CHEMICAL ENGINEERING JOURNAL
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2021
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IF 13.273
Jiajie Chen,Yi Cao,Shiyang Lin,Huicong Niu,Hongjian Zhang,Lei Guan,Chaoqin Shu,Aijun Wu,Yuhai Bian,Yufang Zhu
Traditional therapies for melanoma suffer from many restrictions, that calls for the development of new treatments with high effectiveness and safety. Recently, employing transdermal microneedle (MN) systems for delivering therapeutic agents has obtained increasing interest as the efficient, minimally invasive, painless, and safe natures. Designing an “all-in-one” multifunctional MN system without complicated integration that can realize enhanced tumor therapy has presented huge promising for clinical application but is still a challenging strategy. Herein, a simple responsive MN system is developed for efficient anti-melanoma by combining self-enhanced chemodynamic therapy (CDT) and photothermal therapy (PTT). This MN system, constructed by biocompatible poly(vinylpyrrolidone) (PVP) as substrate and PVP-stabilized CuO 2 nanoparticles (CuO 2 NPs) as therapeutic agent, shows good skin-insertion capability and dissolving property that benefit in penetrating skin efficiently to deliver the therapeutic CuO 2 NPs into melanoma site. The released CuO 2 NPs from MN system can not only produce copper ion (Cu 2+ ) and hydrogen peroxide (H 2 O 2 ) in response to the acidic environment for catalytic hydroxyl radical ( OH) generation and thus achieve the H 2 O 2 self-supplying CDT, but also can be utilized as a glutathione (GSH)-scavenging agent for further enhancing CDT. Moreover, owing to the loading of CuO 2 NPs, such MN system exhibits excellent near-infrared (NIR) photothermal property that can induce local hyperthermia at the melanoma area for PTT. In result, the designed MN system realizes the efficient tumor inhibition with minimal side effects in vivo by the combination therapy , offering a safe and effective melanoma treatment option for patients.
研究领域:
医学
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纳米生物技术
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肿瘤治疗
✓ 已验证
DOI
高影响因子
Drug Delivery and Translational Research
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2023
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IF 5.4
Tang XiaoFei,Qin Huaiying,Zhang XiaoYun,Yang Haiyun,Yang Jianhua,Chen Ping,Jin Yinli,Yang Lu
Transdermal drug delivery systems (TDDS) have drawbacks such as poor absorption, low blood concentration, and delayed effects. Dissolving microneedle has sharp tips and short length, which overcome patients’ pain and improve transdermal efficiency but has low mechanical strength and drug loading capacity. This study thereby proposes a microemulsion-encapsulated and long-time-released transdermal microneedle (MN) delivery system with estradiol (Es) as the model drug. The microemulsion (ME) was optimized by utilizing the pseudo-ternary phase diagram and D-optimal mixture design. The estradiol microemulsion-encapsulated microneedle (Es-ME-MN) was optimized by Box–Behnken design and prepared by freeze–thaw method. The Es-ME-MN obtained was characterized and evaluated through a large variety of studies. Es-ME-MN had sufficient mechanical strength to pierce skin and was safe enough, the length of which was 600 μm, and the Es content was 177.12 ± 0.72 μg/patch without drug-excipient chemical interaction. In vitro permeation study showed that Es-ME-MN has a higher transdermal efficiency and lower retention capacity than commercial estradiol patch and conventional MN. Es plasma concentration began to increase at 3 h and remained at 12.98–23.52 ng/mL until 72 h by pharmacokinetic experiments in the Es-ME-MN group. Es-ME-MN rapidly achieves effective blood concentrations through needle puncture and microemulsion delivery and maintains blood concentrations through the baseplate long-time release. Microemulsion-encapsulated, organic solvent-free, and long-time-released transdermal microneedle will make progress and provide a new idea for transdermal delivery of lipophilic drugs. Graphical Abstract
研究领域:
药剂学
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药物递送系统
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药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 30
·6017-6028
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IF 6.331
Di Shen,Haojie Yu,Li Wang,Xiang Chen,Jingyi Feng,Qian Zhang,Wei Xiong,Jin Pan,Yin Han,Xiaowei Liu
Microneedles with insulin-loaded glucose-responsive particles are promising to control the blood glucose levels of diabetic patients. In particular, the long-term usage of these microneedles calls for biodegradable and cost-effective particles, which are still large challenges. In this paper, glucose-responsive 4-carboxy-3-fluorophenylboronic acid-grafted ε-polylysine (CFPBA-g-PL) was synthesized to meet these requirements. CFPBA-g-PL had low cytotoxicity, good hemocompatibility and no tissue reaction. The pharmacokinetics of CFPBA-g-PL were also studied. The self-assembled particles of CFPBA-g-PL were prepared via simple ultrasonic treatment. The insulin-loaded particles of CFPBA-g-PL (named INS/GRP-12.8) presented a glucose-responsive insulin delivery performance based on the disassembly-related mechanism in vitro. The INS/GRP-12.8-encapsulated microneedle patch with a uniform morphology and moderate skin penetration performance was prepared via a molding strategy. INS/GRP-12.8 lasted for more than 8 hours of normoglycemia on STZ-induced diabetic SD rats via subcutaneous injection and the INS/GRP-12.8-encapsulated microneedle patch also showed a blood-glucose-level-lowering performance in vivo via transdermal administration.
研究领域:
药学
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材料科学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED MATERIALS
·
2022
·Vol. 35
·期 10
·2208648
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IF 32.086
Tao Sheng,Rui Jin,Changwei Yang,Ke Qiu,Mingyang Wang,Jiaqi Shi,Jingyu Zhang,Yuman Gao,Qing Wu,Xin Zhou,Hao Wang,Juan Zhang,Qin Fang,Neng Pan,Yanan Xue,Yue Wang,Rong Xiong,Fei Gao,Yuqi Zhang,Haojian Lu,Jicheng Yu,Zhen Gu
Timely administration of key medications toward patients with sudden diseases is critical to saving lives. However, slow transport of first-aid therapeutics and the potential absence of trained people for drug usage can lead to severe injuries or even death. Herein, an unmanned aerial vehicle (UAV)-mediated first-aid system for targeted delivery (uFAST) is developed. It allows unattended administration of emergency therapeutics-loaded transdermal microneedle (MN) patches toward patients to relieve symptoms by a contact-triggered microneedle applicator (CTMA). The implementability and safety of the uFAST for first aid is demonstrated in a severe hypoglycemic pig model by automatically delivering a glucagon patch with immediate and bioresponsive dual release modes. This platform technique may facilitate the development of UAV-mediated first-aid treatments for other sudden diseases.
研究领域:
生物医学工程
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急诊医学
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药学
✓ 已验证
DOI
PubMed
高影响因子
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
·
2022
·
IF 1.193
Ping-Ping ZHANG,Jia-Cheng ZHU,Bo-Jun ZHAO,Sheng-Hao XU,Lei WANG,Xi-Liang LUO
Daily blood glucose monitoring is the cornerstone of diabetes management. Research efforts have been made on developing non-invasive or minimally invasive point-of-care testing system that can minimize the inconvenience of such daily test bringing to diabetes. Hereby, we develop a wearable and portable microneedle based biosensor for in situ glucose detection in an enzyme free and minimally invasive way. The photonic hydrogel film integrated inside the microneedle platform is functionalized with phenylboronic acid and displays glucose responsiveness. Presence of glucose in the chemical matrix of interstitial fluids can be distinguished with naked-eyes via the color changes of the hydrogel film. Quantification of glucose is achieved by analyzing color of hydrogel film with the facilitation of a mobile phone; thereby fast and direct diagnosis is enabled. Extraction of interstitial fluids and sensing of glucose within the psychological range was successfully demonstrated on porcine skin as human skin model. The developed microneedle platform provides a promising tool for detecting other health related analytes in an enzyme-free way with minimal invasiveness.
研究领域:
生物传感器
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糖尿病管理
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生物医学工程
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微纳加工
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智能医疗
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分析化学
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软材料
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光学传感
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可穿戴设备
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即时诊断
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）