ACS Photonics
·
2017
·
IF 6.756
Tanglue Feng,Qingsen Zeng,Siyu Lu,Xianju Yan,Junjun Liu,Songyuan Tao,Mingxi Yang,Bai Yang
In this paper, a unique strategy is proposed to modulate fluorescence color of carbon dots (CDs) under both aqueous solution and solid state for bright multicolor light-emitting diodes (LEDs) applications. We report facile synthesis of dual-peak-emissive CDs with self-quenching-resistant character under solid state through hydrothermal method, and investigate the origins of dual-peak emission for the first time. In addition, based on the unique dual-peak-emissive phenomenon, acid-mediated PL behaviors were realized by changing the pH value of hydrothermal precursors. We realized the color-tunable fluorescence under aqueous solution from blue (B-CDs) to yellow-green (YG-CDs) color and solid state from yellow to orange-red color. The changed PL behaviors are attributed to the more conjugated structure inside CDs due to elevated carbonization degree. Furthermore, the red-shifted fluorescence from aqueous solution to solid state is ascribed to supramolecular cross-linking between adjacent particles. Thus, by manipulating the supramolecular cross-linking degree of YG-CDs in PVA, a series of luminescent blue-shifted CDs/PVA composite phosphors were obtained. Finally, we fabricate the almost full-color and white color LEDs with decent performances, which indicate their potential for solid-state lighting applications.
研究领域:
材料科学
·
光学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2018
·
IF 3.412
Can Cui,Ailong Shi,Shuang Bai,Pengyu Yan,Qing Li,Kaishun Bi
Grape seed extract contains a high content of proanthocyanidins that can be depolymerized into C-4-substituted (epi)catechin derivatives in the presence of nucleophiles. However, the biological and medicinal values of depolymerization products have been rarely investigated. Recently, we developed a novel depolymerization product (−)-epicatechin-4β-S-captopril methyl ester (ECC) derived from the reaction of grape seed proanthocyanidin extract with captopril in the presence of acidified methanol. A central composite design was employed to select the most appropriate depolymerization temperature and time to obtain the target product ECC with a high yield. A total of 16 metabolites of ECC in rat urine, feces, and plasma were identified using liquid chromatography quadrupole time-of-flight tandem mass spectrometry. The in vivo results suggested that ECC could release captopril methyl ester and epicatechin, followed by the generation of further metabolites captopril and epicatechin sulfate conjugates. Therefore, ECC may be used as a potential prodrug with synergistic or additive hypotensive effects.
研究领域:
药理学
·
分析化学
·
药物化学
✓ 已验证
DOI
PubMed
高影响因子
Phytopathology Research
·
2022
·Vol. 4
·期 1
·1-12
·
IF 3.955
Jiang Long,Xiang Shunyu,Lv Xing,Wang Xiaoyan,Li Fengwei,Liu Weina,Liu Changyun,Ran Mao,Huang Jin,Xu Xiaohong,Ma Xiaozhou,Jin Yabo,Sun Xianchao
Silver (Ag)-containing agents or materials are widely used today in plant protection for their antimicrobial activity. In view of the superior inhibitory ability of biosynthesized (aldehyde-modified sodium alginate based) silver nanoparticles (AgNPs) against plant pathogenic fungi in our previous research, here we explored the antagonistic effect of biosynthesized AgNPs on plant pathogenic bacteria and the underlying mechanism. We selected Pseudomonas syringae pv. tabaci , the causal agent of tobacco wildfire disease, as the target and found that 1.2 μg/mL biosynthesized AgNPs completely inhibited the growth of P. syringae pv. tabaci in vitro and in vivo by partly destroying the cell membrane structure of the pathogen, resulting in cytoplasmic leakage. Moreover, Nicotiana benthamiana treated with 1.2 μg/mL biosynthesized AgNPs exhibited a significant upregulation of nonexpressor of pathogenesis-related genes 1 ( NPR1 ) and pathogenesis-related gene 2 ( PR2 ), the typical markers of the salicylic acid (SA)-mediated defense system, and an increase in peroxidase (POD) and polyphenol oxidase (PPO) activities as well as the production of reactive oxygen species (ROS). Furthermore, biosynthesized AgNPs treatment increased the chlorophyll content and dry weight of N. benthamiana . Overall, we demonstrated that biosynthesized AgNPs at a low concentration have high inhibitory effect on the pathogen causing tobacco wildfire disease by destroying bacterial cell membrane and inducing defense resistance in host plant. These results lay a theoretical foundation for further application of biosynthesized AgNPs in the control of plant bacterial diseases.
研究领域:
植物病理学
·
纳米技术
·
分子植物-微生物互作
✓ 已验证
DOI
高影响因子
Small
·
2025
·
IF 12.1
Tianao Xie,Yukai Shan,Win Topatana,Taorui Yang,Ruijing Shen,Shijie Li,Jiadong Chen,Yiyuan Zhu,Ziyi Lu,Yeling Liu,Tianen Chen,Yujie Gao,Yuchao Sun,Xiujun Cai,Sarun Juengpanich,Mingyu Chen
Hepatocellular carcinoma (HCC) is commonly classified as a “cold tumor” due to its low immunogenicity and poor response to conventional immunotherapies. Reprogramming the tumor immune microenvironment (TIME) via cuproptosis presents a promising strategy to enhance immunotherapies. Herein, sono-activatable N,N,N’,N’-tetrakis(2-pyridinylmethyl)-1,2-ethanediamine (TPEN)-encapsulated cancer-targeted nanoparticles (STCNs) designed to modulate the TIME and potentiate immunotherapy through endogenous cuproptosis are reported, termed “endogenous cuproptosis immunopromotion”. STCNs are rapidly internalized by HCC via folate-mediated endocytosis, and ultrasound irradiation triggers the release of TPEN. TPEN then chelates Cu 2 ⁺ from superoxide dismutase, initiating a Fenton-like reaction induced by glutathione that produces reactive oxygen species (ROS) and Cu⁺. This cascade induces cuproptosis and immunogenic cell death (ICD), promoting robust cytotoxic T lymphocyte infiltration in HCC. The combination of STCNs with anti-programmed cell death protein 1 (PD1) therapy demonstrates significant anti-tumor efficacy in vivo. Moreover, this strategy exhibits similar effectiveness in other solid tumor models, underscoring its broad therapeutic potential. These findings provide a promising framework for enhancing immunotherapy in cold tumors, paving the way for future cancer treatments.
研究领域:
肿瘤学
·
免疫学
·
纳米技术
·
生物化学
·
医学科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
·Vol. 48
·期 41
·17891-17899
·
IF 2.7
Xiang Liu,Weiyi Li,Ping Wang,Zheng Xing
In recent years, hydrogels have been employed to fabricate flexible capacitors (FCs) and wearable sensors. However, achieving a balance between the electrochemical and mechanical properties of hydrogels remains a challenge. Herein, polyacrylamide/sodium alginate (PAM/SA) dual-network hydrogels with good mechanical properties and high electrochemical properties were obtained by nitric acid (HNO3) mediation. The –COO– groups on the SA network inside the hydrogel are partially acidified to –COOH under the action of HNO3, which increases the hydrogen bond density of the hydrogel. The PAM/SA hydrogel exhibited a maximum mechanical strength of 83.4 KPa and a maximum elongation at break of 471.3%. Furthermore, the conductivity (σ) of PAM/SA dual-network hydrogels increased from 36.48 mS cm−1 to 96.4 mS cm−1, and the specific capacitance of the flexible capacitor (FC) composed of the hydrogels increased by about 142.1%. Finally, the hydrogel was prepared as a wearable motion sensor, which is capable of accurately detecting the different motion states of a person. Consequently, the hydrogel has a multitude of applications in the field of FCs and wearable sensors.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2019
·
IF 3.973
Guanghui Hou,Junmin Qian,Weijun Xu,Tiantian Sun,Jinlei Wang,Yaping Wang,Aili Suo
The combination of chemotherapy and photothermal therapy is acknowledged as one of the most promising approaches in cancer treatment. Targeted delivery and controlled drug release are two important factors for combined chemo-photothermal therapy. In this study, a multifunctional nanoplatform based on gold nanorod (GNR) decorated with folate-conjugated poly(ethylene glycol)- b -poly(L-γ-glutamylhydrazine) (FEGGH) containing disulfide linker and dihydroxyphenyl groups was developed for targeted combined chemo-photothermal therapy of breast cancer. FEGGH was synthesized by ring-opening polymerization of γ-benzyl- l -glutamate -N- carboxyanhydride using folate/cystamine-heterobifunctionalized poly(ethylene glycol) as an initiator, following by hydrazinolysis and carbodiimide reactions. FEGGH was decorated onto GNR through Au-catechol bonds. Chemotherapeutic drug doxorubicin (DOX) was loaded onto the nanoplatform through pH-sensitive hydrazone linkage, obtaining final product FEGGH DOX -GNR. The DOX-loaded nanoplatform displayed excellent photostability and reduction/pH dual-responsive drug release behavior. Cytological studies demonstrated the effective internalization of FEGGH DOX -GNR into MCF-7 cells via folate-mediated endocytosis and additive therapeutic effect of combined photothermal-chemotherapy. These results indicate that our nanoplatform may be a promising strategy for targeted combined chemo-photothermal therapy of breast cancer.
研究领域:
纳米医学
·
癌症治疗
·
材料科学
·
聚合物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2015
·
IF 6.723
Zhanfeng Li,Ting Yang,Chunming Lin,Quanshun Li,Songfeng Liu,Fengzhi Xu,Hongyan Wang,Xuejun Cui
A facile sonochemical approach is designed to fabricate protein nanocapsules for hydrophilic drugs (HDs), and HD-loaded multifunctional bovine serum albumin (BSA) nanocapsules (MBNCs) have been prepared for the first time. The as-synthesized HD-loaded MBNCs have a satisfying size range and an excellent magnetic responsive ability. Moreover, high-dose hydrophilic drugs could be loaded into the MBNCs. As carriers, HD-loaded MBNCs also show attractive redox-responsive controlled release ability for hydrophilic drugs and could be internalized selectively by the tumor cells through the folate-mediated endocytosis.
研究领域:
药剂学
·
生物医学工程
·
纳米医学
✓ 已验证
DOI
PubMed
高影响因子
BIOMATERIALS
·
2011
·
IF 7.883
Feihu Wang,Dianrui Zhang,Qiang Zhang,Yuxuan Chen,Dandan Zheng,Leilei Hao,Cunxian Duan,Lejiao Jia,Guangpu Liu,Yue Liu
Multidrug resistance (MDR) in tumor cells is a significant obstacle for successful cancer chemotherapy. Overexpression of drug efflux transporters such as P-glycoprotein (P-gp) is a key factor contributing to the development of tumor drug resistance. Verapamil (VRP), a P-gp inhibitor, has been reported to be able to reverse completely the resistance caused by P-gp. For optimal synergy, the drug and inhibitor combination may need to be temporally colocalized in the tumor cells. Herein, we investigated the effectiveness of simultaneous and targeted delivery of anticancer drug, paclitaxel (PTX), along with VRP, using DOMC-FA micelles to overcome tumor drug resistance. The floate-functionalized dual agent loaded micelles resulted in the similar cytotoxicity to PTX-loaded micelles/free VRP combination and co-administration of two single-agent loaded micelles, which was higher than that of PTX-loaded micelles. Enhanced therapeutic efficacy of dual agent micelles could be ascribe to increased accumulation of PTX in drug-resistant tumor cells. We suggest that the synergistic effect of folate receptor-mediated internalization and VRP-mediated overcoming MDR could be beneficial in treatment of MDR solid tumors by targeting delivery of micellar PTX into tumor cells. As a result, the difunctional micelle systems is a very promising approach to overcome tumor drug resistance.
研究领域:
药学科学
·
肿瘤学
·
药物递送系统
·
癌症治疗
✓ 已验证
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Jing Feng,Yiting Liu,Xiaoran Zheng,Min Gao,Li Wang,Lígia R. Rodrigues,Yuting Wen,Hangcheng Pan,Gege Li,Longjiang Zhang,Bing Wan,Yunlei Zhang
The efficacy of cancer therapies is significantly compromised by the immunosuppressive tumor milieu. Herein, we introduce a previously unidentified therapeutic strategy that harnesses the synergistic potential of chitosan-coated bacterial vesicles and a targeted chemotherapeutic agent to activate dendritic cells, thereby reshaping the immunosuppressive milieu for enhanced cancer therapy. Our study focuses on the protein-mediated modification of bacterium-derived minicells with chitosan molecules, facilitating the precise delivery of Doxorubicin to tumor sites guided by folate-mediated homing cues. These engineered minicells demonstrate remarkable specificity in targeting lung carcinomas, triggering immunogenic cell death and releasing tumor antigens and damage-associated molecular patterns, including calreticulin and high mobility group box 1. Additionally, the chitosan coating, coupled with bacterial DNA from the minicells, initiates the generation of reactive oxygen species and mitochondrial DNA release. These orchestrated events culminate in dendritic cell maturation via activation of the stimulator of interferon genes signaling pathway, resulting in the recruitment of CD4 + and CD8 + cytotoxic T cells and the secretion of interferon-β, interferon-γ, and interleukin-12. Consequently, this integrated approach disrupts the immunosuppressive tumor microenvironment, impeding tumor progression. By leveraging bacterial vesicles as potent dendritic cell activators, our strategy presents a promising paradigm for synergistic cancer treatment, seamlessly integrating chemotherapy and immunotherapy.
研究领域:
癌症治疗
·
免疫疗法
·
生物医学工程
·
药理学
·
分子生物学
·
细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）