Biomedical Spectroscopy and Imaging
·
2015
·Vol. 4
·期 2
·129-137
·
IF 0
Gao Yunlong,Li Da,Shi Jia-jia,Wang Xiaomin,Kang Tingguo,Weng Shifu,Xu Yizhuang,Noda Isao,Wu Jinguang
Two-dimensional (2D) correlation spectroscopy provides an important approach to the study of subtle spectral variations caused by intermolecular interactions. In our previous work, DAOSD (Double Asynchronous Orthogonal Sample Design) scheme was introduced to analyze subtle spectral variations of characteristic peaks of substance under intermolecular interactions. In this paper, we apply DAOSD scheme to probe weak coordination between lanthanide (III) ions and lactone group of organic ligands from natural pharmaceutical. Weak coordinative interaction between Nd3+ and carbonyl group in Nd(ClO4)3/artemisinin in acetonitrile solutions is characterized by using 2D UV/IR hetero-correlation spectroscopy. Experimental results demonstrate that subtle band-shift and variation on the absorptivity can be observed on both carbonyl band of artemisinin and f–f transition band of Nd3+ ions upon coordination.
研究领域:
药学
·
光谱学
·
配位化学
✓ 已验证
DOI
POLYMER
·
2019
·
IF 3.771
Tao Guan,Zhukang Du,Xueyi Chang,Dongli Zhao,Shurui Yang,Ning Sun,Biye Ren
Hydrophobically modified ethoxylated urethanes (HEURs), as a representative class of associative polymers, are widely used as rheology modifiers in waterborne systems such as coatings, emulsions, inks etc. due to their unique associative network structure and finite relaxation behavior in solution. However, conventional HEURs are non-reactive and generally stay free in final cured films, which may induce some damages to the performance of the coatings. To solve the problem, a new concept of reactive HEUR has been proposed. That is, a reactive HEUR should bear reactive hydrophobic end-groups which can chemically crosslink with matrix resins during the curing process of waterborne coatings. In this work, with the help of the hydrogen abstraction photo-initiating reactivity of benzophenone (BP) group, a reactive HEUR (BPC 11 HEUR) end-functionalized by a photo-initiator BP moiety has been prepared. In aqueous solution, as demonstrated by steady shear measurement, an exponential increment of solution viscosity along with the increasing of polymer concentration ( C ) was found when C surpassed its critical percolation concentration ( C p ≈ 23.6 g/L). Besides, ultraviolet (UV) light induced photolysis in aqueous solution manifested a typical photochemical reaction behavior of BPC 11 HEUR polymer with a final photolysis degree ( D ) of approximate 78% after 300 s of irradiation. In situ 1 H NMR and rheological measurements collectively revealed the efficient photo-initiating reactivity of BPC 11 HEUR for waterborne UV monomers or resins. Further, rheological measurements demonstrated that the emulsion zero/low shear viscosity can be greatly enhanced by ca. 50 folds for a commercially available waterborne UV polyurethane acrylate emulsion when the addition amount of BPC 11 HEUR varied from 0 to 1.0 wt%. These results shown that the reactive BPC 11 HEUR polymer can not only be used to efficiently modify the rheological properties of solutions or emulsions but also can chemically crosslink with waterborne UV acrylic monomers or resins by light irradiation . The work may be of interest for development of reactive HEURs used in waterborne UV coatings, inks, and adhesives, etc.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2017
·Vol. 41
·期 4
·877-885
·
IF 2.557
Dan Liu,Ting Qiao,Haiyan Liu,Xiaoling Wang,Zhi-guo Shi
In the present study, a polar-embedded reversed-phase liquid chromatographic stationary phase that contained internal sulfone groups was prepared. The synthesis involved the “thiol-ene” click chemistry between the vinyl functionalized silica and 1-octadecanethiol, followed by the oxidization of sulfide to sulfone groups. The resulting material simultaneously possessed the alkyl chain, i.e. C18, and the internal sulfone groups. Elemental analysis demonstrates that the element contents of the C18/sulfone silica were C 8.94%, H 1.87% and S 0.66%. Chromatographic evaluations indicate that the C18/sulfone stationary phase exhibited a little less retention than the C18/sulfide one. A comparable chromatographic performance of neutral analytes was obtained on these two columns, but much better chromatographic performance in the case of basic and acid analytes was obtained on C18/sulfone stationary phase with additional features such as lower silanol activity, better stability (stable working conditions of pH 1.0–10.0), and better compatibility with 100% aqueous mobile phases. The batch-to-batch reproducibility was acceptable (the RSDs of retention times for the probes were no higher than 1.73%), demonstrating the suitability of the applied synthetic strategy for the new stationary phase. The C18/sulfone is a promising polar-embedded RPLC stationary phase.
研究领域:
分析化学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2025
·
IF 6.2
Yun Ma,Yi Xie,Hui Liu,Yadan Luo,Baojie Liu,Chengrong Qin,Chen Liang,Caoxing Huang,Shuangquan Yao
In this study, eucalyptus hemicellulose was separated using kojic acid (KA), which contains hydroxyl and ketone groups. The maximum selectivity and hemicellulose separation yield were obtained (KA concentration of 10 %, 160 °C, and 50 min). The xylose separation increased from 79.36 ± 2.93 % to 84.36 ± 2.95 % after the KA pretreatment. The lignin separation decreased by 9.56 ± 0.06 % and 4.81 ± 0.26 % compared with acetic acid (AA) and salicylic acid (SA) pretreatment. It had the lowest condensed and highest noncondensed phenolic hydroxyl contents. The depolymerization and condensation of lignin were inhibited by the ketone group in KA. A synergistic effect of the hydroxyl acid and ketone groups on the efficient and selective separation of hemicellulose was discovered. This study provides a new approach for pretreating hemicellulose using novel multifunctional organic acids.
研究领域:
生物化学
·
材料科学
✓ 已验证
DOI
高影响因子
PROCESS BIOCHEMISTRY
·
2020
·
IF 2.952
Xuelian Zhou,Yi Shen,Yong Xu,Venkatesh Balan
2-Keto- d -gluconic acid (2-KGA) is a high-value-added product from lignocellulosic straw-based biorefining process obtained via cell catalysis using Gluconobacter oxydans ( G. oxydans ); nonetheless, the economical production has some limitations because of the formation of undesirable mixture products of keto-gluconic acid from glucose. In this study, it was demonstrated that pulse addition of hydrogen peroxide (H 2 O 2 ) to synthetic media was beneficial to improve the conversion rate of glucose to 2-KGA by 1.47-fold in G. oxydans . Moreover, some lignocellulosic degradation compounds served as substitute and played the role of H 2 O 2 on corn stover hydrolysate for the production of 2-KGA. By conducting qRT-PCR analysis, eight dehydrogenase genes were identified in G. oxydans , which were responsible for regulating 2-KGA production. Moreover, most of the identified genes were found to produce membrane-bound glucose dehydrogenase and gluconate 2-dehydrogenase, and were up-regulated by adding H 2 O 2 or degradation compounds. These up-regulated genes could be responsible for directing cell catalysis of glucose to 2-KGA in G. oxydans .
研究领域:
生物化学
·
微生物学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2024
·
IF 4.1
Xiaoyu Lou,Duanlian Tang,Xuanjie Chen,Lanbin Mo,Yong Li,Changshen Ye,Jie Chen,Ting Qiu
The heavy-metal contamination of aquatic environments presents imminent threat. Herein, we report a class of dual-heteroatomic conjugated microporous poly(aniline)s showing high-affinity separation performance toward heavy metals. The prepared keto-CMPA shows monolayer adsorption capacity for Hg (II) as high as 980 mg g −1 according to the Langmuir model, and ultra-rapid kinetic with h reaching 30.41 mg g −1 that could be described by the pseudo-second-order model. It maintains excellent stability across six reuses under harsh conditions, and furthermore demonstrates ultradeep separation efficiency that could adsorb almost all of heavy metals to ppb level with low usage. For further industrialization, a competent adsorption device was developed to remove heavy metals down to 1 ppb with a remarkable breakthrough over 20,000 BV. Characterizations and DFT calculation showed that the triangular synergistic region formed by the N-O-sites in the singular CMPA structure provided a feasible binding energy to enable the above impressive performance.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Shu Tian,Daoyi Jiang,Jibin Pu,Xiaofeng Sun,Zhanming Li,Bin Wu,Wenru Zheng,Wenqing Liu,Zhixiong Liu
A series of hybrid antifouling coatings consisting of silicone elastomer and nanocomposite hydrogel were successfully prepared. The morphology of the hybrid coatings and the silver nanoparticles (AgNPs) embedded into the coatings were studied by SEM and TEM. The pure silicone coating showed a relatively flat morphology. Smooth spheroidal aggregates self-assembled by hydrophilic polymer with a diameter of 4–14 μm appeared when the polymer chains were introduced. However, with increasing of AgNPs the spheroidal aggregates were gradually covered with a thin silicone film and were firmly embedded into the coatings. The glass transition temperature of the hybrid coatings measured by DSC technique showed that the silicone elastomer and the hydrogel matrix formed interpenetrating polymer networks (IPN). The static water contact angle of the hybrid coatings with different amount of the hydrophilic polymer chains before and after being immersed into water was also measured. Furthermore, these hybrid coatings showed good antimicrobial performance for Escherichia coli and anti-algae property. The result showed that the SH-0.25-1.5 sample could almost kill 100% E. coli. Compared with the control sample, the settlement of the Phaeodactylum tricornutum, Navicula torguatum and Chlorella on the surface of SH-0.25-1.5 sample decreased approximately 37%, 37% and 52%, respectively. The antifouling performances of the hybrid coatings were examined by field tests in South China Sea and the result showed the hybrid coatings with nanocomposite hydrogel exhibited good antifouling property. These hybrid coatings have promising applications in marine antifouling coating and interfaces of biomaterials.
研究领域:
材料科学
·
海洋生物学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
MOLECULES
·
2022
·Vol. 27
·期 9
·2629
·
IF 4.927
Hang Zhang,Xiaoxiao Chen,Shengliang Li,Jianliang Shen,Zong-Wan Mao
As hypoxia is closely associated with tumor progression, proliferation, invasion, metastasis, and strong resistance to therapy, regulating and overcoming the hypoxia tumor microenvironment are two increasingly important aspects of tumor treatment. Herein, we report a phototherapeutic platform that uses the organic photosensitizer diketopyrrolopyrrole (DPP) derivative and inorganic iridium salts (IrCl3) with photothermal activity and the capacity to decompose H2O2efficiently. The characterization of their photophysical properties proved that DPP-Ir nanoparticles are capable of remarkable near-infrared (NIR) absorption, and compared to DPP nanoparticles, the photothermal conversion efficiency (PCE) increases from 42.1% in DPP nanoparticles to 67.0% in DPP-Ir nanoparticles. The hybrid nanoparticles utilize the catalytic decomposition of endogenous H2O2to produce oxygen for the downregulation of the hypoxia-inducible factor 1 subunit alpha (HIF-1α) protein, which could reverse the tumor hypoxic microenvironment. Benefiting from the excellent optical properties and good biocompatibility, the hybrid platform exhibits efficient photothermal therapeutic effects as well as good biological safety. In conclusion, such a hybrid platform could improve photothermal therapy against cancer.Keywords:hypoxia;diketopyrrolopyrrole;photothermal therapy;catalyze H2O2;hybrid platform
研究领域:
肿瘤学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2025
·
IF 9
Zeyuan Liu,Zhansheng Li,Shouhai Zhang,Qian Liu,Zhaoqi Wang,Danhui Wang,Peiqi Xu,Shugang Xu,Han Jiang,Xigao Jian
The highly chlorine-resistant polyester-amide thin-film composite (TFC) nanofiltration (NF) membranes (PEA/PPBES) with specific layers incorporating phthalazinone moieties were prepared by interfacial polymerization. With the addition of 4-(4'-hydroxyphenyl)-2,3-phthalazin-1-one (DHPZ) to an aqueous phase of piperazine (PIP), and by using butanone as a co-solvent in the organic phase with trimesoyl chloride (TMC), the chlorine resistance and permeability of the PEA/PPBES membranes were enhanced simultaneously. When the co-solvent butanone was used, a distinctive ring-fold structure on the surface of the selective layer was observed, which could be the reason for the significantly improved the permeability of the PEA/PPBES membranes. With the addition of 3% butanone to the organic phase, the pure water flux (PWF) of the fabricated membrane was 118 L m -2 h -1 (0.5MPa), and the Na 2 SO 4 rejection reached 97.9%, increasing the water permeability by 2.6 times, compared to the control (without butanone). Additionally, the introduction of the phthalazinone moieties improved filtration performance at high temperatures as well as chlorine resistance. At an operation temperature of 95 °C, the water flux and Na 2 SO 4 rejection achieved 148.5 L m -2 h -1 and 96.4%, respectively. After a total NaClO exposure of 60,000 ppm h, the Na 2 SO 4 rejection and water flux changed slightly, demonstrating excellent chlorine resistance. This work offers a novel approach to fabricate TFC NF membranes with excellent chlorine resistance.
研究领域:
材料科学
·
环境工程
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Chunhui Li,Shuozhen Cheng,Jinfeng Dong,Xuefeng Li
A series of block copolymers poly ( N -2-(methacryloyloxy) ethyl pyrrolidone)- b -poly (benzylmethacrylate) (PNMP 39 - b -PBzMA n ) were developed. These amphiphilic copolymers formed diversified aggregates in water, depending on the degree of polymerization n of the PBzMA segment. There presented the n -induced morphological transition from spherical micelles to vesicles via wormlike micelles. Moreover, PNMP 39 - b -PBzMA n aggregates were excellent dual function emulsifiers, showing similarity with both particles and surfactants simultaneously. The emulsification of PNMP 39 - b -PBzMA n aggregates was affected significantly by the degree of polymerization n of the PBzMA segment and oil. However, the effect of oil was more remarkable in comparison with that of n , in which the compatibility between oil and the hydrophobic PBzMA segment was critical. In general, O/W and W/O emulsions were formed for oils with poor and good compatibility to the PBzMA segment such as nonpolar alkanes and toluene, respectively. In these cases, PNMP 39 - b -PBzMA n aggregates were remained in water in the alkane/water systems, whereas they were transferred into the toluene phase according to the similarity-intermiscibility principle. For isopropyl myristate, a polar oil with the intermediate compatibility to the PBzMA segment, PNMP 39 - b -PBzMA n in water were transferred into the oil phase partially. Accordingly, emulsifiers in water and oil benefit the formation of O/W and W/O emulsions, respectively, as observed in the alkane/water and toluene/water systems. As a result, O/W and W/O emulsions were generated by PNMP 39 - b -PBzMA n with relatively small and large n , respectively. For PNMP 39 - b -PBzMA n with the intermediate n , W/O/W multiple emulsions were formed attributing to the synergistic emulsification of PNMP 39 - b -PBzMA n in water and oil.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2023
·
IF 6
Hongjian Gu,Cheng Liu,Qian Liu,Yu Zhang,Meng Wang,Xi Chen,Yousi Chen,Jinyan Wang,Xigao Jian
A series of poly(bisphthalazinone ether sulfone ketone)s with pendant phenyl groups (POPESKs) were synthesized via aromatic nucleophilic substitution polycondensation. The thermal degradation mechanism of POPESKs was determined investigated by TG-FTIR. The T g s of POPESKs range from 296 to 326 °C and the storage modulus retention is up to 46.1 % at 290 °C. POPESKs have good solubility in dichloroethane, chloroform, tetrachloroethane, N -methyl-2-pyrrolidone and pyridine, and exhibit good film-forming property. The tensile strength, tensile modulus, and tensile elongation of POPESK films are 85–96 MPa, 1.34–1.86 GPa, and 8.9–11.6 %, respectively. Meanwhile, the polymer films exhibit the high light transmittance of up to 83 % at 800 nm and its water contact angle are in the range of 82.3–94.3°. Its superior overall performance shows great potential in aerospace, petrochemical and energy applications.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2025
·
IF 6.2
Yue Zou,Mei Zhu,Zongnan Zhu,Tingting Du,Xing Liu,Yaojia Jiang,Jixiang Chen
1,2,4-Thiadiazole derivatives containing a sulfone moiety were designed and synthesized via scaffold hopping to facilitate the discovery of novel antibacterial agents. Most of the compounds exhibited excellent activity against three plant pathogenic bacteria. The half-maximal effective concentrations (EC50) of compound B7 for Xanthomonas oryzae pv oryzae (Xoo) and X. oryzae pv oryzicola (Xoc) concentrations were 0.4 and 1.0 mg/L, respectively. In addition, the EC50 values of compounds B1 and B24 for Xoo, Xoc, and Pseudomonas syringae pv actinidiae (Psa) were less than 5 mg/L and significantly better than those of the positive control agents thiodiazole copper (121.8, 119.5, and 142.0 mg/L, respectively) and bismerthiazol (73.3, 65.6, and 128.8 mg/L, respectively). Compound B7 exhibited protective and curative activities of 48.1 and 46.7%, respectively, against bacterial leaf blight, which were higher than those of bismerthiazol (35.5 and 36.9%, respectively) and thiodiazole copper (39.3 and 39.5%, respectively). Additionally, compound B7 exerted an effect on the virulence factors of Xoo (production of exopolysaccharides and extracellular enzymes, biofilm formation, and motility), membrane permeability, cell surface morphology, and intracellular content of reactive oxygen species. Transcriptome analysis showed that compound B7 improved the resistance of rice plants to external stress by influencing the metabolic process, biological regulation, catalytic activity of enzymes, and plant–pathogen interaction. Compound B7 can therefore be considered as a potential candidate antibacterial agent and warrants an in-depth investigation in the future.
研究领域:
植物病理学
·
药理学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）