Processes
·
2019
·Vol. 7
·期 6
·351
·
IF 1.963
Yali Liu,Xiaorong Kang,Han Cheng
The addition of Fe2+is considered an effective method for increasing methane production, but the added Fe2+may not be absorbed by anaerobic microorganisms due to complex chemical reactions. In this study, ethylenediaminetetraacetic acid (EDTA) was used as a ligand of Fe2+(EDTA-Fe) to promote the dissolution of Fe, and the anaerobic performances of kitchen wastes (KWs) in a semi-continuous reactor were studied. The results indicated that the biogas yields and methane contents were enhanced to 594–613 mL·g−1VSadd·d−1and 63.6–64.4% at an organic loading rate (OLR) of 2.5 gVSadd·L−1·d−1due to EDTA-Fe addition. Simultaneously, the EDTA-Fe was more effective than Fe2+in preventing the acidification of KWs with a high OLR (5.0 gVSadd·L−1·d−1). In addition, the sequential extraction results showed that the water-soluble fraction of Fe in the R3 (EDTA-Fe addition) was 1.49-fold of that in the R2 with Fe2+addition. The contents of coenzymes F420 and F430 were also improved 1.09 and 1.11 times, respectively. Mechanism analysis confirmed that the EDTA enhanced methane production and operational stability by promoting the dissolution of Fe and maintaining a high content of water-soluble Fe.Keywords:semi-continuous reactor;EDTA;Fe;kitchen wastes;methane
研究领域:
环境科学
·
微生物学
✓ 已验证
产品关联
DOI
高影响因子
Processes
·
2023
·Vol. 11
·期 9
·2644
·
IF 3.5
Shanshan Yang,Lixia Hou,Min Su
Protein crystallization is a widely employed technique for purifying protein drugs, offering notable benefits such as cost-effectiveness and high purity. However, the success of this method is influenced by factors such as the molecular weight and spatial structure of proteins. The challenges associated with achieving crystallization and the prolonged duration required for crystallization induction pose limitations on its widespread industrial implementation. In this study, we employed lysozyme derived from egg white as a representative protein to investigate the polymer-assisted self-assembly of magnetic lysozyme. Through the optimization of the initial interstitial crystallization process of magnetic lysozyme, we manipulated the supersaturation level of lysozyme and applied magnetic nanoparticle treatment. As a result, we successfully reduced the crystallization time from 24 h to 60 min. Subsequently, the findings derived from the analysis of data pertaining to the interstitial crystallization process of lysozyme were utilized to optimize the design and configuration of a push flow crystallizer (PFC) as well as a slug flow crystallizer (SFC). The analysis encompassed the examination of various factors, including the residence time of crystallization, the yield of the process, the shape of the crystals formed, and the distribution of crystal sizes. Ultimately, it was determined that the SFC demonstrated optimal suitability for the crystallization of magnetic lysozyme. The typical V-PFC crystal size is 16 m and the yield is 60%. V-SFC crystals have an average size of 13 m and a yield of 85%.Keywords:lysozyme;continuous crystallisation;tubular;magnetic
研究领域:
生物化学
·
制药工程
✓ 已验证
产品关联
DOI
高影响因子
ORGANIC PROCESS RESEARCH & DEVELOPMENT
·
2014
·
IF 2.549
Kai Dong,Cheng H. Sun,Jian W. Song,Gai X. Wei,Si P. Pang
Synthesis of 2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazaisowurtzitane (TAIW) by catalytic hydrogenolysis of 2,6,8,12-tetraacetyl-4,10-dibenzyl-2,4,6,8,10,12-hexaazaisowurtzitane (TADBIW), a key step for the synthesis of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (HNIW), has been first implemented under continuous flow conditions using the commercially available H-Cube Pro reactor. Several variables (i.e., reaction temperature, flow rate, and pressure) and the stability of the system have been investigated to optimize the operating conditions. The results show that a continuous flow system provides a better yield than a batch system. For instance, the yield is 99% at the optimized conditions, while the best yield from batch reactions is 92%. Continuous flow synthesis of TAIW has potential applications in improving the production technologies of HNIW for its many advantages over batch reactions.
研究领域:
化学合成
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Pharmaceutical Analysis
·
2021
·
IF 4.769
Chenglong Sun,Li Cui,Bingqian Zhou,Xiao Wang,Lanping Guo,Wei Liu
Salvia miltiorrhiza Bge (SMB) has long been used in traditional Chinese medicine to treat cardiovascular and cerebrovascular diseases. Growing clinical usage has led to a huge demand for artificial planting of SMB. Thus, continuous cropping of SMB is an important challenge that needs to be addressed. Continuous cropping can alter the metabolic profile of plants, resulting in poor growth and low yield. In this study, we tried to image the spatial location and variation of endogenous metabolites in continuously cropped SMB using matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI). Spatially resolved expressions of tanshinones, salvianolic acids, polyamines, phenolic acids, amino acids, and oligosaccharides in normal and continuously cropped SMB roots were compared. The expressions of dihydrotanshinone I, tanshinone II A, dehydromiltirone, miltirone, dehydrotanshinone IIA, spermine, salvianolic acid B/E, tetrasaccharide, and pentasaccharide in continuously cropped SMB roots were much lower than those in normal roots. There was little difference in the expressions of caffeic acid and salvianolic acid A in normal and continuously cropped SMB roots. Ferulic acid was more widely distributed in xylem of normal SMB but strongly expressed in xylem, phloem, and cambium of continuously cropped SMB. The spatially resolved metabolite information enhances our understanding of the metabolic signature of continuously cropped SMB and also provides insights into the metabolic effects of continuous cropping in other plants.
研究领域:
植物学
·
药用植物研究
·
代谢组学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Molecular Catalysis
·
2025
·
IF 4.9
Jiali Chen,Chen Huang,Yuqing Zhang,Liya Zhou,Li Ma,Lihui Wang,Yanjun Jiang,Yunting Liu
The conversion of racemic alcohols to enantiopure alcohols and amines is of significant importance yet presents considerable challenges. Herein, we achieved this goal by developing continuous-flow chemoenzymatic systems. In chemical module, a ruthenium (II)-N-heterocyclic carbene (Ru-NHC) catalyst immobilized on dendritic organosilica nanoparticle (DON) was prepared, which exhibited high activity and selectivity in the dehydrogenative oxidation of racemic alcohols to ketones. In enzymatic module, a ketoreductase and an amine dehydrogenase were individually co-immobilized with a cofactor-regenerating enzyme (glucose dehydrogenase) on DON for the enantioselective conversion of ketones to chiral alcohols and amines, respectively. The integration of the two modules in continuous-flow systems enabled the efficient chemoenzymatic deracemization and asymmetric amination of racemic alcohols (9 examples) with the maximum space-time yields of 6.8 and 5.8 g L -1 h -1 , respectively, underscoring the practical utility of the continuous-flow chemoenzymatic systems.
研究领域:
生物化学
·
有机化学
·
合成生物学
✓ 已验证
产品关联
DOI
高影响因子
Frontiers in Chemical Engineering
·
2024
·
IF 2.5
Ge Xue-hui,Wei Nanjie,Hu Xinyue,Xie Qinyin,Wang Xiaoda,Li Ling,Qiu Ting
An integrated microfluidic planar reactor is essential for achieving efficient and enhanced photocatalytic water treatment. Optimization of catalysts is an area of intense study owing to the need to enhance the performances of microreactors. A high-efficiency photocatalytic microreactor is presented here by combining a planar microreactor with a high-efficiency photocatalyst. TiO2 nanoparticles doped with Y and Yb were prepared to improve the photocatalytic reaction efficiency. First, better performance is achieved with the Y, Yb/TiO2 and TiO2 microreactors than conventional bulk reactors because of good photodegradation and a high reaction rate. Then, the Y, Yb/TiO2 film microreactor exhibits not only efficient catalytic activity with UV light but also higher photocatalytic activity under visible light irradiation than that achieved by a TiO2 film microreactor. The reaction rate constant of the Y, Yb/TiO2 film microreactor is approximately 0.530 s–1, which is twice that of the TiO2 film microreactor. Moreover, the performances under continuous and intermittent reactions are compared to evaluate the stability of the microreactor, thereby building the foundation for practical application of continuous water treatment in the microreactor.The planar microreactor provides a convenient platform for studying photodegradation under various conditions, such as different temperatures, flow rates, light irradiation (UV and Vis), and reaction modes (continuous and intermittent).
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2020
·
IF 4.244
Tao Shen,Youqin Hu,Ruijia Hu,Wei Zhuang,Ming Li,Huanqing Niu,Hong Xu,Chenjie Zhu,Hanjie Ying
The continuous production of furfural using vaporization reactor as a continuous stirred tank reactor is reported in this study. 50 g L −1 xylose solution was continuous fed into the reactor and catalyzed by 2 wt% H 2 SO 4 at 433 K gave 82.3% average yield of furfural in 10 h of reaction time. Pulp prehydrolysate derives from prehydrolysis of wood biomass was further used as the raw material for the reaction, and the 78.6% average yield of furfural was achieved for 10 h. According to Aspen Plus simulation, 11.7 tons of saturated steam was required for the production of one ton of furfural under the present reaction system, which is almost half of the traditional one-step method.
研究领域:
生物化学工程
·
可再生资源利用
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2019
·
IF 3.375
Jie Jiang,Wen-Jun Wang,Bo-Geng Li,Shiping Zhu
The tactics of targeting copolymer composition (CC) and molecular weight (MW) via semibatch controlled radical polymerization (CRP) have been extensively studied. However, little effort is made to target copolymer sequence length (CSL) and its triad sequence, which are among the key microstructures determining material properties of the copolymers. This work presents a method to design and synthesize targeted CSL and copolymer triads in a reversible addition–fragmentation chain transfer radical mini-emulsion copolymerization system (RAFT) through a semibatch chain and sequence model coupled with Alfrey Mayo model. The kinetic model was first derived and correlated with experimental results of the batch St/BA copolymerizations. The semibatch RAFT model was then employed to calculate the feed-rate to target CSL and their triads. St/BA copolymers with different uniform CSLs and their triads are synthesized through the programmed semibatch RAFT mini-emulsion copolymerization processes.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
ORGANIC PROCESS RESEARCH & DEVELOPMENT
·
2021
·
IF 3.317
Fei Yu,Yafei Mao,Hongtu Zhao,Xiunan Zhang,Ting Wang,Mingpu Yuan,Suping Ding,Na Wang,Xin Huang,Hongxun Hao
Protein drugs have attracted extensive attention from the academic community. However, crystallization of proteins is difficult and the yield of current main technologies is too low, which limits their large-scale industrial production. In this work, enhancement of continuous crystallization of lysozyme under an ultrasonic field was explored. A plug-flow tubular crystallizer, which was separated into a nucleation zone and a growth zone, was applied. The effect of ultrasound on steady-state time, crystal habit, particle size, particle size distribution, and the process yield was evaluated based on univariate analysis experiments. It was found that ultrasound can shorten the time for continuous crystallization to reach a steady state, reduce the degree of aggregation, and promote nucleation. Furthermore, the separation of the growth zone from the nucleation zone in the ultrasonic-assisted continuous crystallization can further increase the size of the lysozyme crystals, which would help in increasing the yield.
研究领域:
生物化学
·
制药工程
✓ 已验证
产品关联
DOI
高影响因子
Magnetochemistry
·
2023
·Vol. 9
·期 5
·129
·
IF 2.7
Na Li,Daojing Lin,Junfeng Wu,Quan Gan,Xingyue Hu,Niandong Jiao
The utilisation of miniature robots has become essential in the domain of minimally invasive surgery and long-distance delivery of nanomedicine. Among these, the miniature magnetic continuum robot (MCR) stands out because of its simple structure and dexterity, which allow it to penetrate small cavities, transport specialised tools such as a laser, and deliver medications to support surgical treatment. Nevertheless, because of their soft bodies with a single stiffness, conventional MCRs have limited controllability when navigating through intricate cavities. To address this limitation, we propose a novel concentric magnetic continuum robot (C-MCR) comprising a concentric magnetic catheter with a guidewire having varying stiffness. The C-MCR allows substantial curvature bending owing to its difference in stiffness, and its detachable nature allows it to have four working modes to adapt to specific application requirements with improved stiffness controllability. Experiments demonstrate the ability of the C-MCR to navigate complex pathways and deliver nanomedicines over long distances to specific areas via its internal channels using a large homemade eight-coil electromagnetic system. The C-MCR offers promising application prospects for the long-distance delivery of tailored nanomedicines because of its simple operation, reduced risks, and larger attainable workspace.Keywords:magnetic control;continuum robot;stiffness control;drug delivery
研究领域:
医学工程
·
纳米医学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2022
·
IF 7.968
Evans Dovi,Aaron Albert Aryee,Alexander Nti Kani,Farid Mzee Mpatani,Jianjun Li,Lingbo Qu,Runping Han
This research investigated the feasibility of removing hexavalent chromium (Cr(VI) (e.g., HCrO 4 − , CrO 4 2− and Cr 2 O 7 2− ions) from water using walnut shells functionalized with amino groups (ACWNS) in a batch and continuous adsorption mode. The characterization of ACWNS was carried out utilizing FTIR, XPS , SEM, and BET methods. Adsorption was investigated in terms of pH, dose, concentration, and contact duration. Furthermore, at different temperatures, the adsorption isotherms , kinetics, and thermodynamics were studied. The Langmuir model described the experimental batch and column modes, while the Thomas and pseudo-second-order kinetics models predicted continuous and batch adsorption, respectively. The maximum uptake quantity toward Cr(VI) was 236.8 mg g –1 in batch mode and 308.4 mg g –1 in column mode at 303 K. There is some selective adsorption for Cr (VI) with some dyes coexisting in solution. Electrostatic interactions and the reduction process mediated Cr(VI) adsorption by ACWNS. The mass transfer potential (B) and the affinity between ACWNS and Cr(VI) (β) were computed using the modified mass transfer factor model. Since the attraction of Cr (VI) to ACWNS is more robust, the B value increases as the concentration increases. Again, MTZ assessment reveals that as MTZ length rises, diffusion resistance increases, resulting in increased adsorption. The adsorbent demonstrated improved regeneration capacity and therefore showed potential for the uptake of Cr(VI) ions from wastewater. Availability of data and material The dataset produced and processed during this research is available upon reasonable request from the corresponding author.
研究领域:
环境科学
·
化学工程
✓ 已验证
DOI
高影响因子
WATER AIR AND SOIL POLLUTION
·
2024
·Vol. 235
·期 4
·1-12
·
IF 3.8
Liu Yonghong,Yang Xiaoxiao,Wang Ning,Wang Quanhong
While high-efficiency photocatalysts have been extensively researched, there is still a scarcity of reports focusing on enhancing the practical application conditions of low-cost engineering photocatalysts. In this study, a 13.8-L continuous streamer catalytic reactor was developed utilizing low-cost self-made TiO 2 /ACF photocatalyst. Employing the Box-Behnke response surface method, the study assessed the reactor’s efficiency in treating organic wastewater using methylene blue (MB) as the model pollutant. The TiO 2 /ACF photocatalysis was characterized by XRD, EDS, and SEM, and the results showed that the nano-TiO 2 was uniformly loaded with the surface of activated carbon fibers in a lamellar form. Results indicated that with a single cycle time of 134 min and a catalyst amount of 95 cm × 95 cm, the average decolorization rate for 3 mg/L MB wastewater was 90.63%, following quasi-second-order kinetics. The MB wastewater’s decolorization efficiency swiftly reached 89.8% within the initial 120 min, maintaining around 90% during continuous 600-min treatment. The optimal catalyst condition was identified, enhancing photodegradation efficiency of MB organic molecules. The developed photocatalytic equipment exhibited high efficiency and stability in degrading low-concentration organic molecules.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）