JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
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2024
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IF 3.3
Kaihua Liu,Zhijie Liu,Junjian Miao,Yiqun Huang,Keqiang Lai
BACKGROUND N ε-carboxymethyllysine (CML), N ε-carboxyethyllysine (CEL) and α -aminoadipic acid (AAA) are important foodborne hazards and their intake can cause a variety of diseases in humans. It is extremely important to investigate the formation mechanism of CML, CEL and AAA, as well as their association with each other when aiming to control their production. RESULTS A multi-response kinetic model was developed within the glucose-lysine Maillard reaction model system. The concentrations of glucose, lysine, glyoxal (GO), methylglyoxal (MGO), CML, CEL and AAA were quantified at different temperature (100–160 °C) and at different intervals (0–60 min). The experimental data were fitted to the proposed model to calculate kinetic parameters for the corresponding steps. The results indicated that the production of CML was primarily relied on the direct oxidative cleavage of the Amadori product, rather than the reaction between GO and Lys, whereas CEL and AAA were generated through the reaction of MGO with Lys. Significantly, the reaction between α -dicarbonyl compounds and Lys preferentially generated CML and CEL, resulting in the lower concentrations of AAA compared to CML and CEL. CONCLUSION The multi-response kinetic model developed in the present study can be applied well to the Maillard reaction. The relationship between the formation mechanisms of CML, CEL and AAA is also explained. © 2024 Society of Chemical Industry.
研究领域:
食品科学
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生物化学
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DOI
PubMed
高影响因子
Journal of Energy Storage
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2024
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IF 8.9
Shan Zhong,Longyun Dai,Hao Xu,Xin-Chun Yang,Xiaojun Zheng,Shuang Wang
To address the extensive demand for energy storage, the development of unique carbon-based supercapacitors represents a viable solution. We successfully synthesize the unique boron (B), nitrogen (N)-containing porous carbon (denoted as BNPC) from reed biomass through one-step boric acid templated carbonization method, which are used as high-performance carbon electrode for electric double-layer capacitor (EDLC). By the synergistic effects of boric acid template and N-rich melamine , a well-balanced micro‐/meso-porous structure and abundant N and oxygen (O) heteroatoms within BNPC are readily obtained, exhibiting an ultrahigh specific surface area of 2619 m 2 ·g −1 . These distinctive natures endow BNPC electrode with the excellent capacitive behaviors, affording an outstanding specific capacitance of 396.8 F·g −1 at a three-electrode (3E) system with KOH electrolyte. Density functional theory (DFT) method is utilized to further clarify the interaction mechanism between K and designed graphene with various N configurations, revealing the significant roles of Pyridinc-N and Graphitic-N. The two-electrode (2E) symmetric supercapacitor assembled by BNPC electrodes in TEABF 4 electrolyte demonstrates an extremely high energy density of 51.82 Wh·kg −1 at a power density of 375 W·kg −1 and great capacitance retention of 91 % after 6000 cycles. This reed-derived highly porous carbons display superior electrochemical performance, making it the ideal candidates for large capacity supercapacitors in practice.
研究领域:
材料科学
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能源存储
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Jiahui Gong,Mengfei Tian,Mengying Zhang,Xiaolong Yang,Yujiao Song,Hongying Ge,Wenxue Sun,Chunying Li,Chunjian Zhao
In this study, a novel polydopamine modified carboxymethyl chitosan molecularly imprinted resin (CMCS-MIR) was synthetized for selectively adsorbed and separated epicatechin (EC) from Rumex acetosa L. The preparation process involved modifying the surface of DM-130 resin to form the polydopamine (PDA) layer firstly, which facilitated an increase in adsorption sites. Subsequently, carboxymethyl chitosan (CMCS), a green functional monomer, was utilized along with glutaraldehyde as a crosslinking agent and EC as a template molecule to synthesize the CMCS-MIR. The synthesized CMCS-MIR exhibited an adsorption capacity of 53.30 mg·g −1 within 6 h and exhibited excellent selectivity and affinity towards EC (IF = 3.31). Moreover, the CMCS-MIR maintained stable adsorption performance and reusability with the adsorption efficiency remaining above 90 % in the fifth cycle. What's more, the CMCS-MIR can be used as a novel column filler in solid-phase extraction (SPE) to separate EC from extracts of Rumex acetosa L. roots. The adsorption recovery rate of EC is 89.56 %, the desorption recovery rate reaches 88.02 %. The DFT simulation and NMR experiments indicated that the predominant adsorption mechanism was due to the strong hydrogen bonding interactions. This work offers significant insights into the development of green molecularly imprinted materials with excellent selectivity and recognition capabilities.
研究领域:
材料科学
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分析化学
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天然产物化学
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吸附分离技术
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DOI
PubMed
高影响因子
MATERIALS & DESIGN
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2015
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IF 3.501
Xuan Zhang,Yingqi Chen,Huili Lei,Sheng Zhao,Fei Han,Xia Xiang,Yuancong Zhao,Nan Huang,Guojiang Wan
Titanium dioxide film has received a great deal of attention, because of its excellent potentials and implications, in a variety of fields. Practically, the film is required to be well mechanically blended with the substrate (e.g. good compliance or flexibility) together with its surface properties to accomplish multiple functions. In this work, phytic acid (PA) layer template-assisted deposition of thin TiO 2 film was implemented on titanium substrate to produce a good combination of surface properties and bending strength . Relatively smooth, homogenous and thin (ca. 800 nm) anatase TiO 2 films were obtained on the PA pre-templated Ti substrate. Significantly enhanced photoluminescence was observed on the PA template-deposited TiO 2 as compared to the direct deposited TiO 2 . This is correlated with its higher carrier density in the space charge layer as disclosed by the Mott–Schottky investigation. Likewise, the prepared TiO 2 films are super-hydrophilic (with water contact angle less than 5°), which is credited to the higher polar contribution of surface energy. Moreover, the PA template-deposited TiO 2 film withstood plastic deformation up to 180° angle bending without failure. This template-assisted deposition of TiO 2 film via surface-immobilized organic layer on rigid substrate suggests a promising route to enhance both its mechanical and physical performances.
研究领域:
材料科学
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表面工程
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产品关联
DOI
高影响因子
Nanoscale
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2025
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IF 5.1
Wenjing Wang,Shuo Wang,Shengyao Xu,Rong Chai,Jun Yuan,Hao Zhang,Yaqi Li,Xiaohui Pu,Xin Li,Jin Sun,Zhonggui He,Bingjun Sun
The self-assembly prodrugs usually consist of drug modules, activation modules, and assembly modules. The selection of suitable modules to construct prodrug nanoassemblies with self-assembly stability and intelligent activation is still a challenge. As a common assembly module, oleic acid can provide a driving force and steric hindrance for prodrugs self-assembly. However, unsaturated double bond of oleic acid is easily oxidized to affect its chemical stability. Herein, two docetaxel (DTX) prodrugs were designed using disulfide bonds as activation modules and two different fatty acids (isostearic acid and oleic acid) as assembly modules, respectively. Compared with oleic acid, isostearic acid has the advantage of higher chemical stability. At the same time, the terminal propyl structure of isostearic acid makes up for the steric hindrance without double bond. Overall, this structural deformation improved the self-assembly ability and chemical stability of the prodrug nanoassemblies, thus balancing the effectiveness and safety of the prodrugs. Our findings reveal the importance of the assembly modules and provide a guidance for the rational design of prodrug nanoassemblies.
研究领域:
药学
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纳米医学
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肿瘤治疗
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DOI
PubMed
高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
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2023
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IF 5.2
Yixuan Zheng,Weiwei Ning,Quanhua Wang,Xueling Wei,Xingyang Li,Meng Pan
Hierarchical ZSM-5 was successfully prepared using l -carnitine and l -lysine as mesoporous templates, and the influence of the dosage of “secondary template” represented by l -carnitine on the formation of hierarchical zeolite was investigated in detail. Powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), nitrogen adsorption-desorption, nuclear magnetic resonance (NMR), thermogravimetric-derivative thermogravimetry (TG-DTG), pyridine infrared and temperature programmed desorption of ammonia (NH 3 -TPD) were used to characterize the structural and textural properties of the as-prepared samples. The results showed that the hydrophilic property of the amino acid template overcame the phase separation and constructed a mesoporous system with an ultra-small size of 2–10 nm in the as-synthesized zeolite crystals. Not only the morphology and grain size, but also the Si/Al ratio and then the acidity of zeolite were affected by the “secondary template”. Catalytic cracking of triisopropylbenzene was chosen as a probe reaction so as to investigate the effect of the fabricated hierarchical porous system on the catalytic performances of the catalysts. The results showed that the introduction of hierarchical pores elevated the external surfaces of the catalyst and therefore significantly improved the catalytic cracking performance of the catalyst for the heavy molecules triisopropylbenzene. At the same time, the introduced mesopore structure also gave the macromolecule reactant a hierarchically cracking process because of the acid active sites located in the different spaces.
研究领域:
材料科学
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催化化学
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产品关联
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
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2024
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IF 7.1
Jiahui Gong,Mengfei Tian,Ying Liu,Yuting Zhang,Junhui Xing,Qi Liang,Xiaofei Xie,Chunying Li,Chunjian Zhao
In this work, a dual-responsive ionic liquid (DR-IL), namely, [C4mim][FeCl4] was developed for simultaneously extracting and separating hydrophilic phytochemicals, including epicatechin (EC), dihydroquercetin (DQ), ferulic acid (FA), and hydrophobic phytochemicals, such as emodin (ED), chrysophanol (CP), and physcion (PC), from roots of wild Rumex acetosa L. The [C4mim][FeCl4] demonstrates considerable potential for extracting and separating target phytochemicals through temperature adjustment and accelerated phase separation facilitated by a neodymium magnet. Meanwhile, a high recovery yield is obtained by adding a magnetic field. The overall extraction yield of target phytochemicals achieved by [C4mim][FeCl4] reaches 16.12 mg/g under the optimal extraction conditions, representing a 1.53–2.39-fold increase compared to conventional solvents. Furthermore, the molecular simulation and FT-IR analysis reveal that the synergistic effect of van der Waals forces and hydrogen bonds significantly contributed to the higher extraction yields of target phytochemicals.
研究领域:
植物化学
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分析化学
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药用植物研究
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产品关联
DOI
高影响因子
Science Bulletin
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2023
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IF 18.9
Xiaoyong Yue,Liguang Xu,Hengwei Lin,Chuanlai Xu,Si Li
Chiral nanomaterials with different functions have been widely developed, but the deep understanding of the structural effects of nanocatalysts on enantioselective photocatalytic efficiency is still highly demanded. Herein, Pt and Pt-Au-bimetal-doped chiral nanostructures with various morphologies and compositions are facilely constructed using L- / D- arginine ( L- / D- Arg) and mono-sulfonate tetraphenyl porphyrin (H 2 TPPS) assemblies as chiral templates. Interestingly, these Pt and Pt-Au-doped chiral nanostructures, including nanorods (NR) and nanospheres (NS), can be well regulated by controlling pH, ionic strength , and reaction time of the assembling system of Arg and H 2 TPPS. More impressively, specific Au growth direction along the Pt-doped chiral NR ( L- / D- Pt-NR) is observed (from tip to middle) during the preparation of Pt-Au-bimetal-doped chiral NR ( L- / D- Pt-Au-NR) and their compositions can be finely controlled by simply adjusting the concentrations of HAuCl 4 . As expected, the chiral nanostructures exhibit superior enantioselective photocatalytic ability toward chiral organics under visible light: the oxidation rate of L- dihydroxy-phenylalanine ( L- DOPA) catalyzed by L- Pt-NR (or D- DOPA catalyzed by D- Pt-NR) is about 60% higher than that of L- DOPA catalyzed by D- Pt-NR (or L- DOPA catalyzed by D- Pt-NR). This study provides a facile strategy to construct chiral nanostructures for the photocatalytic conversion of chiral organics.
研究领域:
材料科学
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化学工程
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生物化学
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产品关联
DOI
PubMed
高影响因子
BIOCHEMICAL ENGINEERING JOURNAL
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2016
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IF 2.463
Jing Gao,Hao Yu,Liya Zhou,Ying He,Li Ma,Yanjun Jiang
Tannic-acid-templated magnetic mesoporous silica nanoparticles (TA-MMSNs) were synthesized for the first time. The TA-MMSNs were monodisperse spherical particles with a diameter of around 250 nm and a magnetization saturation value of 35.26 emu/g. The specific surface area of TA-MMSNs was 423.4 m 2 /g, and the diameter and cumulative volume of the pores were 9.349 nm and 1.071 cm 3 /g, respectively. The TA-MMSNs were used to prepare immobilized NHase (CLNHAs@TA-MMSNs) by forming cross-linked nitrile hydratase aggregates (CLNHAs) in pores of TA-MMSNs using glutaraldehyde as a cross-linker. CLNHAs@TA-MMSNs and free NHase had the same optimum pH (pH 7), and the optimum temperature of CLNHAs@TA-MMSNs (40 °C) was higher than that of free NHase (30 °C). Compared with free NHase, CLNHAs@TA-MMSNs exhibited improved thermal, pH, mechanical and storage stability. Furthermore, CLNHAs@TA-MMSNs was applied in production of nicotinamide, and yield of nicotinamide could reach more than 98%. The tolerance of CLNHAs@TA-MMSNs to high concentration of substrate was better than that of free NHase, and yield of nicotinamide could still reach 29.74% after seven cycles of reaction. The kinetic parameters were investigated and the results indicated a lower substrate affinity and catalytic efficiency of CLNHAs@TA-MMSNs in comparison with free NHase. This work demonstrated that TA-MMSNs could be efficiently employed as supports for enzyme immobilization.
研究领域:
生物化学
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材料科学
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酶工程
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产品关联
DOI
高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
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2024
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IF 3.3
Chen-Yang Zhang,Yu-Rong Guo,Tian-Yu Hou,Qian-Ru Ning,Wan-Yu Han,Xing-Yun Zhao,Feng Cui,He Li
BACKGROUND Advanced glycation end products (AGEs) are compounds formed by non-enzymatic processes in the Maillard reaction and can cause various chronic diseases. This study explores the AGE formation process in a glucose–amino acid system under both wet- and dry-heating conditions, and analyzes the effect of cysteine in AGE formation. RESULTS Under wet-heating conditions, N ε -carboxymethyllysine (CML) and N ε -carboxyethyllysine (CEL) concentrations rose for the initial 90 min and subsequently declined after 120 min; after 90 min of heating, the maximum yields in the absence of cysteine were 1151.04 ± 14.01 and 3386.90 ± 26.55 ng mL −1 , respectively. The concentration of pyrraline (Pyr) increased after 30 min and then decreased after 60 min with a maximum yield of 777.68 ± 23.36 ng mL −1 . However, in dry-heating models, the AGE concentrations consistently increased with increasing heating time; the maximum yields for CML, CEL and Pyr were 468.66 ± 10.96, 1993.57 ± 14.81 and 1085.74 ± 58.06 ng mL −1 , respectively. The addition of cysteine showed an inhibitory effect on AGE formation, especially for Pyr in the dry-heating model, with inhibition rates ranging from 17.14% to 95.60%. CONCLUSION Although wet-heating models produced more CML and CEL, they produced less Pyr than dry-heating models. The AGE formation in wet-heating models positively correlated with the reaction rate; however, the dry-heating reaction demonstrated a more complex relationship between reaction rate and reaction protocol. Moreover, cysteine exhibited a significant inhibitory effect on AGE production, and the degree of inhibition was proportional to the cysteine concentration. This study provides important insights into the mechanisms for AGE formation under various heating conditions, such as those representing baking (dry-heating) and steaming conditions (wet-heating). © 2024 Society of Chemical Industry.
研究领域:
食品科学
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生物化学
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医学
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产品关联
DOI
PubMed
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2023
·
IF 8.1
Yuanyuan Wang,Maofeng Dong,Limin Guo,Yamin Zhu,Qingqing Jiang,Jianbo Xiao,Mingfu Wang,Yueliang Zhao
Harman and norharman were the most abundant β-carboline-type heterocyclic amines (HCAs) detected in various foodstuffs. Unsaturated fatty acids in foods may undergo rapid oxidative deterioration during transportation, storage and heat treatment, forming reactive carbonyl species (RCS). This work studied the effects of acrolein, a highly reactive RCS, on the formation of harman and norharman in the tryptophan model system. Results showed that 0.005, 0.01, 0.015, 0.02, 0.05, 0.1 and 0.2 mmol of acrolein led to harman production increased by 528 %, 752 %, 981 %, 1172 %, 1375 %, 1288 % and 768 % respectively, and led to norharman formation increased by 116 %, 129 %, 152 %, 169 %, and 197 %, 185 % and 157 %, respectively. Furthermore, acrolein addition reduced the residue of tryptophan (up to 63.19 %), but increased the level of the intermediates including formaldehyde (up to 352 %), acetaldehyde (up to 491 %), (1S,3S)-1-Methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (MTCA, up to 1936 %), and 1,2,3,4-tetrahydro-β-carboline-3-carboxylicacid (THCA, up to 2142 %) in the tryptophan model system. Acrolein might react with tryptophan, harman and norharman to eliminate them directly. These data suggested that acrolein may contribute to harman and norharman formation through participating in the above complex chemical reactions. In addition, the content of harman and norharman produced in roast beef patties made of minced beef oxidized for 2, 4, 6, 8, and 10 days increased by 118 %, 188 %, 267 %, 137 %, and 48 %, respectively, and led to norharman formation increased by 140 %, 132 %, 90 %, 86 %, and 74 %, respectively compared with those made of fresh minced beef, which further illustrated that lipid oxidation products potentially contributed to harman and norharman formation.
研究领域:
食品科学
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化学毒理学
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营养学
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2023
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IF 5.2
Man Zheng,Jiaxian Liu,Kun Shi,Yuxin Zhao,Tong Zhang,Fangxun Liu,Yidan Chen,Yuena Sun,Yufan Zhang,Huan Wang
In this study, we successfully prepared CH-CNT@Fe-Co-Pt x by combining chiral helical nanostructure , high conductivity, high electro-catalytic activity of iron-cobalt transition metals and precious platinum. The material used C 18 - L -Clu as the soft template, polypyrrole as the carbon source and nitrogen source. The precursor cobalt iron ions were then loaded onto the chiral amino acid template. Using the displacement reaction, a spot of platinum metal was successfully introduced into the composite to obtain CH-CNT@Fe-Co-Pt x composite material. According to the reaction mechanism steps of OER/ORR in alkaline solution, Fe-Co-Pt as the active site adsorbed OH - in OER and adsorbed H 2 O molecules in ORR. The tafer slope of OER and ORR for catalyst CH-CNT@Fe-Co-Pt 2 reached 35.0 mV dec −1 and 60.8 mV dec −1 , respectively. And the current density of H-CNT@Fe-Co-Pt 2 retained 84% and 91.5 % respectively after a long time i-t test. Moreover, the number of transferred electrons of CH-CNT@Fe-Co-Pt 2 in the ORR reaction reaches 3.90. This work provides new ideas for the research of chiral carbon nanomaterials in the field of electro-catalytic energy, and provides a new method for the development of efficient and low-cost energy electro-catalysts.
研究领域:
材料科学
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电化学
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纳米技术
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能源材料
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）