Nanoscale
·
2024
·
IF 5.8
Mengjia Cen,Jiawei Wang,Ming Cheng,Ziyan Lei,Ye Li,Zhenming Wang,Xueqian Zhao,Zixuan Wu,Huanian Zhang,Yan Jun Liu
Manipulating circular dichroism in chiral metasurfaces has been increasingly important for a wide range of polarization-sensitive photonic applications. However, simple methods for presenting chiral nanostructures with tunable and considerable chiroptical responses in the near-infrared-I regime remains underexplored. Herein, two sheets of suspended symmetric bilayer metagratings fabricated via single-step electron beam lithography are stacked into a moiré metasurface with its circular dichroism value reaching up to 20.9°. The chirality of the moiré metasurface can be fully tuned in terms of both its sign and magnitude by adjusting the in-plane angle between the two twisted sheets of metagratings. The multilayered design is accessible to the coupling of hybridized plasmons for governing the chiroptical properties in the near-infrared-I regime. The ratio between the resonance wavelength and the grating period is about 1.65, which is much lower compared to that in most existing moiré metasurfaces with strong chiroptical responses. Furthermore, the superchiral fields in the inter-sheet region are further exploited for label-free enantiodiscrimination with ultrahigh sensitivity of 10.17 nm fmol−1 mm2. The proposed moiré metasurfaces with strong near-infrared-I chirality hold great potential for supporting polarization engineering and biomolecular detection, paving a way for advanced applications in medical diagnosis, biomedical imaging, and display technologies.
研究领域:
纳米光子学
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生物医学检测
·
光学工程
✓ 已验证
DOI
PubMed
高影响因子
Journal of Biophotonics
·
2018
·Vol. 12
·期 3
·e201800237
·
IF 3.768
Yubin Liu,Duyang Gao,Mengze Xu,Zhen Yuan
In this study, CuS nanoparticles with optical absorption covering both near-infrared I (NIR-I) and NIR-II biological windows were prepared and served as the contrast agents for multispectral photoacoustic imaging. The physiological parameters including concentrations of deoxyhemoglobin and oxyhemoglobin as well as the water content in the tumor location were quantified based on the multispectral photoacoustic reconstruction method. More importantly, the concentration of CuS nanoparticles/drugs accumulated in the tumor was also recovered after intravenously injection, which are essential for image-guided cancer theranostics. In addition, phantom and in vivo experimental tests were performed to inspect and compare the imaging depth and signal-to-noise ratio (SNR) between the two NIR biological windows. Interestingly, we discovered that a higher SNR was obtained in the NIR-II window than that in the NIR-I window. Meanwhile, the multispectral imaging results also demonstrated that the imaging contrast and penetration depth in the NIR-II window were also significantly improved as compared to those from the NIR-I window.
研究领域:
生物医学工程
·
肿瘤学
·
影像学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2023
·
IF 6.2
Yicai Zhu,Junjun Wang,Yingyong Ni,Qingpeng Rao,Xiaojiao Zhu,Jianhua Yu,Sen Wang,Hongping Zhou
In this work, the phenothiazine fragment with powerful electron-donating ability was specifically selected to construct a multifunctional detector (noted as T1 ) in double-organelle with near-infrared region I (NIR-I) absorption. The changes of SO 2 /H 2 O 2 content in mitochondria and lipid droplets were observed through red/green channels respectively, which was due to the reaction between benzopyrylium fragment of T1 and SO 2 /H 2 O 2 to achieve red/green fluorescence conversion. Additionally, T1 was endowed with photoacoustic properties deriving from NIR-I absorption to reversibly monitor SO 2 /H 2 O 2 in vivo . This work was significant for more accurately deciphering the physiological and pathological processes in living organisms.
研究领域:
分析化学
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生物化学
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生物医学工程
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Inorganic Chemistry Frontiers
·
2025
·
IF 6.4
Min He,Yidong Bin,Lixian Huang,Caiying Li,Yuzhen Ma,Yan-Ni Luo,Shulin Zhao,Jinzhe Liang
In this work, novel zinc(II) phthalocyanine nanoparticles (ZnPcNPs) have been developed and verified to be a promising PTT agent in NIR-I range. Owing to the superior photostability, ZnPcNPs possess a high PCE of 30.01% under 660 nm NIR-I laser exposure. ZnPcNPs with strong adsorption in NIR-I biowindow, photothermal-enhanced cell death and single oxygen formation ability can function as an efficient diagnosis-treatment nanoprobe, thus accelerating the malignant breast cancer cell death. In vitro and in vivo findings verify that ZnPcNPs endow with suitable biosafety, superior photothermal therapeutic efficacy, and outstanding PA imaging performance. Taken together, ZnPcNP-mediated photothermal-enhanced PDT can be used for synergistic bimodal theranostics in future biomedical uses.
研究领域:
纳米技术
·
癌症治疗
·
医学成像
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED MATERIALS
·
2025
·
IF 26.8
Jiwei Jiang,Jing Hu,Mingtong Li,Mingzhi Luo,Bin Dong,Metin Sitti,Xiaohui Yan
Peritumoral subcutaneous injection has been highly envisioned as an efficient yet low-risk administration of photothermal agents for superficial tumor photothermal therapy. However, obstructed by complex subcutaneous tissue, the delivery of injected photothermal agents to the specific tumor remains a critical issue. Herein, the study reports a polydopamine (PDA)-encapsulated spherical core/shell nanomotor with fluorescent indocyanine green (ICG) immobilized on its PDA shell. Upon the first near-infrared (NIR-I) irradiation, this motor can generate favorable photothermal heat, and meantime, emit a robust ICG fluorescence in the second near-infrared window (NIR-II). The heat turns the motor into an active photothermal agent able to perform thermophoretic propulsion along the irradiation direction in subcutaneous tissue, while the ICG fluorescence can direct the subcutaneous propulsion of motors toward specific tumor through real-time NIR-II imaging. These functions endow the motor with the ability of moving to tumor after being injected at peritumoral site, enabling an enhanced photothermal therapy (PTT). The results demonstrated herein suggest an integrated nanorobotic tool for the superficial PTT using peritumoral administration, highlighting an NIR-II imaging-directed subcutaneous propulsion.
研究领域:
生物医学工程
·
纳米技术
·
癌症治疗
·
医学影像
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Laser & Photonics Reviews
·
2023
·
IF 11
Chunli Zhao,Yuan Gao,Jing Wang,Jianbei Qiu
Lead-free rare-earth-based perovskites have received widespread attention for their unique optical properties, although achieving efficient broadband near-infrared (NIR) emission with these materials remains a challenge. Here the synthesis of a rare earth-based double perovskite (Cs 2 NaScCl 6 ) by an improved solid phase method is reported. The doping of Cr 3+ led to the formation of [CrCl 6 ] 3− octahedron, which exhibited a broadband NIR emission peaked at 950 nm and a half-peak width of 162 nm. It is worth noting that with the same actual Cr 3+ content, the luminous intensity of Cs 2 NaScCl 6 synthesized by the improved solid-phase synthesis is four times higher than the product synthesized by the hydrothermal method. an efficient Cl − -Cr 3+ charge transfer sensitization facilitated by localized electrons in [CrCl 6 ] 3− octahedron is the mechanism for the strong NIR emission of Cr 3+ is proposed. Calculations based on density functional theory and Bader charge analysis support the notion that electrons in [CrCl 6 ] 3− octahedrons are strongly localized in Cs 2 NaScCl 6 :Cr 3+ , which is conducive to the Cl − –Cr 3+ charge transfer process, resulting the internal quantum efficiency of 100% and external quantum yield as 42.3%. The highly efficient ultra-broadband NIR emission with excellent stability offers many opportunities for applications in the field of NIR night vision and bio-imaging.
研究领域:
材料科学
·
光学
·
纳米技术
·
光子学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）