SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2024
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IF 4.3
Yingwei Gao,Shuo Zhang,Bo Ge,Hui Zhao,Chuanyu Jin,Hui Yan,Limin Zhao
The high thermal stability and chemical durability of amide-linked covalent organic frameworks (amide COFs) make them a promising material for a range of new applications. Nevertheless, the low reversibility of the amide bond presents a significant challenge to the direct synthesis of amide-bonded COFs. In this paper, we present a simple method for synthesizing amide COFs. The synthesis of imine-linked COFs was initially achieved through the reaction of 2,4,6-tris(4-aminophenyl)-1,3,5-triazine and 2,5-dimethoxybenzene-1,4-dicarboxaldehyde. Subsequently, amide COFs were synthesized via the oxidation of the imine bond into an amide bond, utilizing ammonium persulfate as the oxidizing agent. Due to the difference of link bond, two COFs separately displayed distinct and significant fluorescence enhancement for Al 3+ and Ce 3+ , which was highly sensitive and less affected by environmental factors. The strategy offers a novel approach to the convenient and environmentally benign synthesis of amide COFs, which may facilitate their wider applications.
研究领域:
材料科学
·
化学
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产品关联
DOI
PubMed
高影响因子
MOLECULAR PHARMACEUTICS
·
2016
·
IF 4.342
Yingjie Fu,Qishuai Feng,Yifan Chen,Yajing Shen,Qihang Su,Yinglei Zhang,Xiang Zhou,Yu Cheng
Drug attachment is important in drug delivery for cancer chemotherapy. The elucidation of the release mechanism and biological behavior of a drug is essential for the design of delivery systems. Here, we used a hydrazone bond or an amide bond to attach an anticancer drug, doxorubicin (Dox), to gold nanoparticles (GNPs) and compared the effects of the chemical bond on the anticancer activities of the resulting Dox-GNPs. The drug release efficiency, cytotoxicity, subcellular distribution, and cell apoptosis of hydrazone-linked HDox-GNPs and amide-linked SDox-GNPs were evaluated in several cancer cells. HDox-GNPs exhibited greater potency for drug delivery via triggered release comediated by acidic pH and glutathione (GSH) than SDox-GNPs triggered by GSH alone. Dox released from HDox-GNPs was released in lysosomes and exerted its drug activity by entering the nuclei. Dox from SDox-GNPs was mainly localized in lysosomes, significantly reducing its efficacy against cancer cells. In addition, in vivo studies in tumor-bearing mice demonstrated that HDox-GNPs and SDox-GNPs both accumulate in tumor tissue. However, only HDox-GNPs enhanced inhibition of subcutaneous tumor growth. This study demonstrates that HDox-GNPs display significant advantages in drug release and antitumor efficacy.
研究领域:
药物递送
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癌症化学疗法
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2020
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IF 8.758
Hongjun Yang,Ziye Ren,Yongkang Zuo,Yiye Song,Li Jiang,Qimin Jiang,Xiaoqiang Xue,Wenyan Huang,Kaojin Wang,Bibiao Jiang
The amide bond is one of the most pivotal functional groups in chemistry and biology. It is also the key component of proteins and widely present in synthetic materials. The majority of studies have focused on the formation of the amide group, but its postmodification has scarcely been investigated. Herein, we successfully develop the Michael additions of amide to acrylate, acrylamide, or propiolate in the presence of phosphazene base at room temperature. This amide Michael addition is much more efficient when the secondary amide instead of the primary amide is used under the same conditions. This reaction was applied to postfunctionalize poly(methyl acrylate-co-acrylamide), P(MA-co-Am), and it is shown that the amide groups of P(MA-co-Am) could be completely modified by N,N-dimethylacrylamide (DMA). Interestingly, the resulting copolymer exhibited tailorable fluorescence with emission wavelength ranging from 380 to 613 nm, which is a desired property for luminescent materials. Moreover, the emissions of the copolymer increased with increasing concentration in solution for all excitation wavelengths from 320 to 580 nm. Therefore, this work not only develops an efficient t-BuP4-catalyzed amide Michael addition but also offers a facile method for tunable multicolor photoluminescent polymers, which is expected to find a wide range of applications in many fields, such as in anticounterfeiting technology.
研究领域:
有机化学
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高分子化学
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材料科学
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DOI
高影响因子
ChemSusChem
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2024
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IF 7.5
Rui Xue,Yin-Sheng Liu,Ming-Yue Wang,Hao Guo,Wu Yang,Ji-Xi Guo,Guo-Yu Yang
Graphical The amide linked COFs (Am-COF-T and Am-COF-B) prepared through post-synthetic modification, exhibited excellent photocatalytic performance for oxidation of thioethers and coupling of benzylamines with superior stability. Covalent organic frameworks (COFs) and their applications in photocatalysis have been extensively studied, but the instability of imine-linked COFs is an important factor limiting their performance. In this work, two imine-linked COFs were successfully converted to amide-linked COFs through post synthetic modification (PSM). The oxidized COFs presented lower binding energy to O 2 , exhibited higher photocatalytic activity for oxidation of thioethers and coupling of benzylamines with excellent stability. The present work can serve as a reliable reference for the development of novel highly active and stable COF-based photocatalysts.
研究领域:
材料科学
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化学工程
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产品关联
DOI
PubMed
高影响因子
Molecular Systems Design & Engineering
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2024
·
IF 3.2
Junlong Yao,Zongqiang Fu,Huan Yang,Lin Gao,Xueliang Jiang,Wei Nie,Zhengguang Sun,Haolan Lu,Meiyun Lin,Jinglou Xu
Multifunctional composites with rapid self-healing performance have been widely applied in various fields. However, different types of fillers result in decreased self-healing efficiency and present agglomeration and poor compatibility especially at high filler contents. Here, based on the different surface modifications of barium titanate (BT) and silicon carbide (SiC) and the amide-bond synergistic effects between these fillers, self-healing supramolecular composites with high filler contents (up to 30%) are reported, and exhibit high strength, dielectric and thermal-conduction properties. Modification significantly improves the dispersion of these fillers, and greatly enhances the coexistence and synergy between these fillers. This three-phase amide-bonded supramolecular composite exhibits a high tensile strength of 3.22 MPa compared to other self-healing materials such as self-healing hydrogels, a high dielectric constant of 23, a high thermal conductivity of 0.36 W m−1 K−1 and a superior self-healing efficiency of above 94%. These performances are ascribed to the formation of amide bonds between the amino groups in 3-aminopropyltriethoxysilane (KH550)-modified silicon carbide (SiC-NH2) and the carboxyl groups in tartaric acid (TA)-modified barium titanate (BT-TA), which can provide efficient supramolecular interactions between different fillers, as well as more reversible hydrogen bonding for the matrix. This three-phase amide-bonded supramolecular composite provides an effective strategy to improve the self-healing properties of multifunctional composites, and will bring pioneering functions to electronic packaging materials, dielectric energy storage materials, environmental energy and other fields, which can open up broad application prospects.
研究领域:
材料科学
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化学工程
✓ 已验证
产品关联
DOI
高影响因子
Surfaces and Interfaces
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2025
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IF 6.3
Wei Sun,Jiale Lu,Bo Feng,Amin Jv,Yufei Zhang,Jingwen Wang,Renquan Guan,Chunbo Liu
The construction of highly efficient charge transfer channels is crucial for effectively extending the lifetime of photogenerated carriers in heterostructures and enhancing their photocatalytic activity. In this study, ferrocene carboxylic acid (Fc-COOH) was successfully bonded to the surface of amino-modified titanium (Ti) through amide bonding. This modification not only preserved the excellent structure of MIL-125(Ti) but also broadened the light absorption range and effectively prolonged the lifetime of photogenerated charge carriers. The degradation rate of tetracycline by NTFCC-1.0, which exhibited the highest photocatalytic activity, exceeded 90% within 40 min, significantly outperforming the composite sample without amide bond connection. In addition, the mechanism of enhancing photocatalytic activity was further explored, and the toxic side effects of degradation intermediates on the environment were simulated through software. This work presents a novel approach for modifying MOF-based materials.
研究领域:
环境科学
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材料科学
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光催化
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产品关联
DOI
高影响因子
RESOURCES CONSERVATION AND RECYCLING
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2025
·
IF 10.9
Yusen Wu,Jiahua Lu,Keyi Lin,Jujun Ruan
With the development of the new energy industry, a large number of photovoltaic modules are produced, used, promoted, and will reach the end of their life cycle shortly. The recycling of photovoltaic modules is an important work in the closed-loop development of the new energy industry, and the first step of recycling is decapsulation. Hydrometallurgical decapsulation has been considered an important recovery method due to energy saving and the ability to recover all components of photovoltaic laminates. However, the problems of low decapsulation efficiency and pollutant discharge need to be solved. This article reports a new green linalool solvent employed for decapsulation. The experimental results show that the delamination rate of the glass of the laminates with particle sizes of 0.5, 1, 2, and 3 cm can all reach 100% in 4 hours. Furthermore, we propose a strategy to improve the efficiency of decapsulation by enhancing the bond-breaking tendency of the crosslinking bridge formed by the coupling agent in the EVA-glass interface. It indicates that the Lewis acid properties of Al 3+ and its coordination effect with nitrogen atoms promote the hydrolysis of C N bonds in the amid group. The increase of decapsulation efficiency by adding Al 3+ increases with the decrease of laminate particle size. When the particle size is 0.5 cm and 1 cm, the efficiency is increased nearly two times. This study provides a new idea for improving the green attributes and efficiency of hydrometallurgical decapsulation of photovoltaic laminates.
研究领域:
材料科学
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环境科学
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化学工程
✓ 已验证
产品关联
DOI
高影响因子
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
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2025
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IF 3.3
Zhao Bingshan,Micklefield Jason,Wang Yonghua,Wang Fanghua
N-trans -feruloyltyramine (FLA) is one kind of phenylpropanoid compound found in various plants. Numerous studies have confirmed that it exhibits a wide range of physiological functions, such as antioxidant, ɑ-glucosidase inhibition, and anti-inflammatory activity. However, the low content of FLA in plants greatly limits its potential use in food and pharmaceutical industries. It is, therefore, very important to establish an effective synthesis of FLA. In this study, a green and efficient method to synthesize FLA was sought using an amide bond synthetase (ABS) biocatalyst. Ten kinds of ABS enzymes, including AlCfaL from Azospirillum lipoferum , were screened as the potential biocatalysts for the production of FLA. To obtain optimum reaction conditions, the effects of various parameters on conversion of FLA were firstly evaluated. Under the optimum conditions using 1 mM N-trans -ferulic acid, 50 mM tyramine (substrate ratio of 1:50), 10 mM MgCl₂, 8 mM ATP, and 35 µM AlCfaL enzyme at 30 °C with a shaking speed of 500 r/min for 48 h, maximum conversion rate of 74% was reached. Given that the amidation reaction is mediated by relative expensive ATP, we further optimized reaction systems to incorporate an ATP recycling system consisting of a polyphosphate kinase enzyme (CHU) and an inexpensive polyphosphate (PolyP) as the phosphate donor. Response surface methodology (RSM) based on five-level, five-variable central composite design (CCD) was used to evaluate the optimal parameters for the production of FLA. The effects of AMP, PolyP, AlCfaL, CHU concentrations, and reaction time on the conversion rate of FLA were analyzed. The optimum conditions derived via RSM were 7.12 mM AMP, 5.96 mg/mL PolyP, 39.72 μM AlCfaL, 27.68 μM CHU, and a reaction time of 36 h. Validation experiments conducted under these optimized conditions yielded an actual conversion rate of 63.5%, which compared well to the maximum predicted value of 64.2%.
研究领域:
生物化学
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酶工程
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食品科学
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药学
✓ 已验证
DOI
PubMed
高影响因子
MACROMOLECULAR RESEARCH
·
2012
·Vol. 20
·期 4
·358-365
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IF 1.153
Zeng Rong,Wang Zehu,Wang Hongran,Chen Liqiang,Yang Lin,Qiao Renzhong,Hu Liming,Li Zelin
Two kinds of chitosan-stavudine (d4T) conjugates, chitosan- O -isopropyl-5′- O -d4T monophosphate conjugate (Cs-P-d4T) with a phosphoramide linkage and chitosan-5′- O -succinyl-d4T conjugate (Cs-S-d4T) with a succinic spacer, were synthesized using an Atherton-Todd reaction and carbodiimide coupling reaction, respectively, and then structurally characterized. Their in vitro drug release behaviors and anti-human immunodeficiency virus (HIV) activity were investigated and compared. Both of the chitosan-d4T conjugates more strongly prefer to release corresponding d4T derivatives rather than free d4T in a prolonged manner but have different hydrolysis routes. The anti-HIV activity and cytotoxicity evaluated in the MT4 cell line revealed that the anti-HIV selectivity index was in the following order: Cs-P-d4T > d4T >> Cs-S-d4T since the released d4T-5′-( O -isopropyl) monophosphate from Cs-P-d4T can bypass the rate-limiting bottleneck of nucleoside phosphorylation, while the released 5′- O -succinyl-d4T from Cs-S-d4T has to be hydrolyzed to d4T and then successively phosphorylated to its active form to exert antiviral activity. The results suggested that constructing a chitosan-nucleoside reverse transcriptase inhibitor (NRTI) conjugate with a phosphoramide linkage may be an efficient approach for improving NRTI therapy efficacy in antiretroviral treatment.
研究领域:
药学
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生物化学
·
抗病毒研究
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产品关联
DOI
高影响因子
WASTE MANAGEMENT
·
2021
·
IF 7.145
Zishang Tian,Xiaojie Shao,Jiaojiao Zhang,Lijuan Su,Yingxiong Wang,Tiansheng Deng,Yuqi Wang,Xianglin Hou
Poly-p-phenylene terephthamide (PPTA) is widely applied in bulletproof products and composite materials because of its high strength, high modulus, high temperature resistance and creep resistance. The PPTA molecule with highly symmetrical and regular structure is linear structure formed by the alternating connection of benzene ring and amide bond, and the amide bonds between the molecular chains form strong hydrogen bonds. Therefore, the dissolution and depolymerization of PPTA is very challenging. In this work, an efficient catalytic system was developed for the controllable degradation of waste PPTA, and the high-value added monomers terephthalic acid (TPA) and p-phenylenediamine (PPD) were recovered. The results show that the amide bonds of PPTA can be selectively cleaved by the strong Brönsted base catalysts in alcohols, especially in the NaOH/ n -butanol system. Under the optimal degradation conditions (5 wt% NaOH in n -butanol, 180 °C, 6 h), the percentage degradation of PPTA is 100%, and the yields of TPA and PPD are 92.0% and 91.5%, respectively. In addition, it is found that the wettability of n -alcohols on PPTA monofilament and the addition of a small amount of water have important influences on the degradation of PPTA. The work elucidates the degradation mechanism of PPTA, and reveals the important factors affecting the depolymerization of PPTA.
研究领域:
材料科学
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化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Huidong Wang,Ziyu Gao,Jianmin Sun
Finding robust combination modes between ionic liquids and MOFs is still a challenge. In this work, using a simple one step-synthesis method, the ionic liquid was grafted onto MOF without any additives, and the binding mode of the two was characterized by means of XPS, FT-IR, TGA, SEM etc. It was found that the carboxyl group in the ionic liquid bonded with the amino group in MOF to form an amide bond. Thus, a novel stable composite material MIL-101-NH 2 -1-carboxypropyl-3-methylimidazolium bromine (1-C-3-M@MIL-101-NH 2 ) was synthesized. This composite employed as a catalyst for CO 2 cycloaddition demonstrated excellent catalytic activity, achieving a target product PC (Propylene carbonate) yield of 91.7 % under the conditions of 80 °C, 1.0 MPa, and a reaction time of 4 h, without the addition of any co-catalysts or solvents. The good catalytic activity was benefit from the synergistic effect of Lewis acidic Cr centers and nucleophilic Br - , as well as the high specific surface area and good CO 2 affinity of 1-C-3-M@MIL-101-NH 2 . In addition, owing to this robust bonding configuration, the catalyst can be recycled up to five times without losing activity. It is a potential catalyst for CO 2 capture and conversion.
研究领域:
化学工程
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材料科学
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环境科学
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-10
·
IF 14.7
Xue Yu-Ren,Liu Chang,Ma Zhao-Yu,Zhu Cheng-Ye,Wu Jian,Liang Hong-Qing,Yang Hao-Cheng,Zhang Chao,Xu Zhi-Kang
It is particularly essential to analyze the complex crosslinked networks within polyamide membranes and their correlation with separation efficiency for the insightful tailoring of desalination membranes. However, using the degree of network crosslinking as a descriptor yields abnormal analytical outcomes and limited correlation with desalination performance due to imperfections in segmentation and calculation methods. Herein, we introduce a more rational parameter, denoted as harmonic amide bond density (HABD), to unravel the relationship between the crosslinked networks of polyamide membranes and their desalination performance. HABD quantifies the number of distinct amide bonds per unit mass of polyamide, based on a comprehensive segmentation of polyamide structure and consistent computational protocols derived from X-ray photoelectron spectroscopy data. Compared to its counterpart, HABD overcomes the limitations and offers a more accurate depiction of the crosslinked networks. Empirical data validate that HABD exhibits the expected correlation with the salt rejection and water permeance of reverse osmosis and nanofiltration polyamide membranes. Notably, HABD is applicable for analyzing complex crosslinked polyamide networks formed by highly functional monomers. By offering a powerful toolbox for systematic analysis of crosslinked polyamide networks, HABD facilitates the development of permselective membranes with enhanced performance in desalination applications.
研究领域:
材料科学
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化学工程
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环境工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）