Biomedical Spectroscopy and Imaging
·
2015
·Vol. 4
·期 2
·129-137
·
IF 0
Gao Yunlong,Li Da,Shi Jia-jia,Wang Xiaomin,Kang Tingguo,Weng Shifu,Xu Yizhuang,Noda Isao,Wu Jinguang
Two-dimensional (2D) correlation spectroscopy provides an important approach to the study of subtle spectral variations caused by intermolecular interactions. In our previous work, DAOSD (Double Asynchronous Orthogonal Sample Design) scheme was introduced to analyze subtle spectral variations of characteristic peaks of substance under intermolecular interactions. In this paper, we apply DAOSD scheme to probe weak coordination between lanthanide (III) ions and lactone group of organic ligands from natural pharmaceutical. Weak coordinative interaction between Nd3+ and carbonyl group in Nd(ClO4)3/artemisinin in acetonitrile solutions is characterized by using 2D UV/IR hetero-correlation spectroscopy. Experimental results demonstrate that subtle band-shift and variation on the absorptivity can be observed on both carbonyl band of artemisinin and f–f transition band of Nd3+ ions upon coordination.
研究领域:
药学
·
光谱学
·
配位化学
✓ 已验证
DOI
POLYMER
·
2019
·
IF 3.771
Tao Guan,Zhukang Du,Xueyi Chang,Dongli Zhao,Shurui Yang,Ning Sun,Biye Ren
Hydrophobically modified ethoxylated urethanes (HEURs), as a representative class of associative polymers, are widely used as rheology modifiers in waterborne systems such as coatings, emulsions, inks etc. due to their unique associative network structure and finite relaxation behavior in solution. However, conventional HEURs are non-reactive and generally stay free in final cured films, which may induce some damages to the performance of the coatings. To solve the problem, a new concept of reactive HEUR has been proposed. That is, a reactive HEUR should bear reactive hydrophobic end-groups which can chemically crosslink with matrix resins during the curing process of waterborne coatings. In this work, with the help of the hydrogen abstraction photo-initiating reactivity of benzophenone (BP) group, a reactive HEUR (BPC 11 HEUR) end-functionalized by a photo-initiator BP moiety has been prepared. In aqueous solution, as demonstrated by steady shear measurement, an exponential increment of solution viscosity along with the increasing of polymer concentration ( C ) was found when C surpassed its critical percolation concentration ( C p ≈ 23.6 g/L). Besides, ultraviolet (UV) light induced photolysis in aqueous solution manifested a typical photochemical reaction behavior of BPC 11 HEUR polymer with a final photolysis degree ( D ) of approximate 78% after 300 s of irradiation. In situ 1 H NMR and rheological measurements collectively revealed the efficient photo-initiating reactivity of BPC 11 HEUR for waterborne UV monomers or resins. Further, rheological measurements demonstrated that the emulsion zero/low shear viscosity can be greatly enhanced by ca. 50 folds for a commercially available waterborne UV polyurethane acrylate emulsion when the addition amount of BPC 11 HEUR varied from 0 to 1.0 wt%. These results shown that the reactive BPC 11 HEUR polymer can not only be used to efficiently modify the rheological properties of solutions or emulsions but also can chemically crosslink with waterborne UV acrylic monomers or resins by light irradiation . The work may be of interest for development of reactive HEURs used in waterborne UV coatings, inks, and adhesives, etc.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2017
·Vol. 41
·期 4
·877-885
·
IF 2.557
Dan Liu,Ting Qiao,Haiyan Liu,Xiaoling Wang,Zhi-guo Shi
In the present study, a polar-embedded reversed-phase liquid chromatographic stationary phase that contained internal sulfone groups was prepared. The synthesis involved the “thiol-ene” click chemistry between the vinyl functionalized silica and 1-octadecanethiol, followed by the oxidization of sulfide to sulfone groups. The resulting material simultaneously possessed the alkyl chain, i.e. C18, and the internal sulfone groups. Elemental analysis demonstrates that the element contents of the C18/sulfone silica were C 8.94%, H 1.87% and S 0.66%. Chromatographic evaluations indicate that the C18/sulfone stationary phase exhibited a little less retention than the C18/sulfide one. A comparable chromatographic performance of neutral analytes was obtained on these two columns, but much better chromatographic performance in the case of basic and acid analytes was obtained on C18/sulfone stationary phase with additional features such as lower silanol activity, better stability (stable working conditions of pH 1.0–10.0), and better compatibility with 100% aqueous mobile phases. The batch-to-batch reproducibility was acceptable (the RSDs of retention times for the probes were no higher than 1.73%), demonstrating the suitability of the applied synthetic strategy for the new stationary phase. The C18/sulfone is a promising polar-embedded RPLC stationary phase.
研究领域:
分析化学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2025
·
IF 9
Zeyuan Liu,Zhansheng Li,Shouhai Zhang,Qian Liu,Zhaoqi Wang,Danhui Wang,Peiqi Xu,Shugang Xu,Han Jiang,Xigao Jian
The highly chlorine-resistant polyester-amide thin-film composite (TFC) nanofiltration (NF) membranes (PEA/PPBES) with specific layers incorporating phthalazinone moieties were prepared by interfacial polymerization. With the addition of 4-(4'-hydroxyphenyl)-2,3-phthalazin-1-one (DHPZ) to an aqueous phase of piperazine (PIP), and by using butanone as a co-solvent in the organic phase with trimesoyl chloride (TMC), the chlorine resistance and permeability of the PEA/PPBES membranes were enhanced simultaneously. When the co-solvent butanone was used, a distinctive ring-fold structure on the surface of the selective layer was observed, which could be the reason for the significantly improved the permeability of the PEA/PPBES membranes. With the addition of 3% butanone to the organic phase, the pure water flux (PWF) of the fabricated membrane was 118 L m -2 h -1 (0.5MPa), and the Na 2 SO 4 rejection reached 97.9%, increasing the water permeability by 2.6 times, compared to the control (without butanone). Additionally, the introduction of the phthalazinone moieties improved filtration performance at high temperatures as well as chlorine resistance. At an operation temperature of 95 °C, the water flux and Na 2 SO 4 rejection achieved 148.5 L m -2 h -1 and 96.4%, respectively. After a total NaClO exposure of 60,000 ppm h, the Na 2 SO 4 rejection and water flux changed slightly, demonstrating excellent chlorine resistance. This work offers a novel approach to fabricate TFC NF membranes with excellent chlorine resistance.
研究领域:
材料科学
·
环境工程
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2023
·
IF 6
Hongjian Gu,Cheng Liu,Qian Liu,Yu Zhang,Meng Wang,Xi Chen,Yousi Chen,Jinyan Wang,Xigao Jian
A series of poly(bisphthalazinone ether sulfone ketone)s with pendant phenyl groups (POPESKs) were synthesized via aromatic nucleophilic substitution polycondensation. The thermal degradation mechanism of POPESKs was determined investigated by TG-FTIR. The T g s of POPESKs range from 296 to 326 °C and the storage modulus retention is up to 46.1 % at 290 °C. POPESKs have good solubility in dichloroethane, chloroform, tetrachloroethane, N -methyl-2-pyrrolidone and pyridine, and exhibit good film-forming property. The tensile strength, tensile modulus, and tensile elongation of POPESK films are 85–96 MPa, 1.34–1.86 GPa, and 8.9–11.6 %, respectively. Meanwhile, the polymer films exhibit the high light transmittance of up to 83 % at 800 nm and its water contact angle are in the range of 82.3–94.3°. Its superior overall performance shows great potential in aerospace, petrochemical and energy applications.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2025
·
IF 6.2
Yue Zou,Mei Zhu,Zongnan Zhu,Tingting Du,Xing Liu,Yaojia Jiang,Jixiang Chen
1,2,4-Thiadiazole derivatives containing a sulfone moiety were designed and synthesized via scaffold hopping to facilitate the discovery of novel antibacterial agents. Most of the compounds exhibited excellent activity against three plant pathogenic bacteria. The half-maximal effective concentrations (EC50) of compound B7 for Xanthomonas oryzae pv oryzae (Xoo) and X. oryzae pv oryzicola (Xoc) concentrations were 0.4 and 1.0 mg/L, respectively. In addition, the EC50 values of compounds B1 and B24 for Xoo, Xoc, and Pseudomonas syringae pv actinidiae (Psa) were less than 5 mg/L and significantly better than those of the positive control agents thiodiazole copper (121.8, 119.5, and 142.0 mg/L, respectively) and bismerthiazol (73.3, 65.6, and 128.8 mg/L, respectively). Compound B7 exhibited protective and curative activities of 48.1 and 46.7%, respectively, against bacterial leaf blight, which were higher than those of bismerthiazol (35.5 and 36.9%, respectively) and thiodiazole copper (39.3 and 39.5%, respectively). Additionally, compound B7 exerted an effect on the virulence factors of Xoo (production of exopolysaccharides and extracellular enzymes, biofilm formation, and motility), membrane permeability, cell surface morphology, and intracellular content of reactive oxygen species. Transcriptome analysis showed that compound B7 improved the resistance of rice plants to external stress by influencing the metabolic process, biological regulation, catalytic activity of enzymes, and plant–pathogen interaction. Compound B7 can therefore be considered as a potential candidate antibacterial agent and warrants an in-depth investigation in the future.
研究领域:
植物病理学
·
药理学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Heping Jiao,Ruixiang Bi,Aihua Xu,Guimin Zhang,Lihai Zhai,Houhuan Dong,Ligang Hu,Caifeng Dai,Bing Li,Zhenhua Wang
Covalent organic frameworks (COFs) have been widely employed for metal ion adsorption owing to their inherent advantages, encompassing low crystal density, well-organized organic unit structures, adjustable pore size, and remarkable structural stability. However, it is still a great challenge to design excellent COFs with high adsorption and advanced purification capabilities for Pb 2+ and Cd 2+ ions. Herein, hydrazine-linked COFs (COF-TCH) were prepared for effective adsorption and advanced purification of metal ions. The adsorption capacity of COF-TCH for Pb 2+ and Cd 2+ ions are 395.3 and 153.5 mg/g, respectively. Moreover, the Pb 2+ and Cd 2+ ions in water can be treated from 75 and 30 mg L −1 to less than 0.01 and 0.003 mg L −1 , respectively, indicating the excellent adsorption and advanced purification capability of COF-TCH. This is a rare example of COFs adsorbent that deeply purify water to meet the guideline values in drinking water for the World Health Organization. FT-IR, XPS and quantum mechanics calculation were performed to understand the adsorption mechanism. The remarkable adsorption and advanced purification capability of COF-TCH for Pb 2+ and Cd 2+ ions can be attributed to the synergistic interaction between the amine and thione groups, which can easily complex with Pb 2+ and Cd 2+ ions to form stable five-membered ring structure in COF-TCH. In addition, COF-TCH still remains an adsorption capacity of over 90% after ten adsorption-desorption cycles, indicating its excellent reusability and stability. COF-TCH with high adsorption and advanced purification capability, high stability, low cost and reusability has enormous practical application potential in high-performance remediation of Pb 2+ and Cd 2+ contaminated water.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2021
·Vol. 10
·期 3
·406-417
·
IF 6.331
Jinyan Tan,Xiao Liang,Jinlong Yang,Shuxue Zhou
Current environmentally friendly marine antifouling (AF) coatings are mainly polymeric with a relatively low hardness. Hard sol–gel-derived AF coatings for underwater robot-cleaning are seldom used. In this work, two new organoalkoxysilanes, i.e., (N-methoxyacylethyl)-3-aminopropyltriethoxysilane and 2-(2-hydroxy-3-(3-(trimethoxysilyl)propoxy)propyl)benzo[d]isothiazol-3(2H)-one, were synthesized by a facile method. These two precursors were used with tetraethoxysilane (TEOS) to produce three series of hybrid AF coatings with zwitterionic group (Z-χ), antibacterial group (1,2-benzisothiazolin-3-one) (A-χ) and zwitterionic and antibacterial groups (S-χ) by a sol–gel process. The hardness of the coatings was measured using a pencil hardness tester and the AF behaviors of the coatings were examined by laboratory and field assays. A pencil hardness up to 5 H was achieved and slight deterioration was observed after 9 months of immersion in artificial seawater for the A-χ and S-χ coatings at a sufficiently high TEOS content. A synergistic effect between the zwitterion and antimicrobial agents existed but was not obvious. A higher TEOS content led to a higher hardness and better AF performance regardless of the type of AF group. Even with the same biofilm formation after field assay, coatings with a higher TEOS content exhibited a better resistance to mussel settlement.
研究领域:
材料科学
·
化学
·
海洋科学
·
涂层与薄膜
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
·
2020
·
IF 2.751
Xiang Zhou,Yiqiang Ye,Shasha Liu,Wubin Shao,Liwei Liu,Song Yang,Zhibing Wu
Plant viral diseases, known as “plant cancer”, with high contagiosity can substantially reduce crop quality and yield. To identify potential anti- tobacco mosaic virus (TMV) agents with different mechanisms, a series of novel α-aminophosphonate derivatives containing a chalcone moiety were designed and synthesized. Bioassay results revealed that some target compounds exhibited improved curative activity against TMV in vivo, and the EC 50 value of compound B 3 was 356.7 mg L −1 . The activities of the defensive enzymes POD and CAT from tobacco leaves treated with B 3 and B 17 showed that these target compounds could improve the photosynthetic ability of the leaves and activate plant host resistance against TMV infection. The binding constant between B 3 and TMV Coat Protein (CP) (2.51 × 10 8 M −1 ), calculated by the fluorescence titration experiment and docking results, revealed that B 3 has a strong interaction with TMV CP. Further docking analysis revealed that B 3 was embedded between two layers of the TMV CP, which was consistent with the 2:1 binding mode of TMV CP and B 3 determined by the binding affinity experiment. The TEM morphological study of TMV treated with B 3 and B 17 indicated that this series of target compounds may trigger the disassembly of TMV by interacting directly with TMV CP. This study provides new insight for the discovery of antiviral compounds with two different mechanisms of action.
研究领域:
植物病毒学
·
有机化学
·
植物病理学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2022
·Vol. 20
·期 1
·1-17
·
IF 9.429
Gu Jiayi,Wang Xueling,Chen Yuming,Xu Ke,Yu Dehong,Wu Hao
Background Excessive accumulation of reactive oxygen species (ROS) has been documented as the crucial cellular mechanism of cisplatin-induced ototoxicity. However, numerous antioxidants have failed in clinical studies partly due to inefficient drug delivery to the cochlea. A drug delivery system is an attractive strategy to overcome this drawback.Methods and resultsIn the present study, we proposed the combination of antioxidant astaxanthin (ATX) and ROS-responsive/consuming nanoparticles (PPS-NP) to combat cisplatin-induced ototoxicity. ATX-PPS-NP were constructed by the self-assembly of an amphiphilic hyperbranched polyphosphoester containing thioketal units, which scavenged ROS and disintegrate to release the encapsulated ATX. The ROS-sensitivity was confirmed by 1H nuclear magnetic resonance spectroscopy, transmission electron microscopy and an H2O2 ON/OFF stimulated model. Enhanced release profiles stimulated by H2O2 were verified in artificial perilymph, the HEI-OC1 cell line and guinea pigs. In addition, ATX-PPS-NP efficiently inhibited cisplatin-induced HEI-OC1 cell cytotoxicity and apoptosis compared with ATX or PPS-NP alone, suggesting an enhanced effect of the combination of the natural active compound ATX and ROS-consuming PPS-NP. Moreover, ATX-PPS-NP attenuated outer hair cell losses in cultured organ of Corti. In guinea pigs, NiRe-PPS-NP verified a quick penetration across the round window membrane and ATX-PPS-NP showed protective effect on spiral ganglion neurons, which further attenuated cisplatin-induced moderate hearing loss. Further studies revealed that the protective mechanisms involved decreasing excessive ROS generation, reducing inflammatory chemokine (interleukin-6) release, increasing antioxidant glutathione expression and inhibiting the mitochondrial apoptotic pathway.Conclusion sThus, this ROS-responsive nanoparticle encapsulating ATX has favorable potential in the prevention of cisplatin-induced hearing loss.Graphical Abstract
研究领域:
药学
·
纳米技术
·
耳科学
·
药物递送系统
·
抗氧化治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Anqi Chen,Qinghui Zeng,Wen Wen,Xin Wen,Zhenfeng Li,Yu Liu,Jiazhu Guan,Honghao Wang,Wei Liu,Pingping Chen,Liaoyun Zhang
Solid polymer electrolytes (SPEs) have great potential to be used in high-safety lithium-ion batteries (LIBs). However, it is still a significant challenge for SPEs to develop high ionic conductivity, high mechanical strength, and good interior interfacial compatibility. In this work, a ketone-based all-solid-state electrolyte (PAD) resulting from allyl acetoacetate (AAA), diacetone acrylamide (DAAM), and poly(ethylene glycol) diacrylate (PEGDA) was prepared by UV-inducing photopolymerization. The abundant ketone groups endow the prepared PAD all-solid-state electrolyte with strong dissociation of lithium salts and weak coordination interactions between ketone groups and Li+. Depending on the unique properties of the ketone groups in the electrolyte system, the prepared polymer electrolytes show a high lithium-ion transference number of 0.87 and a wide electrochemical window of 4.95 V. Furthermore, the PAD electrolyte also exhibits superior viscoelasticity, which is beneficial for good contact with electrodes. As a result, the assembled LFP/PAD/Li cells with PAD electrolytes show good cycle performance and rate performance. Concretely, the all-solid-state symmetric lithium cells with the PAD electrolyte can achieve stable lithium plating and stripping at 0.05 mA cm–2 for over 1000 h at 60 °C. This work highlights the advantages of ketone-based electrolyte as a polymer electrolyte and provides a design method for advanced polymer electrolytes applied in high-performance solid lithium batteries.
研究领域:
材料科学
·
能源存储
·
聚合物化学
·
电化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）