Nature Sustainability
·
2025
·
IF 27.1
Cen Guanjun,Yu Hailong,Xiao Ruijuan,Ben Liubin,Qiao Ronghan,Zhu Jing,Zhang Xinxin,Liu Gaozhan,Jiang Kemin,Yao Xiayin,Zhang Heng,Huang Xuejie
All-solid-state lithium metal (Li°) batteries (ASSLMBs) are a promising next-generation energy storage technology due to their use of non-flammable solid electrolytes for enhanced safety and the potential for higher energy density. However, void formation and evolution at the interface between anode and solid electrolyte remains a major challenge, leading to accelerated performance degradation. Departing from traditional interfacial design strategies, here we introduce dynamically adaptive interphases, formed by controllable migration of pre-installed anions in solid electrolytes, to operate ASSLMBs stably under low external pressure. The interphases adapt to the Li° anode volume changes, maintaining close physical contact between the Li° anode and ‘rigid’ solid electrolyte under low or zero external pressure. The dynamically adaptive interphase enables Li° full cells to deliver excellent rate performance and 90.7% of capacity retention after 2,400 cycles at a current density of 1.25 mA cm − 2 . Notably, pouch cells with zero external pressure are assembled with 74.4% of capacity retention after 300 cycles. The present work resolves the critical issue of the continuous solid–solid contact loss between Li° anodes and high-modulus solid electrolytes, advancing the practical deployment of ASSLMBs as high-energy, sustainable electrochemical storage systems.
研究领域:
材料科学
·
电化学
·
能源存储
·
固体离子学
·
电池技术
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED MATERIALS
·
2024
·
IF 27.4
Weiming Tang,Yaohui Zhan,Jingrun Yang,Xue Meng,Xingyue Zhu,Yong Li,Tianyi Lin,Lei jiang,Ziguang Zhao,Shutao Wang
Passive radiative cooling is a promising technology for heat dissipation that does not consume energy. However, current radiative cooling materials can only exhibit subambient cooling under atmospheric conditions and struggle to process specific heat accumulation. Thus, a passive thermal regulation mechanism adapted to wide-temperature-range applications is required to match device heating systems. Herein, a heteroporous nanocomposite film (HENF) with thermo-adaptive radiation cooling performance is reported. Compared to conventional porous cooling films with limited scattering efficiencies, the HENFs with multistage scattering have a strong emissivity of 96.5% (8–13 µm) and a high reflectivity of 97.3% (0.3–2.5 µm), resulting in an ultrahigh cooling power of 114 W m −2 . In such HENFs, theoretical analyses have confirmed the spectrum management superiority of the heteroporous unit in terms of the scattering efficiency strength, with their cascading effect enhancing the overall film-cooling efficiency. The high mechanical performance, phase-transition features, and environmental adaptive properties of HENFs are also exhibited. Importantly, HENFs synergistically couple thermal dissipation and absorption to effectively process heat accumulation and counteract thermal shock in heating devices. It is anticipated that thermo-adaptive HENFs will act as a promising platform for device surface thermal regulation over a wide temperature range.
研究领域:
材料科学
·
热能工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Advanced Research
·
2024
·
IF 11.4
Kai Lin,Lei Yue,Longyu Yuan,Kui Kang,Yibing Zhang,Rui Pang,Wenqing Zhang
Introduction During the adaptation to host plant resistance, herbivorous insects faced the challenge of overcoming plant defenses while ensuring their own development and reproductive success. To achieve this, a strategic allocation of energy resources for detoxification and ecological fitness maintenance became essential. Objective This study aimed to elucidate the intricate energy allocation mechanisms involved in herbivore adaptation that are currently poorly understood. Methods The rice Oryza sativa and its monophagous pest, the brown planthopper (BPH), Nilaparvata lugens were used as a model system. An integrated analysis of metabolomes and transcriptomes from different BPH populations were conducted to identify the biomarkers. RNA interference of key genes and exogenous injection of key metabolites were performed to validate the function of biomarkers. Results We found that alanine was one of the key biomarkers of BPH adaptation to resistant rice variety IR36. We also found that alanine flow determined the adaptation of BPH to IR36 rice. The alanine aminotransferase (ALT)-mediated alanine transfer to pyruvate was necessary and sufficient for the adaptation. This pathway may be conserved, at least to some extent, in BPH adaptation to multiple rice cultivars with different resistance genes. More importantly, ALT-mediated alanine metabolism is the foundation of downstream energy resource allocation for the adaptation. The adapted BPH population exhibited a significantly higher level of energy reserves in the fat body and ovary when fed with IR36 rice, compared to the unadapted population. This rendered the elevated detoxification in the adapted BPH and their ecological fitness recovery. Conclusion Overall, our findings demonstrated the crucial role of ALT-mediated alanine metabolism in energy allocation during the adaptation to resistant rice in BPH. This will provide novel knowledge regarding the co-evolutionary mechanisms between herbivores and their host plants.
研究领域:
昆虫学
·
植物科学
·
分子生物学
·
生态学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
WATER RESEARCH
·
2025
·
IF 12.4
Qian-He Liu,Li Yuan,Zheng-Hao Li,Kenneth Mei Yee Leung,Guo-Ping Sheng
Agricultural wastewater, a significant component of the anthropogenic water cycle, often contains complex mixtures of contaminants, including non-antibiotic feed additives, posing largely uncharacterized risks for antimicrobial resistance (AMR) evolution. This study addresses the critical knowledge gap regarding the combined impact of commonly co-occurring roxarsone (ROX) and heavy metals (Zn, Cu) at environmentally relevant concentrations on the de novo evolution and persistence of multidrug resistance in aquatic environments. Using a 90-day laboratory evolution experiment with Escherichia coli , we demonstrate that while ROX alone induced moderate resistance (e.g., 6.2-fold increase in minimum inhibitory concentration (MIC) for chloramphenicol), co-exposure with Zn and Cu synergistically drove multidrug tolerance to nine antibiotics and selected for stable, heritable resistance to chloramphenicol, tetracycline, and kanamycin (up to 8.2-fold MIC increase). This robust resistance persisted even after pollutant removal, highlighting a significant long-term threat to water quality and public health via the dissemination of resilient AMR bacteria from agricultural sources. Co-exposure intensified oxidative stress-induced mutagenesis and selected for key adaptive strategies enhancing bacterial survival and AMR persistence in contaminated water. These include upregulated efflux pumps, increased secretion of extracellular polymeric substances (1.1-3.2-fold), enhanced motility (1.1-1.5-fold), and cell filamentation (lengths 2.4-8.2-fold greater). These findings illuminate a potent, previously underestimated environmental pathway where mixtures of common agricultural pollutants in wastewater synergistically select for persistent multidrug resistance. This research underscores the urgent need to revise water quality criteria and wastewater treatment paradigms to address the co-selection pressures exerted by non-antibiotic chemical mixtures in aquatic ecosystems.
研究领域:
环境微生物学
·
抗生素耐药性
·
水环境污染
·
分子生态毒理学
·
细菌进化
·
环境健康
✓ 已验证
DOI
PubMed
高影响因子
ACS Nano
·
2024
·
IF 15.8
Xiangkai Luo,Wei Deng,Fangming Sheng,Xiaobin Ren,Zishen Zhao,Chun Zhao,Yang Liu,Jialin Shi,Zeke Liu,Xiujuan Zhang,Jiansheng Jie
Human vision excels in perceiving nighttime low illumination due to biological feedforward adaptation. Replicating this ability in biomimetic vision using solid-state devices has been highly sought after. However, emulating scotopic adaptation, entailing a confluence of efficient photoexcitation and dynamic carrier modulation, presents formidable challenges. Here, we demonstrate a low-power and bionic scotopic adaptation transistor by coupling a light-absorption layer and an electron-trapping layer at the bottom of the semiconducting channel, enabling simultaneous achievement of efficient generation of free photocarriers and adaptive carrier accumulation within a single device. This innovation empowers our transistor to exhibit sensitivity-potentiated characteristics after adaptation, detecting scotopic-level illumination (0.001 lx) with exceptional photosensitivity up to 103 at low voltages below 2 V. Moreover, we have successfully replicated diverse scotopic vision functions, encompassing time-dependent visual threshold enhancement, light intensity-dependent adaptation index, imaging contrast enhancement for nighttime low illumination imaging, opening an opportunity for artificial night vision.
研究领域:
电子学
·
光子学
·
仿生学
·
成像技术
·
半导体器件
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Marine Drugs
·
2021
·Vol. 19
·期 11
·596
·
IF 5.118
Lin-Lin Zhang,Xiao-Hua Jiang,Xin-Feng Xiao,Wen-Xiu Zhang,Yi-Qian Shi,Zhi-Peng Wang,Hai-Xiang Zhou
(1) Background: Chitooligosaccharides (COS) have numerous applications due to their excellent properties. Chitosan hydrolysis using chitosanases has been proposed as an advisable method for COS preparation. Although many chitosanases from various sources have been identified, the cold-adapted ones with high stability are still rather rare but required. (2) Methods: A novel chitosanase named CsnY from marine bacteriumRenibacteriumsp. Y82 was expressed inEscherichia coli, following sequence analysis. Then, the characterizations of recombinant CsnY purified through Ni–NTA affinity chromatography were conducted, including effects of pH and temperature, effects of metal ions and chemicals, and final product analysis. (3) Results: The GH46 family chitosanase CsnY possessed promising thermostability at broad temperature range (0–50 °C), and with optimal activity at 40 °C and pH 6.0, especially showing relatively high activity (over 80% of its maximum activity) at low temperatures (20–30 °C), which demonstrated the cold-adapted property. Common metal ions or chemicals had no obvious effect on CsnY except Mn2+and Co2+. Finally, CsnY was determined to be an endo-type chitosanase generating chitodisaccharides and -trisaccharides as main products, whose total concentration reached 56.74 mM within 2 h against 2% (w/v) initial chitosan substrate. (4) Conclusions: The results suggest the cold-adapted CsnY with favorable stability has desirable potential for the industrial production of COS.Keywords:chitosanase;cold adaptation;chitooligosaccharide;Renibacteriumsp.
研究领域:
生物化学
·
生物技术
·
海洋生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Autophagy
·
2025
·
IF 14.3
Minghong Leng,Fenghe Yang,Junhui Zhao,Yufei Xiong,Yiqing Zhou,Mingyang Zhao,Shi Jia,Limei Liu,Qiaoxia Zheng,Lebin Gan,Jingjing Ye,Ming Zheng
Endurance exercise triggers adaptive responses especially in slow-twitch myofibers of skeletal muscles, leading to the remodeling of myofiber structure and the mitochondrial network. However, molecular mechanisms underlying these adaptive responses, with a focus on the fiber type-specific perspective, remains largely unknown. In this study we analyzed the alterations of transcriptomics and metabolomics in distinct skeletal myofibers in response to endurance exercise. We determined that genes associated with sphingolipid metabolism, namely those encoding SPHK1, S1PR1, and S1PR2, are enriched in slow-twitch but not fast-twitch myofibers from both mouse and human skeletal muscles, and found that the SPHK1-S1PR pathway is essential for adaptive responses of slow-twitch to endurance exercise. Importantly, we demonstrate that endurance exercise causes the accumulation of ceramides on stressed mitochondria, and the mitophagic degradation of ceramides results in an increase of the sphingosine-1-phosphate (S1P) level. The elevated S1P thereby facilitates mitochondrial adaptation and enhances endurance capacity via the SPHK1-S1PR1/S1PR2 axis in slow-twitch muscles. Moreover, administration of S1P improves endurance performance in muscle atrophy mice by emulating these adaptive responses. Our findings reveal that the SPHK1-S1P-S1PR1/S1PR2 axis through mitophagic degradation of ceramides in slow-twitch myofibers is the central mediator to endurance exercise and highlight a potential therapeutic target for ameliorating muscle atrophy diseases.Abbreviations CQ: chloroquine; DMD: Duchenne muscular dystrophy; EDL: extensor digitorum longus; FCCP: carbonyl cyanide p-trifluoromethoxyphenyl hydrazone; FUNDC1: FUN14 domain containing 1; GTEx: genotype-tissue expression; MYH: myosin heavy chain; mtDNA: mitochondrial DNA; PPARGC1A/PGC-1α: peroxisome proliferator activated receptor, gamma, coactivator 1 alpha; RG: red gastrocnemius; S1P: sphingosine-1-phosphate; S1PR: sphingosine-1-phosphate receptor; Sol: soleus; SPHK1: sphingosine kinase 1; TA: tibialis anterior; WG: white gastrocnemius
研究领域:
运动生理学
·
分子生物学
·
代谢组学
·
肌肉生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TRENDS IN MICROBIOLOGY
·
2022
·
IF 18.23
Noreen Ashraf,Fiaz Ahmad,Yandu Lu
Microalga–microbiome interactions are central to both health and disease of aquatic environments. Despite impressive advances in deciphering how microorganisms participate in and impact aquatic ecosystems, the evolution and ecological involvement of microalgae and the microbiome in polluted waters are typically studied independently. Here, the phycosphere (i.e., the consortia of microalgae and the related microbiome) is regarded as an independent and integrated life form, and we summarize the survival strategies exhibited by this symbiont when exposed to anthropogenic pollution. We highlight the cellular strategies and discuss the modulation at the transcriptional and population levels, which reciprocally alters community structure or genome composition for medium-term acclimation or long-term adaptation. We propose a ‘PollutantBiome’ concept to help the understanding of microalga–microbiome interactions and development of beneficial microbial synthetic communities for pollutant remediation.
研究领域:
环境科学
·
微生物学
✓ 已验证
DOI
PubMed
高影响因子
Nano Research
·
2023
·Vol. 17
·期 4
·3120-3129
·
IF 9.9
Hu Lulin,Yu Xinxin,Hao Jingcheng,Xu Lu
Owing to their low flexibility, poor processability and a lack of responsiveness, inorganic materials are usually non-ideal for constructing a living organism. Hence, to date, lifelike materials with structural hierarchies and adaptive properties usually rely on light and soft organic molecules, although few exceptions have been acquired using two-dimensional (2D) inorganic nanosheets. Herein, with a systematic study on the gelation behavior of carbon-based 0D quantum dots, 1D nanotubes, and 3D fullerenes, we find that acidified 1D carbon nanotubes (CNTs) can serve as an alternative building block for fabricating purely inorganic biomimetic soft materials. The as-prepared CNT gels exhibit not only a pH- or photothermal-triggered mechanical and tribological adaptivity, which allows them to simulate the behavior of sea cucumbers, peacock mantis shrimps, and mammalian muscles or cortical bones, but also a unique damping property that is similar to spider’s cuticular pad. Their high elasticity, effective lubrication, excellent biocompatibility, and controllable friction and wear also allow them to function as a new type of smart lubricants, whose tribological properties can be regulated either by its internal pH changes or spatiotemporally by near-infrared (NIR) light irradiations, free of any toxic and flammable base oils or additives.
研究领域:
材料科学
·
纳米技术
·
柔性机器人
·
仿生学
·
摩擦学
✓ 已验证
DOI
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2021
·
IF 5.89
Li Bingyu,Hou Chaofan,Ju Xian,Feng Yong,Ye Zhi-Qiang,Xiao Yunzhu,Gu Mingyao,Fu Chunxiang,Wei Chaoliang,You Conghui
Motility is finely regulated and is crucial to bacterial processes including colonization and biofilm formation. There is a trade-off between motility and growth in bacteria with molecular mechanisms not fully understood. Hypermotile Escherichia coli could be isolated by evolving non-motile cells on soft agar plates. Most of the isolates carried mutations located upstream of the flhDC promoter region, which upregulate the transcriptional expression of the master regulator of the flagellum biosynthesis, FlhDC. Here, we identified that spontaneous mutations in clpX boosted the motility of E. coli largely, inducing several folds of changes in swimming speed. Among the mutations identified, we further elucidated the molecular mechanism underlying the ClpXV78F mutation on the regulation of E. coli motility. We found that the V78F mutation affected ATP binding to ClpX, resulting in the inability of the mutated ClpXP protease to degrade FlhD as indicated by both structure modeling and in vitro protein degradation assays. Moreover, our proteomic data indicated that the ClpXV78F mutation elevated the stability of known ClpXP targets to various degrees with FlhD as one of the most affected. In addition, the specific tag at the C-terminus of FlhD being recognized for ClpXP degradation was identified. Finally, our transcriptome data characterized that the enhanced expression of the motility genes in the ClpXV78F mutations was intrinsically accompanied by the reduced expression of stress resistance genes relating to the reduced fitness of the hypermotile strains. A similar pattern was observed for previously isolated hypermotile E. coli strains showing high expression of flhDC at the transcriptional level. Hence, clpX appears to be a hot locus comparable to the upstream of the flhDC promoter region evolved to boost bacterial motility, and our finding provides insight into the reduced fitness of the hypermotile bacteria.
研究领域:
微生物学
·
分子生物学
·
遗传学
·
细菌遗传学
·
细菌生理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Min Mao,Qiangli Zhao,Jiahao Kang,Qiang Mu,Jie Tao,Xiaoliang Zhao,Xinhai He,Jianwei Li
Green cellulose-based triboelectric materials are increasingly in demand for self-powered flexible sensors and energy harvesting applications. However, cellulose exhibits low polarity, limited surface charge generation capacity, weak positive triboelectric properties, and susceptibility to excessive hydration in high-humidity environments, leading to poor structural stability, charge dissipation, and consequently reduced triboelectric performance. In this study, microcrystalline cellulose was utilized as the matrix, while polyethyleneimine and Fe 3+ were incorporated with ethanol fumigation to construct recyclable, biodegradable, and biocompatible composite films. These films feature multi-crosslinked structures and abundant surface/interface morphologies. Ethanol fumigation enhanced the triboelectric output voltage of the film-based TENG by 198 % (248.3 V). The TENG demonstrated exceptional pressure sensitivity (3.136 V/N), high-humidity sensing capability (80–98 % RH, 3.8 V/RH), humidity adaptability, and fatigue resistance (98 % RH, 21,000 cycles). The TENG could simultaneously power up to 500 LEDs and shows potential applications in human health monitoring and intelligent recognition. This study proposes a convenient and scalable strategy to enhance both the triboelectric output and humidity adaptability of cellulose-based triboelectric materials, effectively expanding their practical applications.
研究领域:
材料科学
·
能源技术
✓ 已验证
DOI
高影响因子
FOOD CHEMISTRY
·
2018
·
IF 4.946
Zhen Qin,Qiming Chen,Si Lin,Sa Luo,Yongjun Qiu,Liming Zhao
Chitooligosaccharide is widely used as a functional food additive and a valuable pharmacological agent. The transformation of chitinous biomass into valuable bioactive chitooligosaccharides is one of the most exciting applications of chitosanase. A novel glycoside hydrolase (GH) family 46 chitosanase (GsCsn46A) from rhizobacterium Gynuella sunshinyii was cloned and heterologously expressed in Escherichia coli . GsCsn46A showed maximal activity at pH 5.5 and 30 °C. GsCsn46A featured remarkable cold-adapted property, which controllably hydrolyzed chitosan to three types of chitooligosaccharides at the mild reaction condition (reaction condition: pH 5.5 at 30 °C; method for stopping the reaction: 50 °C for 30 min). The yields of three types of chitooligosaccharides products (degree of polymerization (DP): 2–7, 2–5 and 2–3) were 70.9%, 87.1% and 94.6% respectively. This novel cold-adapted chitosanase provides a cleaner production process for the controllable preparation of chitooligosaccharides with the specific DP.
研究领域:
生物化学
·
酶工程
·
食品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）