·Vol. 14
·期 1
·1-12
·
IF 16.6
Sun FuYao,Liu LongFei,Liu Tong,Wang XueBin,Qi Qi,Hang ZuSheng,Chen Kai,Xu JianHua,Fu JiaJun
Catastrophically mechanical failure of soft self-healing materials is unavoidable due to their inherently poor resistance to crack propagation. Here, with a model system, i.e., soft self-healing polyurea, we present a biomimetic strategy of surpassing trade-off between soft self-healing and high fracture toughness, enabling the conversion of soft and weak into soft yet tough self-healing material. Such an achievement is inspired by vascular smooth muscles, where core-shell structured Galinstan micro-droplets are introduced through molecularly interfacial metal-coordinated assembly, resulting in an increased crack-resistant strain and fracture toughness of 12.2 and 34.9 times without sacrificing softness. The obtained fracture toughness is up to 111.16 ± 8.76 kJ/m 2 , even higher than that of Al and Zn alloys. Moreover, the resultant composite delivers fast self-healing kinetics (1 min) upon local near-infrared irradiation, and possesses ultra-high dielectric constants (~14.57), thus being able to be fabricated into sensitive and self-healing capacitive strain-sensors tolerant towards cracks potentially evolved in service.
研究领域:
材料科学
·
仿生学
·
机械工程
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传感技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Nanomedicine
·
2022
·
IF 7.033
Xin Zhang,Yang Zhang,Ning Wang,Yetong Shen,Qing Chen,Lu Han,Bo Hu
NCs (1:1:4, 6 μL) to synergistically reduce the viability of HCT116 cells to 15.63± 2.90%.Conclusion: By using NIR-irradiation, the “transitive” nanoheaters can remotely control the activity of both bacteria (germinated from spore) and cancer cells. This discovery provides basis and a feasible plan for controllable safer treatment of bacteria therapy, especially anaerobes with spores in hypoxic areas of the malignant solid tumors.
研究领域:
癌症研究
·
生物医学工程
·
纳米技术
·
治疗递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Xinyuan Zhang,Yongkang Lai,Liang Zhang,Zheng Chen,Jiulong Zhao,Shige Wang,Zhaoshen Li
Helicobacter pylori ( H. pylori ) is one of the major causes of gastrointestinal diseases, including gastric cancer. However, the acidic environment of the stomach and H. pylori resistance severely impair the antimicrobial efficacy of oral drugs. Here, a biocompatible chitosan-modified molybdenum selenide (MoSe 2 @CS) was designed for the simultaneous photothermal treatment of H. pylori infection and gastric cancer. MoSe 2 @CS showed a photothermal conversion efficiency was as high as 45.7 %. In the H. pylori -infected mice model, MoSe 2 @CS displayed a high bacteriostasis ratio of 99.9 % upon near-infrared irradiation. The antimicrobial functionality was also proved by transcriptomic sequencing study, which showed that MoSe 2 @CS combined with NIR laser irradiation modulated the gene expression of a variety of H. pylori bioprocesses, including cell proliferation and inflammation-related pathways. Further gut flora analysis results indicated that MoSe 2 @CS mediated PTT of H. pylori did not affect the homeostasis of gut flora, which highlights its advantages over traditional antibiotic therapy. In addition, MoSe 2 @CS exhibited a good photothermal ablation effect and significantly inhibited gastric tumor growth in vitro and in vivo . The comprehensive application of MoSe 2 @CS in the PTT of H. pylori infection and gastric cancer provides a new avenue for the clinical treatment of H. pylori infection and related diseases.
研究领域:
生物医学工程
·
微生物学
·
癌症研究
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2014
·Vol. 6
·期 15
·8743-8753
·
IF 6.739
Hao Wan,Yi Zhang,Zheyi Liu,Guiju Xu,Guang Huang,Yongsheng Ji,Zhichao Xiong,Quanqing Zhang,Jing Dong,Weibing Zhang,Hanfa Zou
Remote-controlled nanocarriers for drug delivery are of great promise to provide timely, sensitive and spatiotemporally selective treatments for cancer therapy. Due to convenient and precise manipulation, deep penetration through tissues and excellent biocompatibility, near-infrared (NIR) irradiation is a preferred external stimulus for triggering the release of loaded drugs. In this work, for spatiotemporally controlled chemo-photothermal synergistic cancer therapy, a NIR responsive nanocarrier was fabricated using reduced graphene oxide nanosheets (rNGO) decorated with mesoporous silica shell and the subsequent functionalization of the thermoresponsive polymer brushes (pNIPAM-co-pAAm) at the outlet of the silica pore channels. rNGO, which combined with the mesoporous silica shell provide a high loading capacity for anticancer drugs (doxorubicin, DOX), was assigned to sense NIR irradiation for the manipulation of pNIPAM-co-pAAm valve to control the diffusion of loaded DOX. Under NIR irradiation, rNGO would generate heat, which could not only elevate the surrounding temperature over the low critical solution temperature (LCST) of pNIPAM-co-pAAm to open the thermoresponsive polymer valve and promote the diffusion of DOX, but also kill the cancer cells through the hypothermia effect. By manipulating NIR irradiation, the nanocarrier exhibited efficiently controlled release of loaded DOX both in the buffer and in living HeLa cells (the model cancer cells), providing powerful and site-targeted treatments, which can be attributed to synergistic effects of chemo-photothermal therapy. To sum up, this novel nanocarrier is an excellent drug delivery platform in remote-controlled chemo-photothermal synergistic cancer therapy via NIR irradiation.
研究领域:
癌症治疗
·
材料科学
·
纳米技术
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2021
·Vol. 32
·期 12
·2107267
·
IF 18.808
Jianpu Tang,Junhan Ou,Chenxu Zhu,Chi Yao,Dayong Yang
Deoxyribonucleic acid (DNA) hydrogel has been synthesized generally via the molecular interaction of either DNA base-pairing, covalent bonding, or physical entanglement. To surmount the limitations of DNA as the sole module in materials, new assembly modes are desired to incorporate to expand the functionalities of DNA hydrogel. Herein, a supramacromolecular assembly-based strategy is reported to prepare a hybrid DNA hydrogel via interfacial assembly of DNA chains and upconversion nanoparticles (UCNPs), remarkably of which the synthesis process finished within one second, termed as flash synthesis. The flash synthesis is accomplished through the electrostatic attraction, interfacial assembly, and cross-linking of DNA chains on the surface of UCNPs. The length of DNA and the crystalline form of UCNPs are proven to be essential factors in the construction of a hydrogel network. The rationally designed DNA endowed hydrogel with functions to precisely recognize and isolate specific cells, and lanthanide ions-doped UCNPs protected cells from the damage of near-infrared irradiation through the upconversion effect. It is envisioned that the flash synthesis provides a new mode to prepare the DNA hydrogel and expands the functionalities to realize more real-world applications.
研究领域:
材料科学
·
生物技术
·
纳米技术
·
细胞生物学
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 37
·7725-7733
·
IF 6.331
Lubing Liu,Qingqing Wang,Huaiwei Liao,Jing Ye,Jinjun Huang,Shisheng Li,Haichuan Peng,Xiang Yu,Huicai Wen,Xiaolei Wang
Skin necrosis is the most serious complication of flap plastic surgery, which means the failure of the operation. Systemic administration rarely benefits the local area and can lead to side effects, while topical administration has poor permeability due to the skin barrier function. Currently, few of these common medical interventions can totally respond to the blood supply of the skin after surgery. Herein, a soluble microneedle (MN) patch made of hyaluronic acid was used to target the ischemic area in a painless and precise manner for transdermal drug delivery. Based on the important role of nitric oxide (NO) in angiogenesis, the thermosensitive NO donor (BNN6) and gold nanorods (GNRs) acting as photothermal agents were introduced into the microneedles (MNs). The hyperthermia induced by GNRs under near infrared (NIR, 808 nm) irradiation could enhance the penetration of drugs and facilitate NO release from BNN6. A series of corresponding experiments proved that the system played a significant promotion role in vascular regeneration, providing a painless, precise and NO-assisted treatment method for the ischemic perforator flaps.
研究领域:
生物医学工程
·
药学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
ACS Nano
·
2023
·
IF 17.1
Yijing Lin,Qingqing Yin,Dongyan Tian,Xuewei Yang,Shuangshuang Liu,Xueying Sun,Qiaoying Chen,Bingqing Fang,Hui Liang,Li Li,Deli Zhuge,Haonan Wang,Cuiye Weng,Jie Xu,Chunnan Hu,Jiafeng Xie,Xufei Zhang,Linzhi Yan,Xiaosheng Lu,Fang Wang,Caixia Liu,Yunliang Hu,Mengchun Chen,Ledan Wang,Yijie Chen
Phototherapy is an effective strategy to control Candida albicans (C. albicans) infection without raising the concern of drug resistance. Despite its effectiveness, a higher dose of phototherapeutic power is required for C. albicans elimination compared to bacteria that have to be used, which is readily accompanied by off-target heat and toxic singlet oxygen to damage normal cells, thus limiting its usefulness for antifungal applications. Here to overcome this, we develop a “three-in-one” biomimetic nanoplatform consisting of an oxygen-dissolved perfluorocarbon camouflaged by a photosensitizer-loaded vaginal epithelial cell membrane. With a cell membrane coating, the nanoplatform is capable of specifically binding with C. albicans at the superficial or deep vaginal epithelium, thereby centering the phototherapeutic agents on C. albicans. Meanwhile, the cell membrane coating endows the nanoplatform to competitively protect healthy cells from candidalysin-medicated cytotoxicity. Upon candidalysin sequestration, pore-forming on the surface of the nanoplatform accelerates release of the preloaded photosensitizer and oxygen, resulting in enhanced phototherapeutic power for improved anti-C. albicans efficacy under near-infrared irradiation. In an intravaginal C. albicans-infected murine model, treatment with the nanoplatform leads to a significantly decreased C. albicans burden, particularly when leveraging candidalysin for further elevated phototherapy and C. albicans inhibition. Also, the same trends hold true when using the nanoplatform to treat the clinical C. albicans isolates. Overall, this biomimetic nanoplatform can target and bind with C. albicans and simultaneously neutralize the candidalysin and then transform such toxins that are always considered a positive part in driving C. albicans infection with the power of enhancing phototherapy for improved anti-C. albicans efficacy.
研究领域:
纳米技术
·
药学
·
微生物学
·
治疗学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）