In the present work, molecular imprinting silica xerogel (MISX) with selective recognition function aiming to regulate drug therapy was synthesized using biomimetic method with poly(ethyleneimine)s (PEIs) as the polymer template and levorotatory ofloxacin (LOFL) as recognition template. Ultraviolet spectroscopy wavelength scanning was used to test the removal process of LOFL, and characteristics of selective loading ofloxacin (OFL) into MISX were investigated using Fourier transform infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC). Molecular recognition functionality of MISX was intensively studied, including OFL loading and release. The results suggested that MISX possessed ability to recognize and selectively adsorb LOFL into MISX in OFL aqueous solution. Amorphous phase of adsorbed molecules contributed to molecular recognition because amorphous state increased the stability of LOFL that were selectively adsorbed into MISX, which induced stronger hydrogen bonding formed between LOFL and MISX so as to improve LOFL recognition ability. In vitro release revealed that OFL-MISX tablet initially released LOFL and later gradually OFL into dissolution medium. Thus conversion of drug release with different pharmacological activity had special value in delivering systems.
Changling Yan,Jin Li,Tingting Meng,Xun Liu,Ruixing Zhang,Yujuan Chen,Gongke Wang
A simple and reliable method was proposed for rapid detecting ciprofloxacin, based on molecularly imprinted technology. The molecularly imprinted ciprofloxacin hydrochloride (CPX) sensor was prepared by electropolymerization of pyrrole (Py) and o-phenylenediamine (o-PD) on the pencil graphite electrode (PGE). The performance of the sensor was characterized by square wave voltammetry (SWV) using potassium ferricyanide as molecular probe. Under optimal conditions, the sensor displayed high selectivity and stability towards CPX. A linear relationship between the change in current (Δi) and the logarithm of CPX concentrations from 1×10 −9 to 1×10 −3 mol/L was obtained with a detection limit of 7.58×10 −11 mol/L (S/N=3). Furthermore, the MIP sensor was applied for the analysis of real tablet samples with high accuracies.
危险品化学品经营许可证（带存储）