RSC Advances
·
2014
·Vol. 4
·期 93
·51696-51702
·
IF 3.708
Jingwen Zhao,Shichao Jiang,Reila Zheng,Xin Zhao,Xinliang Chen,Cunyi Fan,Wenguo Cui
A smart and stable electrospun fibrous drug carrier was fabricated to release an incorporated drug in response to the local presence of acid and to provide a favourable micro-environment for tissue regeneration. To fabricate the electrospun fibrous scaffolds responsive to the local pH variation, sodium bicarbonate, a component of acid response, was facilely incorporated into drug-loaded electrospun fibers by co-electrospinning. The analysis of X-ray photoelectron spectroscopy, Fourier-transform infrared spectrometry, X-ray diffraction, Differential scanning calorimetry and water contact angles demonstrated that the sodium bicarbonate was successfully incorporated into the electrospun fibers. The in vitro drug release results showed that the release rate of an anti-cancer drug 5-fluorouracil in an acidic environment from the electrospun fibrous scaffolds was proportional to the concentration of sodium bicarbonate, and the structure of the electrospun fibrous scaffolds was well maintained before and after the drug release. The acid-responsive release of 5-fluorouracil for a short time was found to effectively inhibit osteosarcoma cell growth, and the electrospun fibrous scaffolds with long-term stability supported fibroblast adhesion and proliferation, indicating the potential for subsequent tissue regeneration.
研究领域:
生物材料学
·
肿瘤学
·
药剂学
✓ 已验证
DOI
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
·
2014
·
IF 4.245
Zheng Wang,Chao Chen,Qi Zhang,Min Gao,Ju Zhang,Deling Kong,Yanjun Zhao
To precisely manipulate the intracellular delivery of pleiotropic curcumin , this work reports two types of acid-responsive polymer–curcumin conjugates with different structures. One or two amphiphilic poly(ethylene glycol)-co-poly(lactic acid) (PEG-PLA) copolymer(s) were linked to curcumin via pH-liable hydrazone, producing a linear or phospholipid-like conjugate, respectively. Both conjugates efficiently self-assembled into micellar nanocarriers with enhanced stability in contrast to the paralleling PEG-PLA micelles. In comparison to the micelles assembled by phospholipid-like conjugates, the linear conjugate micelles exhibited similar size, doubled loading dose, higher release rate, and hence enhanced cellular uptake and cytotoxicity at the cost of increased critical micelle concentration. This work highlighted the importance of precise tuning of polymer–drug conjugate architecture in determining the pharmaceutical properties and thus delivery efficiency of the corresponding conjugate micelles.
研究领域:
药剂学
·
生物医学工程
·
高分子化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2020
·
IF 6.785
Yanjing Yang,Yao He,Zhiwei Deng,Jiacheng Li,Jin Huang,Shian Zhong
The design of an intelligent nanoprobe capable of intracellular controlled release of apoptosis inducers and subsequent high-fidelity imaging of the drug-induced apoptosis is highly desirable for precise cancer treatment. Herein, we report an intelligent nanoprobe that combined therapeutic and imaging functions in one agent. Briefly, a gold nanoparticle is designed to be conjugated with acid-responsive DNA duplexes (Dox intercalates in this region) and caspase-3-specific cleavable peptides (labeled with fluorophore). We demonstrated that the nanoprobe could efficiently deliver an anticancer drug (Dox) into cancer cells and achieve acid-responsive drug release. Furthermore, the apoptotic process was in situ-monitored by detection of fluorescence through the cleavage of the peptide linker by caspase-3, which is one of the executioner caspases involved in apoptosis. This newly developed nanoprobe could serve as a theranostic agent for targeted responsive chemotherapy and also provide feedback apoptosis imaging of the self-therapeutic effect.
研究领域:
生物医学工程
·
分子生物学
·
纳米医学
✓ 已验证
DOI
PubMed
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2016
·Vol. 17
·期 3
·1600227
·
IF 3.68
Chunran Wang,Jinze Wang,Xiaofei Chen,Xu Zheng,Zhigang Xie,Li Chen,Xuesi Chen
Herein, a kind of dual acid-sensitive nanoparticles based on monomethoxy poly(ethylene glycol)-imine-β-cyclodextrin is constructed by a facile phenylboronic acid-cross-linked way. The data of dynamic light scattering and transmission electron microscope reveal the cross-linked nanoparticles have improved stability. The cross-linked nanoparticles could easily self-assemble and load the anticancer drug at neutral pH condition. However, when the drug-loaded nanoparticles are delivered to extracellular tumor sites (pH ≈6.8), the surface of the nanoparticles would be amino positively charged and easily internalized by tumor cell due to the cleavage of the acid-labile benzoic–imine. Subsequently, with the acidity in subcellular compartments significantly increasing (such as the endosome pH ≈5.3), the loaded drug would fast release from the endocytosis carriers due to the hydrolysis of boronate ester. These features suggest that these dual acid-sensitive cross-linked nanoparticles not only possess excellent biocompatibility but also can efficiently load and deliver anticancer drug into tumor cells to enhance the inhibition of cellular proliferation, outlining a favorable platform as drug carriers.
研究领域:
药剂学
·
肿瘤学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Zhiting Yang,Jiahua Tang,Yan Zhang,Xianzhi Hu,Futing Zi,Yue Lin,Jin Wu
Acid mine drainage (AMD) is a persistent and challenging environmental pollution problem. The consequences of AMD include soil pollution, biodiversity loss, and ecosystem collapse. Our study found that rhodamine B acylhydrazone (RBA) exhibits high sensitivity to Fe3+ and can be used as a corrosion inhibitor. This finding led us to hypothesize that the application of RBA is an effective strategy for constructing self-warning and self-healing integrated pH-responsive mercaptopropyl trimethoxysilane (PeopS-SH) coatings. We herein successfully prepared RBA-loaded mesoporous silica nanoparticles (MSN@RBA) designed to exhibit localized, acid-responsive behavior to avoid oxidation site diffusion and enhance wound healing. These MSN@RBA were sensitive to acidic environments, triggering the rapid release of RBA. The experiments showed that MSN@RBA effectively inhibited the oxidation rate of pyrite and enhanced the long-term passivation effect of the coating. Our findings further demonstrated that MSN@RBA reduced the corrosion current density (0.17 μA cm−2), increased the corrosion potential (335 mV), and improved the thickness and density of the coating. The results of release experiments, electrochemical tests and chemical leaching indicate that MSN@RBA releases RBA in acidic environments, and its spironolactam structure opens and forms a complex with Fe3+. The damaged site is fluorescently labeled and repaired. In conclusion, this acid-responsive nanoparticle system presents a new strategy for the treatment of tailings in harsh environments for a long time.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Biomaterials Science
·
2025
·
IF 5.7
Xinyu Wang,Qingbin He,Lining Wang,Chengzhilin Li,Wenyu Zhang,Zhonghou Rong,Qingqing Yin,Yingchun Zhao
Sepsis, an inflammatory disease caused by bacterial infection, has become a global public health crisis. Excessive reactive oxygen species (ROS) in sepsis patients act as the primary trigger for activating intracellular immune pathways, ultimately leading to multiple organ dysfunction syndrome. The overexpression of acidic metabolites and ROS, characteristic of the infected microenvironment, significantly impedes sepsis treatment. Cyclic GMP-AMP synthase (cGAS), a cytosolic DNA sensor, plays a key role in inflammatory diseases. The detrimental effects of STING in sepsis have been well documented. Here, we developed a pH-responsive nanotherapy platform (DMSNM@C-178/PAA) that combines ROS scavenging with cGAS-STING pathway inhibition for anti-inflammatory therapy. This nanoparticle is selectively released in the infected microenvironment, where reduced molybdenum-based polyoxometalates (Mo-POM) efficiently neutralize toxic ROS in vivo, while C-178 selectively inhibits the cGAS-STING pathway, thereby attenuating the inflammatory response and preventing organ deterioration. In vitro and in vivo studies demonstrate that DMSNM@C-178/PAA treats sepsis by eliminating excess ROS and modulating autoimmune dysfunction via the cGAS-STING pathway, providing a novel therapeutic strategy for sepsis management.
研究领域:
医学
·
免疫学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2022
·Vol. 10
·期 44
·9266-9279
·
IF 7.571
Zhihao Guo,Junhui Sui,Yumei Li,Qinchuan Wei,Cailing Wei,Linyun Xiu,Ruohua Zhu,Yong Sun,Jianshe Hu,Ji-Liang Li
Nanotechnology-mediated drug delivery systems suffer from insufficient retention in tumor tissues and unreliable drug release at specific target sites. Herein, we developed an epidermal growth factor receptor-targeted multifunctional micellar nanoplatform (GE11-DOX+CEL-M) by encapsulating celecoxib into polymeric micelles based on the conjugate of GE11-poly(ethylene glycol)-b-poly(trimethylene carbonate) with doxorubicin to suppress tumor growth and metastasis. The polymeric micelles maintained stable nanostructures under physiological conditions but quickly disintegrated in a weakly acidic environment, which is conducive to controlled drug release. Importantly, GE11-DOX+CEL-M micelles effectively delivered the drug combination to tumor sites and enhanced tumor cell uptake through GE11-mediated active tumor targeting. Subsequently, GE11-DOX+CEL-M micelles dissociated in response to intracellular slightly acidic microenvironmental stimuli, resulting in rapid release of celecoxib and doxorubicin to synergistically inhibit the proliferation and migration of tumor cells. Systemic administration of GE11-DOX+CEL-M micelles into mice bearing subcutaneous 4T1 tumor models resulted in higher tumor growth suppression and decreased lung metastasis of tumor cells compared with micelles without GE11 decoration or delivering only doxorubicin. Furthermore, the micelles effectively reduced the systemic toxicity of the chemotherapy drugs. This nanotherapeutic system provides a promising strategy for safe and effective cancer therapy.
研究领域:
纳米医学
·
肿瘤学
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2025
·
IF 9.6
Xingjun Zhao,Jiaxin Li,Peng Zhang,Chunsheng Xiao,Li Chen
Diseases caused by bacterial infections place a significant burden on global public health. Sonodynamic therapy (SDT), as an emerging antibacterial treatment, faces clinical challenges due to the non-polar nature of most sonosensitizers. To address this, an acid-responsive zinc-porphyrin-based sonosensitizer (Zn-TCPP) is developed via a simple thermal reaction, which is then coated with phenylboronic acid-modified hyaluronic acid (B-HA), to fabricate B-HA@Zn-TCPP. While in the mildly acidic microenvironment mimicking an infected wound site, the released B-HA@Zn-TCPP achieves effective SDT activity. The disruption of the bacterial membrane and the levels of intracellular reactive oxygen species (ROS) verified that the inhibition rate can reach 99% within 5 min, without any development of resistance after 15 consecutive generations of culture. Additionally, under ultrasound (US) -mediated cavitation, B-HA@Zn-TCPP exhibits excellent penetration into biofilms, achieving a 90.04% bactericidal rate for bacteria within biofilms. In vivo studies further demonstrated that B-HA@Zn-TCPP can effectively accelerate the healing of bacterial infected wounds with a wound healing rate of 98.65% within 9 days. Therefore, B-HA@Zn-TCPP as a novel sonosensitizer offers a viable strategy to overcome the limitations of traditional sonosensitizers for the bacterial wound infections.
研究领域:
医学
·
药学
·
生物材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2021
·
IF 3.882
Gaihuan Ren,Bo Li,Lulu Ren,Wenwen Di,Lulu Tian,Pan Zhang,Weili Shao,Jianxin He,Dejun Sun
Acid-responsive nonaqueous (glycerol in n-decane) Pickering emulsions were prepared using preferentially oil-wetted dynamic covalent silica (SiO2–pDB) nanoparticles as the Pickering emulsifiers. The acid-responsive Pickering emulsifier SiO2–pDB was prepared based on a Schiff base reaction between amino silica (SiO2–NH2) and p-decanoxybenzaldehyde (pDBA). The formation of SiO2–pDB was characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, and elemental analysis. The preferentially oil-wetted character of SiO2–pDB was indicated by contact angle measurement. Stable nonaqueous Pickering emulsions were prepared using preferentially oil-wetted SiO2–pDB as the Pickering emulsifier. However, after adjusting the nonaqueous Pickering emulsions to an acidic environment, complete phase separation occurred. In the acidic environment, preferentially oil-wetted SiO2–pDB decomposed into hydrophilic SiO2–NH2 and hydrophobic pDBA due to the decomposition of the dynamic imine bond in the SiO2–pDB. Then, the hydrophilic SiO2–NH2 and hydrophobic pDBA desorbed from the two-phase interface, resulting in complete phase separation of the initially stable nonaqueous Pickering emulsions. The acid-responsive nonaqueous Pickering emulsions show great potential in application in water sensitive systems, such as oil-based drilling fluids.
研究领域:
材料科学
·
化学工程
·
界面科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2015
·Vol. 4
·期 1
·104-114
·
IF 3.831
Chunran Wang,Xiaofei Chen,Xuemei Yao,Li Chen,Xuesi Chen
Considering the specific pH gradients of tumour microenvironments, a dual acid-responsive drug delivery system, which can respond to the tumor extracellular and intercellular pH stimuli, has been fabricated via simple host–guest recognition. Firstly, we synthesise 2,4,6-trimethoxybenzaldehyde modified dextran (Dex-TMBA) and mPEG-imine-β-cyclodextrin (PIC), respectively. And then, through the host–guest recognition between the cyclodextrin (CD) of PIC and the benzene ring of Dex-TMBA, a kind of dual acid-responsive supramolecular drug delivery system can be fabricated. Under neutral pH conditions, anticancer drugs can be loaded by forming supramolecular nanoparticles via the host–guest recognition. While, at tumor extracellular pH (∼6.8), the acid-labile benzoic–imine of PIC cleaves and the nanoparticles are amino positively charged to facilitate cell internalization. Subsequently, due to the hydrolysis of acetal bonds in Dex-TMBA under significantly increased acidity in subcellular compartments such as the endosomes (∼5.3), the loaded doxorubicin releases from the endocytosed drug delivery. This dual acid-responsive nanoparticles can efficiently load and release drugs, acting as drug delivery systems for enhancing anticancer efficiency.
研究领域:
药剂学
·
生物医学工程
·
肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2024
·
IF 6.5
Qiang Liu,Hao Li,Ling Kong,Yiming Du,Yunsheng Da,Zhouping Sun,Yong Dong,Yanyan Liu,Xingyou Tian,Hua Wang
Waterborne epoxy (EP) is considered a promising environmentally friendly anticorrosive technology with extensive potential applications. However, its limited anticorrosive ability poses significant challenges in practical usage. In this study, we use dopamine (DA) polymerization to load 2-mercaptobenzimidazole (MBI) onto the surface of g-C 3 N 4 (CN) nanosheets, resulting in the synthesis of MBI-PDA@g-C 3 N 4 (MBI-PDA@CN) nanosheet composites. The MBI-PDA@CN composite exhibits favorable hydrophilicity and high loading capacity of 35.8 %, enabling the formation of compact bonding layer at the interface with the EP. Simultaneously, the MBI-PDA@CN nanosheets exhibit a fully lamellar structure, thereby effectively impeding the infiltration of corrosive agents. Electrochemical tests show that the coating resistance ( R p ) of MBI-PDA@CN/EP coating (8.5 × 10 7 Ω cm 2 ) exhibited a significantly higher magnitude compared to that of the EP (2.6 × 10 6 Ω cm 2 ) after being immersed in 3.5 wt% NaCl solution for 30 days. It is worth mentioning that the MBI-PDA@CN nanosheets possess the capability to gradually release MBI-PDA molecules in acidic environments. Given that MBI and PDA function as outstanding metal corrosion inhibitors, they substantially augment the corrosion resistance of the coating in acidic conditions. This study presents an intriguing approach to fabricating robust corrosion-resistant composite coatings.
研究领域:
材料科学
·
腐蚀与防护
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
APPLIED CLAY SCIENCE
·
2020
·
IF 4.605
Xuteng Xing,Dan Zhou,Erjun Tang,Shaojie Liu,Xiaomeng Chu,Xiaodong Xu,Yongquan Xu
The natural halloysite nanotubes were used as the nanocontainer to load Na 2 MoO 4 corrosion inhibitor , and the release rate of Na 2 MoO 4 was further controlled by wrapped with the CaMoO 4 end stopper through adding with Ca 2+ . The variable release rates were fulfilled by the formation of CaMoO 4 end stopper with different strength, and the release time can be adjusted from one to dozens of hours. Moreover, the prepared complex corrosion inhibitor is also an acid-responsive smart material, which can quickly release the large amount of corrosion inhibitors under acidic conditions through the decomposition of insoluble CaMoO 4 complex on the surface or end of halloysite. In addition, the epoxy coating mixed with 10 wt% Ca 2+ treated Na 2 MoO 4 loaded halloysite can provide the highest corrosion resistance and sustained release of the corrosion inhibitor to achieve corrosion healing in the coating defects.
研究领域:
材料科学
·
腐蚀与防护
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）