SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Weirui Chen,Muxin Lin,Jiaxin Zhou,Xukai Li,Xipeng Wei,Gaozu Liao,Jing Wang,Laisheng Li
Lewis acid site was vital center for activating O 3 during catalytic ozonation process. Herein, we proposed a strategy to enhance the Lewis acid strength of Fe-MCM-48 (FeM) by fluorination. Fluorinated Fe-MCM-48 (FFeM) exhibited the better catalytic ozonation efficiency towards Ketoprofen (KET), a kind of nonsteroidal anti-inflammatory drug. 87.4 % TOC removal was obtained by F 2.5 Fe 0.8 M/O 3 process, but only 27.5 % and 52.7 % were found by sole ozonation and Fe 0.8 M/O 3 processes, respectively. Comparative characterizations, experiments and DFT calculations showed that fluorinated FFeM was regular sphere with three dimensional duct channel and large S BET . Doping of F reduced particle size, implanted electron withdrawing Si-F group and formed the electron poor center around Fe atom, which enhanced Lewis acid strength of FFeM. Protonated hydroxyl groups on Lewis acid sites were the main active sites for O 3 activation. Greater amount of O 3 were absorbed on the surface of FFeM and the greater O 3 utilization rate, •OH and •O 2 – generation rates were obtained by FFeM/O 3 process. Common anions such as Cl − , SO 4 2− and NO 3 – and Humic acids (HA) had little effect on KET removal but inhibited TOC removal in FFeM/O 3 process. •OH, •O 2 – and Fe(IV) = O oxidation were accounted for KET degradation. 16 kinds of intermediates generated from KET degradation and 4 pathways were deduced.
研究领域:
环境科学
·
化学工程
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2021
·
IF 5.875
Jiajie Hu,Zhuoyao Ni,Hui Zhu,Hanglin Li,Yinghong Chen,Yazhuo Shang,Daijie Chen,Honglai Liu
Liquid crystals (LCs) are widely used for drug delivery due to their controlled and sustained drug release properties. In this paper, drug crystallization encapsulated liquid crystal emulsion, a novel drug delivery system, was proposed. The lamellar liquid crystals formed by hydrogenated lecithin, which are similar to the skin stratum corneum lipid structure, are adopted as the drug carrier to encapsulate non-steroidal anti-inflammatory drugs (NSAIDs). As the model drug, ketoprofen exists in the hydrophobic core of emulsion as a drug crystal when squalane is used as the oil phase. The microstructure, sustained drug release behaviors, physicochemical property and biocompatibility of the system were examined by polarized light microscopy, rheological measurements, differential scanning calorimetry, X-ray diffraction, small-angle X-ray scattering, in vitro release study, and in vitro cellular cytotoxicity assay. The results have shown that the novel system lowers the drug crystal melting point and improves the thermal stability of liquid crystal structure. Besides, the excellent biocompatibility and sustained release property through the additional dissolution step of drug crystal show its application potentials in the topical cosmeceuticals. The results will also be helpful for in-depth understanding of the physical state of encapsulated drug in the liquid crystal carrier systems.
研究领域:
药剂学
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药物递送系统
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材料科学
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产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Zhilun Liu,Lei Zhao,Shuang Lu,Xiaohan Hou,Ding Hou,Bo Sun,Min Zhao,Xueyan Li,Jun Ma
In recent years, biochar catalysts have shown great potential in activating persulfate (PS) for organic pollutant degradation in water. However, current challenges persist in biochar-activated PS systems: variations in pyrolysis conditions and precursors compromise long-term operational stability, complex aqueous environments lead to suboptimal degradation efficiency, and activation mechanisms remain scientifically contentious. The characterizations of the mushroom derived biochar (MBC) showed the unique sieve tube structure, rich surface functional groups and large specific surface area (SSA) (632.08 m 2 /g). The rich surface functional groups and large SSA could facilitate mass transfer and provide rich active sites for activating peroxymonosulfate (PMS). In the MBC-800/PMS system, the degradation efficiency of ketoprofen (KTP) could reach 88.83 %, which higher than other biomass derived biochar and many synthetic activators. The free radical degradation and non-free radical degradation were both involved in this activation reaction, and the sulfate radicals (SO 4 •– ) were the dominant oxidative species for KTP degradation. According to the XPS analysis results, the ketone groups and carboxyl groups were the active sites for activating PMS. In addition, the main intermediates of KTP were analyzed and the pathway of KTP degradation was investigated. This study could provide an effective catalyst for activating PMS and insight into the mechanism of the radicals produced in the biochar/PMS system, which could provide high value for the research of biomass activator to activate PMS.
研究领域:
环境科学
·
催化材料
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产品关联
DOI
高影响因子
CATALYSIS COMMUNICATIONS
·
2023
·
IF 3.7
Shuxuan Feng,Chu Dai,Yunjie Huang,Guiqiu Wu,Yulun Nie,Xike Tian
This study focuses on the feasibility of boron nitride as a catalyst for ozonation of ketoprofen. The defective boron nitride was prepared by calcination of boric acid and melamine and characterized by XRD, SEM, FT-IR, XPS, temperature programmed desorption, Raman and UV–Vis diffuse reflectance spectra. The apparent rate constant and removal efficiency of chemical oxygen demand in the boron nitride catalyzed system were 2.7 times and 1.6 times higher than those of the ozonation alone at the pH of 7, respectively. The catalytic active sites were found to be acidic B OH and could be generated by manufacturing defects during preparation.
研究领域:
环境科学
·
材料科学
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产品关联
DOI
高影响因子
RSC Advances
·
2018
·Vol. 8
·期 19
·10541-10548
·
IF 2.936
Yongqin Zeng,Xiaoxuan Lin,Fuhua Li,Ping Chen,Qingqing Kong,Guoguang Liu,Wenying Lv
In this study, nitrate ion (NO3−) was found to collaborate with ozone thereby accelerating the degradation of ketoprofen. NO3− was discovered to induce the generation of hydroxyl radicals (·OH), which was crucial to the decomposition of PPCPs in wastewater treatment plants. Kinetic studies on the decomposition of ketoprofen were investigated under different concentrations of NO3−. The impact mechanisms and degradation by-products were experimentally determined. The results revealed that all reactions fitted the pseudo-first-order kinetic model well. The presence of NO3− had the capacity to accelerate the ozonation of ketoprofen. The reaction by-products were evaluated by UPLC-Q-TOF-MS, and a total of five intermediates generated via the ozonation of ketoprofen were assessed. The transformation pathways were concluded to be hydroxylation, nitration, and debenzophenone and ketonized reactions. Additionally, the toxicity of the by-products was evaluated by employing Chlorella and Daphnia magna.
研究领域:
环境科学
·
毒理学
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2017
·
IF 3.887
Heyu Li,Kailin Liu,Qingqing Sang,Gareth R. Williams,Junzi Wu,Haijun Wang,Jianrong Wu,Li-Min Zhu
In this study, the thermosensitive polymer poly(di(ethylene glycol) methyl ether methacrylate) (PDEGMA) was synthesized and electrospun into fibers by blending with ethyl cellulose (EC). Fibers were additionally prepared loaded with ketoprofen (KET) as a model drug. Smooth cylindrical fibers could generally be observed by electron microscopy, although there were some beads and fused fibers visible in the KET-loaded materials. KET was found to be amorphously distributed in the fibers on the basis of X-ray diffraction data. From water contact angle measurements, it was clear that the wettability of the EC/PDEGMA systems changed as the temperature increased, with the fibers becoming markedly more hydrophobic. In vitro drug release studies showed that KET was released over a prolonged period of time with the fibers having different profiles at 25 and 37 °C, reflecting their thermosensitive properties. Furthermore, the materials were found to have good biocompatibility towards L929 fibroblasts. Thus, the fibers prepared in this work have potential as smart stimuli-responsive drug delivery systems.
研究领域:
药剂学
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材料科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2022
·
IF 5.062
Lijuan Ye,Weibin Chen,Yuan Chen,Yuqin Qiu,Jun Yi,Xiaofang Li,Qiuxiao Lin,Bohong Guo
Transdermal administration is a promising non-invasive and convenient method of drug delivery in clinic and avoid serious gastrointestinal adverse reactions. In this study, a hybrid nanocarrier was developed to facilitate transdermal delivery of drugs. The low water-soluble ketoprofen (KP) was ultrasonically loaded on functionalized multi-walled carbon nanotubes (f-MWCNTs), and the preparation process was optimized using Box-Behnken design. Then, KP-loaded f-MWCNTs composite ethosomes (f-MWCNTs-KP-ES) were prepared by a single-step injection technology. Over the study period, the preparation was verified by a series of characterizations, and ex vivo release characteristics, ex vivo permeation of rat skin and in vivo pharmacokinetics were studied. The characterization results consistently showed that f-MWCNTs-KP-ES were successfully prepared. The preparation can obviously improve the solubility of KP. Ex vivo permeation experiments showed that had a sustained release effect and the skin penetration rate of f-MWCNTs-KP-ES gel is the fastest, with a cumulative permeation amount of 602.35 ± 41.06 μg/cm 2 . In addition, both ethosomes and f-MWCNTs could increase the retention of drugs and form drug reservoirs. Fluorescence microscope images of rat skin clearly illustrated the faster and deeper penetration of f-MWCNTs composite ethosomes formulation loaded with rhodamine B (RB) (f-MWCNT-RB-ES). In vivo pharmacokinetic experiments showed the area under the drug time curve (AUC 0-t ) and elimination half-life (T 1/2β ) of f-MWCNTs-KP-ES gel group were significantly increased and prolonged compared with KP commercial gel group, respectively. The overall data indicate that the f-MWCNTs composite ethosomes formulation is a promising transdermal drug delivery system .
研究领域:
药剂学
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生物医学工程
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药物递送系统
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产品关联
DOI
高影响因子
PHARMAZIE
·
2023
·Vol. 78
·期 5
·31-36
·
IF 1.6
Xiaowei J.,Lijuan Y.,Yanling L.,Qiuxiao L.,Bohong G.
The purpose of this study was to combine carbon nanotube with ethosomes in order to obtain hybrid nanocarriers for transdermal delivery of ketoprofen (KP). KP-loaded functionalized single-walled carbon nanotube (f-SWCNTs) composite ethosomes (f-SWCNTs-KP-ES) were designed and were verified
by a series of characterizations. The particle size of the preparation is less than 400 nm. DSC and XRD experiments showed that KP existed in an amorphous state after it was adsorbed and loaded on f-SWCNTs. TEM experiments showed that the structure of SWCNTs remained intact after oxidation
and modification by PEI. FTIR results showed that PEI were successfully modified on the surface of SWCNT-COOH, and KP was successfully loaded on f-SWCNTs. In vitro release characteristics showed that the preparation had sustained release behavior and conformed to the first-order kinetic
equation model. In addition, f-SWCNTs-KP-ES gel were prepared and in vitro skin permeation and in vivo pharmacokinetics were studied. The results showed that f-SWCNTs-KP-ES gel could enhance the skin permeation rate of KP and increase the drug retention of drugs in the skin.
The characterization results consistently showed f-SWCNTs is a promising drug carrier. The hybrid nanocarrier prepared by the combination of f-SWCNTs and ethosomes can enhance the transdermal absorption of drugs and improve the bioavailability of drugs, which has a certain significance for
the development of advanced hybrid nano-preparations.
研究领域:
药剂学
·
纳米医学
·
药物递送系统
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产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2017
·Vol. 41
·期 17
·9321-9329
·
IF 3.269
Nadeem Muhammad,Weixia Li,Qamar Subhani,Fenglian Wang,Yong-Gang Zhao,Yan Zhu
The aim of this novel study was to introduce a cheap, simple, sensitive, and green methodology involving the dual application of synthesized porous SnO2 nanoparticles (NPs) for selective conversion of non-fluorescent ketoprofen (KP) into a highly fluorescent species and as a sorbent in a μ-sample preparation method for extraction of KP from the three complex human serum, urine, and canal water samples. The clean separation and sensitive fluorescence determination of KP from these complex samples were carried out by coupling an ion chromatograph with a fluorescence detector (IC-FLD). The sorbent was prepared by a simple chemical precipitation method in water and characterized via various techniques. The porous SnO2 NPs, in addition to their role in the selective conversion of KP into a highly fluorescent species, also act as an effective sorbent for the selective degradation and elimination of polar organics, inorganic matrices, and heavy metals in complex samples. The optimized analytical method exhibited satisfactory linearity for ketoprofen in the concentration range of 0.2–1.5 mg kg−1 with a correlation coefficient (r2) of 0.997. The limit of detection (LOD) and quantification (LOQ) in human serum, urine, and canal water samples were 0.1 μg kg−1, 0.5 μg kg−1, and 0.39 μg kg−1 and 1.3 μg kg−1, 0.3 μg kg−1, and 1.7 μg kg−1, respectively. The method also showed good intra-day and inter-day precisions at the two concentration levels of 0.5 mg kg−1 and 1.3 mg kg−1 in complex samples with the relative standard deviations (RSDs) less than 16.3% (n = 5), and satisfactory recoveries were retrieved in the range of 85.1–101.4% with minimum or no matrix effect.
研究领域:
分析化学
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环境科学
·
药物分析
✓ 已验证
DOI
高影响因子
Analytical Methods
·
2021
·Vol. 13
·期 25
·2836-2846
·
IF 2.896
Shan Chen,Shu Zhou,Jinli Fu,Sisi Tang,Xiaodan Wu,Pengfei Zhao,Zhaohui Zhang
A novel near infrared fluorescence imprinted sensor based on polyethyleneimine passivated copper-doped CdS quantum dots and zinc oxide nanorods for rapid recognition of ketoprofen was successfully prepared by sol–gel imprinting technology. The results showed that the copper-doped CdS quantum dots passivated with polyethyleneimine could improve the fluorescence lifetime and stability. Zinc oxide nanorods as carriers could improve the fluorescence response speed and sensitivity of the imprinted sensor toward ketoprofen. And the fluorescence imprinted sensor could rapidly recognize ketoprofen in just 1.0 minute. Under optimum conditions, the fluorescence intensity of the fluorescence imprinted sensor was quenched linearly by ketoprofen in the concentration range of 0.05–35.5 μM with a detection limit of 1.36 nM. The fluorescence response mechanism of the fluorescence imprinted sensor toward ketoprofen was discussed in detail, and the fluorescence quenching of the fluorescence imprinted sensor by ketoprofen was attributed to the electron transfer. The fluorescence imprinted sensor was applied to recognize ketoprofen in tap water, lake water, waste water and human urine samples rapidly with the recoveries of 97.3–103.7%. The near infrared fluorescence imprinted sensor provided a new reliable method for rapid and sensitive recognition of drugs in complex samples selectively.
研究领域:
分析化学
·
材料科学
·
药物检测
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Jian Chen,Jinbo Ouyang,Wenqian Chen,Zepeng Zheng,Zhen Yang,Zhirong Liu,Limin Zhou
Porous chitosan/Zr-MOF (UiO-66) composite foams (CSF@UiO-66) were facilely prepared by grafting UiO-66 into polymerized chitosan using epichlorohydrin as the linking agent. The flexible foams with high loadings of UiO-66 exhibited low density (15.0 ∼ 23.4 mg/cm 3 ) and superior liquid–solid separation performance. The hierarchical pores and abundant functional groups contributed to the effective removal of ketoprofen (KPF) from water by the composite foams, achieving a maximum adsorption capacity of 209.7 mg/g at pH 4, outperforming most reported adsorbents. Batch adsorption experiments demonstrated that the adsorption of KPF could be described by the Langmuir isotherm and pseudo-second-order kinetic model. Importantly, the composite foams showed excellent performance even in the presence of some ions and good reusability for engineering applications. Furthermore, density functional theory (DFT) calculations revealed that the adsorption mechanism between the composite foams and KPF could be attributed to hydrogen bonding and π-π interaction. In essence, this work provides an innovative strategy for the fabrication of a blocky composite foam with high loadings of MOF for efficient adsorptive removal of KPF in liquids, which can overcome the disadvantages of agglomeration due to small particle size and poor stability of MOFs.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2018
·Vol. 25
·期 31
·31486-31496
·
IF 2.8
Wu Lin,Yang Ningwei,Li Binghua,Bi Erping
Hydrophobic acid (HoA) and hydrophilic neutral (HiN) are two major fractions of dissolved organic matter (DOM). Their role in the sorption of ketoprofen (KTP) to wheat straw-derived biochars pyrolyzed at 300 °C (WS300) and 700 °C (WS700) was investigated to further probe the mechanisms responsible. WS700 has much higher pore volume and specific surface area (SSA) than WS300. Loading of HoA and HiN resulted in surface coverage of biochars. HoA with larger molecular size led to more pore blockage of biochars than HiN. Higher HoA binding affinity also caused a stronger competition with KTP on biochars. These factors reduced the accessibility of sorption sites for KTP, and significantly inhibited KTP sorption to biochar of lower SSA (i.e., WS300) by HoA. Water solubility ( S w ) of KTP was slightly enhanced (3%) in the presence of HoA. In contrast, the presence of HiN reduced (22%) S w of KTP. The decreased S w of KTP by HiN exerted a more dominant influence than its competitive and loading effects, thus led to apparent enhanced sorption of KTP, especially to biochar of higher SSA (i.e., WS700). The results demonstrated the diverse effects of HoA and HiN on KTP sorption, which is helpful in understanding pharmaceutical-DOM-biochar interactions and environmental behaviors of pharmaceuticals.
研究领域:
环境科学
·
污染生态学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）