Toxics
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2024
·Vol. 12
·期 10
·702
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IF 3.9
Moyong Xue,Ming Jia,Yuchang Qin,Jing Li,Ting Yao,Frédéric Francis,Xu Gu
Knowledge regarding the combined toxicity mechanism of bisphenol compounds and microplastics (MPs) on organisms remains limited. In this study, we first developed an accurate and sensitive method to simultaneously quantify two bisphenol compounds and evaluate their accumulation and tissue distribution after co-exposure with MPs in zebrafish. Then, we determined the bioaccumulation potential of bisphenol A (BPA) and bisphenol S (BPS) in adult zebrafish in the absence and presence of MPs. Bisphenol compounds were found to accumulate in different tissues of zebrafish, with BPS showing lower accumulation levels compared to BPA. Importantly, we discovered that the presence of MPs could exacerbate the accumulation of bisphenol compounds in biological tissues. These findings highlight the enhanced bioavailability and risk posed by the co-exposure of bisphenol compounds and MPs, underscoring the need for further investigation into their combined environmental and biological health impacts.
研究领域:
环境科学
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毒理学
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分析化学
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DOI
PubMed
高影响因子
Surfaces and Interfaces
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2025
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IF 6.3
Huanxian Shi,Xiaofei Zhang,Guolong Li,Yanlei Zhang,Zhishu Tang,Chongbo Zhao,Jing Sun,Jun Wan
The development of a recoverable photocatalyst with exceptional photocatalytic activity is an idea strategy for wastewater purification. In this study, a novel recoverable magnetic biochar/Bi 4 O 5 Br 2 heterojunction with high-efficient removal efficiency for polyphenolic compounds was successfully prepared. Under 30 min visible light irradiation, approximately 98 % of polyphenolic compounds (catechin) was effectively eliminated, which is ∼2.77-folds and 4-folds to that of pure Bi 4 O 5 Br 2 and magnetic biochar, respectively. The influence of catalyst dosage, solution pH and initial concentration of catechin on the removal efficiency of magnetic biochar/Bi 4 O 5 Br 2 heterojunction were systematically investigated. Furthermore, the degradation pathway of polyphenolic compounds was studied using a LC–MS. The mechanism investigations revealed that h + , ·O 2 − , and ·OH are the primary active substances responsible for polyphenolic compounds degradation. The enhanced removal rate of magnetic biochar/Bi 4 O 5 Br 2 heterojunction can be attributed to the synergistic effects of adsorption and photocatalytic reaction. Additionally, a n-p transfer pathway at the interface of the magnetic biochar/Bi 4 O 5 Br 2 heterojunction was proposed, which improved the efficiency of charge separation and transfer, resulting in the enhanced photocatalytic activity. This work provides a valuable insight into designing a recoverable and high-efficient biochar-based photocatalyst for pharmaceutical wastewater purification.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
ACS Applied Materials & Interfaces
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2025
·
IF 8.2
Hanzhong Xiao,Baicun Hao,Xinman Li,Wan Zheng,Yujia Wang,Yang Shi,Xin Huang
Spreading is a critical step for emulsion separation. However, the spreading of emulsions on porous size-sieving materials is constrained by their small size-sieving pores formed on rough surface that frequently evolved into lyophobic air-solid-liquid interface to repel emulsions, resulting in poor separation flux. Herein, we demonstrated for the first time that endowing size-sieving materials with amphiphilicity was a promising and universal alternative to manipulate the spreading kinetics of emulsions for accomplishing high-flux separation. A variety of porous materials with varied chemical composition and high porosity, including metal-organic frameworks (ZIF-67, ZIF-8 and HKUST-1), activated carbon and γ-Al2O3, were endowed with amphiphilicity by polyphenolic chemistry-derived noncovalent amphiphilic decoration of polyphenols-iron ions complexes. The endowed amphiphilicity prevented the formation of lyophobic interface on the rough surface of the porous materials, which boosted the emulsion spreading kinetics by up to 11.8-fold, and a significant enhancement (492.3%) on separation flux was achieved by the amphiphilic size-sieving strategy. Our findings exploited a novel strategy for the big family of size-sieving materials to accomplish high-flux separation performances.
研究领域:
材料科学
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界面化学
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分离工程
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DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2020
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IF 3.232
Xiupei Yang,Dan Wang,Na Luo,Min Feng,Xiaohui Peng,Xiangjun Liao
A simple and green approach for the synthesis of photoluminescent N,S-carbon dots (N,S-CDs) has been proposed using a single natural source precursor (bamboo leaf) as raw materials. The as-synthesized N,S-CDs exhibited a highly stable, excitation wavelength-dependent emission, excellent photobleaching, alkali, and salt tolerance. Here, the mechanism of N,S-CDs luminescence was studied via the UV–vis absorption spectrum and photoluminescence spectroscopy . Based on the quenching properties of nitrophenol compounds on the fluorescence of N,S-CDs, the interaction between N,S-CDs and nitrophenol compounds was investigated on detail in aqueous solution. More importantly, the study on photophysical properties of the N,S-CDs may provide the basis for the development of the N,S-CDs for the fluorescent probe of nitrophenol compounds.
研究领域:
材料科学
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环境科学
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DOI
PubMed
高影响因子
GREEN CHEMISTRY
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2025
·
IF 9.2
He Wan,Yang Liu,Chunhui Yu,Kuiyuan Cao,Yongwei Han,Zhong Sun,Junyou Shi,Xixin Duan
Mild condition and high selectivity are challenging in oxidative depolymerization of lignin to phenolic compounds. In this study, choline chloride (ChCl) was introduced to selectively prepare monophenol compounds from the fractionation of larch lignin with the catalyst of g-C3N4 (CN) supported by H4PMo11VO40 (HPMoV). When the yield of bio-oil was 35%, the novel product of 1-(4-hydroxy-3- methoxyphenyl) butan-1-one (HMB) was obtained with the 11% yield under optimized conditions of 0.2 g 25% HPMoV/CN, ChCl: p-toluene sulfonic acid (PTS) (molar ratio 1:2), 1 mL H2O, 6 h, 80 °C, 220 W xenon lamp and air atmosphere. Results from different deep eutectic solvents (DES) indicated that ChCl was essential for HMB generation. The cleavage of β-O-4 bonds was dominant in the fraction of larch lignin and five representative lignin model compounds (LMCs) under optimum conditions. In addition, distinct degradation mechanisms of native lignin and different LMCs were deduced separately. Compared with other reported products in depolymerizing lignin by chemical oxidative procedures, the presentation of HMB was different because of the conjugate addition of ·CH3 from ChCl accompanying the participation of H2O. Overall, the integrative catalysis from acidic DES, strong oxidizing HPMoV, and visible light in this work provides new insights for valorizing lignocellulose into value-added aromatic products in an ambient, convenient, and photocatalytic reaction system.
研究领域:
化学工程
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生物质转化
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光催化材料
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DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2018
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IF 4.439
Yiming Bu,Jingjing Huang,Shiyu Zhang,Yinghua Wang,Shaojin Gu,Genyang Cao,Hongjun Yang,Dezhan Ye,Yingshan Zhou,Weilin Xu
With the ever-increasing oil spillages, oil-water separation has attracted widespread concern in recent years. In this work, a nature-inspired polyphenol method has been developed to fabricate the durable superhydrophobic surfaces for the oil-water separation. Inspiring from the adhesion of polyphenol and reducing capacity of free catechol/pyrogallol groups in polyphenol, firstly, the simple immersion of commercial materials (melamine sponge, PET, and nonwoven cotton fabrics) in tannic acid (TA) solution allows to form a multifunctional coating on the surface of sponge or fabrics, which was used as reducing reagent to generate Ag nanoparticles (NPs). Then, decoration of 1 H , 1 H , 2 H , 2 H -perfluorodecanethiol (PFDT) molecules produced superhydrophobic surfaces. The surface topological structure, chemical composition, and superhydrophobic property of the as-prepared surface are characterized by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), energy dispersive spectroscopy (EDS), and water contact angle (WCA) measurements. The WCAs of as-prepared sponge and fabrics were higher than 150°. The stability, absorption capacity, and recyclability of as-prepared sponge and fabrics were investigated. The as-prepared sponge demonstrates high oil/water selectivity and high absorption capacity (66–150 g/g) for a broad variety of oils and organic solvents, and was chemically resistant, robust against abrasion, and long-term durability in harsh environments. Most important of all, it can continuously separate various kinds of oils or organic pollutants from the surface of water. This study presents a facile strategy to fabricate superhydrophobic materials for continuous oil-water separation, displaying great potential in large-scale practical application.
研究领域:
材料科学
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环境科学
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产品关联
DOI
高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
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2017
·
IF 2.981
Rui Jiang,Xiao-Hao Xu,Ke Wang,Xin-Zhao Yang,Ying-Fei Bi,Yao Yan,Jian-Zeng Liu,Xue-Nan Chen,Zhen-Zhong Wang,Xiao-Li Guo,Da-Qing Zhao,Li-Wei Sun
Ethnopharmacological relevance Hyperpigmentation disease involves darkening of the skin color due to melanin overproduction. Panax ginseng C.A. Meyer is a well-known traditional Chinese medicine and has a long history of use as a skin lightener to inhibit melanin formation in China, Korea and some other Asian countries. However, the constituents and the molecular mechanisms by which they affect melanogenesis are not fully clear. Aim of the study The purpose of this study was to identify the active ingredient in Panax ginseng C.A. Meyer extract that inhibits mushroom tyrosinase activity and to investigate the antioxidative capacity and molecular mechanisms of the effective extract on melanogenesis in B16 mouse melanoma cells. Materials and methods Aqueous extracts of Panax ginseng C.A. Meyer were successively fractionated with an equal volume of chloroform, ethyl acetate , and n-butyl alcohol to determine the effects by examining the activity of mushroom tyrosinase. The effective fraction was analyzed using HPLC and LC-MS. The antioxidative capacity and the inhibitory effects on melanin content, cell intracellular tyrosinase activity, and melanogenesis protein levels were determined in α-melanocyte-stimulating hormone (α-MSH)-treated B16 mouse melanoma cells. Results The ethyl acetate extract from Panax ginseng C.A. Meyer (PG-2) had the highest inhibiting effect on mushroom tyrosinase, mainly contained phenolic acids, including protocatechuic acid , vanillic acid , p -coumaric acid, salicylic acid , and caffeic acid , and exhibited apparent antioxidant activity in vitro. PG-2 and its main constituents significantly decreased melanin content, suppressed cellular tyrosinase activity, and reduced expression of tyrosinase protein to inhibit B16 cells melanogenesis induced by α-MSH, and no cytotoxic effects were observed. They also inhibited cellular reactive oxygen species (ROS) generation, increased superoxide dismutase (SOD) activity and glutathione (GSH) level in α-MSH-treated B16 cells effectively. And those activities of its main constituents could reach more than 80% of PG-2. The ROS scavengers N-acetyl- L -cysteine (NAC) had a similar inhibitory effect on melanogenesis. Conclusions These results suggest that ethyl acetate extract from Panax ginseng C.A. Meyer has the highest effect on inhibiting melanogenesis, and that its main components are polyphenolic compounds , which may inhibit melanogenesis by suppressing oxidative stress. This work provides new insight into the active constituents and molecular mechanisms underlying skin-lightening effect of Panax ginseng C.A. Meyer.
研究领域:
药理学
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皮肤科学
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植物化学
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DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2014
·Vol. 182
·期 1
·201-208
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IF 3.719
Luo Jinmei,Zhang Jiahui,Lin Jianxing,Wang Jinhui,Yang Peihui
We report on a simple and rapid method for the enrichment of polyphenolic compounds (pPhCs) by means of gold nanorods whose surface was functionalized with a monolayer of β-cyclodextrin (β-CD-AuNRs) via thiol chemistry. Enrichment is based on the formation of inclusion complexes between pPhCs and β-cyclodextrin through hydrophobic interactions and hydrogen bonding. Fourier transform infrared spectroscopy, mass spectrometry, and transmission electron microscopy were applied to confirm the inclusion of the pPhCs. Moreover, binding leads to a quenching of the red fluorescence of the AuNRs. This effect can be applied to quantify the polyphenols mangiferin, chrysin, and daphnetin with detection limits at 5 nM, 15 nM, and 20 nM concentrations, respectively. Water samples were spiked with pPhCs, and their extraction by using β-CD-AuNRs gave recoveries ranging from 97.6 to 110.2 %.
Gold nanorods were functionalized with β-cyclodextrin via thiol chemistry. Based on the formation of inclusion complexes between polyphenolic compounds (pPhCs) and β-cyclodextrin through hydrophobic interactions and hydrogen bonding, β-cyclodextrin functionalized gold nanorods as fluorescent probe to simple, rapid and quantitative detect polyphenolic compounds
研究领域:
分析化学
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纳米技术
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食品科学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Yuanlong Guo,Juchun Liu,Tianlong He,Tao Wu,Tonghui Xu,Yunqi Li,Haibo Xie
Traditional phenolic resins (PF) are extremely widely applied in industrial and daily life due to their low cost and outstanding adhesion. However, they are also limited by the toxicity of phenol and formaldehyde as well as the petroleum-based origin at the same time. Herein, a comprehensive strategy for the development of formaldehyde-free lignin-based furfural resin (LFR) with dual functions for adhesive and photothermal conversion materials was presented. Firstly, a newly developed phenolated lignin was obtained via the transesterification of 3,4-dihydrocoumarin (DHC) and aliphatic hydroxyl group of lignin under organocatalysis. Then, the phenolated lignin can be regarded as a highly versatile and precise building block polymer for the design and development of LFR. LFR exhibited excellent adhesion performance from 1.12 to 2.75 MPa on various substrates. Additionally, the low-temperature and wet adhesion strength of LFR were also investigated. Different from traditional thermosetting PF, LFR was hot-melt and possessed outstanding photothermal conversion and hydrophobicity properties, which provided the possibility for its use as a photothermal power generation coating and anti/de-icing material. The maximum temperature and output voltage as well as current of LFR-2 coating could reach 154 °C, 310 mV and 43.2 mA via a thermoelectric generator, respectively. Finally, the hydrophobic, smooth and self-cleaning surface of LFR-2 could effectively help melt and remove ice even in a − 20 °C environment, which was beneficial for the utilization of photothermal material in real environment.
研究领域:
材料科学
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化学工程
·
可再生资源利用
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2021
·
IF 2.694
Qiaoyan Shang,Jifa Xiao,Yan Li,Wenge Liu,Xiaojuan Liu,Guanwei Cui,Xifeng Shi,Shuqian Xia,Bo Tang
Biomass pyrolysis oil is considered to be a promising alternative to fossil energy for the synthesis of high value-added chemicals and fuels. 2-Methoxy-4-methyl phenol (MMP), 4-ethylphenol (EP), 3,5-dimethylphenol (DMP), and m-Cresol (MC) are the important phenolic compounds in pyrolysis oil. The investigation of phase equilibrium is crucial to design separation processes. In this work, the isobaric vapor–liquid equilibrium (VLE) experiment, correlation, and estimation of binary systems (cyclohexane + MMP/EP/DMP/MC) were investigated. The experimental data were verified by the Herington test and van Ness test, and all were thermodynamically consistent entirely. The binary energy interaction parameters were obtained by correlating the experimental data using NRTL, Wilson, and UNIQUAC activity coefficient models. The average absolute relative deviations (ARD %) of T, x1, and y1 correlated by NRTL, Wilson, and UNIQUAC models for four binary systems are below 0.2. In addition, the VLE data were correlated and estimated by the UNIFAC-DMD model. The new interaction parameters of the C–CH2 group in the UNIFAC-DMD model were obtained and used to estimate cyclohexane + DMP systems. The ARD % of T and y1 for cyclohexane + DMP systems were 1.02 and 0.43, respectively. The estimation accuracy of UNIFAC-DMD with new parameters was significantly improved.
研究领域:
化学工程
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能源科学
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DOI
高影响因子
Pharmaceuticals
·
2024
·Vol. 17
·期 12
·1634
·
IF 4.3
Qiang He,Jie Wang,Jingjing Li,Wenchao Yang
Background/Objective:Bee pollen, a rich nutritional food, was employed to develop a raw material for skin whitening.Methods:The polyphenol profile and antioxidant, antityrosinase, and anti-melanogenesis activities of the ethanol extracts of five species of bee pollens (EEBPs) were determined.Results:The results showed that there were a total of 121 phenolic compounds in these EEBPs. Each type of bee pollen had unique substances. The best anti-melanogenesis activity was observed for sunflower EEBP, about 25% at a concentration of 25 μg/mL BEEP. The anti-melanogenesis activities of EEBPs from high to low were sunflower, apricot, camellia, rapeseed, and lotus EEBPs. The anti-melanogenesis activity in B16F10 cells was positively correlated with the antityrosinase activity and total phenol content, with coefficients of 0.987 and 0.940. The Kyoto Encyclopedia of Genes and Genomes enrichment analysis results of untargeted proteomics revealed that sunflower EEBP inhibited melanogenesis in B16F10 cells by reducing the expression of the proteins MAP2K1, NFKB2, RELB, RPS6KA3, CASP3, TRAF6, MAP2K5, MAPKAPK3, STRADA, CCNA2, and FASN involved in the cAMP, MAPK, and TNF signaling pathways, even though these pathways were not significantly different from the control group.Conclusions:The sunflower EEBP has high inhibition effect on melanogenesis than other species EEBPs. The results provide a basis for the future industrial development of a raw material for skin whitening.
研究领域:
食品科学
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生物化学
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药理学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY A
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2013
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IF 4.612
Dan Tang,Jia-Xiao Zhu,An-Guo Wu,You-Hua Xu,Ting-Ting Duan,Zhao-Guang Zheng,Ru-Shang Wang,Dan Li,Quan Zhu
Methylglyoxal (MGO), a very reactive metabolite of glucose, plays a pivotal role in the pathogenesis of several chronic diseases associated with diabetes, and it has been validated as an attractive target for them. In the present study, a simple and effective method, namely pre-column incubation followed by fast high performance liquid chromatography based on superficially porous particles (shell), coupled with diode array detection and tandem mass spectrometry (UHPLC-DAD-MS n ), was proposed for rapid and high-throughput screening of natural MGO scavengers directly from the crude extract of Polygonum cuspidatum Sieb. et Zucc, a well-known traditional Chinese medicine which was used for treatment of diabetic complications. The hypothesis is that upon reaction with MGO, the peak areas of components with MGO scavenging potency in the chromatogram will be significantly reduced or disappear, and the structural characterization could be achieved by UHPLC-DAD-MS n hyphenated technique. First of all, 12 compounds in P. cuspidatum were well separated within shorter time (∼12 min) than previous methods and identified, and two of them, i.e. 3,5,4′-trihydroxystilbene-3 -O -(6″-galloyl)-glucoside ( 3 ) and emodin-8 -O -(6′-malonyl)-glucoside ( 8 ) were firstly reported ingredients. After incubation with MGO, four stilbene derivatives were demonstrated to possess potential MGO trapping activities. Furthermore, it was proved that both polydatin (piceid) and resveratrol exhibited effective MGO-trapping capacity by UHPLC analysis, and they could significantly inhibit the formation of advanced glycation end products (AGEs) in the human serum albumin (HSA)-MGO assay, indicating that they were potential candidate agents for delaying and preventing diabetic complications. Additionally, MGO trapping mechanism exploration by UHPLC-MS n showed that the positions 2 and 4 of the A ring of stilbene were major active sites for trapping MGO to form both mono- and di-MGO adducts, however, the glucosylation of the hydroxyl group would significantly decrease the trapping efficiency. Collectively, the current work provides a very promising method for rapid discovery of natural MGO scavengers directly from complex matrices such as herbal medicines with huge resources.
研究领域:
药理学
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分析化学
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糖尿病研究
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）