MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Yong Li,Junjie He,Tianhu Long,Jing Liu,Yulun Nie,Shaowei Li
An MOF-based molecularly imprinted nanozyme was designed and prepared. • The nanozyme was acted as ratiometric sensor for fluorescence detection of carbaryl. • The sensor possessed the highly selectivity and sensitivity for carbaryl recognition. • The detection mechanism of MOF based nanozyme for carbaryl was investigated. Metal-organic framework (MOF) nanozymes are widely utilized in environmental pollutant detection, but their practical application is often restricted by a lack of intrinsic selectivity. To address this challenge, we developed a molecularly imprinted polymer coated Fe-MOF nanozyme (Fe-MOF@MIP) via a metal coordination and hydrogen-bonding assembly strategy. Fe-MOF@MIP integrates the peroxidase activity of Fe-MOF core with the specific recognition capability of the carbaryl-imprinted shell. And the binding of carbaryl to the specific imprinted cavities sterically blocks the surface channels, preventing the generation of reactive oxygen species and thereby modulating the fluorescence signal. Based on this inhibition mechanism, a ratiometric fluorescence sensor was constructed for sensitive detection of carbaryl with a detection limit of 0.039 μM, accompanying with the fluorescence color changing from yellow to blue under a UV lamp. More importantly, Fe-MOF@MIP exhibited high selectivity and anti-interference ability for carbaryl detection. The sensor was successfully applied to the analysis of real water and fruit samples, demonstrating their robustness. This study provides a cost-effective and simple strategy to overcome the selectivity bottleneck of nanozymes, offering a promising platform for carbaryl monitoring. Download: Download high-res image (88KB) Download: Download full-size image
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Shenghui Chen,Luming Xu,Wei Yu,Xiaobin Zhang,Shijuan Cao,Bo Liang,Ying Xu
A MIP/AuNPs/GCE electrode was constructed for simultaneous detection of CAP and MNZ. • The sensor shows a wide linear range (50–1500 μM) and low LODs of 1.70 and 2.09 μM. • Wavelet transform expands the feature dimensions of the DPV signals to enhance model prediction accuracy. • TPE-optimized XGBoost realizes accurate and robust dual-analyte concentration prediction. • The method achieves satisfactory recoveries in milk, fish, and egg real samples. Food safety concerns have increased the demand for reliable simultaneous detection of chloramphenicol (CAP) and metronidazole (MNZ), as these antibiotics are strictly regulated due to their potential health risks. However, the presence of aromatic nitro groups in both compounds poses a challenge for their simultaneous detection. In this study, an electrochemical sensor integrating electrodeposited gold nanoparticles (AuNPs) with a dual-template molecularly imprinted polymer (MIP) film was developed to achieve selective recognition and signal enhancement for both analytes. However, competitive adsorption at active sites in multi-component systems leads to nonlinear signal responses, rendering traditional linear calibration ineffective. To overcome this limitation, differential pulse voltammetry (DPV) signals were transformed into two-dimensional wavelet spectrograms, from which quantitative image features were extracted, and the necessity and robustness of these features were verified using SHAP analysis. An XGBoost regression model optimized via a Tree-structured Parzen Estimator (TPE) was subsequently constructed, yielding significantly improved predictive performance. The sensor exhibited a wide linear range for both CAP and MNZ (50–1500 μM) and low detection limits (1.70 μM and 2.09 μM, respectively). Satisfactory recoveries (89.37–107.31%) were obtained in spiked milk and fish samples. The proposed TPE-XGBoost-assisted dual-template molecular sensor provides a robust and generalizable strategy for rapid and accurate multi-residue detection in complex food matrices. Download: Download high-res image (218KB) Download: Download full-size image
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Zuyao Fu,Lingfeng Yang,Yuanyuan Zhang,Xuanjun Zhang,Jing Xie,Zhaoyang Ding
HRP was covalently immobilized on MAF to form a biocomposite with high activity and fluorescence. • HRP@MAF exhibited a remarkable fluorescence quantum yield of 97.77%. • HRP@MAF showed superior substrate affinity with a Km value 25-fold lower than HRP. • A dual-mode colorimetric/ratiometric fluorescent sensor was developed for histamine. Integrating strong fluorescence and efficient biocatalysis within a single metal-organic framework (MOF) is attractive for advanced optical sensing. Herein, a highly emissive metal-organic framework (denoted as MAF) was constructed using ligands with aggregation-induced emission (AIE) properties, followed by horseradish peroxidase (HRP) immobilization to yield HRP@MAF with high catalytic activity and strong fluorescence. The resulting HRP@MAF exhibited a fluorescence quantum yield of 97.77%. Benefiting from the high surface area and porous structure of MAF, HRP@MAF showed markedly improved stability and substrate affinity toward 3,3′,5,5′-tetramethylbenzidine (TMB), with a K m value 25-fold lower than that of free HRP. Based on its catalytic and optical properties, a colorimetric/ratiometric fluorescence sensor was developed for histamine detection with detection limits of 1.71 μM and 0.56 μM, respectively. In addition, smartphone-integrated on-site detection was achieved with linear ranges of 10–1000 μM for the colorimetric mode and 1–1000 μM for the ratiometric fluorescence mode. This work establishes an effective strategy for constructing multifunctional sensing platforms by coupling AIEgens derived highly emissive MOFs with immobilized enzymes. Download: Download high-res image (151KB) Download: Download full-size image
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ANALYTICAL CHEMISTRY
·
2026
·Vol. 98
·期 30
·22374-22386
·
IF 7.3
Bu Zhijian,Wang Linjie,Yao Yuxuan,Chen Xinyu,Tang Zheng,Du Dan,Wu Shengtao,Lin Yuehe,Liang Hao,Niu Xiangheng
As alternatives to bioenzymes, nanozymes find promising
applications
in biochemical sensing thanks to their recognized superiorities, but
their lack of specific interactions with targets of interest seriously
hinders the exploration of selective analytical strategies when no
external receptors are employed. Additionally, most nanozymes exhibit
poor catalytic efficiency, much lower than their natural counterparts,
thus restricting the sensitivity of detection. Different from the
explored “turn-off” analytical principle relying on
the coordination of the target with a nanozyme catalytic product,
here we proposed an analyte-unique “signal-on” strategy
based on the direct target–nanozyme interaction for the sensitive
sensing of uranyl via temperature-programming the peroxidase (POD)-mimetic
activity of CoO x . As wet-chemical temperature
increased, the oxygen vacancy (O V ) content on CoO x surfaces exhibited a volcano-type trend, and its
catalytic efficiency correlated with the former positively. UO 2 2+ was found to stimulate the POD-like activity
of CoO x via increasing O V ,
exhibiting excellent specificity against other common species. Leveraging
the unique CoO x –UO 2 2+ interaction and the temperature-programmed activity of CoO x , we validated a “light-up”
colorimetric approach for UO 2 2+ selective determination,
achieving a wide detection range (0.01–2 μM) and a low
limit (5 nM). A deployable device based on intelligent reading was
further fabricated to enable on-site monitoring of the analyte. Our
work provides a “signal-on” nanozyme sensing strategy
for the quantification of UO 2 2+ , featuring specific
response, catalytic signal amplification, and free from bioreceptors.
Also, it proves a facile route to achieve dual modulation of enzyme-mimetic
activity and analyte response for broader applications.
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INDUSTRIAL CROPS AND PRODUCTS
·
2026
·
IF 6.4
Yuan Li,Qingbo Xiao,Zixuan Ding,Emad M. Hafez,Wenlong Xu,Zhiyang Zhang
A light-triggered nanozyme (YTzymes) with catalase-like activity and yellow-light emission mitigates frost stress in winter oilseed rape. • YTzymes synergistically scavenge ROS and use emitted light to reprogram linoleic acid and TCA metabolism, maintaining membrane and redox homeostasis. • Foliar application (600 mg/L) enhances frost recovery, increasing shoot/root dry weight by 21.56%/11.15% and improving Ca²⁺/K⁺ homeostasis. Winter oilseed rape is a vital industrial crop, primarily cultivated for the production of vegetable oil, biodiesel, and industrial lubricants. Mitigation of frost damage in winter oilseed rape is critical for ensuring stable yields and quality. To address this challenge, we engineered a multifunctional light-triggered catalase like nanozyme (denoted as YTzymes) integrating catalase-like activity with yellow-light emission, specifically designed to counteract frost-induced adversity in winter oilseed rape. The dual-action mechanism of YTzymes underpins its efficacy:1) Intrinsic catalase-like activity directly scavenges excess reactive oxygen species (ROS) that accumulate rapidly in plant cells under frost stress, thereby alleviating oxidative damage to crop cells; 2) Yellow light emission from the nanozyme triggers targeted metabolic reprogramming, modulating linoleic acid metabolism (a key component of membrane lipids) to maintain integrity of cell membranes, while simultaneously enhancing the tricarboxylic acid (TCA) cycle flux to boost energy supply and redox homeostasis. Foliar application of 600 mg/L YTzymes solution significantly promoted frost recovery in winter oilseed rape. Compared to untreated frost-stressed plants, the dry weight of shoots and roots in the nanozyme-treated group increased by 21.56% and 11.15%, respectively, accompanied by improved cell membrane integrity. Meanwhile, the reduction of Ca 2 + concentration and increment of K + concentration could further reduce the osmotic pressure of the cell, reducing the cell dehydration in freezing conditions. This light-triggered nanozyme approach offers an efficient solution to mitigate frost damage, thereby contributing to the development of sustainable crop production under changing climate conditions. Download: Download high-res image (136KB) Download: Download full-size image YTzymes, integrating catalase-like activity and yellow-light emission, enhances frost resilience in winter oilseed rape by scavenging ROS to reduce oxidative stress and reprogramming metabolism to reinforce membrane integrity (through linoleic acid regulation) and energy supply (via TCA cycle enhancement). Foliar application of 600 mg/L YTzymes elevated shoot and root dry weights by 21.56% and 11.15%, improved ion homeostasis (Ca²⁺ reduction, K⁺ elevation), and alleviated cellular dehydration.
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Yinuo Liu,Zhengyuan Dai,Ying Wang,Shanshan Fu,Xiaoyu Yang,Jingcui Huang,Li Li,Yaping Ding
Ratiometric probe (blue/yellow CDs) offers visual color change and improved accuracy. • Molecularly imprinted polymers provide high selectivity against food interferents. • Smartphone with Color Picker App enables on-site visual quantitative detection. • Successfully applied to milk and ice cream with recoveries of 95.6–104.2%. A ratiometric fluorescence sensor (B-CDs@MIPs/Y-CDs) based on blue/yellow dual-emission carbon dots and molecularly imprinted polymers was constructed for visual detection of vanillin. The addition of vanillin resulted in selective quenching of the blue fluorescence of B-CDs at 438 nm via static quenching, whereas the yellow emission at 542 nm stayed constant, leading to a progressive color shift from blue to green and ultimately to yellow. Under optimized conditions, the linear range was 2.0–120.0 μM with a detection limit of 0.22 μM. Recoveries from spiked milk and ice cream samples ranged from 95.6% to 104.2% (RSD < 1.77%). Combined with a smartphone using the Color Picker App for RGB analysis, rapid visual detection was achieved. This method is low-cost, easy to operate, and sensitive, showing great potential for food safety monitoring. Download: Download high-res image (125KB) Download: Download full-size image
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REACTIVE & FUNCTIONAL POLYMERS
·
2026
·
IF 5.4
Xingyu Hu,Zhiyong Li,Xiaoge Li,Xiangyan Ji,Jingjing Meng
A highly conjugated biobased liquid HPE monomer was fabricated from HMF. • The benzimidazole motif HPE contributes to a relatively mild curing behavior. • The HPE endows the resin with favorable mechanical properties and dimensional stability. • The HPE networks showed good solvent resistance and shape memory. • This strategy provided a tractable biocomposite fabrication. A novel bio-based epoxy monomer (HPE) bearing a rigid benzimidazole-furan skeleton was synthesized from 5-hydroxymethylfurfural (5-HMF). The activation energy for HPE-derived networks was relatively lower than that of the DGEBA counterparts, indicating favorable curing conditions. The cured HPE-thermosets exhibited exceptional mechanical properties. For instance, HPE/APB achieved good tensile strength (105.67 ± 13.43 MPa), flexural strength (125.43 ± 16.65 MPa), and impact strength (17.99 ± 1.10 kJ m −2 ). Moreover, the thermomechanical investigation also suggested its advantageous storage modulus of 3.55 GPa at 30 °C, which surpassed the petroleum-based DGEBA counterparts. Notably, HPE-networks displayed unique dimensional stability with a thermal expansion coefficient ranging from 87 to 115.4 ppm °C −1 below 200 °C. In contrast to DDM-cured thermoset, APB-cured networks also favored decreasing dielectric constant and loss. On the whole, the APB hardener outperformed the DDM in most cases. Furthermore, glass fiber-reinforced HPE composites demonstrated 90.8% peeling off in DMF under microwave-assisted conditions, making sustainable fiber recycling possible. This work provides a promising strategy for HMF-related renewable epoxy resins. Download: Download high-res image (147KB) Download: Download full-size image
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JOURNAL OF LUMINESCENCE
·
2026
·
IF 3.8
Xiao Cheng,Hao Zhang,Zixu Chen,Haozhuo Dong,Ting Yu,Ruifang Guan
Room-temperature phosphorescent carbon dots (RTP-CDs) exhibit exceptional biocompatibility and tunable luminescence but are limited by short lifetimes and exciton quenching. Herein, we develop a one-step pyrolysis strategy using m-phenylenediamine and boric acid to fabricate boron-doped RTP-CDs (M-CDs) with ultralong green afterglow (16 s) and extended lifetime (37.03 ms). The rigid polycrystalline boron oxide matrix effectively confines molecular motion, isolates quenchers, and stabilizes triplet excitons, while boron doping reduces the singlet-triplet energy gap (ΔE ST = 0.206 eV) to promote intersystem crossing (ISC). Further heavy-atom doping (Cl/Br) enhances spin-orbit coupling, boosting afterglow to 18 s and lifetime to 41.16 ms, whereas iodine disrupts the matrix. Leveraging tunable afterglow dynamics, we demonstrate dynamic information encryption with visible/UV-switchable patterns. This work provides a cost-effective route to high-performance RTP-CDs and clarifies synergistic regulation mechanisms for advanced optoelectronic applications.
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Biosensors-Basel
·
2026
·Vol. 16
·期 7
·372
·
IF 6.2
Ling Yang,Dandan Peng,Haihu Tan,Yahu Wang,Xin Lu,Fanming Zeng,Shigang Liu,Yuejun Liu
Accurate discrimination of multiple heavy metal ions is essential for environmental monitoring. This study developed a simple fluorescent sensing array utilizing carbon dots derived from black plum peels (PCDs) for the precise identification of metal ions in environmental waters. Three structurally distinct PCDs were hydrothermally synthesized using phenylenediamine isomers as nitrogen dopants, exhibiting distinct fluorescence response patterns to target ions. Pattern recognition was performed using linear discriminant analysis (LDA) and hierarchical clustering analysis (HCA). The optimized system (pH 5–7) achieved high discrimination accuracy for eight metal ions (Sn2+, Ag+, Hg2+, Fe3+, Cr3+, Pb2+, Sb3+, and Cu2+) at 5–400 μM concentrations. The array effectively identified the binary and ternary mixtures of Hg2+/Cu2+/Cr3+and successfully detected target ions in river water samples. This cost-effective and scalable approach demonstrates strong potential for applications in water quality monitoring and food safety.
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ADVANCED FUNCTIONAL MATERIALS
·
2026
·
IF 19
Sijie Shao,Liman Qiu,Hai Cai,Huilan Zhuang,Yan Chen,Lizhi Jiang,Xuemei Zeng,Shuangqian Yan
Cholesterol accumulation in tumors contributes to therapeutic resistance and attenuates treatment efficacy. Here, we report a bimetallic sulfide nanozyme-copper-doped cobalt sulfide (CCS)-derived from metal–organic framework (MOF) precursors, for synergistic tumor therapy. Copper doping narrows the bandgap, facilitates electron transfer, and lowers the activation barrier of cobalt sulfide, thereby enhancing photothermal and catalytic performance, as validated by experimental and computational analyses. Surface PEGylation and co-loading with cholesterol oxidase (ChOx) and a thermolabile radical initiator (AIPH) yields a multifunctional nanoplatform termed CCSCA. This construct simultaneously depletes tumoral cholesterol and glutathione, elevating reactive oxygen species (ROS) levels. Upon 808 nm laser irradiation, CCSCA generates hyperthermia and pyrolyzes AIPH to produce alkyl radicals, enabling combined photothermal and thermodynamic therapy. Released copper and cobalt ions further enhance ChOx activity, catalyzing cholesterol oxidation to cholestenone and H 2 O 2 . Cholesterol reduction and cobalt ions from CCSCA downregulate heat shock proteins, sensitizing tumors to hyperthermia. This multi-pronged strategy synergistically induces ferroptosis and apoptosis, resulting in potent antitumor efficacy in murine models with minimal systemic toxicity. Our findings highlight a rational design for multifunctional nanozymes and underscore cholesterol modulation as a viable strategy for overcoming tumor resistance.
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Analytical Methods
·
2026
·
IF 3
Ying Wang,Xuyuan Sun,Minmin Liu,Zhengyuan Dai,Xiaoyu Yang,Li Li,Yaping Ding
As a core medication for the prevention and treatment of cerebral vasospasm, especially after aneurysmal subarachnoid hemorrhage, real-time monitoring of nimodipine (NMD) concentration helps evaluate the adequacy of drug therapy and holds great significance for ensuring patient life and health. Herein, based on dual functional monomers, a molecularly imprinted electrochemical sensor (MIECS) for the detection of NMD with nitrogen-doped multi-walled carbon nanotubes (N-CNTs) and Fe-MOFs was developed. Fe-MOFs provided a large specific surface area, offering more space for generating imprinting sites, while N-CNTs enhanced the conductivity of the electrode. 2-Amino-5-mercapto-1,3,4-thiadiazole (AMT) and o-phenylenediamine (o-PD) served as dual functional monomers and NMD as the template molecule. A molecularly imprinted polymer (MIP) membrane was prepared on the electrode surface by electropolymerization. Compared to single functional monomers, the dual functional monomers exhibited better selectivity and specificity in NMD recognition. Under optimal experimental conditions, the response of the MIECS to NMD showed a linear relationship ranging from 10−14 M to 10−8 M, with a detection limit of 2.97 × 10−15 M. Satisfactory recovery rates were obtained in the detection of human serum and tablets. This multi-parametric enhancement establishes a new paradigm for therapeutic drug monitoring in clinical neurology and pharmaceutical quality control.
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Nanoscale
·
2026
·
IF 5.2
Zhenxi Xie,Guiling Zeng,Mingtao Zheng,Haoran Zhang,Xiaoqin Pan,Wei Li,Bingfu Lei
Diazotrophs-plant symbiosis model system has been developed, but the nitrogen-fixation efficiency of engineered systems remains suboptimal compared with wild-type counterparts. In this study, carbon dots (CDs) with benzoquinone and phenazine structures, prepared from o-phenylenediamine (o-PD) and catechol (CAT), were selected as an electron donor and an electron relay to construct a CDs/microalgae hybrid nitrogen-fixation system. The photocurrent response confirmed the photoelectron-donor capability of the CDs. Nostoc commune Vauch was chosen as the diazotroph. The hybrid system produced 1.32-fold more ethylene than pure microalgae. When integrated with a lettuce hydroponic platform, the system enabled lettuce to utilize atmospheric nitrogen as an ammonia fertilizer. The net photosynthetic rate, total fresh weight, total chlorophyll content, and total soluble protein content of lettuce grown in the established platform increased by 1.20-, 1.12-, 1.14-, and 1.32-fold, respectively, contributing to the sustainable development of agriculture.
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