INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Yanzhen Lou,Xinxiang Chai,Minglin Ji,Yanfang Sun,Foziljon M. Turakulov,Khaydar E. Yunusov,Guohua Jiang
In this study, a dual-network, dynamically cross-linked composite hydrogel was developed for wound closure and healing. The combined action of dopamine iron coordination reaction and Schiff base linkage between dopamine-modified oxidized hyaluronic acid (OHA) and polyacrylamide (PAM) was employed to form a dual-network, dynamically cross-linked structure in hydrogel. Then viscid germander herb (Vgb) extracted from total saponins was incorporated into the composite hydrogel to fabricate hydrogel wound dressing. The resultant hydrogel wound dressing demonstrated good biocompatibility in accelerating cell proliferation and migration. In vivo results demonstrated that compared with commercial dressings, the resultant hydrogel wound dressing facilitated wound healing on an infected full-thickness skin defect model by upregulating the gene expression of growth factors such as CD-31 and downregulating that of inflammatory factor IL-6. The transcriptomic results revealed that the biological mechanism by which Vgb regulated NF-κB and the innate immune system signaling pathways in the wound closure and healing processes.
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ANALYTICA CHIMICA ACTA
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2026
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IF 6.1
Haoyuan Deng,Shan Li,Chunfei Bao,Daoyuan Zhao,Yubin Ding
Background Although sensor arrays are powerful for discriminating glycosaminoglycans, the construction of a sensor array is usually cost and labour inefficient. With the purpose to acquire a high dimensional response data using only a limited number of dyes, the rational assembly of fluorescent dye molecules may provide an alternative approach. We envision that co-assembling different dyes within a supramolecular structure can trigger multiple photophysical processes, which should produce high dimensional optical signals. Results A supramolecular AIEgen-porphyrin co-assembly is synthesized by assembling a negatively charged AIEgen ( TPE ) and meso-tetra(4-carboxyphenyl)porphine ( TCPP ) on the surface of a cationic polymer saying poly(diallyldimethylammonium chloride) ( PDDA ). With the co-assembly strategy, the aggregation-induced emission of TPE , the aggregation-caused quenching characteristic of TCPP , and especially, the Förster Resonance Energy Transfer efficiency from TPE to TCPP can be manipulated by a dynamic dye assembly approach. A sensor array is thus readily constructed by varying the loading ratio of TPE and TCPP on the surface of PDDA . Significance The sensor array is determined to be powerful for pattern recognition of various glycosaminoglycans even in 100% serum media through competitive compaction or removal of the aggregated TPE and TCPP dyes on the PDDA surface. It can be successfully applied for accurate and reliable detecting trace GAG analogues in Hep samples and identifying unknown GAG samples with an accuracy of 96.88%.
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Drug Delivery and Translational Research
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2026
·
IF 6.9
Lin Bixia,Fan Fangfei,Xu Hui,Li Xin,Li Yufei,Qin Chunya,Zhang Xiaoyun,Zhang Shiqiang,Gao Yang,Niu Lirong
Fungal keratitis (FK) is a severe ocular disease that may cause blindness in severe cases. The only FDA-approved first-line treatment drug is natamycin (NAT). However, NAT bioavailability is less than 2% due to special environment of the eye. To address this issue, hydroxypropyl-β-cyclodextrin (HPCD) was applied in this study to form a hydrophilic coating on the surface of nanoparticles. The FTIR analysis suggested interactions between HPCD and the nanoparticle components, which may contribute to the enhanced colloidal stability. As a result, the nanoparticles with a hydrophilic membrane (F2) demonstrated more superior stability than the plain nanoparticle (F1). Furthermore, compared to the NAT suspension, surface wetting of F2 enhanced significantly, the cumulative drug release reduced by 27.34% at 72 h, isolated corneal permeability increased 2.89-fold, as well as protein binding was upgraded 6.1-fold at 30 s. Subsequently, F2 was incorporated into a temperature- and osmolarity dual-responsive ophthalmic gel (Tem-Osm gel). The Tem-Osm gel behaved a shear-thinning non-Newtonian fluid, which exhibited excellent biocompatibility and higher ocular bioavailability. Moreover, the in vitro antifungal experiments demonstrated that F2 and Tem-Osm gel exhibited more superior antifungal activity, lower MIC/EC50 values and larger inhibition zones than the NAT suspension. Overall, the study indicates that the novel combination of nanoparticle and multi-responsive ocular gel sustained-release delivery system holds promising potential as a therapeutic approach for fungal keratitis.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Xiaorui Chen,Xiao Xiao,Wei Zhao,Bin Liu,Hongzhou Lian,He Ding,Piaoping Yang,Ping'an Ma,Lingjie Song,Shifang Luan,Ziyong Cheng,Jun Lin
Biomineralization of bacterial as a ultrasound (US)-triggered CO generator. • Engineered bacteria can decompose through acid-response in tumor microenvironment. • Self-supplying H 2 O 2 , amelioration of hypoxia, Ca 2+ -induced mitochondria damage. • US-triggered CO release for apoptosis in tumor cells. • Activating anti-tumor immune responses for significant inhibition of tumor growth. Carbon monoxide (CO) gas therapy is emerging as a highly promising strategy in cancer treatment. However, the tumor-targeted delivery and on-demand release of CO remain formidable challenges, and monotherapeutic efficacy is inherently limited. To address these issues, we report a self-guided “CO-releasing bomb” constructed by armoring Escherichia coli ( E. coli ) with 3-hydroxyflavone-D-alanine (HF-D-Ala) and calcium peroxide (CaO 2 ) nanoparticles (EHC). Upon reaching the acidic, hypoxic tumor microenvironment (TME), CaO 2 instantly generates Ca 2+ and H 2 O 2 ; the bacterium then self-catalyzes H 2 O 2 to produce a local O 2 burst. Subsequent ultrasound irradiation triggers HF-D-Ala to liberate a high concentration of CO owing to the O 2 -rich environment, selectively damaging tumor-cell mitochondria and inducing apoptotic death. Moreover, the O 2 generation alleviates tumor hypoxia and reverses the immunosuppressive TME. Concurrently, E. coli antigens promote dendritic cell maturation and enhance T-lymphocyte recruitment and infiltration. In vivo studies demonstrate that the EHC under US irradiation significantly suppresses tumor growth and potently activates antitumor immunity. These findings provide compelling evidence to support the potential application of combined CO gas therapy and immunotherapy for in vivo tumor treatment. Download: Download high-res image (58KB) Download: Download full-size image
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Chemosensors
·
2026
·Vol. 14
·期 2
·51
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IF 4.4
Nana Ma,Xueling Dong,Ruinan Li,Chuang Du,Yawen Wang,Jiaxin Bai,Run Ran,Xulin Liu,Dianshuo Zhang,Haikui Zou
Heparin (Hep) and its clinical antidote protamine (PRO) play essential yet antagonistic roles in anticoagulant therapy, necessitating reliable analytical tools to monitor their levels and interactions. Herein, we report that coptisine chloride (COP), a natural isoquinoline alkaloid, acts as an aggregation-induced emission (AIE) sensor enabling dual-responsive fluorescence modulation toward Hep and PRO. Owing to its rigid polycyclic and intrinsically twisted molecular framework, COP displays typical AIE behavior. In a DMSO/PBS mixture (PBS fraction = 99%,v/v), COP forms strongly emissive aggregates with Hep through electrostatically driven complexation, allowing sensitive Hep detection with a limit of detection (LOD) of 0.70 μg/mL. Subsequent competitive binding of PRO to Hep disrupts the COP–Hep aggregates, giving rise to fluorescence quenching and reversible PRO sensing (LOD: 0.49 μg/mL). Theoretical calculations together with multiple characterization techniques reveal an aggregation–disaggregation mechanism governing the dual fluorescence modulation. Moreover, COP achieves accurate Hep quantification in spiked diluted human serum, affording satisfactory linearity and recoveries (LOD = 0.71 μg/mL; recoveries 98.3–101.6%). These results demonstrate that COP, a structurally simple natural AIE luminogen, serves as a sustainable, biocompatible, and accessible tool for reversible Hep and PRO analysis in complex media.
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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2026
·Vol. 123
·期 3
·e2519305123
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IF 9.1
Yujie Yang,Huasheng Tian,Aixin Song,Lu Xu,Jingcheng Hao
Assembly of liquid droplets into ordered patterns and architectures has gained great interests in recent years in view of its tremendous prospects in achieving advanced biological, biochemical, and biomimetic functions. Nevertheless, current assembly techniques using lipids or colloidal particles are generally of complicated preparations, long periods, and limited droplet sizes. Here, we develop a simple and ultrafast route to assemble macroscopic water droplets into three reconfigurable structures defined as “connection”, “arrest coalescence”, and “total coalescence”, respectively, in dodecane using jammed nanoparticle surfactant films (termed as “POSS surfactants”) with tunable interfacial properties. Further with the POSS surfactants facilitating a sturdy and nearly instant connection between the macrodroplets, they can act as one kind of compartmentalized 3D printing inks for constructing all-liquid patterns and more integrated, sophisticated architectures capable of functioning as microreactors for transporting cargo molecules over controlled macroscale distances and dimensions. Our study can serve as a useful complement to conventional approaches that are normally used for assembling microsized droplets.
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FOOD RESEARCH INTERNATIONAL
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2026
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IF 8.8
Qian Wang,Xuan Liu,Daohang Xing,Lihan Jian,Zhichun Yang,Xiaoqin Wang,Linjuan Huang,Zhongfu Wang
Complex-structured pectin polysaccharides are efficient natural food-grade emulsifiers and stabilizers. However, the relationship between the structure features of pectin polysaccharides from different plant sources and their emulsifying properties remains unclear, limiting the fabrication of stable pectin emulsions and their application. In this study, pectin polysaccharides were extracted from sunflower disk, beet root, apple pomace, grapefruit peel and citrus peel. Of the five polysaccharides, citrus pectin (CP) was found to exhibit the best emulsifying performance, which was attributed to its higher content of polysaccharides-covalently bound protein, higher degree of methyl-esterification, and higher branching degree in RG-I region. CP emulsions with varying CP concentrations (c) and oil volume fractions (φ) were prepared and analyzed for the structure and stability. When φ ≤ 30%, 2.0% CP emulsion with smaller particle size exhibited higher storage stability. When φ > 30%, the stability of 1.0% CP emulsion was relatively higher. In particular, c2.0%-φ20% emulsion exerted the highest stability against heating and ionic strength, which also had a high encapsulation efficiency (84.09% ± 0.53) for Lycium barbarum extract (LBE). LBE-loaded CP emulsion showed no cytotoxicity, and demonstrated higher antioxidant activity and inhibition rates against tyrosinase, elastase and hyaluronidase activities, which holds promise as a novel anti-aging emulsion for cosmetic application.
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JOURNAL OF PHYSICAL CHEMISTRY B
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2026
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IF 3.2
Tao Zhu,Xujing Zhang,Yan Xu,Wu Wang,jiahao Ma,Zhitao Yin,Yutong Chen
This study prepared a composite hydrogel using polyethylene glycol diacrylate (PEGDA) and 2-acrylamido-2-methylpropanesulfonic acid (AMPS) as raw materials, aiming to investigate the relationship between its hydration lubrication mechanism and friction behavior. By adjusting the mass fractions of PEGDA and AMPS, the hydrogel’s mechanical properties were matched to those of articular cartilage, achieving a compressive modulus of 3.63 MPa. Friction tests revealed that the hydrogel exhibited a low coefficient of friction, consistently maintained within the range of 0.01–0.03 under various frequencies and load conditions, while demonstrating excellent lubrication stability throughout 7200 cycles of testing. Wetting and swelling tests demonstrate that AMPS effectively enhances the hydrogel’s hydrophilicity while suppressing swelling, simultaneously increasing the bound water content within the system. Molecular dynamics simulations validate the excellent compatibility between PEGDA and AMPS. Constrained shear simulations reveal the hydrated lubrication layer’s crucial role in mitigating shear stress, dispersing heat dissipation, and maintaining lubrication stability.
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PACKAGING TECHNOLOGY AND SCIENCE
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2026
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IF 4.7
Jianfu Qiao,Biyang Ling,Kunning Wu,Xinyi Han,Yin Liu,Qi Wang
Developing safe, non-toxic and high-efficiency coating materials for food preservation has become a critical research focus in the field of food packaging. In this study, a catechaldehyde-cross-linked gelatin/sodium hyaluronate (GHAP) composite coating was engineered to improve the antibacterial and antioxidant functionalities of gelatin. By optimizing the cross-linking ratio, a GHAP4 film with superior overall properties was obtained. Fourier transform infrared (FTIR) analysis confirmed that the aldehyde groups of catechaldehyde participated in cross-linking reactions with the amino groups of the gelatin–sodium hyaluronate matrix. The GHAP4 film exhibited excellent antioxidant activity, achieving a DPPH radical scavenging rate of 96.8%, and showed strong antibacterial effects against Escherichia coli and Staphylococcus aureus . Furthermore, cytotoxicity tests suggested that all concentrations of GHAP4 solution exhibited cell viability exceeding 100%. Zebrafish toxicity tests showed that the GHAP film had no significant toxicity to zebrafish, with no deformities or deaths observed. Preservation experiments using strawberries as a model sample showed that the GHAP4 coating effectively slowed down changes in colour, titratable acidity and soluble solid content, extending the shelf life from 4 to 8 days. This study provides new ideas and a theoretical basis for the application of natural polymer-based functional coatings in fruit and vegetable preservation.
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Advanced Healthcare Materials
·
2026
·
IF 11
Xueqiang Deng,Zhiqiang Li,Xuan Yi,Dong Ruan,Xiang Chen,Jun Luo
Osteoporosis poses a significant threat to human health and severely impairs patients' quality of life. Conventional pharmacological interventions are limited by poor patient compliance and suboptimal efficacy. Imbalanced macrophage polarization is a key driver in osteoporosis pathogenesis, and precise regulation toward the anti-inflammatory M2 phenotype represents a critical therapeutic target. A calcium-polyphenol network-functionalized black phosphorus nanosheet system (HCBP) is developed as a bone-targeted cascade-responsive nanoplatform. After intravenous administration, bone-targeting peptides mediate efficient accumulation in bone tissue. The system dissociates in the acidic osteoporotic microenvironment and releases phosphate ions, which combine with calcium ions to form bioactive calcium phosphate. HCBP alleviates inflammation, sustains M2 macrophage polarization, scavenges reactive oxygen species, enhances osteogenesis, and suppresses osteoclast differentiation. Transcriptomic analysis confirms regulation of the TNF-α/NF-κB, IL-17, and osteoclast differentiation pathways, together with inhibited glycolysis. This multifunctional strategy overcomes the limitations of single-target osteoporosis therapies and facilitates the clinical translation of nanomedicines for metabolic bone diseases.
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ACS Applied Materials & Interfaces
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2026
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IF 7.8
Wenting Du,Lu Yu,Yuanyuan Liu,Jieyi Fu,Siyi Li,Yin Yi,Yu Shu,Gang Wang,Pengfei Zhou,Panpan Liang,Xiaohong Wu
Patients’ quality of life is severely compromised by full-thickness oral mucosal abnormalities, and traditional treatment approaches are severely hampered by the dynamic wet environment and tissue heterogeneity. Hydrogels have demonstrated remarkable efficacy in promoting skin wound repair; however, their ability to adhere effectively and sustain functionality within the oral cavity remains inadequate. This work used hyaluronic acid (HA), 3-aminophenylboronic acid (3-APBA), tannic acid (TA), and deferoxamine (DFO) as major components to create a multifunctional hydrogel called HPTA@DFO (abbreviated as HTD), which was inspired by the wet adhesion mechanism of marine mussels. This system was created using dynamic covalent cross-linking (Schiff base and borate ester linkages), which gave it tissue-conformable adhesive qualities, injectability, and the ability to heal itself. The antibacterial, antioxidant, anti-inflammatory, and pro-angiogenic properties of the HTD hydrogel were confirmed by experimental data. In a rat model of full-thickness oral mucosal defects, the HTD hydrogel effectively promoted wound healing and tissue regeneration, demonstrating good biocompatibility. This work offers an innovative design approach and experimental basis for creating intelligent dressings appropriate for the intricate oral environment.
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Food Bioscience
·
2026
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IF 6.2
Hang Si,Qinggele Borjihan,Xin Li,Hairihan Li,Changming Zhang,Yongfu Chen
Ready-to-use probiotics have shown promising safety and patient acceptability in inflammatory bowel disease (IBD), yet their efficacy is limited by poor tolerance and inadequate targeting. Here, we developed a dual-precisely engineered prebiotic coating for the robust probiotic Lacticaseibacillus rhamnosus Probio-M9. The coating features an inner tannic acid–iron (Fe/TA) network for reactive oxygen species (ROS) scavenging and an outer hyaluronic acid (HA) layer that enables targeted binding to inflamed mucosa and enhances epithelial adhesion. This synergistic design alleviates inflammation, repairs the epithelial barrier, modulates gut microbiota, and ultimately achieves superior therapeutic outcomes in IBD. This strategy provides a new perspective and a feasible path for probiotic-based IBD intervention research.
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