MOLECULES
·
2024
·Vol. 29
·期 17
·4001
·
IF 4.2
Sijia Wang,Huifang Xu,Yuanyuan Li,Lingyi Zhang,Shouhong Xu
Stimulus-responsive materials hold significant promise for antitumor applications due to their variable structures and physical properties. In this paper, a series of peptides with a responsive viologen derivative, Pep-CnV (n= 1, 2, 3) were designed and synthesized. The process and mechanism of the interaction were studied and discussed. An ultraviolet–visible (UV) spectrophotometer and fluorescence spectrophotometer were used to study their redox responsiveness. Additionally, their secondary structures were measured by Circular Dichroism (CD) in the presence or absence of the reductant, Na2SO3. DPPC and DPPG liposomes were prepared to mimic normal and tumor cell membranes. The interaction between Pep-CnV and biomembranes was investigated by the measurements of surface tension and cargo leakage. Results proved Pep-CnV was more likely to interact with the DPPG liposome and destroy its biomembrane under the stimulus of the reductant. And the destruction increased with the length of the hydrophobic tail chain. Pep-CnV showed its potential as an intelligent antitumor agent.
研究领域:
生物化学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2017
·Vol. 218
·期 11
·1700002
·
IF 2.5
Yongqi Yang,Guanghui Gao
A great extent of past work has focused on the development of stimuli-responsive hydrogels that can primarily achieve a two-state transition, such as sol-gel translation. In the current work, a reversible hydrogel with three-state transition is designed. The three transformations between original, oxidized, and reduced states are achieved via controlling the external stimuli conditions. Hydrogels in their original state possess a weak self-healing property and negligible fluidity. The oxidized state hydrogel can keep molding, however, losing the self-healing property. In contrast, the reduced state hydrogels exhibit strong self-healing property. Moreover, the hydrogel becomes injectable subsequent to dithiothreitol addition. Thereafter, under UV-light irradiation or NaClO immersion, the hydrogels can be remolded to any desired shapes. These properties provide novel designing strategies and potential applications for smart and reusable materials.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2016
·
IF 3.42
Meifang Song,Yanan Xue,Lidi Chen,Xiaoyang Xia,Yang Zhou,Lei Liu,Bo Yu,Sihui Long,Shiwen Huang,Faquan Yu
A superparamagnetic nanogel featured with a logic “and”-type pH/reduction combinational stimulated release mode was fabricated as a drug delivery system by virtue of parallel crosslinking. The disulfide bond and electrostatic interaction between thiolated alginate (SA–SH) and thiolated/aminated iron oxide nanoparticles (SH–MION–NH 2 ) were employed to achieve the mechanism. The obtained DOX-loaded magnetic nanogel is 122.7 ± 20.3 nm in size with superparamagnetism. The combinational conditions of pH 5.0/10 mM glutathione (GSH) stimulated a significantly high accumulative release. However, either pH 7.4/10 mM (GSH) or pH 5.0 alone induced much low release. This verified the typical logic “and”-type combinationally stimulated release mode. In vitro cytotoxicity tests clearly illustrated the effective selectivity of killing the human cervical cancer cells (HeLa) with IC 50 of 1.01 μg/mL and the human hepatoma cells (HepG2) with IC 50 of 1.57 μg/mL but significantly low cytotoxicity to the cercopithecus aethiops kidney cells (Vero). CLSM presented the internationalization of the nanogel into cytoplasm and nuclei with time. In vivo investigation revealed that the selective intratumoral accumulation and antitumor efficacy were considerably advantageous over free DOX whereas low systemic toxicity exhibited up-regulated security as compared to free DOX. Overall, the DOX-loaded magnetic nanogel with enhanced antitumor efficacy and down-regulated adverse effect was a promising nanoplatform for the clinical chemotherapy of malignancy.
研究领域:
药剂学
·
生物医学工程
·
肿瘤学
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2020
·
IF 3.99
Kaili Wang,Xian Li,Huili Wang,Hongyan Lu,Donghua Di,Qinfu Zhao,Siling Wang
Incorporation of degradable groups such as thioether bonds can make nanoparticles susceptible to be degraded by biological redox stimulus. Few studies have paid attention to effects of different surface properties of carriers on degradation behaviors between traditional mesoporous silica carriers and hybrid organosilica carriers, caused by inserted thioether groups. In this work, colloidal mesoporous silica (CMS) and hybrid colloidal mesoporous silica (HCMS) with different contents of doped thioether bonds are constructed to compare their physicochemical properties and degradability. With the increased amounts of doped thioether bonds, specific surface areas and Zeta potentials of HCMS nanoparticles decrease. Additionally, dynamic contact angle and the oil-water distribution coefficient are combined to characterize the hydrophobicity of CMS and HCMS nanoparticles. Therefore, after incorporating thioether bonds into the structure of carriers, the degradation behavior of HCMS nanoparticles in the medium were the result of weighing the advantages of degradable thioether bonds and disadvantages of decreased specific surface area and enhanced hydrophobicity of carriers. Experimental results displayed that, in the high concentration of reductive environment, HCMS carriers with doping proper proportion of thioether groups showed the fast degradation rate due to the cleaved thioether bonds as the dominant factor. The present work breaks the common views that all thioether bonds-bridged organosilica could become excellent biodegradable carriers, providing an objective perspective to evaluate the degradability of hybrid organosilica carriers.
研究领域:
材料科学
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
POLYMER
·
2019
·
IF 3.771
Yi Xi Song,Min Zhi Rong,Ming Qiu Zhang
As an ideal smart wearable natural material, α-keratin type mammalian hairs have proved to exhibit multiple-responsive shape memory effects under water, wet, xenon and redox stimuli, in which the inherent disulfide bonds played the roles of either netpoints or switching units. Accordingly, here in this work, we proposed to increase the content of disulfide bonds of representative mammalian hairs - wool fibers , which are widely used in daily life, by means of three chemical methods so as to improve their multiple-responsive shape memory effects. On the basis of systematic researches, it was found that the treatment with cystamine gave the highest efficiency of introducing disulfide bonds due to full use of the free functional groups of wool, while the valuable crystalline phases of wool were nearly not affected. As a result, the cystamine modified wool fibers possessed greater shape recovery ratio under water and heat conditions, and larger shape fixation ratio under xenon and redox conditions , in comparison with the untreated version. The mechanisms involved were carefully analyzed. The application scope of the on-demand programmed wool in intelligent fabrics and textiles would thus be broadened.
研究领域:
材料科学
·
纺织工程
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
LANGMUIR
·
2019
·
IF 3.683
Jing Zhang,Liqun Chen,Biao Shen,Lingdong Chen,Jiaying Mo,Jie Feng
A dual-sensitive drug delivery system (DDS) based on graphene oxide (GO) which is simultaneously loaded with proapoptotic peptides and anticancer drugs was rationally designed and fabricated for cancer synergetic therapy. Specifically, a kind of cell apoptosis peptide (KLAKLAK)2 (KLA) was anchored on the surface of GO via a disulfide bond to obtain GO-SS-KLA. Then, the aromatic anticancer drug doxorubicin (DOX) was loaded on GO through π–π conjugation and hydrogen bonding interactions. Finally, bovine serum albumin (BSA) was used to coat the GO carrier to obtain a biological medium-stable GO-based DDS, DOX@GO-SS-KLA/BSA. The results show that KLA and DOX can be released responding to the reductive and pH stimulus inside the cells, respectively, and achieve a synergetic therapy for cancer. Moreover, the results of stability studies show that DOX@GO-SS-KLA/BSA could be stably dispersed in water for more than 8 days and in 10% fetal bovine serum for at least 6 days. The constructed DOX@GO-SS-KLA/BSA exhibits great potential as a drug carrier for co-delivery of various therapeutic agents.
研究领域:
纳米医学
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癌症研究
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药物递送
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生物材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NANOTECHNOLOGY
·
2020
·Vol. 31
·期 47
·475102
·
IF 3.551
Lei Zhang,Feng Wei,Abdulrahman Al-Ammari,Dongping Sun
To date, numerous drug delivery systems based on mesoporous silica nanoparticles (MSNs) have been explored, but little has been done on optimizing the structure and composition of MSNs to achieve effective drug delivery for cancer cells. Ideal mesoporous drug carriers should incorporate drugs in a way that prevents pre-release in biological surroundings before reaching the targeted area, which usually requires the capping of the open ends on the surface and the incorporation of targeting ligands on the exterior of nanocarriers. In this study, an MSN-based drug carrier system was synthesized with biocompatible Au nanoparticles (NPs) as the 'hard caps', and folic acid conjugated to the surface for targeting folate receptor-overexpressed cancer cells. Disulfide bonds linking Au and MSN NPs were introduced to the MSN surface as the redox-sensitive and chemically removable components. To study the effect of structures of MSNs in drug release, three types of MSNs were compared, including hollow mesoporous silica NPs, large-pore hollow mesoporous silica NPs and typical nano-sized pores on the surface (MSN). To achieve optimal coverage of thiol groups, two methods of functionalization were compared in effecting drug loading and release in vitro. Finally, the effect of residual surfactant was also discussed in anticancer studies. Therefore, the appropriate MSN nanostructure for redox-sensitive and targeted drug delivery was optimized.
研究领域:
纳米技术
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药学
·
生物医学工程
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癌症研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2020
·
IF 3.333
Chao Yu,Xing Tan,Zhenzhu Xu,Guodian Zhu,Wenqi Teng,Qingzhen Zhao,Zhong Liang,Zhimin Wu,Di Xiong
A series of amphiphilic polymer mPEG-PUSS-mPEG were developed by a combination of ring opening polymerization (ROP) and polyaddition reaction and its self-assembled micelles were developed for hydrophobic anticancer drugs delivery. Polymeric critical micellar concentration (CMC) values in aqueous solution were about 2.8–5.5 mg/L. And the partition equilibrium constant ( K v ) of pyrene in micellar solutions ranged from 1.52 × 10 5 to 2.20 × 10 5 . The average sizes of the self-assembled blank and DOX-loaded micelles were 160–180 nm determined by dynamic light scattering (DLS). The morphology of the DOX-loaded micelles was spherical by transmission electron microscopy (TEM) and scanning electron microscopy (SEM).The in vitro drug release behaviors of DOX and PTX from mPEG-PUSS-mPEG micelles were investigated at different simulated conditions. We found that the PTX release was significantly accelerated by redox stimuli compared with DOX-loaded reduction-sensitive PU micelles. The change of the size of this system under different conditions was further evaluated by DLS. DOX-loaded mPEG-PUSS-mPEG micelles in 50% fetal bovine serum (FBS) were evaluated the hemocompatibility. In addition, the self-assembly process of polymers mPEG-PUSS-mPEG in aqueous solution for micellar formation was also investigated by means of dissipative particle dynamics (DPD) simulations.AndCCK-8 assays revealed that the mPEG-PUSS-mPEG materials had low toxicity, but the DOX-loaded micelles showed a high cytotoxicity against HepG2 tumor cells. All results demonstrate that mPEG-PUSS-mPEG self-assembled micelles are a very promising for hydrophobic anticancer drugs delivery.
研究领域:
材料科学
·
药剂学
·
生物医学工程
·
癌症研究
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Li Hao,Ziting Yin,Mei Guan,Qiangcheng Zheng,Zitao Feng,Jialin Zeng,Jinhui Wang,Huayao Chen,Jinhao Zhao,Hongjun Zhou,Xinhua Zhou
Bacterial wilt caused by Ralstonia solanacearum severely impacts agricultural production, urgently requiring effective control measures. Herein, we designed a strategy via boron nitride nanosheets with enhanced adhesion ability as nanocarriers to improve the antibacterial efficacy of active ingredients. To achieve this, we utilized three sulfur-containing amino acids (SAAs), including methionine (MET), cysteine (CYS), and cystine (CYST) for the simultaneously exfoliation and functionalization of boron nitride nanosheets (BNNS) through mechanochemical method, and compared their structure–activity relationship. The obtained BNNS-SAAs exhibited size around 160–250 nm and thickness near 1.5–2.0 nm. The presence of disulfide bond (S-S) within BNNS-CYS and BNNS-CYST promoted them with the responsiveness by redox stimuli. BNNS-CYST acquired highest functionalization degree of 63.44 % among three BNNS-SAAs. And tea tree essential oil (TTO) loading capacity within BNNS-SAAs was around 36.40–37.11 %. The existence of SAAs within BNNS significantly inhibited the volatilization of TTO via nanoconfinement effect fitting to Logistic model, specially, BNNS-CYST held with slowest release rate among the BN-based carriers, due to the stronger attachment or affinity. Furthermore, BNNS-CYST-TTO exhibited the most excellent synergistic antibacterial effect with the increased inhibition zone diameter by 26.89 % against Ralstonia solanacearum in comparison with pure TTO, with the minimum inhibition concentration reduced from 1.8 mg·mL −1 to 0.6 mg·mL −1 . The enhanced antibacterial mechanism was proposed based on physical disruption via strong adhesion. BNNS-SAAs also presented superior adhesion and wettability on seed and foliar surfaces, and also promoted seed germination by providing more S nutrients, and exhibited no significant cytotoxicity. Our system provides a green and effective platform response to redox stimuli to load and release essential oils for application in bacterial wilt control.
研究领域:
纳米技术
·
材料科学
·
植物病理学
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农业科学
·
生物技术
✓ 已验证
产品关联
DOI
高影响因子
BIOMATERIALS
·
2022
·
IF 15.304
Yannan Chen,Wentao Su,Shanshan Tie,Weina Cui,Xiaoting Yu,Lijuan Zhang,Zheng Hua,Mingqian Tan
Orally targeted strategy of anti-inflammatory agents has attracted tremendous attention for reducing highly health-care costs and enhancing the intervention efficiency of ulcerative colitis (UC). Herein, we developed a new kind of sequence-targeted astaxanthin nanoparticles for UC treatment. Astaxanthin nanoparticles were firstly designed by self-assembly method using (3-carboxypentyl) (triphenyl) phosphonium bromide (TPP)-modified whey protein isolate (WPI)-dextran (DX) conjugates. Subsequently, lipoic acid (LA) modified hyaluronic acid (HA) was coated on the surface of the nanoparticles by double emulsion evaporation method. Exhilaratingly, the constructed sequence-targeted astaxanthin nanoparticle exhibited excellent macrophages and mitochondria targeting ability, with a Pearson's correlation coefficient of 0.84 adstnd 0.92, respectively. In vivo imaging elucidated an obvious accumulation of the sequence-targeted nanoparticles in colon tissues in UC mice. Meanwhile, the reduction stimulus release features of astaxanthin were observed in the presence of 10 mM of glutathione (GSH) at pH 7.4. Most importantly, in vivo experiments indicated that sequence-targeted astaxanthin nanoparticles could markedly alleviate inflammation by moderating the TLR4/MyD88/NF-κB signaling pathway . What's more, the composition of gut microbiota and the production of short chain fatty acid were also improved upon the uptake of sequence-targeted astaxanthin nanoparticles. Our results suggested this novel astaxanthin nanoparticles, which showed sequence-targeted ability and reduction response feature, could be exploited as a promising strategy for effective UC treatment.
研究领域:
药学
·
纳米技术
·
炎症性肠病
·
药物递送系统
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2022
·
IF 6.633
Haiyan Du,Jinfeng Wang,Na Xu,Yunlong Yu,Shaoze Liu
Self-healable, shape memory poly(vinyl alcohol) (PVA)/ionic liquid (PVA/IL) hydrogels were assembled from poly(vinyl alcohol) and 1-butyl-3-methylimidazolium tetrafluoroborate solutions by a one-step strategy at room temperature. The gelation was due to the judicious design of the supermolecular interactions between PVA and IL, including electrostatic interactions and hydrogen bonding. Differential scanning calorimetry and tensile tests etc. were applied to study the effect of IL on the hydrogels. The results showed that the optimum thermal and mechanical properties of the hydrogel are obtained with higher IL content. The tensile strength and elongation at break of PVA/IL-1.00 hydrogel were 1.447 MPa and 750%, respectively. The self-healing efficiency reached up to 92.60%. Due to the reversible metal ion cooperation in ferric sulfate and the reduction of Fe 3+ in ascorbic acid, the hydrogels exhibited a redox-stimulated shape memory effect. The cytotoxicity test indicated the promising applications for biomedical materials including artificial skin and wound dressings.
研究领域:
材料科学
·
聚合物化学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Qi Zhou,Xuelin Dong,Yuxiang Xiong,Binbin Zhang,Shan Lu,Qin Wang,Yonggui Liao,Yajiang Yang,Hong Wang
In this work, we reported a multi-responsive luminescent hydrogel with properties of encryption, naked eye sensing of glucose, shape memory, self-healing, and antibacterial activity. The hydrogel (GA/CCS/DNSA/Eu3+) was obtained by mixing phenylboronic acid-modified gelatin (GA-DBA), catechol-modified carboxymethyl chitosan (CCS-PCA), 3,5-dinitrosalicylic acid (DNSA), and Eu3+ ions through a facile heating–cooling process. The resultant hydrogel exhibits reversible luminescence and color and phase changes in response to temperature, acid/base, salt, and redox stimuli. Based on the multiple responsiveness, information encryption and decryption, naked eye sensing of glucose, remarkable shape memory, and enhanced mechanical properties of the as-prepared hydrogel were realized. In addition, the self-healing capacity was also achieved due to the dynamic bonds in GA/CCS/DNSA/Eu3+ hydrogels. Specifically, the GA/CCS/DNSA/Eu3+ hydrogels possess antibacterial activity owing to the bacteriostasis of the CCS-PCA and DNSA/Eu3+ complex. Thus, GA/CCS/DNSA/Eu3+ hydrogels have potential applications in the fields of anticounterfeiting, wearable devices, biomedicine, sensing, etc.
研究领域:
材料科学
·
纳米技术
·
生物材料
·
化学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）