PEST MANAGEMENT SCIENCE
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2025
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IF 3.8
Liwang Fei,Rahila Hafeez,Junliang Zhang,Shiquan Fu,Ying Xu,Lingyun Hao
BACKGROUND Rice blast, caused by Pyricularia oryzae , is a devastating fungal disease threatening global rice production. Overreliance on chemical fungicides has raised environmental concerns and led to resistant strains, necessitating the development of sustainable alternatives. This study integrated marine microbiology and natural antifungal compounds to create eco-friendly alternatives to chemical fungicides for disease management. RESULTS We identified Pseudomonas aeruginosa R64 with broad-spectrum antimicrobial activity from mangrove soil in the Mai Po Nature Reserve. The R64 fermentation extract (RFE) exhibited multifaceted inhibition of P. oryzae , suppressing mycelial growth, conidiation, conidial germination and appressorial formation, while disturbing cell wall and membrane function. It also attenuated virulence by impairing appressorial penetration and invasive growth. Further chemical analysis identified phenazines and quinolines as the primary compounds in RFE, corroborated by PCR detection of corresponding phenazine biosynthetic gene clusters. Comparative bioassays with two main bioactive components of RFE, phenazine-1-carboxamide (PCN) and phenazine-1-carboxylic acid (PCA), against P. oryzae implicated PCN as the principal antifungal effector. RFE and PCN had higher efficacy than tricyclazole in P. oryzae growth inhibition, but were less effective than isoprothiolane. Furthermore, RFE and PCN displayed lower acute ecotoxicity to an environmental indicator organism than isoprothiolane, suggesting their potential as sustainable biopesticides for rice blast management. CONCLUSION Natural products from mangrove soil bacterium P. aeruginosa R64 inhibited key developmental and infection processes of P. oryzae , effectively reducing rice blast development. The promising disease inhibition and low ecotoxicity of mangrove-associated bacteria highlight their untapped potential for innovative, eco-friendly fungicide mining for sustainable agriculture. © 2025 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
研究领域:
植物病理学
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微生物学
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农业科学
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产品关联
DOI
PubMed
高影响因子
Chemical Science
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2023
·Vol. 14
·期 44
·12570-12581
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IF 8.4
Mingli Xu,Fengxue Zhang,Yanhui Zhang,Chen Wu,Xue Zhou,Xinping Ai,Jiangfeng Qian
Exploring a sodium-enriched cathode (i.e. Na4V2(PO4)3, which differs from its traditional stoichiometric counterpart Na3V2(PO4)3 that can provide extra endogenous sodium reserves to mitigate the irreversible capacity loss of the anode material (i.e. hard carbon), is an intriguing presodiation method for the development of high energy sodium-ion batteries. To meet this challenge, herein, we first propose a redox-potential-matched chemical sodiation approach, utilizing phenazine-sodium (PNZ-Na) as the optimal reagent to sodiate the Na3V2(PO4)3 precursor into Na-enriched Na4V2(PO4)3. The spontaneous sodiation reaction enables a fast reduction of one-half V ions from V3+ to V2+, followed by the insertion of one Na+ ion into the NASICON framework, which only takes 90 s to obtain the phase-pure Na4V2(PO4)3 product. When paired with a hard carbon anode, the resulting Na4VP‖HC full cell exhibits a high energy density of 251 W h kg−1, which is 58% higher than that of 159 W h kg−1 for the Na3VP‖HC control cell. Our chemical sodiation methodology provides an innovative approach for designing sodium-rich cathode materials and could serve as an impetus to the development of advanced sodium-ion batteries.
研究领域:
材料科学
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电化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
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2018
·Vol. 93
·期 11
·3176-3184
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IF 2.587
Muhammad Bilal,Sheng-Jie Yue,Hong-Bo Hu,Wei Wang,Xue-Hong Zhang
BACKGROUND Pseudomonas chlororaphis GP72 is a biocontrol strain with great capacity to produce a wide range of secondary metabolites including phenazine derivatives. Phenazine-1-carboxylic acid (PCA) is an environmentally friendly antibiotic with broad-spectrum biological and pharmaceutical activities. Many studies have been focused on engineering high-yielding strains and optimizing fermentation bioprocesses to enhance PCA biosynthesis. However, the separation and purification of PCA in biotechnological production remain to be addressed. In this context, the present work intended to develop a simple and proficient technique for the separation and purification of PCA from the fermentation broth of engineered P. chlororaphis GP72AN. RESULTS Five macroporous adsorbents with different physicochemical characteristics were screened to present their PCA separation potential. Among them, HP-20 resin was found highly suitable based on its promising adsorption and desorption performance in a static batch process. Langmuir and Freundlich isotherms deciphered the solute binding affinity towards HP-20 adsorbent at varying temperatures, and the experimental data fitted best to the Langmuir isotherm model. The column-assisted dynamic adsorption–desorption trials were executed to optimize the functional parameters for PCA separation. Under standardized separating conditions, the average adsorption capacity and desorption ratio of PCA were 24.4 ± 1.5 mg g −1 dry resin and 86.5 ± 1.3%, respectively. After treatment with HP-20 resin, PCA contents in the product were considerably increased with a recovery yield of 78.4 ± 2.4%. CONCLUSION In conclusion, the method proposed herein achieved effective separation and purification of PCA by applying HP-20 resin. The results obtained also suggest an encouraging basis for scale-up preparation of PCA and other high-value phenazine compounds of industrial interests. © 2018 Society of Chemical Industry
研究领域:
生物工程
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微生物学
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DOI
高影响因子
DYES AND PIGMENTS
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2021
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IF 4.889
Shengzhong Li,Shuangyu Zhang,Shu Mei,Xiangfei Kong,Miao Yang,Wenjun Wu,Shuhua Zhang,Haijun Tan
A novel porphyrin dye T-2 with phenoxazine (POZ) as donor unit has been synthesized and utilized for dye-sensitized solar cells (DSSC). Compare with porphyrin dye T-1 (in which triphenylamine as a donor unit), the DSSC based on T-2 exhibited a significantly higher J sc (16.35 mA cm −2 ) and V oc (670 mV) than that of T-1 (9.13 mA cm −2 , 610 mV), which attribute to the higher IPCE and τ of the device based on T-2 . Correspondingly, the T-2-based device achieved a photoelectric conversion efficiency (PCE) of 7.64% (N719, 8.45%). By detailed investigation of the relationship between structure and performance, we found the butterfly-shaped structure, stronger electron-donating capability, and the extra alkyl chain of POZ are the main reasons leading to better performance of T-2 than that of T-1 in the DSSC device.
研究领域:
材料科学
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能源科学
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DOI
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
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2017
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IF 3.756
Yu Huang,Jin-Mei Li,Zhi-Hui Lai,Jun Wu,Tong-Bu Lu,Jia-Mei Chen
Both cocrystal and nanocrystal technologies have been widely used in the pharmaceutical development for poorly soluble drugs. However, the synergistic effects due to the integration of these two technologies have not been well investigated. The aim of this study is to develop a nano-sized cocrystal of phenazopyridine (PAP) with phthalimide (PI) to enhance the release rate and oral bioavailability of PAP. A PAP–PI nano-cocrystal with particle diameter of 21.4 ± 0.1 nm was successfully prepared via a sonochemical approach and characterized by powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and dynamic light scattering (DLS) analysis. An in vitro release study revealed a significant release rate enhancement for PAP–PI nano-cocrystal as compared to PAP–PI cocrystal and PAP hydrochloride salt. Further, a comparative oral bioavailability study in rats indicated significant improvement in C max and oral bioavailability (AUC 0 − ∞ ) by 1.39- and 2.44-fold, respectively. This study demonstrated that this novel nano-cocrystal technology can be a new promising option to improve release rate and absorption of poorly soluble compounds in the pharmaceutical industry.
研究领域:
药剂学
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药物递送
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纳米医学
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药物代谢
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晶体工程
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DOI
高影响因子
Journal of Energy Storage
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2024
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IF 8.9
Mengna Qin,Guibao Wu,Kai Zheng,Xiaofei Yu,Juan Xu,Jianyu Cao
The pH-neutral aqueous redox flow battery (ARFB) is one of the most attractive flow batteries due to its non-corrosiveness, low-cost, and wider electrochemical stability window compared to those with acidic or alkaline electrolytes. However, there are few families of organic redox-active molecules available as catholyte materials for pH-neutral ARFBs. Herein, through incorporation of quaternary ammonium moiety into the redox-active phenoxazine nucleus, an organic catholyte material, N , N , N -trimethyl-2-(10H-phenoxazin-10-yl) ethan-1-aminium chloride (NEt-POZ) is achieved for pH-neutral ARFBs. The NEt-POZ has a high redox potential of 0.79 V versus SHE and rapid redox kinetics (0.23 cm s −1 ) as well as high water-solubility (∼2.6 M in H 2 O). Paired with a methyl viologen (MV) anolyte in the pH-neutral aqueous electrolyte, a viologen-phenoxazine ARFB full cell is assembled, which shows an open circuit voltage of ∼1.23 V. However, the results of long-term cycling experiments indicate low Coulomb efficiency and rapid declining capacity of the NEt-POZ catholyte. The mechanism analysis unveils that the unstable doubly oxidized tri-cations (NEt-POZ 3+ ) formed via the disproportionation of radical di-cations (NEt-POZ 2+ ) in solution readily react with chloride anions to form poly-chlorinated derivatives, which precipitate from the catholyte due to their poor water solubility, leading to a rapid decrease in capacity. When there is no chloride present in the electrolyte solution, highly reactive NEt-POZ 3+ cations can interact with other counter-anions (such as sulfate and carbonate ions) and even water to form complex adducts.
研究领域:
能源化学
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电化学
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材料科学
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
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2021
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IF 9.229
Liwei Cheng,Qiaonan Zhu,Jiandong Liang,Mengyao Tang,Yan Yang,Sicong Wang,Puguang Ji,Gongkai Wang,Wenxing Chen,Xiuhui Zhang,Hua Wang
Aqueous zinc-ion batteries (ZIBs) are regarded as a promising candidate for ultrafast charge storage owing to the high ionic conductivity of aqueous electrolytes and high theoretical capacity of zinc metal anodes. However, the strong electrostatic interaction between high-charge-density zinc ions and host materials generally leads to sluggish ion-transport kinetics and structural collapse of rigid cathode materials during the charge/discharge process, so searching for suitable cathode materials for ultrafast and long-term stable ZIBs remains a great challenge. Herein, flexible electron-rich ion channels enabling fast-charging and stable aqueous ZIBs have been demonstrated. Because of the nitrogen-rich conjugated structure of organic phenazine (PNZ) molecules, electron-rich ion channels are formed with the C═N redox centers situated on the channel surface, where zinc ions can transport rapidly and react with active moieties directly. Meanwhile, the π-conjugated systems and inherent flexibility of PNZ molecules can accommodate rapid strain changes and maintain their structural stability during zinc-ion intercalation/deintercalation. Consequently, they exhibit a high capacity of 94.2 mAh g–1 at an ultrahigh rate of 700C (208.6 A g–1) and an ultralong life over 100,000 cycles at 100C, which are superior to those of previously reported aqueous ZIBs. Our work presents a new way for developing ultrafast and ultrastable aqueous ZIBs.
研究领域:
电化学储能
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材料化学
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能源科学
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纳米材料
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电化学
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功能材料
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）