JOURNAL OF APPLIED POLYMER SCIENCE
·
2023
·Vol. 140
·期 12
·e53640
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IF 3
Zezhen Zhang,Shuman Feng,Qianyu Wei,Lili Wu
Low dialysis and blood incompatibility efficiency are key issues to be addressed for polymeric hemodialysis membranes. To improve the comprehensive performance of hemodialysis membranes, polyethersulfone (PES)/tannic acid (TA) coblended ultrafiltration membranes were prepared and modified with a heparin-like functionalized TA coating. The coblended TA improved the pore structure of the PES ultrafiltration membrane. And it could also undergo π-π conjugation with the heparin-like functionalized TA in the modified solution, resulting in a greater abundance of modified groups loaded on the membrane surface and pores close to the surface. The modified coating further improved the membrane performance. The physicochemical properties, solute filtration, and blood compatibility properties of the membrane were tested. The effect of TA on the pore structure of the membrane and the presence of modified layers were demonstrated by morphological and chemical structure analyses. The final modified membrane had an ultrahigh water flux (1053 L/m 2 ·h), improved dialysis performance (BSA retention >99%, Lysozyme clearance >30% and Urea clearance >90%), and excellent hemocompatibility (The hemolysis rate was 1.31%, and APTT, PT, and TT values were increased by 40.8%, 74.2%, and 85.9%, respectively). This study shows that TA has great potential for improving the pore structure of polymeric membranes.
研究领域:
材料科学
·
医学工程
·
生物医学
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产品关联
DOI
高影响因子
ACS Biomaterials Science & Engineering
·
2016
·
IF 0
Zhu Xiong,Fu Liu,Haibo Lin,Jinglong Li,Yi Wang
The hemocompatibility of the dialysis membrane has been considered the key factor influencing the dialysis performance for curing the kidney malfunction. In this work, the commonly used anticoagulant heparin in the clinic was directly bonded to the poly(lactic acid) (PLA) membrane to improve the hemocompatibility via the glycidyl ether reaction. A novel precopolymer P(VP-VTES-GMA) was first prepared via free radical polymerization. The surface cross-linking of the precopolymer containing GMA segments enabled the membrane to anchor heparin through the glycidyl ether reaction. The chemical structure of the precopolymer was confirmed by 1H NMR. The surface chemistry was analyzed by XPS, toluidine blue staining, and solubility tests. The crystallization behavior, heat resistance, morphology, hydrophilicity, pore size, and pure water flux were investigated. The hemocompatibility was comprehensively investigated via APTT, PRT, PT, FIB, and platelet adhesion tests. The simulated dialysis performances relating to urea, creatinine, lysozyme, and BSA clearance were measured. All results demonstrated that the covalent bonding of heparin provided the PLA membrane with excellent hemcompatibility, hydrophilicity, heat resistance, and dialysis performance as well.
研究领域:
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
JOURNAL OF MEMBRANE SCIENCE
·
2013
·
IF 4.093
Ailin Gao,Fu Liu,Lixin Xue
Bio-based poly (lactic acid) membrane with asymmetric porous structure was developed for hemodialysis via phase inversion for the first time. Heparin was immobilized to PLA membrane surface through the strong adhesion ability of dopamine, as confirmed by attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy and X-ray photoelectron spectroscopy (XPS) respectively. The morphologies variations of PLA membranes induced by dopamine coating and heparin immobilization were analyzed by scanning electron microscope (SEM) and atomic force microscopy (AFM). Hydrophilicity and permeability of PLA membranes before and after modification were characterized. Particularly, platelet adsorption, plasma recalcification time and hemolysis ratio were executed to evaluate the blood compatibility of PLA membranes decorated by heparin. The in vitro results demonstrated that surface heparinization improved the hemocompatibility of PLA membrane, suppressed the adhesion of platelet, extended plasma recalcilication time, and also decreased hemolysis ratio. The dialysis simulation experiments including urea and lysozyme clearance as well as bovine serum albumin (BSA) rejection were implemented to determine the dialysis performances. The results showed that 79% of urea and 18% of lysozyme were cleaned and over 90% of BSA was retained. This study disclosed a window of opportunity to produce novel hemodialysis membranes using bio-based materials.
研究领域:
生物医学工程
·
材料科学
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产品关联
DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 95
·78306-78314
·
IF 3.84
Xuemin Yu,Fu Liu,Linghui Wang,Zhu Xiong,Yunze Wang
Poly(lactic acid) (PLA) is a sustainable membrane candidate for liquid separation and purification. However, the inherent brittleness restrains its practical application, especially for a porous membrane with thin thickness and high porosity. We aim to prepare PLA membranes with controlled pore structure and dialysis performance with improved mechanical and thermal stability by incorporating polysulfone-graft-poly(lactic acid) (PSf-g-PLA) copolymer. Different from the common rubbery elastomer, the brush-like PSf-g-PLA copolymer with a rigid backbone chain and soft side chains was elaborately synthesized to toughen and modify PLA membranes via a phase inversion process. 1H NMR, FTIR and GPC were conducted to determine the structure and molecular weight of the PSf-g-PLA. The influences of chloromethylation substitution and the content of copolymer on the membrane microstructure, the mechanical and thermal stability, and the dialysis performance were investigated in detail. It was demonstrated that the modified PLA membrane exhibited a pure water flux of 54 L m−2 h−1, 95% rejection to BSA, and 65% and 18% clearance of urea and lysozyme, respectively. Besides, both mechanical and thermal stability of the modified PLA membrane were improved by incorporating brush-like PSf-g-PLA.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2024
·
IF 2.7
Xingtong Gao,Kai Liu,Wenjin Hu,Aixiang Li,Zijian Lyu,Haiqiang Chen,Hu Zhu
Currently, the incidence of kidney failure is increasing worldwide. Hemodialysis is the main method for the treatment of kidney diseases, and the continuous development of new hemodialysis membranes is the key to improve the treatment effect and the quality of life of patients. In this study, heparinized multi-walled carbon nanotube/cellulose acetate (Hep/MWCNTs@CA) membranes were prepared by non-solvent induced phase separation (NIPS). The morphology and pore structure of Hep/MWCNTs@CA membranes were characterized by scanning electron microscopy (SEM). The elongation at break and tensile strength of the membranes were characterized by a mechanical property universal tester. The results showed that mechanical properties of 0.1 wt% MWCNTs enhanced the membrane is best. The water contact angle test confirmed that MWCNTs can improve the membrane hydrophilicity, and combined with the adsorption test results for proteins, it was found that the hydrophilicity can reduce the adsorption of proteins to the composite membrane and improve the blood compatibility of the material. The dialysis performance of urea and lysozyme was tested by a self-made simulated hemodialysis device, and the clearance rates of urea and lysozyme were 84% and 47.2%, respectively, which showed that the interfacial gap between MWCNTs and CA matrix can make the composite membrane retain a high retention rate of macromolecular proteins (92.3%) and further improved the clearance rate of small and medium molecular toxins. In addition, the good blood compatibility and biocompatible properties of the materials were confirmed by hemolysis, recalcification and cytotoxicity tests on Hep/MWCNTs@CA membranes. In conclusion, the prepared Hep/MWCNTs@CA holds great potential for application in the field of hemodialysis.
研究领域:
材料科学
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医学
·
生物工程
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2018
·Vol. 9
·期 1
·1-11
·
IF 12.353
Yang Facui,Tao Fei,Li Chen,Gao Lingxiang,Yang Peng
The design and scalable construction of robust ultrathin protein membranes with tunable separation properties remain a key challenge in chemistry and materials science. Here, we report a macroscopic ultrathin protein membrane with the potential for scaled-up fabrication and excellent separation efficiency. This membrane, which is formed by fast amyloid-like lysozyme aggregation at air/water interface, has a controllable thickness that can be tuned to 30–250 nm and pores with a mean size that can be tailored from 1.8 to 3.2 nm by the protein concentration. This membrane can retain > 3 nm molecules and particles while permitting the transport of small molecules at a rate that is 1~4 orders of magnitude faster than the rate of existing materials. This membrane further exhibits excellent hemodialysis performance, especially for the removal of middle-molecular-weight uremic toxins, which is 5~6 times higher in the clearance per unit area than the typical literature values reported to date.
研究领域:
材料科学
·
化学
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生物技术
·
膜技术
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2020
·
IF 7.183
Qi Chen,Yang He,Yiping Zhao,Li Chen
Oxidative stress is a compelling risk factor during hemodialysis in patients with renal failure to elevated mortality risk. Intervening the effect of oxidative stress in the pathogenesis of dialysis-associated complications requires developing a more direct hemodialysis membrane route to prevent and relieve oxidative stress in the dialysis process. In this work, combining the anti-oxidative property of tannic acid (TA) and high biocompatibility of poly (N-acryloyl morpholine) (PACMO), the TA-PACMO functionalized poly (ether sulfone) (PES) hemodialysis membranes have been fabricated using the hydrogen-bonded layer-by-layer (HB-LbL) assembly technology. The functionalized membranes directly quenched excess reactive oxygen species, improved the serum total antioxidant capacity, and suppressed lipid peroxidation and protein glycosylation. More interestingly, the TA-PACMO functionalized hemodialysis membranes effectively protected cardiomyocytes (H9C2), and vascular endothelial cells (HUVEC) from oxidative damage the improvement of antioxidant enzymes activities such as superoxide dismutase and catalase. The introduction of PACMO indicated in considerable improvement of blood compatibility and reduction of complement activation compared to a single TA modified hemodialysis membrane. The typical toxins, including urea and lysozyme, were efficiently removed from the dialysis simulant experiment, confirming the feasibility of the TA-PACMO HB-LbL functionalized strategy. The results revealed that, with the TA-PACMO content increasing, the functionalized membranes with superior comprehensive performances had stronger anti-oxidative stress, better biocompatibility, and more efficient dialysis performance. The present work provided a promising candidate in the development and application of hemodialysis membrane against oxidative stress, which alleviated patients' complications to address the long-term hemodialysis.
研究领域:
生物医学工程
·
材料科学
·
肾病学
·
生物材料
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）